Incidental Mutation 'IGL02750:Vmn2r2'
ID 306237
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r2
Ensembl Gene ENSMUSG00000043897
Gene Name vomeronasal 2, receptor 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # IGL02750
Quality Score
Status
Chromosome 3
Chromosomal Location 64022699-64049349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 64024823 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 586 (C586F)
Ref Sequence ENSEMBL: ENSMUSP00000135110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]
AlphaFold L7N2E9
Predicted Effect probably damaging
Transcript: ENSMUST00000077958
AA Change: C502F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: C502F

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 4.5e-80 PFAM
Pfam:NCD3G 458 511 8.3e-18 PFAM
Pfam:7tm_3 542 779 1.3e-75 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000177151
AA Change: C586F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: C586F

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 83 500 1.6e-84 PFAM
Pfam:NCD3G 542 595 2.6e-17 PFAM
Pfam:7tm_3 628 862 1.9e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amotl1 T C 9: 14,460,087 (GRCm39) K884R probably benign Het
Ano3 T A 2: 110,496,329 (GRCm39) probably benign Het
Baz2b C A 2: 59,799,002 (GRCm39) S374I possibly damaging Het
Brd4 G A 17: 32,417,353 (GRCm39) probably benign Het
Cd3g C A 9: 44,882,608 (GRCm39) probably benign Het
Ckmt1 C T 2: 121,194,096 (GRCm39) probably benign Het
Clcnkb T C 4: 141,132,673 (GRCm39) probably null Het
Dkkl1 C T 7: 44,859,536 (GRCm39) probably null Het
Ehmt1 G A 2: 24,753,881 (GRCm39) T161I probably damaging Het
Ern2 A G 7: 121,780,629 (GRCm39) probably benign Het
Fmnl2 T C 2: 52,993,709 (GRCm39) I368T possibly damaging Het
Gabra5 G T 7: 57,157,739 (GRCm39) S25Y probably benign Het
Gemin7 C T 7: 19,299,344 (GRCm39) V84M probably null Het
Gm17654 A G 14: 43,815,656 (GRCm39) probably benign Het
Grk6 T C 13: 55,599,356 (GRCm39) F186S probably damaging Het
Gtf2ird2 A G 5: 134,245,731 (GRCm39) H663R probably damaging Het
Gtf3c1 T A 7: 125,275,684 (GRCm39) I581F probably damaging Het
Herc2 T A 7: 55,854,127 (GRCm39) probably benign Het
Hook3 A T 8: 26,585,782 (GRCm39) probably benign Het
Ints4 T A 7: 97,166,964 (GRCm39) probably null Het
Kpna6 T C 4: 129,555,170 (GRCm39) N20D probably damaging Het
Krtap29-1 T C 11: 99,869,510 (GRCm39) S124G probably benign Het
Krtap4-16 C A 11: 99,742,106 (GRCm39) R98L possibly damaging Het
Lrrc28 T C 7: 67,181,431 (GRCm39) D268G probably damaging Het
Mcm6 T A 1: 128,271,209 (GRCm39) Q470L probably damaging Het
Neb T C 2: 52,181,067 (GRCm39) H1180R probably benign Het
Nxpe3 C A 16: 55,680,738 (GRCm39) V285L probably benign Het
Or10al2 T A 17: 37,983,500 (GRCm39) C195* probably null Het
Or14a260 T A 7: 85,984,752 (GRCm39) N284I probably damaging Het
Or4k37 A G 2: 111,159,633 (GRCm39) R290G probably damaging Het
