Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02749:Prss35'

306183

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss35

Ensembl Gene

ENSMUSG00000033491

Gene Name

protease, serine 35

Synonyms

6030424L22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

IGL02749

Quality Score

Status

Chromosome

Chromosomal Location

86743649-86758443 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 86756244 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamine at position 356 (K356Q)

Ref Sequence

ENSEMBL: ENSMUSP00000137445 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036426] [ENSMUST00000179574]

AlphaFold

Q8C0F9

Predicted Effect

probably damaging
Transcript: ENSMUST00000036426
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000035271
Gene: ENSMUSG00000033491
AA Change: K356Q

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	68	83	N/A	INTRINSIC
Tryp_SPc	132	399	4.13e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000179574
AA Change: K356Q

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000137445
Gene: ENSMUSG00000033491
AA Change: K356Q

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	68	83	N/A	INTRINSIC
Tryp_SPc	132	399	4.13e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5830473C10Rik	T	C	5: 90,571,765	V240A	possibly damaging	Het
9230104M06Rik	T	C	12: 113,000,175	D61G	probably benign	Het
Ascc2	G	A	11: 4,640,481		probably null	Het
Atrn	C	T	2: 130,970,144	Q670*	probably null	Het
Atrn	G	T	2: 130,947,734		probably benign	Het
Calr	A	C	8: 84,844,488	W236G	probably damaging	Het
Camk2g	T	A	14: 20,766,016		probably null	Het
Cd101	G	T	3: 101,020,399	T122K	probably damaging	Het
Col4a3bp	T	A	13: 96,629,135	N469K	possibly damaging	Het
Cryl1	T	C	14: 57,303,724	T168A	probably benign	Het
Diaph3	A	G	14: 86,918,825	I684T	probably damaging	Het
Ednrb	A	T	14: 103,823,059	M266K	possibly damaging	Het
Eif4h	T	C	5: 134,639,292	D3G	probably damaging	Het
Eny2	C	T	15: 44,429,635	R28C	possibly damaging	Het
Epsti1	A	G	14: 77,939,923	E181G	probably damaging	Het
Ezh2	A	G	6: 47,533,764	F598S	probably damaging	Het
Fat3	G	T	9: 16,006,711	T1472K	possibly damaging	Het
Gabra4	T	A	5: 71,638,147	I262F	probably benign	Het
Gm15448	A	G	7: 3,822,625	I415T	probably damaging	Het
Gpat4	A	T	8: 23,180,870	Y109N	probably damaging	Het
Gpsm1	C	T	2: 26,339,675	T36I	probably damaging	Het
Hikeshi	C	T	7: 89,935,889	V36I	possibly damaging	Het
Hip1	T	C	5: 135,444,751	M238V	probably benign	Het
Hnrnpll	A	T	17: 80,061,991	M1K	probably null	Het
Irx2	G	A	13: 72,631,310	D238N	probably damaging	Het
Kcnip4	T	A	5: 48,409,785		probably benign	Het
Lair1	G	A	7: 4,028,901	T69I	possibly damaging	Het
Lamc1	A	G	1: 153,249,853	I558T	possibly damaging	Het
Map4k5	C	T	12: 69,815,806	E639K	probably benign	Het
Mc4r	A	G	18: 66,859,662	S127P	probably damaging	Het
Mmp23	A	G	4: 155,651,532	M221T	possibly damaging	Het
Mre11a	T	C	9: 14,826,591	S587P	possibly damaging	Het
Myh9	A	T	15: 77,807,986	Y124*	probably null	Het
Nek9	C	A	12: 85,305,507	A861S	probably benign	Het
Nup155	T	A	15: 8,134,076	Y576N	probably damaging	Het
Olfr1128	C	T	2: 87,544,657	V296M	probably damaging	Het
Pcca	A	T	14: 122,534,388	T8S	probably benign	Het
Pcdh15	A	G	10: 74,631,068	D1573G	probably benign	Het
Pdpr	T	A	8: 111,118,090	V373E	probably benign	Het
Pdzph1	A	T	17: 58,932,483	L950Q	possibly damaging	Het
Psg22	A	T	7: 18,723,019	T237S	possibly damaging	Het
Rdh13	A	G	7: 4,427,704	Y252H	probably damaging	Het
Sema3d	T	C	5: 12,563,145		probably benign	Het
Slc35b2	G	A	17: 45,566,567	V207I	probably benign	Het
Sparcl1	T	G	5: 104,092,880	E226A	possibly damaging	Het
Srms	C	A	2: 181,209,509	A155S	possibly damaging	Het
Tas2r107	A	T	6: 131,659,954	I44N	probably damaging	Het
Tmem236	C	T	2: 14,219,321	T307M	probably damaging	Het
Ush2a	C	T	1: 188,946,958	P4788S	probably damaging	Het
Vmn1r170	A	T	7: 23,606,291	L39F	probably benign	Het
Vmn2r90	T	A	17: 17,726,860	*121R	probably null	Het

