Incidental Mutation 'R0373:Sipa1l2'
| ID |
30620 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l2
|
| Ensembl Gene |
ENSMUSG00000001995 |
| Gene Name |
signal-induced proliferation-associated 1 like 2 |
| Synonyms |
|
| MMRRC Submission |
038579-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R0373 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
125418063-125569808 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 125464410 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Phenylalanine
at position 947
(C947F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148557
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108775]
[ENSMUST00000212168]
[ENSMUST00000212987]
|
| AlphaFold |
Q80TE4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108775
AA Change: C947F
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104405
Gene: ENSMUSG00000001995
AA Change: C947F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
53 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
163 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
261 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
625 |
807 |
2.6e-67 |
PFAM |
|
PDZ
|
960 |
1026 |
6.47e-9 |
SMART |
|
low complexity region
|
1091 |
1103 |
N/A |
INTRINSIC |
|
low complexity region
|
1120 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1238 |
N/A |
INTRINSIC |
|
low complexity region
|
1299 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1321 |
1329 |
N/A |
INTRINSIC |
|
low complexity region
|
1334 |
1355 |
N/A |
INTRINSIC |
|
low complexity region
|
1404 |
1418 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1421 |
1666 |
2.5e-76 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212168
AA Change: C947F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212987
AA Change: C947F
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.8%
- 20x: 91.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930579F01Rik |
A |
T |
3: 138,173,582 (GRCm38) |
L235Q |
probably damaging |
Het |
| Aadacl4fm4 |
A |
T |
4: 144,686,220 (GRCm38) |
M50K |
possibly damaging |
Het |
| Adam6b |
T |
A |
12: 113,490,655 (GRCm38) |
V364D |
probably benign |
Het |
| Akap13 |
T |
A |
7: 75,730,500 (GRCm38) |
S2193T |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,609,929 (GRCm38) |
L767P |
probably benign |
Het |
| Anapc11 |
T |
C |
11: 120,605,377 (GRCm38) |
V69A |
probably benign |
Het |
| Ankmy1 |
C |
T |
1: 92,896,190 (GRCm38) |
R118Q |
probably damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,638,053 (GRCm38) |
S931P |
probably benign |
Het |
| Atp6v1c2 |
G |
A |
12: 17,288,168 (GRCm38) |
R280C |
probably damaging |
Het |
| Bbs10 |
T |
A |
10: 111,300,052 (GRCm38) |
I342N |
probably damaging |
Het |
| Calhm2 |
T |
C |
19: 47,132,950 (GRCm38) |
D260G |
possibly damaging |
Het |
| Camk2a |
A |
G |
18: 60,958,238 (GRCm38) |
E264G |
probably damaging |
Het |
| Ccdc146 |
T |
A |
5: 21,319,545 (GRCm38) |
M270L |
probably benign |
Het |
| Cdc16 |
A |
G |
8: 13,779,264 (GRCm38) |
T517A |
probably benign |
Het |
| Ces1g |
T |
C |
8: 93,331,193 (GRCm38) |
H160R |
probably benign |
Het |
| Chst4 |
T |
C |
8: 110,030,394 (GRCm38) |
N196S |
probably damaging |
Het |
| Ciz1 |
A |
T |
2: 32,367,467 (GRCm38) |
N175Y |
probably damaging |
Het |
| Cyb5r4 |
G |
A |
9: 87,027,040 (GRCm38) |
V57I |
probably damaging |
Het |
| Cyth3 |
A |
G |
5: 143,684,426 (GRCm38) |
|
probably benign |
Het |
| Def6 |
A |
G |
17: 28,220,180 (GRCm38) |
E255G |
probably damaging |
Het |
| Dhtkd1 |
T |
G |
2: 5,911,870 (GRCm38) |
Q665P |
probably damaging |
Het |
| Dsg3 |
A |
C |
18: 20,539,747 (GRCm38) |
D825A |