Pdcd1 A G 1: 93,967,269 (GRCm39) probably benign Het
Pnkp A G 7: 44,509,611 (GRCm39) probably benign Het
Pou4f2 A T 8: 79,161,692 (GRCm39) F304I probably damaging Het
Rita1 G A 5: 120,747,716 (GRCm39) T194M possibly damaging Het
Rnpc3 T C 3: 113,415,588 (GRCm39) T150A possibly damaging Het
Sema3b T C 9: 107,480,363 (GRCm39) T168A probably benign Het
Skint5 T A 4: 113,396,559 (GRCm39) M1205L unknown Het
Sox13 A C 1: 133,311,534 (GRCm39) I566S probably benign Het
Tbc1d32 T C 10: 56,074,587 (GRCm39) T209A possibly damaging Het
Tonsl G T 15: 76,517,589 (GRCm39) P710Q probably damaging Het
Trpm5 T C 7: 142,628,221 (GRCm39) H1018R possibly damaging Het
Ubr2 A T 17: 47,280,208 (GRCm39) M647K probably benign Het
Ubr7 A T 12: 102,737,537 (GRCm39) T395S possibly damaging Het
Uri1 G A 7: 37,666,906 (GRCm39) R176* probably null Het
Vmn1r188 A T 13: 22,272,900 (GRCm39) I285F probably damaging Het
Vmn2r116 T A 17: 23,616,608 (GRCm39) probably benign Het
Vmn2r96 T A 17: 18,802,851 (GRCm39) W62R probably benign Het
Zfp24 A T 18: 24,150,410 (GRCm39) S167T possibly damaging Het
Zfp462 A G 4: 55,060,236 (GRCm39) K1254R probably null Het
Other mutations in Vmn2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Vmn2r2 APN 3 64,041,319 (GRCm39) splice site probably benign
IGL00980:Vmn2r2 APN 3 64,024,601 (GRCm39) missense probably benign 0.11
IGL01389:Vmn2r2 APN 3 64,024,430 (GRCm39) missense probably damaging 0.97
IGL01804:Vmn2r2 APN 3 64,041,677 (GRCm39) missense possibly damaging 0.91
IGL02829:Vmn2r2 APN 3 64,026,172 (GRCm39) splice site probably benign
IGL03036:Vmn2r2 APN 3 64,024,321 (GRCm39) missense probably benign 0.01
IGL03174:Vmn2r2 APN 3 64,024,544 (GRCm39) nonsense probably null
PIT4151001:Vmn2r2 UTSW 3 64,024,334 (GRCm39) missense possibly damaging 0.67
R0029:Vmn2r2 UTSW 3 64,024,365 (GRCm39) missense probably benign 0.00
R0310:Vmn2r2 UTSW 3 64,042,039 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r2 UTSW 3 64,041,320 (GRCm39) splice site probably null
R0637:Vmn2r2 UTSW 3 64,033,999 (GRCm39) missense probably benign 0.00
R1626:Vmn2r2 UTSW 3 64,041,921 (GRCm39) missense possibly damaging 0.61
R1662:Vmn2r2 UTSW 3 64,024,551 (GRCm39) missense probably benign 0.00
R1710:Vmn2r2 UTSW 3 64,024,820 (GRCm39) missense probably benign 0.19
R1797:Vmn2r2 UTSW 3 64,042,128 (GRCm39) missense probably benign 0.00
R1862:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R1971:Vmn2r2 UTSW 3 64,034,121 (GRCm39) missense probably damaging 1.00
R2051:Vmn2r2 UTSW 3 64,024,766 (GRCm39) missense possibly damaging 0.77
R2099:Vmn2r2 UTSW 3 64,024,474 (GRCm39) missense probably damaging 1.00
R2275:Vmn2r2 UTSW 3 64,023,930 (GRCm39) missense probably benign 0.00
R3078:Vmn2r2 UTSW 3 64,042,053 (GRCm39) missense probably benign 0.22
R3418:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3419:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3959:Vmn2r2 UTSW 3 64,047,947 (GRCm39) missense probably benign
