Incidental Mutation 'R0373:Anapc11'
ID 30636
Institutional Source Beutler Lab
Gene Symbol Anapc11
Ensembl Gene ENSMUSG00000025135
Gene Name anaphase promoting complex subunit 11
MMRRC Submission 038579-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.871) question?
Stock # R0373 (G1)
Quality Score 164
Status Not validated
Chromosome 11
Chromosomal Location 120598421-120608198 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120605377 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 69 (V69A)
Ref Sequence ENSEMBL: ENSMUSP00000097714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026128] [ENSMUST00000026129] [ENSMUST00000061309] [ENSMUST00000093140] [ENSMUST00000106194] [ENSMUST00000106195]
AlphaFold Q9CPX9
Predicted Effect probably benign
Transcript: ENSMUST00000026128
AA Change: V69A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000026128
Gene: ENSMUSG00000025135
AA Change: V69A

RING 23 76 4.48e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000026129
SMART Domains Protein: ENSMUSP00000026129
Gene: ENSMUSG00000025137

Pfam:CTP_transf_like 26 152 2.6e-32 PFAM
Pfam:CTP_transf_like 235 384 8.9e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000061309
SMART Domains Protein: ENSMUSP00000050092
Gene: ENSMUSG00000044034

Pfam:NPBW 2 107 1.3e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000093140
AA Change: V69A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097714
Gene: ENSMUSG00000025135
AA Change: V69A

RING 23 76 4.48e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106194
SMART Domains Protein: ENSMUSP00000101800
Gene: ENSMUSG00000044034

Pfam:NPBW 2 115 5.2e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106195
SMART Domains Protein: ENSMUSP00000101801
Gene: ENSMUSG00000044034

