Incidental Mutation 'IGL02749:Srms'
ID306210
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Srms
Ensembl Gene ENSMUSG00000027579
Gene Namesrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
SynonymsA230069J08Rik, srm
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.823) question?
Stock #IGL02749
Quality Score
Status
Chromosome2
Chromosomal Location181205562-181213185 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 181209509 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Serine at position 155 (A155S)
Ref Sequence ENSEMBL: ENSMUSP00000016498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016498]
Predicted Effect possibly damaging
Transcript: ENSMUST00000016498
AA Change: A155S

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000016498
Gene: ENSMUSG00000027579
AA Change: A155S

DomainStartEndE-ValueType
SH3 69 126 3.13e-9 SMART
SH2 133 218 5.29e-32 SMART
TyrKc 245 495 2.75e-135 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice exhibit no detectable abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830473C10Rik T C 5: 90,571,765 V240A possibly damaging Het
9230104M06Rik T C 12: 113,000,175 D61G probably benign Het
Ascc2 G A 11: 4,640,481 probably null Het
Atrn G T 2: 130,947,734 probably benign Het
Atrn C T 2: 130,970,144 Q670* probably null Het
Calr A C 8: 84,844,488 W236G probably damaging Het
Camk2g T A 14: 20,766,016 probably null Het
Cd101 G T 3: 101,020,399 T122K probably damaging Het
Col4a3bp T A 13: 96,629,135 N469K possibly damaging Het
Cryl1 T C 14: 57,303,724 T168A probably benign Het
Diaph3 A G 14: 86,918,825 I684T probably damaging Het
Ednrb A T 14: 103,823,059 M266K possibly damaging Het
Eif4h T C 5: 134,639,292 D3G probably damaging Het
Eny2 C T 15: 44,429,635 R28C possibly damaging Het
Epsti1 A G 14: 77,939,923 E181G probably damaging Het
Ezh2 A G 6: 47,533,764 F598S probably damaging Het
Fat3 G T 9: 16,006,711 T1472K possibly damaging Het
Gabra4 T A 5: 71,638,147 I262F probably benign Het
Gm15448 A G 7: 3,822,625 I415T probably damaging Het
Gpat4 A T 8: 23,180,870 Y109N probably damaging Het
Gpsm1 C T 2: 26,339,675 T36I probably damaging Het
Hikeshi C T 7: 89,935,889 V36I possibly damaging Het
Hip1 T C 5: 135,444,751 M238V probably benign Het
Hnrnpll A T 17: 80,061,991 M1K probably null Het
Irx2 G A 13: 72,631,310 D238N probably damaging Het
Kcnip4 T A 5: 48,409,785 probably benign Het
Lair1 G A 7: 4,028,901 T69I possibly damaging Het
Lamc1 A G 1: 153,249,853 I558T possibly damaging Het
Map4k5 C T 12: 69,815,806 E639K probably benign Het
Mc4r A G 18: 66,859,662 S127P probably damaging Het
Mmp23 A G 4: 155,651,532 M221T possibly damaging Het
Mre11a T C 9: 14,826,591 S587P possibly damaging Het
Myh9 A T 15: 77,807,986 Y124* probably null Het
Nek9 C A 12: 85,305,507 A861S probably benign Het
Nup155 T A 15: 8,134,076 Y576N probably damaging Het
Olfr1128 C T 2: 87,544,657 V296M probably damaging Het
Pcca A T 14: 122,534,388 T8S probably benign Het
Pcdh15 A G 10: 74,631,068 D1573G probably benign Het
Pdpr T A 8: 111,118,090 V373E probably benign Het
Pdzph1 A T 17: 58,932,483 L950Q possibly damaging Het
Prss35 A C 9: 86,756,244 K356Q probably damaging Het
Psg22 A T 7: 18,723,019 T237S possibly damaging Het
Rdh13 A G 7: 4,427,704 Y252H probably damaging Het
Sema3d T C 5: 12,563,145 probably benign Het
Slc35b2 G A 17: 45,566,567 V207I probably benign Het
Sparcl1 T G 5: 104,092,880 E226A possibly damaging Het
Tas2r107 A T 6: 131,659,954 I44N probably damaging Het
Tmem236 C T 2: 14,219,321 T307M probably damaging Het
Ush2a C T 1: 188,946,958 P4788S probably damaging Het
Vmn1r170 A T 7: 23,606,291 L39F probably benign Het
Vmn2r90 T A 17: 17,726,860 *121R probably null Het
Other mutations in Srms
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Srms APN 2 181207772 missense probably benign 0.02
IGL01084:Srms APN 2 181206384 splice site probably null
IGL01086:Srms APN 2 181212423 missense probably damaging 1.00
IGL02808:Srms APN 2 181207708 missense probably damaging 1.00
IGL02986:Srms APN 2 181212497 missense possibly damaging 0.73
IGL03180:Srms APN 2 181212780 utr 5 prime probably benign
R0226:Srms UTSW 2 181212382 missense probably benign 0.00
R0685:Srms UTSW 2 181212633 missense probably benign 0.00
R2171:Srms UTSW 2 181208780 nonsense probably null
R5808:Srms UTSW 2 181208755 missense probably benign 0.02
R6112:Srms UTSW 2 181207987 nonsense probably null
R6277:Srms UTSW 2 181206245 missense possibly damaging 0.58
R6572:Srms UTSW 2 181212657 missense probably benign
R6737:Srms UTSW 2 181209460 missense probably damaging 1.00
R8069:Srms UTSW 2 181206958 missense probably damaging 1.00
R8264:Srms UTSW 2 181212550 missense probably benign 0.10
Posted On2015-04-16