Incidental Mutation 'IGL02748:Olfr262'
ID306147
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr262
Ensembl Gene ENSMUSG00000067519
Gene Nameolfactory receptor 262
SynonymsMOR214-1, GA_x6K02T2N4A9-18144-19082, MOR214-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL02748
Quality Score
Status
Chromosome19
Chromosomal Location12240721-12241659 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 12240840 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 274 (F274L)
Ref Sequence ENSEMBL: ENSMUSP00000085120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087818]
Predicted Effect probably benign
Transcript: ENSMUST00000087818
AA Change: F274L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000085120
Gene: ENSMUSG00000067519
AA Change: F274L

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.3e-55 PFAM
Pfam:7tm_1 42 291 1.2e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Baiap2l1 T A 5: 144,266,605 probably benign Het
Btbd9 T C 17: 30,334,297 N397S possibly damaging Het
Crlf3 A G 11: 80,059,319 S162P probably damaging Het
Dctn2 C T 10: 127,277,273 R231C probably damaging Het
Dhcr24 T C 4: 106,564,392 probably benign Het
Efcab12 T A 6: 115,820,102 T364S probably damaging Het
Eps8l3 A G 3: 107,879,368 probably benign Het
Ezh2 A G 6: 47,558,239 L92P probably damaging Het
Fbxw15 A G 9: 109,558,210 I239T possibly damaging Het
Fndc4 T C 5: 31,294,786 T96A possibly damaging Het
Gcn1l1 G A 5: 115,610,800 probably null Het
Ifna13 A G 4: 88,643,860 S176P probably damaging Het
Kcnh1 A G 1: 192,221,420 H56R probably damaging Het
Lrp1b T C 2: 40,702,749 D3786G probably damaging Het
Mcm3ap T A 10: 76,501,248 V1339E probably damaging Het
Mthfd1l T C 10: 4,018,587 V414A possibly damaging Het
Mthfd1l T G 10: 3,980,268 probably null Het
Olfr1118 T A 2: 87,309,665 L312Q probably damaging Het
Olfr1414 A G 1: 92,511,467 L187P probably damaging Het
Pcdhb15 T C 18: 37,475,220 S502P probably damaging Het
Pde5a T A 3: 122,760,892 N242K probably damaging Het
Pik3cb A T 9: 99,062,968 probably benign Het
Rab3gap1 A G 1: 127,937,461 M729V probably damaging Het
Rai14 A G 15: 10,589,335 V259A probably benign Het
Rassf4 T C 6: 116,639,457 I298V possibly damaging Het
Senp7 C T 16: 56,186,094 T927M probably damaging Het
Snx27 A T 3: 94,503,565 I426N probably benign Het
Syce1l A T 8: 113,655,465 probably benign Het
Tmem18 T C 12: 30,588,745 *141Q probably null Het
Tnrc6c T C 11: 117,732,170 S1006P probably benign Het
Utp20 T C 10: 88,817,295 T308A probably benign Het
Vmn2r24 T A 6: 123,816,098 C795S possibly damaging Het
Zdhhc20 A G 14: 57,858,553 S143P probably benign Het
Other mutations in Olfr262
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Olfr262 APN 19 12241527 missense probably damaging 0.99
IGL02170:Olfr262 APN 19 12240756 missense probably benign
IGL02896:Olfr262 APN 19 12240989 nonsense probably null
R0365:Olfr262 UTSW 19 12241076 missense probably benign 0.13
R0374:Olfr262 UTSW 19 12241141 missense probably damaging 1.00
R1226:Olfr262 UTSW 19 12241586 missense probably benign
R1319:Olfr262 UTSW 19 12241502 missense probably damaging 1.00
R1426:Olfr262 UTSW 19 12241182 missense possibly damaging 0.81
R1453:Olfr262 UTSW 19 12241592 missense probably benign
R1675:Olfr262 UTSW 19 12240831 missense probably benign 0.37
R1773:Olfr262 UTSW 19 12241659 start codon destroyed probably null 0.03
R1778:Olfr262 UTSW 19 12241455 missense probably benign
R1820:Olfr262 UTSW 19 12241248 missense probably damaging 1.00
R3161:Olfr262 UTSW 19 12241496 missense probably benign 0.06
R3412:Olfr262 UTSW 19 12241590 missense probably benign 0.00
R4387:Olfr262 UTSW 19 12241139 missense probably damaging 0.98
R4389:Olfr262 UTSW 19 12241139 missense probably damaging 0.98
R4782:Olfr262 UTSW 19 12241572 missense probably benign 0.01
R4885:Olfr262 UTSW 19 12240718 unclassified probably null
R4915:Olfr262 UTSW 19 12241373 missense probably benign 0.31
R5254:Olfr262 UTSW 19 12241248 missense probably damaging 1.00
R5726:Olfr262 UTSW 19 12241280 missense probably damaging 0.99
R6579:Olfr262 UTSW 19 12241362 missense probably benign
R7062:Olfr262 UTSW 19 12240725 missense probably benign
R7424:Olfr262 UTSW 19 12240954 missense possibly damaging 0.65
Posted On2015-04-16