Pfam:NPBW 5 118 6.9e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129263
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148114
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.8%
  • 20x: 91.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930579F01Rik A T 3: 138,173,582 (GRCm38) L235Q probably damaging Het
Adam6b T A 12: 113,490,655 (GRCm38) V364D probably benign Het
Akap13 T A 7: 75,730,500 (GRCm38) S2193T probably damaging Het
Akap13 T C 7: 75,609,929 (GRCm38) L767P probably benign Het
Ankmy1 C T 1: 92,896,190 (GRCm38) R118Q probably damaging Het
Ankrd27 T C 7: 35,638,053 (GRCm38) S931P probably benign Het
Atp6v1c2 G A 12: 17,288,168 (GRCm38) R280C probably damaging Het
Bbs10 T A 10: 111,300,052 (GRCm38) I342N probably damaging Het
Calhm2 T C 19: 47,132,950 (GRCm38) D260G possibly damaging Het
Camk2a A G 18: 60,958,238 (GRCm38) E264G probably damaging Het
Ccdc146 T A 5: 21,319,545 (GRCm38) M270L probably benign Het
Cdc16 A G 8: 13,779,264 (GRCm38) T517A probably benign Het
Ces1g T C 8: 93,331,193 (GRCm38) H160R probably benign Het
Chst4 T C 8: 110,030,394 (GRCm38) N196S probably damaging Het
Ciz1 A T 2: 32,367,467 (GRCm38) N175Y probably damaging Het
Cyb5r4 G A 9: 87,027,040 (GRCm38) V57I probably damaging Het
Cyth3 A G 5: 143,684,426 (GRCm38) probably benign Het
Def6 A G 17: 28,220,180 (GRCm38) E255G probably damaging Het
Dhtkd1 T G 2: 5,911,870 (GRCm38) Q665P probably damaging Het
Dsg3 A C 18: 20,539,747 (GRCm38) D825A probably damaging Het
Eif3m T C 2: 105,005,000 (GRCm38) T242A probably benign Het
Emilin3 A G 2: 160,909,817 (GRCm38) F101L probably benign Het
Epha7 A G 4: 28,935,700 (GRCm38) probably null Het
Fam205a1 T C 4: 42,851,161 (GRCm38) I332V probably benign Het
Fbxo45 A T 16: 32,238,405 (GRCm38) Y224N probably damaging Het
Fhod3 A T 18: 25,090,104 (GRCm38) M836L possibly damaging Het
Fut4 C A 9: 14,751,210 (GRCm38) V263F probably damaging Het
Ggt1 C T 10: 75,579,270 (GRCm38) T206M probably benign Het
Gls T C 1: 52,188,699 (GRCm38) R79G probably damaging Het
Gm436 A T 4: 144,686,220 (GRCm38) M50K possibly damaging Het
Grhl1 T C 12: 24,581,515 (GRCm38) S156P probably benign Het
Ipo8 C T 6: 148,775,042 (GRCm38) S983N probably benign Het
Kcna7 C T 7: 45,409,444 (GRCm38) A385V probably damaging Het
Kpnb1 A T 11: 97,185,090 (GRCm38) L40Q probably damaging Het
Matn1 A T 4: 130,950,106 (GRCm38) S209C probably damaging Het
Mcc A G 18: 44,475,222 (GRCm38) I501T probably benign Het
Mdp1 A T 14: 55,659,375 (GRCm38) F104L probably damaging Het
Mib2 A T 4: 155,656,288 (GRCm38) N626K probably damaging Het
Mrgprh T C 17: 12,876,956 (GRCm38) S28P possibly damaging Het
Mup-ps23 T A 4: 61,856,149 (GRCm38) noncoding transcript Het
Myh15 A G 16: 49,182,959 (GRCm38) T1794A possibly damaging Het
Myo18a C G 11: 77,821,042 (GRCm38) P680A probably benign Het
Myom2 G T 8: 15,098,419 (GRCm38) D532Y possibly damaging Het
Ndufaf5 A G 2: 140,170,881 (GRCm38) N57S probably benign Het
Nectin3 C T 16: 46,458,187 (GRCm38) V282M probably damaging Het
Nup188 G T 2: 30,330,988 (GRCm38) D997Y probably damaging Het
Olfm3 T C 3: 115,122,805 (GRCm38) V462A probably damaging Het
Olfr1044 A C 2: 86,171,706 (GRCm38) F37C probably damaging Het
Olfr1225 A T 2: 89,170,413 (GRCm38) F266L probably benign Het
Olfr305 A T 7: 86,363,805 (GRCm38) C177* probably null Het
Opcml A G 9: 28,813,398 (GRCm38) H164R possibly damaging Het
Pacrg A G 17: 10,403,418 (GRCm38) I209T probably damaging Het
Pcf11 T C 7: 92,661,215 (GRCm38) M522V probably benign Het
Pck1 T A 2: 173,153,390 (GRCm38) M1K probably null Het
Pcm1 G T 8: 41,276,111 (GRCm38) E707* probably null Het
Pcsk5 G A 19: 17,654,849 (GRCm38) R318W probably damaging Het
Phf11d A T 14: 59,353,344 (GRCm38) M188K possibly damaging Het
Ppip5k2 A T 1: 97,740,537 (GRCm38) C615* probably null Het
Prkdc T A 16: 15,791,927 (GRCm38) S3132T probably damaging Het
Prl2c5 A T 13: 13,183,024 (GRCm38) probably benign Het
Prpsap2 A G 11: 61,741,000 (GRCm38) I177T possibly damaging Het
Rad50 A G 11: 53,650,519 (GRCm38) S1297P probably damaging Het
Rasip1 T A 7: 45,635,244 (GRCm38) N678K possibly damaging Het
Rubcn A G 16: 32,835,980 (GRCm38) S544P probably damaging Het
Rwdd2a A T 9: 86,574,400 (GRCm38) T210S possibly damaging Het
Scd2 A G 19: 44,303,040 (GRCm38) D306G probably damaging Het
Sema3b T C 9: 107,602,918 (GRCm38) N207S probably benign Het
Sf3b2 C T 19: 5,274,824 (GRCm38) D845N probably damaging Het
Sipa1l2 C A 8: 125,464,410 (GRCm38) C947F probably damaging Het
Slc12a1 A T 2: 125,226,031 (GRCm38) T1013S probably damaging Het
Slc18a2 A T 19: 59,287,367 (GRCm38) I461L probably benign Het
Slc1a6 C A 10: 78,801,922 (GRCm38) Y427* probably null Het
Slc30a4 A T 2: 122,689,399 (GRCm38) I231K probably damaging Het
Sos1 G T 17: 80,453,763 (GRCm38) A168D probably damaging Het
Sptb T C 12: 76,621,371 (GRCm38) S651G probably benign Het
Stk36 T C 1: 74,633,620 (GRCm38) L1007P probably damaging Het
Tek A T 4: 94,804,341 (GRCm38) N229Y probably damaging Het
Tep1 A G 14: 50,836,768 (GRCm38) F1887L possibly damaging Het
Tet1 A T 10: 62,878,209 (GRCm38) C602* probably null Het
Tnfrsf19 A G 14: 60,972,036 (GRCm38) S262P possibly damaging Het
Trim5 T C 7: 104,265,684 (GRCm38) I393V probably benign Het
Trpm6 A G 19: 18,853,587 (GRCm38) E1272G probably benign Het
Ttc21b A T 2: 66,188,326 (GRCm38) Y1246N probably damaging Het
Ttll3 T A 6: 113,398,777 (GRCm38) L151H probably damaging Het
U2surp C T 9: 95,484,443 (GRCm38) V470I probably benign Het
Ubr1 A T 2: 120,946,657 (GRCm38) Y276N probably benign Het
Uggt1 A G 1: 36,179,670 (GRCm38) S59P probably benign Het
Unc45a T C 7: 80,326,344 (GRCm38) T796A probably damaging Het
Unc5b C A 10: 60,778,940 (GRCm38) V193F possibly damaging Het
Upp1 G T 11: 9,129,590 (GRCm38) M50I probably benign Het
Vps18 C T 2: 119,293,905 (GRCm38) R438C probably damaging Het
Zfp715 T C 7: 43,299,336 (GRCm38) Y400C possibly damaging Het
Zfp955b T C 17: 33,302,522 (GRCm38) Y322H probably benign Het
Other mutations in Anapc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Anapc11 APN 11 120,599,347 (GRCm38) missense possibly damaging 0.95
IGL02689:Anapc11 APN 11 120,599,342 (GRCm38) missense probably benign 0.06
IGL02738:Anapc11 APN 11 120,599,276 (GRCm38) missense probably benign 0.07
R0575:Anapc11 UTSW 11 120,599,366 (GRCm38) missense probably benign 0.00
R8167:Anapc11 UTSW 11 120,599,286 (GRCm38) missense probably benign 0.04
R9480:Anapc11 UTSW 11 120,605,350 (GRCm38) missense probably damaging 1.00
R9487:Anapc11 UTSW 11 120,605,424 (GRCm38) makesense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-04-24