Other mutations in Prss35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01548:Prss35	APN	9	86,755,274 (GRCm38)	missense	probably benign	0.00
R0346:Prss35	UTSW	9	86,755,351 (GRCm38)	missense	probably benign	0.04
R0403:Prss35	UTSW	9	86,756,037 (GRCm38)	missense	probably damaging	1.00
R1664:Prss35	UTSW	9	86,755,647 (GRCm38)	missense	probably benign	0.29
R2016:Prss35	UTSW	9	86,755,512 (GRCm38)	missense	probably benign	0.37
R2017:Prss35	UTSW	9	86,755,512 (GRCm38)	missense	probably benign	0.37
R2325:Prss35	UTSW	9	86,756,304 (GRCm38)	missense	probably damaging	1.00
R2429:Prss35	UTSW	9	86,755,345 (GRCm38)	missense	probably benign
R2965:Prss35	UTSW	9	86,755,582 (GRCm38)	missense	probably damaging	1.00
R2966:Prss35	UTSW	9	86,755,582 (GRCm38)	missense	probably damaging	1.00
R3961:Prss35	UTSW	9	86,755,749 (GRCm38)	missense	probably benign	0.02
R4792:Prss35	UTSW	9	86,755,669 (GRCm38)	missense	probably damaging	1.00
R4902:Prss35	UTSW	9	86,756,122 (GRCm38)	missense	probably damaging	1.00
R6169:Prss35	UTSW	9	86,755,438 (GRCm38)	missense	probably benign	0.00
R6446:Prss35	UTSW	9	86,755,653 (GRCm38)	missense	probably damaging	0.99
R6753:Prss35	UTSW	9	86,756,100 (GRCm38)	missense	probably damaging	1.00
R7008:Prss35	UTSW	9	86,756,308 (GRCm38)	missense	probably benign	0.01
R7387:Prss35	UTSW	9	86,755,921 (GRCm38)	missense	probably damaging	1.00
R7523:Prss35	UTSW	9	86,755,374 (GRCm38)	missense	probably damaging	1.00
R7587:Prss35	UTSW	9	86,755,374 (GRCm38)	missense	probably damaging	1.00
R7652:Prss35	UTSW	9	86,755,970 (GRCm38)	missense	probably benign
R8013:Prss35	UTSW	9	86,755,425 (GRCm38)	missense	probably damaging	1.00
R8194:Prss35	UTSW	9	86,755,613 (GRCm38)	missense	possibly damaging	0.94
R8871:Prss35	UTSW	9	86,755,191 (GRCm38)	missense	possibly damaging	0.84
R9444:Prss35	UTSW	9	86,756,104 (GRCm38)	missense	probably damaging	1.00
R9462:Prss35	UTSW	9	86,756,339 (GRCm38)	missense
R9695:Prss35	UTSW	9	86,755,708 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16