Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02745:Vmn2r109'

306123

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02745

Quality Score

Status

Chromosome

Chromosomal Location

20760779-20785018 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20761512 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 615 (V615A)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably damaging
Transcript: ENSMUST00000167093
AA Change: V615A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: V615A

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4galt	T	C	15: 83,112,282 (GRCm39)	E167G	probably benign	Het
Aldh1a1	A	G	19: 20,614,028 (GRCm39)		probably benign	Het
Ankrd44	T	C	1: 54,805,950 (GRCm39)	H152R	probably damaging	Het
Bpifb4	T	A	2: 153,789,141 (GRCm39)	L316Q	probably damaging	Het
C2cd5	A	T	6: 142,987,256 (GRCm39)	L155I	probably benign	Het
Chrdl2	T	A	7: 99,670,170 (GRCm39)	C98S	probably damaging	Het
Clnk	A	G	5: 38,893,662 (GRCm39)	S232P	probably benign	Het
Csf3	A	G	11: 98,593,303 (GRCm39)	D140G	probably damaging	Het
Dnah7b	T	A	1: 46,234,189 (GRCm39)		probably benign	Het
Fetub	T	C	16: 22,756,676 (GRCm39)	V259A	probably damaging	Het
Gga2	G	T	7: 121,607,592 (GRCm39)	R108S	probably damaging	Het
Hip1r	C	A	5: 124,129,002 (GRCm39)		probably null	Het
Hsd17b3	A	G	13: 64,234,990 (GRCm39)	F62L	probably benign	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Man1a	C	T	10: 53,853,206 (GRCm39)	R304Q	probably damaging	Het
Med17	A	G	9: 15,176,642 (GRCm39)		probably benign	Het
Mrgprb4	T	C	7: 47,848,106 (GRCm39)	Y274C	probably damaging	Het
Myh8	C	T	11: 67,188,327 (GRCm39)	T996I	possibly damaging	Het
Niban3	G	T	8: 72,057,682 (GRCm39)		probably null	Het
Nlrp4e	T	A	7: 23,020,716 (GRCm39)	L401Q	probably damaging	Het
Oas1h	G	A	5: 120,999,542 (GRCm39)	R9Q	probably benign	Het
Or4c111	A	G	2: 88,844,232 (GRCm39)	Y59H	probably damaging	Het
Or4d10b	C	T	19: 12,036,565 (GRCm39)	V184I	probably benign	Het
Or8g51	T	C	9: 38,609,494 (GRCm39)	H56R	probably damaging	Het
Otor	A	G	2: 142,923,076 (GRCm39)	D122G	possibly damaging	Het
Pcdh18	T	A	3: 49,710,340 (GRCm39)	Q325L	probably damaging	Het
Ppfibp1	T	C	6: 146,923,852 (GRCm39)		probably benign	Het
Pramel16	A	T	4: 143,677,294 (GRCm39)	L95Q	probably damaging	Het
Prlr	T	A	15: 10,328,680 (GRCm39)	I385N	possibly damaging	Het
Rap1gds1	A	G	3: 138,662,002 (GRCm39)	V418A	probably damaging	Het
Rdh1	A	T	10: 127,601,288 (GRCm39)	T279S	probably benign	Het
Slc17a3	C	A	13: 24,026,469 (GRCm39)	Q13K	probably benign	Het
Slc22a20	T	C	19: 6,022,901 (GRCm39)	N414S	probably damaging	Het
Slc4a1	C	A	11: 102,247,093 (GRCm39)	C498F	probably damaging	Het
Sp8	G	A	12: 118,813,326 (GRCm39)	G394S	probably damaging	Het
Ssh2	C	T	11: 77,346,233 (GRCm39)	T1406I	probably damaging	Het
Stra6	T	A	9: 58,059,321 (GRCm39)	D561E	probably damaging	Het
Stxbp5l	G	A	16: 37,007,016 (GRCm39)	Q726*	probably null	Het
Synpo2	G	A	3: 122,907,261 (GRCm39)	T685I	probably damaging	Het
Tasor2	A	T	13: 3,635,140 (GRCm39)	S556T	probably benign	Het
Ttc27	A	G	17: 75,046,728 (GRCm39)	D263G	probably benign	Het
Ttn	G	A	2: 76,594,332 (GRCm39)	P18793S	possibly damaging	Het
Vmn2r76	T	G	7: 85,879,495 (GRCm39)	K268N	probably benign	Het
Zeb2	A	G	2: 44,884,487 (GRCm39)		probably benign	Het
Zfp286	C	A	11: 62,671,700 (GRCm39)	K124N	probably damaging	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20,770,419 (GRCm39)	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20,761,383 (GRCm39)	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20,761,671 (GRCm39)	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20,774,654 (GRCm39)	missense	probably benign
IGL01864:Vmn2r109	APN	17	20,761,396 (GRCm39)	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20,761,342 (GRCm39)	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20,774,603 (GRCm39)	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20,774,422 (GRCm39)	missense	probably benign	0.01
IGL02474:Vmn2r109	APN	17	20,761,150 (GRCm39)	missense	probably benign
IGL02490:Vmn2r109	APN	17	20,761,246 (GRCm39)	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20,760,963 (GRCm39)	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20,774,518 (GRCm39)	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20,774,062 (GRCm39)	missense	probably benign
