Incidental Mutation 'IGL02749:Prss35'
ID 306183
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss35
Ensembl Gene ENSMUSG00000033491
Gene Name protease, serine 35
Synonyms 6030424L22Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # IGL02749
Quality Score
Status
Chromosome 9
Chromosomal Location 86743649-86758443 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 86756244 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamine at position 356 (K356Q)
Ref Sequence ENSEMBL: ENSMUSP00000137445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036426] [ENSMUST00000179574]
AlphaFold Q8C0F9
Predicted Effect probably damaging
Transcript: ENSMUST00000036426
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000035271
Gene: ENSMUSG00000033491
AA Change: K356Q

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 68 83 N/A INTRINSIC
Tryp_SPc 132 399 4.13e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000179574
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000137445
Gene: ENSMUSG00000033491
AA Change: K356Q

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 68 83 N/A INTRINSIC
Tryp_SPc 132 399 4.13e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830473C10Rik T C 5: 90,571,765 V240A possibly damaging Het
9230104M06Rik T C 12: 113,000,175 D61G probably benign Het
Ascc2 G A 11: 4,640,481 probably null Het
Atrn C T 2: 130,970,144 Q670* probably null Het
Atrn G T 2: 130,947,734 probably benign Het
Calr A C 8: 84,844,488 W236G probably damaging Het
Camk2g T A 14: 20,766,016 probably null Het
Cd101 G T 3: 101,020,399 T122K probably damaging Het
Col4a3bp T A 13: 96,629,135 N469K possibly damaging Het
Cryl1 T C 14: 57,303,724 T168A probably benign Het
Diaph3 A G 14: 86,918,825 I684T probably damaging Het
Ednrb A T 14: 103,823,059 M266K possibly damaging Het
Eif4h T C 5: 134,639,292 D3G probably damaging Het
Eny2 C T 15: 44,429,635 R28C possibly damaging Het
Epsti1 A G 14: 77,939,923 E181G probably damaging Het
Ezh2 A G 6: 47,533,764 F598S probably damaging Het
Fat3 G T 9: 16,006,711 T1472K possibly damaging Het
Gabra4 T A 5: 71,638,147 I262F probably benign Het
Gm15448 A G 7: 3,822,625 I415T probably damaging Het
Gpat4 A T 8: 23,180,870 Y109N probably damaging Het
Gpsm1 C T 2: 26,339,675 T36I probably damaging Het
Hikeshi C T 7: 89,935,889 V36I possibly damaging Het
Hip1 T C 5: 135,444,751 M238V probably benign Het
Hnrnpll A T 17: 80,061,991 M1K probably null Het
Irx2 G A 13: 72,631,310 D238N probably damaging Het
Kcnip4 T A 5: 48,409,785 probably benign Het
Lair1 G A 7: 4,028,901 T69I possibly damaging Het
Lamc1 A G 1: 153,249,853 I558T possibly damaging Het
Map4k5 C T 12: 69,815,806 E639K probably benign Het
Mc4r A G 18: 66,859,662 S127P probably damaging Het
Mmp23 A G 4: 155,651,532 M221T possibly damaging Het
Mre11a T C 9: 14,826,591 S587P possibly damaging Het
Myh9 A T 15: 77,807,986 Y124* probably null Het
Nek9 C A 12: 85,305,507 A861S probably benign Het
Nup155 T A 15: 8,134,076 Y576N probably damaging Het
Olfr1128 C T 2: 87,544,657 V296M probably damaging Het
Pcca A T 14: 122,534,388 T8S probably benign Het
Pcdh15 A G 10: 74,631,068 D1573G probably benign Het
Pdpr T A 8: 111,118,090 V373E probably benign Het
Pdzph1 A T 17: 58,932,483 L950Q possibly damaging Het
Psg22 A T 7: 18,723,019 T237S possibly damaging Het
Rdh13 A G 7: 4,427,704 Y252H probably damaging Het
Sema3d T C 5: 12,563,145 probably benign Het
Slc35b2 G A 17: 45,566,567 V207I probably benign Het
Sparcl1 T G 5: 104,092,880 E226A possibly damaging Het
Srms C A 2: 181,209,509 A155S possibly damaging Het
Tas2r107 A T 6: 131,659,954 I44N probably damaging Het
Tmem236 C T 2: 14,219,321 T307M probably damaging Het
Ush2a C T 1: 188,946,958 P4788S probably damaging Het
Vmn1r170 A T 7: 23,606,291 L39F probably benign Het
Vmn2r90 T A 17: 17,726,860 *121R probably null Het
Other mutations in Prss35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Prss35 APN 9 86,755,274 (GRCm38) missense probably benign 0.00
R0346:Prss35 UTSW 9 86,755,351 (GRCm38) missense probably benign 0.04
R0403:Prss35 UTSW 9 86,756,037 (GRCm38) missense probably damaging 1.00
R1664:Prss35 UTSW 9 86,755,647 (GRCm38) missense probably benign 0.29
R2016:Prss35 UTSW 9 86,755,512 (GRCm38) missense probably benign 0.37
R2017:Prss35 UTSW 9 86,755,512 (GRCm38) missense probably benign 0.37
R2325:Prss35 UTSW 9 86,756,304 (GRCm38) missense probably damaging 1.00
R2429:Prss35 UTSW 9 86,755,345 (GRCm38) missense probably benign
R2965:Prss35 UTSW 9 86,755,582 (GRCm38) missense probably damaging 1.00
R2966:Prss35 UTSW 9 86,755,582 (GRCm38) missense probably damaging 1.00
R3961:Prss35 UTSW 9 86,755,749 (GRCm38) missense probably benign 0.02
R4792:Prss35 UTSW 9 86,755,669 (GRCm38) missense probably damaging 1.00
R4902:Prss35 UTSW 9 86,756,122 (GRCm38) missense probably damaging 1.00
R6169:Prss35 UTSW 9 86,755,438 (GRCm38) missense probably benign 0.00
R6446:Prss35 UTSW 9 86,755,653 (GRCm38) missense probably damaging 0.99
R6753:Prss35 UTSW 9 86,756,100 (GRCm38) missense probably damaging 1.00
R7008:Prss35 UTSW 9 86,756,308 (GRCm38) missense probably benign 0.01
R7387:Prss35 UTSW 9 86,755,921 (GRCm38) missense probably damaging 1.00
R7523:Prss35 UTSW 9 86,755,374 (GRCm38) missense probably damaging 1.00
R7587:Prss35 UTSW 9 86,755,374 (GRCm38) missense probably damaging 1.00
R7652:Prss35 UTSW 9 86,755,970 (GRCm38) missense probably benign
R8013:Prss35 UTSW 9 86,755,425 (GRCm38) missense probably damaging 1.00
R8194:Prss35 UTSW 9 86,755,613 (GRCm38) missense possibly damaging 0.94
R8871:Prss35 UTSW 9 86,755,191 (GRCm38) missense possibly damaging 0.84
R9444:Prss35 UTSW 9 86,756,104 (GRCm38) missense probably damaging 1.00
R9462:Prss35 UTSW 9 86,756,339 (GRCm38) missense
R9695:Prss35 UTSW 9 86,755,708 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16