probably damaging |
Het |
| Eif3m |
T |
C |
2: 105,005,000 (GRCm38) |
T242A |
probably benign |
Het |
| Emilin3 |
A |
G |
2: 160,909,817 (GRCm38) |
F101L |
probably benign |
Het |
| Epha7 |
A |
G |
4: 28,935,700 (GRCm38) |
|
probably null |
Het |
| Fbxo45 |
A |
T |
16: 32,238,405 (GRCm38) |
Y224N |
probably damaging |
Het |
| Fhod3 |
A |
T |
18: 25,090,104 (GRCm38) |
M836L |
possibly damaging |
Het |
| Fut4 |
C |
A |
9: 14,751,210 (GRCm38) |
V263F |
probably damaging |
Het |
| Ggt1 |
C |
T |
10: 75,579,270 (GRCm38) |
T206M |
probably benign |
Het |
| Gls |
T |
C |
1: 52,188,699 (GRCm38) |
R79G |
probably damaging |
Het |
| Grhl1 |
T |
C |
12: 24,581,515 (GRCm38) |
S156P |
probably benign |
Het |
| Ipo8 |
C |
T |
6: 148,775,042 (GRCm38) |
S983N |
probably benign |
Het |
| Kcna7 |
C |
T |
7: 45,409,444 (GRCm38) |
A385V |
probably damaging |
Het |
| Kpnb1 |
A |
T |
11: 97,185,090 (GRCm38) |
L40Q |
probably damaging |
Het |
| Matn1 |
A |
T |
4: 130,950,106 (GRCm38) |
S209C |
probably damaging |
Het |
| Mcc |
A |
G |
18: 44,475,222 (GRCm38) |
I501T |
probably benign |
Het |
| Mdp1 |
A |
T |
14: 55,659,375 (GRCm38) |
F104L |
probably damaging |
Het |
| Mib2 |
A |
T |
4: 155,656,288 (GRCm38) |
N626K |
probably damaging |
Het |
| Mrgprh |
T |
C |
17: 12,876,956 (GRCm38) |
S28P |
possibly damaging |
Het |
| Mup-ps23 |
T |
A |
4: 61,856,149 (GRCm38) |
|
noncoding transcript |
Het |
| Myh15 |
A |
G |
16: 49,182,959 (GRCm38) |
T1794A |
possibly damaging |
Het |
| Myo18a |
C |
G |
11: 77,821,042 (GRCm38) |
P680A |
probably benign |
Het |
| Myom2 |
G |
T |
8: 15,098,419 (GRCm38) |
D532Y |
possibly damaging |
Het |
| Ndufaf5 |
A |
G |
2: 140,170,881 (GRCm38) |
N57S |
probably benign |
Het |
| Nectin3 |
C |
T |
16: 46,458,187 (GRCm38) |
V282M |
probably damaging |
Het |
| Nup188 |
G |
T |
2: 30,330,988 (GRCm38) |
D997Y |
probably damaging |
Het |
| Olfm3 |
T |
C |
3: 115,122,805 (GRCm38) |
V462A |
probably damaging |
Het |
| Opcml |
A |
G |
9: 28,813,398 (GRCm38) |
H164R |
possibly damaging |
Het |
| Or14a259 |
A |
T |
7: 86,363,805 (GRCm38) |
C177* |
probably null |
Het |
| Or4c120 |
A |
T |
2: 89,170,413 (GRCm38) |
F266L |
probably benign |
Het |
| Or8u9 |
A |
C |
2: 86,171,706 (GRCm38) |
F37C |
probably damaging |
Het |
| Pacrg |
A |
G |
17: 10,403,418 (GRCm38) |
I209T |
probably damaging |
Het |
| Pcf11 |
T |
C |
7: 92,661,215 (GRCm38) |
M522V |
probably benign |
Het |
| Pck1 |
T |
A |
2: 173,153,390 (GRCm38) |
M1K |
probably null |
Het |
| Pcm1 |
G |
T |
8: 41,276,111 (GRCm38) |
E707* |
probably null |
Het |
| Pcsk5 |
G |
A |
19: 17,654,849 (GRCm38) |
R318W |
probably damaging |
Het |
| Phf11d |
A |
T |
14: 59,353,344 (GRCm38) |
M188K |
possibly damaging |
Het |
| Ppip5k2 |
A |
T |
1: 97,740,537 (GRCm38) |
C615* |
probably null |
Het |
| Prkdc |
T |
A |
16: 15,791,927 (GRCm38) |
S3132T |
probably damaging |
Het |
| Prl2c5 |
A |
T |
13: 13,183,024 (GRCm38) |
|
probably benign |
Het |
| Prpsap2 |
A |
G |
11: 61,741,000 (GRCm38) |
I177T |
possibly damaging |
Het |
| Rad50 |
A |
G |
11: 53,650,519 (GRCm38) |
S1297P |
probably damaging |
Het |
| Rasip1 |
T |
A |
7: 45,635,244 (GRCm38) |
N678K |
possibly damaging |
Het |
| Rubcn |
A |
G |
16: 32,835,980 (GRCm38) |
S544P |
probably damaging |
Het |
| Rwdd2a |
A |
T |
9: 86,574,400 (GRCm38) |
T210S |
possibly damaging |
Het |
| Scd2 |
A |
G |
19: 44,303,040 (GRCm38) |
D306G |
probably damaging |
Het |
| Sema3b |
T |
C |
9: 107,602,918 (GRCm38) |
N207S |
probably benign |
Het |
| Sf3b2 |
C |
T |
19: 5,274,824 (GRCm38) |
D845N |
probably damaging |
Het |
| Slc12a1 |
A |
T |
2: 125,226,031 (GRCm38) |
T1013S |
probably damaging |
Het |