PIT4142001:Vmn2r109	UTSW	17	20,774,839 (GRCm39)	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20,761,336 (GRCm39)	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20,773,148 (GRCm39)	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20,760,937 (GRCm39)	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20,761,670 (GRCm39)	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20,774,842 (GRCm39)	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20,775,503 (GRCm39)	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20,761,002 (GRCm39)	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20,774,072 (GRCm39)	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20,784,969 (GRCm39)	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20,774,185 (GRCm39)	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20,761,448 (GRCm39)	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20,784,974 (GRCm39)	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20,774,798 (GRCm39)	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20,761,248 (GRCm39)	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20,774,704 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20,774,074 (GRCm39)	missense	probably benign
R4428:Vmn2r109	UTSW	17	20,773,286 (GRCm39)	missense	probably benign
R4584:Vmn2r109	UTSW	17	20,774,820 (GRCm39)	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20,761,656 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20,761,605 (GRCm39)	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20,774,153 (GRCm39)	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20,761,494 (GRCm39)	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20,770,348 (GRCm39)	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20,775,451 (GRCm39)	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20,774,603 (GRCm39)	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20,761,189 (GRCm39)	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20,760,933 (GRCm39)	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20,760,781 (GRCm39)	makesense	probably null
R5702:Vmn2r109	UTSW	17	20,774,407 (GRCm39)	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20,774,567 (GRCm39)	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20,773,121 (GRCm39)	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20,761,318 (GRCm39)	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20,760,981 (GRCm39)	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20,761,440 (GRCm39)	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20,784,796 (GRCm39)	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20,774,785 (GRCm39)	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20,760,932 (GRCm39)	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20,760,973 (GRCm39)	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20,785,006 (GRCm39)	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20,761,225 (GRCm39)	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20,761,336 (GRCm39)	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20,760,945 (GRCm39)	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20,761,700 (GRCm39)	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20,761,043 (GRCm39)	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20,761,536 (GRCm39)	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20,774,665 (GRCm39)	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20,760,942 (GRCm39)	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20,773,117 (GRCm39)	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20,761,436 (GRCm39)	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20,760,782 (GRCm39)	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20,774,729 (GRCm39)	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20,784,969 (GRCm39)	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20,774,531 (GRCm39)	missense	possibly damaging	0.96
R9687:Vmn2r109	UTSW	17	20,775,332 (GRCm39)	missense
Z1176:Vmn2r109	UTSW	17	20,773,256 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16