Incidental Mutation 'IGL02745:Or4d10b'
ID 306101
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4d10b
Ensembl Gene ENSMUSG00000067528
Gene Name olfactory receptor family 4 subfamily D member 10B
Synonyms GA_x6K02T2RE5P-2418550-2417609, MOR239-2, Olfr1424
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL02745
Quality Score
Status
Chromosome 19
Chromosomal Location 12036173-12037114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 12036565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 184 (V184I)
Ref Sequence ENSEMBL: ENSMUSP00000146552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087830] [ENSMUST00000207681]
AlphaFold Q8VFV1
Predicted Effect probably benign
Transcript: ENSMUST00000087830
AA Change: V184I

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000085132
Gene: ENSMUSG00000067528
AA Change: V184I

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.4e-47 PFAM
Pfam:7tm_1 41 306 2.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207681
AA Change: V184I

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4galt T C 15: 83,112,282 (GRCm39) E167G probably benign Het
Aldh1a1 A G 19: 20,614,028 (GRCm39) probably benign Het
Ankrd44 T C 1: 54,805,950 (GRCm39) H152R probably damaging Het
Bpifb4 T A 2: 153,789,141 (GRCm39) L316Q probably damaging Het
C2cd5 A T 6: 142,987,256 (GRCm39) L155I probably benign Het
Chrdl2 T A 7: 99,670,170 (GRCm39) C98S probably damaging Het
Clnk A G 5: 38,893,662 (GRCm39) S232P probably benign Het
Csf3 A G 11: 98,593,303 (GRCm39) D140G probably damaging Het
Dnah7b T A 1: 46,234,189 (GRCm39) probably benign Het
Fetub T C 16: 22,756,676 (GRCm39) V259A probably damaging Het
Gga2 G T 7: 121,607,592 (GRCm39) R108S probably damaging Het
Hip1r C A 5: 124,129,002 (GRCm39) probably null Het
Hsd17b3 A G 13: 64,234,990 (GRCm39) F62L probably benign Het
Krt16 A T 11: 100,137,162 (GRCm39) probably benign Het
Man1a C T 10: 53,853,206 (GRCm39) R304Q probably damaging Het
Med17 A G 9: 15,176,642 (GRCm39) probably benign Het
Mrgprb4 T C 7: 47,848,106 (GRCm39) Y274C probably damaging Het
Myh8 C T 11: 67,188,327 (GRCm39) T996I possibly damaging Het
Niban3 G T 8: 72,057,682 (GRCm39) probably null Het
Nlrp4e T A 7: 23,020,716 (GRCm39) L401Q probably damaging Het
Oas1h G A 5: 120,999,542 (GRCm39) R9Q probably benign Het
Or4c111 A G 2: 88,844,232 (GRCm39) Y59H probably damaging Het
Or8g51 T C 9: 38,609,494 (GRCm39) H56R probably damaging Het
Otor A G 2: 142,923,076 (GRCm39) D122G possibly damaging Het
Pcdh18 T A 3: 49,710,340 (GRCm39) Q325L probably damaging Het
Ppfibp1 T C 6: 146,923,852 (GRCm39) probably benign Het
Pramel16 A T 4: 143,677,294 (GRCm39) L95Q probably damaging Het
Prlr T A 15: 10,328,680 (GRCm39) I385N possibly damaging Het
Rap1gds1 A G 3: 138,662,002 (GRCm39) V418A probably damaging Het
Rdh1 A T 10: 127,601,288 (GRCm39) T279S probably benign Het
Slc17a3 C A 13: 24,026,469 (GRCm39) Q13K probably benign Het
Slc22a20 T C 19: 6,022,901 (GRCm39) N414S probably damaging Het
Slc4a1 C A 11: 102,247,093 (GRCm39) C498F probably damaging Het
Sp8 G A 12: 118,813,326 (GRCm39) G394S probably damaging Het
Ssh2 C T 11: 77,346,233 (GRCm39) T1406I probably damaging Het
Stra6 T A 9: 58,059,321 (GRCm39) D561E probably damaging Het
Stxbp5l G A 16: 37,007,016 (GRCm39) Q726* probably null Het
Synpo2 G A 3: 122,907,261 (GRCm39) T685I probably damaging Het
Tasor2 A T 13: 3,635,140 (GRCm39) S556T probably benign Het
Ttc27 A G 17: 75,046,728 (GRCm39) D263G probably benign Het
Ttn G A 2: 76,594,332 (GRCm39) P18793S possibly damaging Het
Vmn2r109 A G 17: 20,761,512 (GRCm39) V615A probably damaging Het
Vmn2r76 T G 7: 85,879,495 (GRCm39) K268N probably benign Het
Zeb2 A G 2: 44,884,487 (GRCm39) probably benign Het
Zfp286 C A 11: 62,671,700 (GRCm39) K124N probably damaging Het
Other mutations in Or4d10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02045:Or4d10b APN 19 12,036,253 (GRCm39) missense possibly damaging 0.96
IGL02095:Or4d10b APN 19 12,036,913 (GRCm39) missense probably benign 0.00
IGL02743:Or4d10b APN 19 12,036,811 (GRCm39) missense probably damaging 1.00
R0834:Or4d10b UTSW 19 12,036,979 (GRCm39) missense probably benign 0.00
R1474:Or4d10b UTSW 19 12,036,844 (GRCm39) missense probably benign 0.30
R5590:Or4d10b UTSW 19 12,036,642 (GRCm39) missense probably benign 0.01
R6386:Or4d10b UTSW 19 12,036,920 (GRCm39) missense probably damaging 0.98
R6864:Or4d10b UTSW 19 12,036,777 (GRCm39) missense probably damaging 1.00
R8207:Or4d10b UTSW 19 12,036,222 (GRCm39) missense possibly damaging 0.94
R8213:Or4d10b UTSW 19 12,036,456 (GRCm39) missense probably benign 0.32
R9284:Or4d10b UTSW 19 12,036,273 (GRCm39) missense probably damaging 0.98
R9773:Or4d10b UTSW 19 12,036,939 (GRCm39) missense possibly damaging 0.94
Z1088:Or4d10b UTSW 19 12,036,493 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16