| Slc18a2 |
A |
T |
19: 59,287,367 (GRCm38) |
I461L |
probably benign |
Het |
| Slc1a6 |
C |
A |
10: 78,801,922 (GRCm38) |
Y427* |
probably null |
Het |
| Slc30a4 |
A |
T |
2: 122,689,399 (GRCm38) |
I231K |
probably damaging |
Het |
| Sos1 |
G |
T |
17: 80,453,763 (GRCm38) |
A168D |
probably damaging |
Het |
| Spata31f1a |
T |
C |
4: 42,851,161 (GRCm38) |
I332V |
probably benign |
Het |
| Sptb |
T |
C |
12: 76,621,371 (GRCm38) |
S651G |
probably benign |
Het |
| Stk36 |
T |
C |
1: 74,633,620 (GRCm38) |
L1007P |
probably damaging |
Het |
| Tek |
A |
T |
4: 94,804,341 (GRCm38) |
N229Y |
probably damaging |
Het |
| Tep1 |
A |
G |
14: 50,836,768 (GRCm38) |
F1887L |
possibly damaging |
Het |
| Tet1 |
A |
T |
10: 62,878,209 (GRCm38) |
C602* |
probably null |
Het |
| Tnfrsf19 |
A |
G |
14: 60,972,036 (GRCm38) |
S262P |
possibly damaging |
Het |
| Trim5 |
T |
C |
7: 104,265,684 (GRCm38) |
I393V |
probably benign |
Het |
| Trpm6 |
A |
G |
19: 18,853,587 (GRCm38) |
E1272G |
probably benign |
Het |
| Ttc21b |
A |
T |
2: 66,188,326 (GRCm38) |
Y1246N |
probably damaging |
Het |
| Ttll3 |
T |
A |
6: 113,398,777 (GRCm38) |
L151H |
probably damaging |
Het |
| U2surp |
C |
T |
9: 95,484,443 (GRCm38) |
V470I |
probably benign |
Het |
| Ubr1 |
A |
T |
2: 120,946,657 (GRCm38) |
Y276N |
probably benign |
Het |
| Uggt1 |
A |
G |
1: 36,179,670 (GRCm38) |
S59P |
probably benign |
Het |
| Unc45a |
T |
C |
7: 80,326,344 (GRCm38) |
T796A |
probably damaging |
Het |
| Unc5b |
C |
A |
10: 60,778,940 (GRCm38) |
V193F |
possibly damaging |
Het |
| Upp1 |
G |
T |
11: 9,129,590 (GRCm38) |
M50I |
probably benign |
Het |
| Vps18 |
C |
T |
2: 119,293,905 (GRCm38) |
R438C |
probably damaging |
Het |
| Zfp715 |
T |
C |
7: 43,299,336 (GRCm38) |
Y400C |
possibly damaging |
Het |
| Zfp955b |
T |
C |
17: 33,302,522 (GRCm38) |
Y322H |
probably benign |
Het |
|
| Other mutations in Sipa1l2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00534:Sipa1l2
|
APN |
8 |
125,491,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00939:Sipa1l2
|
APN |
8 |
125,464,435 (GRCm38) |
splice site |
probably benign |
|
|
IGL00965:Sipa1l2
|
APN |
8 |
125,447,874 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01321:Sipa1l2
|
APN |
8 |
125,491,518 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01450:Sipa1l2
|
APN |
8 |
125,422,577 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01753:Sipa1l2
|
APN |
8 |
125,453,292 (GRCm38) |
splice site |
probably benign |
|
|
IGL01930:Sipa1l2
|
APN |
8 |
125,419,239 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02041:Sipa1l2
|
APN |
8 |
125,491,819 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02215:Sipa1l2
|
APN |
8 |
125,447,837 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02272:Sipa1l2
|
APN |
8 |
125,492,011 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02370:Sipa1l2
|
APN |
8 |
125,480,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02538:Sipa1l2
|
APN |
8 |
125,451,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02633:Sipa1l2
|
APN |
8 |
125,447,768 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03394:Sipa1l2
|
APN |
8 |
125,491,659 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Rebellious
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0144:Sipa1l2
|
UTSW |
8 |
125,449,876 (GRCm38) |
splice site |
probably null |
|
|
R0153:Sipa1l2
|
UTSW |
8 |
125,421,898 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0276:Sipa1l2
|
UTSW |
8 |
125,421,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0318:Sipa1l2
|
UTSW |
8 |
125,447,697 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R0427:Sipa1l2
|
UTSW |
