Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02742:Tmem168'

305953

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem168

Ensembl Gene

ENSMUSG00000029569

Gene Name

transmembrane protein 168

Synonyms

5730526F17Rik, 8430437G11Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL02742

Quality Score

Status

Chromosome

Chromosomal Location

13580687-13608100 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13603262 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 35 (Y35C)

Ref Sequence

ENSEMBL: ENSMUSP00000031554 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031554] [ENSMUST00000149123]

AlphaFold

Q91VX9

Predicted Effect

probably benign
Transcript: ENSMUST00000031554
AA Change: Y35C

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000031554
Gene: ENSMUSG00000029569
AA Change: Y35C

Domain	Start	End	E-Value	Type
transmembrane domain	35	57	N/A	INTRINSIC
transmembrane domain	63	85	N/A	INTRINSIC
transmembrane domain	92	109	N/A	INTRINSIC
low complexity region	152	163	N/A	INTRINSIC
transmembrane domain	170	192	N/A	INTRINSIC
transmembrane domain	199	216	N/A	INTRINSIC
transmembrane domain	226	248	N/A	INTRINSIC
transmembrane domain	261	283	N/A	INTRINSIC
transmembrane domain	298	320	N/A	INTRINSIC
transmembrane domain	359	378	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127050

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138637

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140750

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146139

Predicted Effect

probably benign
Transcript: ENSMUST00000149123

SMART Domains

Protein: ENSMUSP00000145372
Gene: ENSMUSG00000029569

Domain	Start	End	E-Value	Type
SCOP:d1jxqa_	29	167	8e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155179

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad11	A	G	9: 104,095,625	T506A	probably damaging	Het
AI314180	A	G	4: 58,840,757	V667A	probably damaging	Het
Ankib1	A	C	5: 3,693,479	D845E	probably benign	Het
Atxn2	T	C	5: 121,781,336	V369A	possibly damaging	Het
Ccdc50	T	A	16: 27,406,784		probably benign	Het
Clec2g	A	G	6: 128,980,261	I61V	possibly damaging	Het
Col16a1	G	A	4: 130,061,379		probably benign	Het
Dapk2	A	G	9: 66,231,814	Y139C	probably damaging	Het
Fnip1	T	C	11: 54,493,351	L334P	probably damaging	Het
Igf1r	A	G	7: 68,189,991	E682G	possibly damaging	Het
Ints8	T	C	4: 11,241,627	E272G	possibly damaging	Het
Jph2	G	A	2: 163,375,779	P326S	probably damaging	Het
Krtap1-4	T	C	11: 99,583,114		probably benign	Het
Lrp5	A	G	19: 3,604,022	I1135T	probably damaging	Het
Lrrk1	A	G	7: 66,308,691	V320A	probably benign	Het
Myh6	A	C	14: 54,953,924	I820S	possibly damaging	Het
Napg	A	T	18: 62,986,248	T110S	probably damaging	Het
Nova1	G	A	12: 46,720,692	Q56*	probably null	Het
Phyhip	A	G	14: 70,461,927		probably null	Het
Pkd2l2	C	A	18: 34,416,917	S205*	probably null	Het
Ppp2r1a	G	T	17: 20,959,003	C101F	probably benign	Het
Serpinb3c	G	A	1: 107,273,142	R182*	probably null	Het
St18	A	C	1: 6,802,316		probably benign	Het
St6galnac4	C	T	2: 32,597,084	R264C	possibly damaging	Het
Tmem219	A	G	7: 126,897,048	L74P	probably damaging	Het
Trpc4	T	A	3: 54,299,246	N622K	probably damaging	Het
Trpm6	A	C	19: 18,830,012		probably benign	Het
Ttl	C	A	2: 129,066,293	F49L	possibly damaging	Het
Vmn1r123	A	T	7: 21,163,043	I287F	possibly damaging	Het
Vmn2r97	T	G	17: 18,929,170	I273M	probably damaging	Het
Wdr5	C	A	2: 27,520,425		probably benign	Het
Zcchc6	C	T	13: 59,816,342	D250N	probably damaging	Het
Zfp37	C	A	4: 62,192,311	C172F	possibly damaging	Het

Other mutations in Tmem168

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00786:Tmem168	APN	6	13602675	missense	probably benign	0.06
IGL01305:Tmem168	APN	6	13583046	missense	probably damaging	1.00
IGL01843:Tmem168	APN	6	13582941	missense	probably damaging	1.00
IGL02863:Tmem168	APN	6	13582918	missense	probably damaging	0.98
ANU22:Tmem168	UTSW	6	13583046	missense	probably damaging	1.00
R0193:Tmem168	UTSW	6	13583313	missense	possibly damaging	0.81
R0537:Tmem168	UTSW	6	13603361	missense	probably damaging	1.00
R0630:Tmem168	UTSW	6	13583065	missense	probably benign
R0890:Tmem168	UTSW	6	13603272	missense	probably damaging	1.00
R1416:Tmem168	UTSW	6	13591401	missense	probably damaging	0.96
R1900:Tmem168	UTSW	6	13583071	missense	probably benign	0.02
R3947:Tmem168	UTSW	6	13583052	missense	probably damaging	1.00
R4362:Tmem168	UTSW	6	13595073	missense	probably benign	0.31
R4620:Tmem168	UTSW	6	13594953	missense	probably benign	0.03
R5693:Tmem168	UTSW	6	13602321	missense	probably benign	0.01
R6142:Tmem168	UTSW	6	13591369	missense	probably benign
R6328:Tmem168	UTSW	6	13602711	missense	probably benign
R6438:Tmem168	UTSW	6	13602674	missense	probably benign	0.06
R6711:Tmem168	UTSW	6	13603121	missense	probably damaging	1.00
R6827:Tmem168	UTSW	6	13582838	missense	probably damaging	0.99
R6987:Tmem168	UTSW	6	13591477	missense	possibly damaging	0.82
R7696:Tmem168	UTSW	6	13602938	missense	probably benign	0.01
R8295:Tmem168	UTSW	6	13602851	missense	probably damaging	0.99
R8344:Tmem168	UTSW	6	13583325	missense	probably benign
R8432:Tmem168	UTSW	6	13602536	missense	probably benign	0.30
R8992:Tmem168	UTSW	6	13602850	missense	possibly damaging	0.72
R9003:Tmem168	UTSW	6	13591447	missense	probably benign	0.06
R9325:Tmem168	UTSW	6	13583254	missense	probably benign

Posted On

2015-04-16