Incidental Mutation 'IGL02741:Vmn1r73'
| ID |
305894 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r73
|
| Ensembl Gene |
ENSMUSG00000051687 |
| Gene Name |
vomeronasal 1 receptor 73 |
| Synonyms |
V1rg2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
IGL02741
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11490184-11491095 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 11490710 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 176
(V176A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153827
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055070]
[ENSMUST00000226516]
|
| AlphaFold |
Q8R293 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055070
AA Change: V176A
PolyPhen 2
Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000055353
Gene: ENSMUSG00000051687
AA Change: V176A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
301 |
7.5e-7 |
PFAM |
|
Pfam:V1R
|
32 |
297 |
1.9e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226516
AA Change: V176A
PolyPhen 2
Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A930004D18Rik |
T |
C |
2: 18,032,007 (GRCm39) |
Y37C |
unknown |
Het |
| Arhgap20 |
T |
A |
9: 51,759,945 (GRCm39) |
C599S |
probably benign |
Het |
| Bcl6b |
C |
A |
11: 70,119,942 (GRCm39) |
R15L |
probably damaging |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Dchs1 |
C |
T |
7: 105,406,530 (GRCm39) |
D2262N |
probably damaging |
Het |
| Dsg4 |
A |
G |
18: 20,604,553 (GRCm39) |
M1007V |
probably benign |
Het |
| Fgd6 |
A |
G |
10: 93,959,152 (GRCm39) |
K1032R |
possibly damaging |
Het |
| Fras1 |
T |
A |
5: 96,839,230 (GRCm39) |
M1583K |
probably benign |
Het |
| Gjc3 |
A |
T |
5: 137,955,726 (GRCm39) |
C186* |
probably null |
Het |
| Gm14496 |
A |
G |
2: 181,633,136 (GRCm39) |
R40G |
probably benign |
Het |
| Ibtk |
T |
C |
9: 85,608,665 (GRCm39) |
R416G |
probably damaging |
Het |
| Kcnc4 |
A |
G |
3: 107,355,294 (GRCm39) |
F385L |
probably damaging |
Het |
| Mapk8ip2 |
T |
C |
15: 89,341,700 (GRCm39) |
S304P |
probably damaging |
Het |
| Mbd6 |
A |
G |
10: 127,123,263 (GRCm39) |
|
probably null |
Het |
| Mroh2b |
T |
C |
15: 4,935,114 (GRCm39) |
F183S |
probably benign |
Het |
| Nrg1 |
T |
A |
8: 32,312,316 (GRCm39) |
T334S |
probably damaging |
Het |
| Pigw |
C |
T |
11: 84,769,192 (GRCm39) |
V46I |
probably benign |
Het |
| Pkdrej |
T |
C |
15: 85,701,631 (GRCm39) |
E1435G |
probably benign |
Het |
| Pkhd1 |
T |
C |
1: 20,290,253 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
T |
16: 15,570,590 (GRCm39) |
|
probably benign |
Het |
| Ptprd |
A |
T |
4: 76,051,521 (GRCm39) |
I247N |
probably damaging |
Het |
| Rfx1 |
A |
G |
8: 84,822,471 (GRCm39) |
Q923R |
possibly damaging |
Het |
| Rgs11 |
G |
A |
17: 26,426,605 (GRCm39) |
V279I |
probably benign |
Het |
| Rps6ka2 |
T |
A |
17: 7,563,415 (GRCm39) |
F608I |
probably benign |
Het |
| Slc13a1 |
A |
T |
6: 24,150,707 (GRCm39) |
|
probably null |
Het |
| Slc6a20b |
C |
T |
9: 123,436,667 (GRCm39) |
V249M |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,401,961 (GRCm39) |
I783V |
possibly damaging |
Het |
| Swap70 |
G |
T |
7: 109,873,856 (GRCm39) |
M401I |
probably benign |
Het |
| Tmco4 |
A |
T |
4: 138,757,188 (GRCm39) |
I407F |
probably damaging |
Het |
| Trpm4 |
T |
A |
7: 44,967,912 (GRCm39) |
S340C |
possibly damaging |
Het |
| Tsc2 |
T |
C |
17: 24,848,943 (GRCm39) |
E79G |
probably damaging |
Het |
| Ubr1 |
A |
C |
2: 120,771,572 (GRCm39) |
S439A |
probably benign |
Het |
| Vmn2r17 |
G |
A |
5: 109,568,077 (GRCm39) |
D67N |
probably benign |
Het |
| Wasf1 |
C |
T |
10: 40,806,705 (GRCm39) |
T116M |
probably damaging |
Het |
| Zkscan3 |
A |
T |
13: 21,578,164 (GRCm39) |
M241K |
probably benign |
Het |
|
| Other mutations in Vmn1r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01782:Vmn1r73
|
APN |
7 |
11,490,665 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02337:Vmn1r73
|
APN |
7 |
11,490,640 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02666:Vmn1r73
|
APN |
7 |
11,490,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02756:Vmn1r73
|
APN |
7 |
11,490,574 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03113:Vmn1r73
|
APN |
7 |
11,490,527 (GRCm39) |
missense |
probably benign |
|
|
IGL03195:Vmn1r73
|
APN |
7 |
11,491,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0023:Vmn1r73
|
UTSW |
7 |
11,490,997 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0379:Vmn1r73
|
UTSW |
7 |
11,490,773 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3941:Vmn1r73
|
UTSW |
7 |
11,490,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4224:Vmn1r73
|
UTSW |
7 |
11,490,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4631:Vmn1r73
|
UTSW |
7 |
11,490,758 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4912:Vmn1r73
|
UTSW |
7 |
11,490,596 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5060:Vmn1r73
|
UTSW |
7 |
11,490,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5450:Vmn1r73
|
UTSW |
7 |
11,490,376 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5609:Vmn1r73
|
UTSW |
7 |
11,490,591 (GRCm39) |
nonsense |
probably null |
|
|
R6059:Vmn1r73
|
UTSW |
7 |
11,490,538 (GRCm39) |
missense |
probably benign |
0.40 |
|
R6508:Vmn1r73
|
UTSW |
7 |
11,490,631 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6967:Vmn1r73
|
UTSW |
7 |
11,490,544 (GRCm39) |
nonsense |
probably null |
|
|
R7099:Vmn1r73
|
UTSW |
7 |
11,490,320 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7304:Vmn1r73
|
UTSW |
7 |
11,490,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7579:Vmn1r73
|
UTSW |
7 |
11,491,082 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7891:Vmn1r73
|
UTSW |
7 |
11,491,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8914:Vmn1r73
|
UTSW |
7 |
11,490,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9072:Vmn1r73
|
UTSW |
7 |
11,490,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9073:Vmn1r73
|
UTSW |
7 |
11,490,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9275:Vmn1r73
|
UTSW |
7 |
11,490,479 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9632:Vmn1r73
|
UTSW |
7 |
11,490,407 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9710:Vmn1r73
|
UTSW |
7 |
11,490,407 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1176:Vmn1r73
|
UTSW |
7 |
11,490,883 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2015-04-16 |
Incidental Mutation