R4230:Vmn2r2 UTSW 3 64,041,912 (GRCm39) missense probably benign 0.00
R4258:Vmn2r2 UTSW 3 64,042,118 (GRCm39) missense probably damaging 1.00
R4810:Vmn2r2 UTSW 3 64,044,883 (GRCm39) missense probably damaging 1.00
R4822:Vmn2r2 UTSW 3 64,041,960 (GRCm39) missense probably damaging 0.99
R4919:Vmn2r2 UTSW 3 64,024,578 (GRCm39) missense possibly damaging 0.56
R4925:Vmn2r2 UTSW 3 64,044,892 (GRCm39) start codon destroyed probably null 0.03
R4954:Vmn2r2 UTSW 3 64,047,905 (GRCm39) missense probably benign 0.00
R5071:Vmn2r2 UTSW 3 64,024,321 (GRCm39) missense probably benign 0.01
R5315:Vmn2r2 UTSW 3 64,024,377 (GRCm39) missense probably benign 0.37
R5450:Vmn2r2 UTSW 3 64,034,011 (GRCm39) missense probably benign
R5577:Vmn2r2 UTSW 3 64,024,416 (GRCm39) missense probably benign 0.00
R5595:Vmn2r2 UTSW 3 64,034,036 (GRCm39) missense possibly damaging 0.74
R5727:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.41
R5810:Vmn2r2 UTSW 3 64,024,815 (GRCm39) missense probably damaging 1.00
R5919:Vmn2r2 UTSW 3 64,044,723 (GRCm39) missense probably benign 0.39
R6052:Vmn2r2 UTSW 3 64,024,782 (GRCm39) missense possibly damaging 0.56
R6084:Vmn2r2 UTSW 3 64,024,467 (GRCm39) missense probably benign 0.01
R6299:Vmn2r2 UTSW 3 64,024,074 (GRCm39) nonsense probably null
R6762:Vmn2r2 UTSW 3 64,041,870 (GRCm39) missense probably damaging 1.00
R6858:Vmn2r2 UTSW 3 64,044,915 (GRCm39) missense probably damaging 1.00
R6889:Vmn2r2 UTSW 3 64,024,688 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.02
R7195:Vmn2r2 UTSW 3 64,023,900 (GRCm39) missense probably benign 0.01
R7269:Vmn2r2 UTSW 3 64,033,998 (GRCm39) missense probably benign 0.32
R7699:Vmn2r2 UTSW 3 64,024,536 (GRCm39) missense possibly damaging 0.69
R7717:Vmn2r2 UTSW 3 64,042,019 (GRCm39) missense possibly damaging 0.95
R7798:Vmn2r2 UTSW 3 64,041,518 (GRCm39) missense possibly damaging 0.60
R7914:Vmn2r2 UTSW 3 64,041,526 (GRCm39) missense probably benign 0.20
R7974:Vmn2r2 UTSW 3 64,024,808 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r2 UTSW 3 64,044,858 (GRCm39) missense probably damaging 1.00
R8478:Vmn2r2 UTSW 3 64,024,257 (GRCm39) missense possibly damaging 0.87
R8731:Vmn2r2 UTSW 3 64,024,404 (GRCm39) missense probably benign 0.16
R9035:Vmn2r2 UTSW 3 64,024,172 (GRCm39) missense probably damaging 1.00
R9182:Vmn2r2 UTSW 3 64,044,802 (GRCm39) missense probably damaging 1.00
R9225:Vmn2r2 UTSW 3 64,034,021 (GRCm39) missense probably benign 0.00
R9266:Vmn2r2 UTSW 3 64,024,057 (GRCm39) missense probably damaging 0.98
R9427:Vmn2r2 UTSW 3 64,041,945 (GRCm39) missense probably damaging 1.00
R9659:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R9666:Vmn2r2 UTSW 3 64,023,870 (GRCm39) missense probably benign 0.08
R9771:Vmn2r2 UTSW 3 64,042,079 (GRCm39) missense possibly damaging 0.88
R9788:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
X0024:Vmn2r2 UTSW 3 64,044,707 (GRCm39) nonsense probably null
Posted On 2015-04-16