Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02749:Prss35'

306183

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss35

Ensembl Gene

ENSMUSG00000033491

Gene Name

protease, serine 35

Synonyms

6030424L22Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL02749

Quality Score

Status

Chromosome

Chromosomal Location

86743649-86758443 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 86756244 bp

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamine at position 356 (K356Q)

Ref Sequence

ENSEMBL: ENSMUSP00000137445 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036426] [ENSMUST00000179574]

Predicted Effect

probably damaging
Transcript: ENSMUST00000036426
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000035271
Gene: ENSMUSG00000033491
AA Change: K356Q

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	68	83	N/A	INTRINSIC
Tryp_SPc	132	399	4.13e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000179574
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000137445
Gene: ENSMUSG00000033491
AA Change: K356Q

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	68	83	N/A	INTRINSIC
Tryp_SPc	132	399	4.13e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5830473C10Rik	T	C	5: 90,571,765	V240A	possibly damaging	Het
9230104M06Rik	T	C	12: 113,000,175	D61G	probably benign	Het
Ascc2	G	A	11: 4,640,481		probably null	Het
Atrn	G	T	2: 130,947,734		probably benign	Het
Atrn	C	T	2: 130,970,144	Q670*	probably null	Het
Calr	A	C	8: 84,844,488	W236G	probably damaging	Het
Camk2g	T	A	14: 20,766,016		probably null	Het
Cd101	G	T	3: 101,020,399	T122K	probably damaging	Het
Col4a3bp	T	A	13: 96,629,135	N469K	possibly damaging	Het
Cryl1	T	C	14: 57,303,724	T168A	probably benign	Het
Diaph3	A	G	14: 86,918,825	I684T	probably damaging	Het
Ednrb	A	T	14: 103,823,059	M266K	possibly damaging	Het
Eif4h	T	C	5: 134,639,292	D3G	probably damaging	Het
Eny2	C	T	15: 44,429,635	R28C	possibly damaging	Het
Epsti1	A	G	14: 77,939,923	E181G	probably damaging	Het
Ezh2	A	G	6: 47,533,764	F598S	probably damaging	Het
Fat3	G	T	9: 16,006,711	T1472K	possibly damaging	Het
Gabra4	T	A	5: 71,638,147	I262F	probably benign	Het
Gm15448	A	G	7: 3,822,625	I415T	probably damaging	Het
Gpat4	A	T	8: 23,180,870	Y109N	probably damaging	Het
Gpsm1	C	T	2: 26,339,675	T36I	probably damaging	Het
Hikeshi	C	T	7: 89,935,889	V36I	possibly damaging	Het
Hip1	T	C	5: 135,444,751	M238V	probably benign	Het
Hnrnpll	A	T	17: 80,061,991	M1K	probably null	Het
Irx2	G	A	13: 72,631,310	D238N	probably damaging	Het
Kcnip4	T	A	5: 48,409,785		probably benign	Het
Lair1	G	A	7: 4,028,901	T69I	possibly damaging	Het
Lamc1	A	G	1: 153,249,853	I558T	possibly damaging	Het
Map4k5	C	T	12: 69,815,806	E639K	probably benign	Het
Mc4r	A	G	18: 66,859,662	S127P	probably damaging	Het
Mmp23	A	G	4: 155,651,532	M221T	possibly damaging	Het
Mre11a	T	C	9: 14,826,591	S587P	possibly damaging	Het
Myh9	A	T	15: 77,807,986	Y124*	probably null	Het
Nek9	C	A	12: 85,305,507	A861S	probably benign	Het
Nup155	T	A	15: 8,134,076	Y576N	probably damaging	Het
Olfr1128	C	T	2: 87,544,657	V296M	probably damaging	Het
Pcca	A	T	14: 122,534,388	T8S	probably benign	Het
Pcdh15	A	G	10: 74,631,068	D1573G	probably benign	Het
Pdpr	T	A	8: 111,118,090	V373E	probably benign	Het
Pdzph1	A	T	17: 58,932,483	L950Q	possibly damaging	Het
Psg22	A	T	7: 18,723,019	T237S	possibly damaging	Het
Rdh13	A	G	7: 4,427,704	Y252H	probably damaging	Het
Sema3d	T	C	5: 12,563,145		probably benign	Het
Slc35b2	G	A	17: 45,566,567	V207I	probably benign	Het
Sparcl1	T	G	5: 104,092,880	E226A	possibly damaging	Het
Srms	C	A	2: 181,209,509	A155S	possibly damaging	Het
Tas2r107	A	T	6: 131,659,954	I44N	probably damaging	Het
Tmem236	C	T	2: 14,219,321	T307M	probably damaging	Het
Ush2a	C	T	1: 188,946,958	P4788S	probably damaging	Het
Vmn1r170	A	T	7: 23,606,291	L39F	probably benign	Het
Vmn2r90	T	A	17: 17,726,860	*121R	probably null	Het

Other mutations in Prss35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01548:Prss35	APN	9	86755274	missense	probably benign	0.00
R0346:Prss35	UTSW	9	86755351	missense	probably benign	0.04
R0403:Prss35	UTSW	9	86756037	missense	probably damaging	1.00
R1664:Prss35	UTSW	9	86755647	missense	probably benign	0.29
R2016:Prss35	UTSW	9	86755512	missense	probably benign	0.37
R2017:Prss35	UTSW	9	86755512	missense	probably benign	0.37
R2325:Prss35	UTSW	9	86756304	missense	probably damaging	1.00
R2429:Prss35	UTSW	9	86755345	missense	probably benign
R2965:Prss35	UTSW	9	86755582	missense	probably damaging	1.00
R2966:Prss35	UTSW	9	86755582	missense	probably damaging	1.00
R3961:Prss35	UTSW	9	86755749	missense	probably benign	0.02
R4792:Prss35	UTSW	9	86755669	missense	probably damaging	1.00
R4902:Prss35	UTSW	9	86756122	missense	probably damaging	1.00
R6169:Prss35	UTSW	9	86755438	missense	probably benign	0.00
R6446:Prss35	UTSW	9	86755653	missense	probably damaging	0.99
R6753:Prss35	UTSW	9	86756100	missense	probably damaging	1.00
R7008:Prss35	UTSW	9	86756308	missense	probably benign	0.01
R7387:Prss35	UTSW	9	86755921	missense	probably damaging	1.00
R7523:Prss35	UTSW	9	86755374	missense	probably damaging	1.00
R7587:Prss35	UTSW	9	86755374	missense	probably damaging	1.00
R7652:Prss35	UTSW	9	86755970	missense	probably benign
R8013:Prss35	UTSW	9	86755425	missense	probably damaging	1.00
R8194:Prss35	UTSW	9	86755613	missense	possibly damaging	0.94

Posted On

2015-04-16