8 |
125,480,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0634:Sipa1l2
|
UTSW |
8 |
125,422,624 (GRCm38) |
nonsense |
probably null |
|
|
R1377:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1435:Sipa1l2
|
UTSW |
8 |
125,468,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1523:Sipa1l2
|
UTSW |
8 |
125,447,613 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1577:Sipa1l2
|
UTSW |
8 |
125,492,262 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1581:Sipa1l2
|
UTSW |
8 |
125,491,617 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1583:Sipa1l2
|
UTSW |
8 |
125,421,895 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1719:Sipa1l2
|
UTSW |
8 |
125,444,535 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1730:Sipa1l2
|
UTSW |
8 |
125,480,141 (GRCm38) |
splice site |
probably null |
|
|
R1940:Sipa1l2
|
UTSW |
8 |
125,480,148 (GRCm38) |
splice site |
probably benign |
|
|
R2007:Sipa1l2
|
UTSW |
8 |
125,439,437 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2141:Sipa1l2
|
UTSW |
8 |
125,491,491 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2203:Sipa1l2
|
UTSW |
8 |
125,491,627 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2764:Sipa1l2
|
UTSW |
8 |
125,492,374 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3722:Sipa1l2
|
UTSW |
8 |
125,473,584 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,450,383 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,423,205 (GRCm38) |
missense |
probably benign |
|
|
R4106:Sipa1l2
|
UTSW |
8 |
125,492,308 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4117:Sipa1l2
|
UTSW |
8 |
125,468,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4194:Sipa1l2
|
UTSW |
8 |
125,491,672 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4237:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4240:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4448:Sipa1l2
|
UTSW |
8 |
125,492,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4515:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4519:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4523:Sipa1l2
|
UTSW |
8 |
125,492,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4557:Sipa1l2
|
UTSW |
8 |
125,464,415 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4667:Sipa1l2
|
UTSW |
8 |
125,453,470 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R4687:Sipa1l2
|
UTSW |
8 |
125,491,245 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4854:Sipa1l2
|
UTSW |
8 |
125,473,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4890:Sipa1l2
|
UTSW |
8 |
125,491,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5065:Sipa1l2
|
UTSW |
8 |
125,491,585 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5194:Sipa1l2
|
UTSW |
8 |
125,439,273 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R5266:Sipa1l2
|
UTSW |
8 |
125,492,126 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5475:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5718:Sipa1l2
|
UTSW |
8 |
125,491,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5910:Sipa1l2
|
UTSW |
8 |
125,491,684 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5916:Sipa1l2
|
UTSW |
8 |
125,468,573 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5941:Sipa1l2
|
UTSW |
8 |
125,473,536 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6083:Sipa1l2
|
UTSW |
8 |
125,468,473 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6185:Sipa1l2
|
UTSW |
8 |
125,468,253 (GRCm38) |
nonsense |
probably null |
|
|
R6235:Sipa1l2
|
UTSW |
8 |
125,474,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6274:Sipa1l2
|
UTSW |
8 |
125,469,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6299:Sipa1l2
