Incidental Mutation 'IGL02749:Psg22'
ID 306177
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Psg22
Ensembl Gene ENSMUSG00000044903
Gene Name pregnancy-specific beta-1-glycoprotein 22
Synonyms cea9
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02749
Quality Score
Status
Chromosome 7
Chromosomal Location 18452015-18461173 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18456944 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 237 (T237S)
Ref Sequence ENSEMBL: ENSMUSP00000146795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051973] [ENSMUST00000108481] [ENSMUST00000208221]
AlphaFold Q810J1
Predicted Effect possibly damaging
Transcript: ENSMUST00000051973
AA Change: T237S

PolyPhen 2 Score 0.503 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050633
Gene: ENSMUSG00000044903
AA Change: T237S

DomainStartEndE-ValueType
low complexity region 19 30 N/A INTRINSIC
IG 40 141 7.59e-4 SMART
IG 160 261 1.13e-2 SMART
IG 280 381 3.74e-3 SMART
IGc2 397 461 7.35e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108481
AA Change: T276S

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000104121
Gene: ENSMUSG00000044903
AA Change: T276S

DomainStartEndE-ValueType
low complexity region 58 69 N/A INTRINSIC
IG 79 180 7.59e-4 SMART
IG 199 300 1.13e-2 SMART
IG 319 420 3.74e-3 SMART
IGc2 436 500 7.35e-11 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000208221
AA Change: T237S

PolyPhen 2 Score 0.503 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230104M06Rik T C 12: 112,963,795 (GRCm39) D61G probably benign Het
Albfm1 T C 5: 90,719,624 (GRCm39) V240A possibly damaging Het
Ascc2 G A 11: 4,590,481 (GRCm39) probably null Het
Atrn C T 2: 130,812,064 (GRCm39) Q670* probably null Het
Atrn G T 2: 130,789,654 (GRCm39) probably benign Het
Calr A C 8: 85,571,117 (GRCm39) W236G probably damaging Het
Camk2g T A 14: 20,816,084 (GRCm39) probably null Het
Cd101 G T 3: 100,927,715 (GRCm39) T122K probably damaging Het
Cert1 T A 13: 96,765,643 (GRCm39) N469K possibly damaging Het
Cryl1 T C 14: 57,541,181 (GRCm39) T168A probably benign Het
Diaph3 A G 14: 87,156,261 (GRCm39) I684T probably damaging Het
Ednrb A T 14: 104,060,495 (GRCm39) M266K possibly damaging Het
Eif4h T C 5: 134,668,146 (GRCm39) D3G probably damaging Het
Eny2 C T 15: 44,293,031 (GRCm39) R28C possibly damaging Het
Epsti1 A G 14: 78,177,363 (GRCm39) E181G probably damaging Het
Ezh2 A G 6: 47,510,698 (GRCm39) F598S probably damaging Het
Fat3 G T 9: 15,918,007 (GRCm39) T1472K possibly damaging Het
Gabra4 T A 5: 71,795,490 (GRCm39) I262F probably benign Het
Gpat4 A T 8: 23,670,886 (GRCm39) Y109N probably damaging Het
Gpsm1 C T 2: 26,229,687 (GRCm39) T36I probably damaging Het
Hikeshi C T 7: 89,585,097 (GRCm39) V36I possibly damaging Het
Hip1 T C 5: 135,473,605 (GRCm39) M238V probably benign Het
Hnrnpll A T 17: 80,369,420 (GRCm39) M1K probably null Het
Irx2 G A 13: 72,779,429 (GRCm39) D238N probably damaging Het
Kcnip4 T A 5: 48,567,127 (GRCm39) probably benign Het
Lair1 G A 7: 4,031,900 (GRCm39) T69I possibly damaging Het
Lamc1 A G 1: 153,125,599 (GRCm39) I558T possibly damaging Het
Map4k5 C T 12: 69,862,580 (GRCm39) E639K probably benign Het
Mc4r A G 18: 66,992,733 (GRCm39) S127P probably damaging Het
Mmp23 A G 4: 155,735,989 (GRCm39) M221T possibly damaging Het
Mre11a T C 9: 14,737,887 (GRCm39) S587P possibly damaging Het
Myh9 A T 15: 77,692,186 (GRCm39) Y124* probably null Het
Nek9 C A 12: 85,352,281 (GRCm39) A861S probably benign Het
Nup155 T A 15: 8,163,560 (GRCm39) Y576N probably damaging Het
Or5w10 C T 2: 87,375,001 (GRCm39) V296M probably damaging Het
Pcca A T 14: 122,771,800 (GRCm39) T8S probably benign Het
Pcdh15 A G 10: 74,466,900 (GRCm39) D1573G probably benign Het
Pdpr T A 8: 111,844,722 (GRCm39) V373E probably benign Het
Pdzph1 A T 17: 59,239,478 (GRCm39) L950Q possibly damaging Het
Pira13 A G 7: 3,825,624 (GRCm39) I415T probably damaging Het
Prss35 A C 9: 86,638,297 (GRCm39) K356Q probably damaging Het
Rdh13 A G 7: 4,430,703 (GRCm39) Y252H probably damaging Het
Sema3d T C 5: 12,613,112 (GRCm39) probably benign Het
Slc35b2 G A 17: 45,877,493 (GRCm39) V207I probably benign Het
Sparcl1 T G 5: 104,240,746 (GRCm39) E226A possibly damaging Het
Srms C A 2: 180,851,302 (GRCm39) A155S possibly damaging Het
Tas2r107 A T 6: 131,636,917 (GRCm39) I44N probably damaging Het
Tmem236 C T 2: 14,224,132 (GRCm39) T307M probably damaging Het
Ush2a C T 1: 188,679,155 (GRCm39) P4788S probably damaging Het
Vmn1r170 A T 7: 23,305,716 (GRCm39) L39F probably benign Het
Vmn2r90 T A 17: 17,947,122 (GRCm39) *121R probably null Het
Other mutations in Psg22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00797:Psg22 APN 7 18,452,200 (GRCm39) missense probably benign 0.00
IGL00839:Psg22 APN 7 18,456,893 (GRCm39) missense probably benign 0.01
IGL00898:Psg22 APN 7 18,458,392 (GRCm39) missense probably damaging 1.00
IGL02262:Psg22 APN 7 18,458,496 (GRCm39) missense probably damaging 0.98
IGL02678:Psg22 APN 7 18,453,418 (GRCm39) missense probably damaging 0.99
IGL02928:Psg22 APN 7 18,453,458 (GRCm39) missense probably damaging 0.98
IGL02977:Psg22 APN 7 18,453,524 (GRCm39) missense probably benign 0.20
R0470:Psg22 UTSW 7 18,453,589 (GRCm39) missense probably damaging 0.99
R1902:Psg22 UTSW 7 18,458,363 (GRCm39) nonsense probably null
R1935:Psg22 UTSW 7 18,453,635 (GRCm39) missense probably damaging 0.99
R1936:Psg22 UTSW 7 18,453,635 (GRCm39) missense probably damaging 0.99
R2013:Psg22 UTSW 7 18,453,560 (GRCm39) missense possibly damaging 0.93
R2278:Psg22 UTSW 7 18,460,762 (GRCm39) missense possibly damaging 0.80
R4258:Psg22 UTSW 7 18,458,554 (GRCm39) missense probably damaging 1.00
R5029:Psg22 UTSW 7 18,453,662 (GRCm39) missense probably damaging 1.00
R5885:Psg22 UTSW 7 18,452,257 (GRCm39) missense probably damaging 0.98
R6084:Psg22 UTSW 7 18,453,705 (GRCm39) missense probably benign 0.01
R6143:Psg22 UTSW 7 18,456,723 (GRCm39) missense probably benign 0.03
R6209:Psg22 UTSW 7 18,453,599 (GRCm39) missense probably damaging 1.00
R7017:Psg22 UTSW 7 18,458,366 (GRCm39) missense probably benign 0.01
R7337:Psg22 UTSW 7 18,453,499 (GRCm39) missense probably benign 0.20
R7417:Psg22 UTSW 7 18,456,891 (GRCm39) missense probably damaging 1.00
R7460:Psg22 UTSW 7 18,458,329 (GRCm39) missense probably benign 0.03
R7570:Psg22 UTSW 7 18,456,660 (GRCm39) missense possibly damaging 0.95
R7650:Psg22 UTSW 7 18,460,684 (GRCm39) missense possibly damaging 0.66
R7711:Psg22 UTSW 7 18,452,267 (GRCm39) critical splice donor site probably null
R7991:Psg22 UTSW 7 18,460,861 (GRCm39) missense probably damaging 1.00
R8001:Psg22 UTSW 7 18,453,671 (GRCm39) missense possibly damaging 0.79
R8003:Psg22 UTSW 7 18,458,350 (GRCm39) missense probably damaging 1.00
R8066:Psg22 UTSW 7 18,452,218 (GRCm39) missense possibly damaging 0.88
R8113:Psg22 UTSW 7 18,456,987 (GRCm39) missense probably benign 0.00
R9136:Psg22 UTSW 7 18,460,811 (GRCm39) missense probably damaging 1.00
R9148:Psg22 UTSW 7 18,460,682 (GRCm39) missense probably benign 0.09
R9152:Psg22 UTSW 7 18,460,646 (GRCm39) missense probably damaging 0.97
R9344:Psg22 UTSW 7 18,460,816 (GRCm39) missense possibly damaging 0.69
R9666:Psg22 UTSW 7 18,458,248 (GRCm39) missense probably benign
R9801:Psg22 UTSW 7 18,456,899 (GRCm39) missense probably benign 0.11
X0064:Psg22 UTSW 7 18,452,106 (GRCm39) missense probably benign 0.01
Z1177:Psg22 UTSW 7 18,453,602 (GRCm39) missense probably benign 0.19
Posted On 2015-04-16