|
UTSW |
8 |
125,453,464 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6374:Sipa1l2
|
UTSW |
8 |
125,444,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6459:Sipa1l2
|
UTSW |
8 |
125,444,484 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6462:Sipa1l2
|
UTSW |
8 |
125,491,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6496:Sipa1l2
|
UTSW |
8 |
125,449,894 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6543:Sipa1l2
|
UTSW |
8 |
125,450,362 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R7154:Sipa1l2
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7192:Sipa1l2
|
UTSW |
8 |
125,422,609 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7240:Sipa1l2
|
UTSW |
8 |
125,469,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7361:Sipa1l2
|
UTSW |
8 |
125,453,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7383:Sipa1l2
|
UTSW |
8 |
125,447,646 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7417:Sipa1l2
|
UTSW |
8 |
125,482,106 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7604:Sipa1l2
|
UTSW |
8 |
125,419,272 (GRCm38) |
missense |
probably benign |
0.45 |
|
R7658:Sipa1l2
|
UTSW |
8 |
125,492,290 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7743:Sipa1l2
|
UTSW |
8 |
125,464,233 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7781:Sipa1l2
|
UTSW |
8 |
125,491,827 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7812:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7829:Sipa1l2
|
UTSW |
8 |
125,451,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7880:Sipa1l2
|
UTSW |
8 |
125,464,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7884:Sipa1l2
|
UTSW |
8 |
125,447,598 (GRCm38) |
missense |
probably benign |
|
|
R8057:Sipa1l2
|
UTSW |
8 |
125,468,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8082:Sipa1l2
|
UTSW |
8 |
125,491,809 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8092:Sipa1l2
|
UTSW |
8 |
125,419,168 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8247:Sipa1l2
|
UTSW |
8 |
125,422,633 (GRCm38) |
missense |
probably benign |
0.29 |
|
R8252:Sipa1l2
|
UTSW |
8 |
125,468,671 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8386:Sipa1l2
|
UTSW |
8 |
125,492,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8466:Sipa1l2
|
UTSW |
8 |
125,492,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8697:Sipa1l2
|
UTSW |
8 |
125,482,116 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8725:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R8727:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R9048:Sipa1l2
|
UTSW |
8 |
125,447,726 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9224:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9279:Sipa1l2
|
UTSW |
8 |
125,482,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9392:Sipa1l2
|
UTSW |
8 |
125,468,221 (GRCm38) |
missense |
probably benign |
|
|
R9574:Sipa1l2
|
UTSW |
8 |
125,442,714 (GRCm38) |
missense |
probably benign |
|
|
R9591:Sipa1l2
|
UTSW |
8 |
125,492,373 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9614:Sipa1l2
|
UTSW |
8 |
125,469,826 (GRCm38) |
missense |
probably null |
0.01 |
|
R9690:Sipa1l2
|
UTSW |
8 |
125,492,257 (GRCm38) |
missense |
probably benign |
|
|
X0027:Sipa1l2
|
UTSW |
8 |
125,492,136 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Sipa1l2
|
UTSW |
8 |
125,447,556 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGTCACAGATGTCCGCAGTAAG -3'
(R):5'- TGCCACATGAGCCAGGGTAAAAC -3'
Sequencing Primer
(F):5'- GCAGTAAGTCAATCATCTGCTCG -3'
(R):5'- GGTAAAACCCAGCTTTGGTTC -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation