Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02755:Wscd2'

306379

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wscd2

Ensembl Gene

ENSMUSG00000063430

Gene Name

WSC domain containing 2

Synonyms

4933413A10Rik, C530024P05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02755

Quality Score

Status

Chromosome

Chromosomal Location

113638199-113727786 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 113712092 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 337 (M337K)

Ref Sequence

ENSEMBL: ENSMUSP00000092021 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094452]

AlphaFold

D4PHA7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094452
AA Change: M337K

PolyPhen 2 Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000092021
Gene: ENSMUSG00000063430
AA Change: M337K

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
low complexity region	44	61	N/A	INTRINSIC
WSC	133	225	6.11e-44	SMART
WSC	236	330	9.49e-41	SMART
Blast:WSC	389	409	2e-6	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181294

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198673

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930512M02Rik	T	A	11: 11,539,358 (GRCm39)	N189I	unknown	Het
Adamts19	T	A	18: 59,103,005 (GRCm39)	I682K	probably benign	Het
Adra1a	G	A	14: 66,965,110 (GRCm39)	V367I	probably benign	Het
Alpk3	A	G	7: 80,743,507 (GRCm39)	E1108G	possibly damaging	Het
Ccdc186	A	T	19: 56,801,828 (GRCm39)	N96K	probably benign	Het
Ccnb1	A	G	13: 100,918,168 (GRCm39)	Y160H	possibly damaging	Het
Cebpz	A	T	17: 79,238,759 (GRCm39)	V683E	probably damaging	Het
Cep104	A	G	4: 154,081,416 (GRCm39)	H786R	possibly damaging	Het
Chd9	T	C	8: 91,760,210 (GRCm39)	I1985T	probably benign	Het
Cntn2	T	A	1: 132,457,040 (GRCm39)	T36S	probably benign	Het
Cntnap5c	T	C	17: 58,671,189 (GRCm39)	S1126P	probably benign	Het
Cpt2	A	T	4: 107,764,972 (GRCm39)	V264E	probably damaging	Het
Degs2	T	C	12: 108,658,842 (GRCm39)	T46A	probably benign	Het
Dip2c	T	C	13: 9,600,356 (GRCm39)		probably null	Het
Dnaaf1	A	G	8: 120,317,410 (GRCm39)	D313G	probably damaging	Het
Ephb3	T	G	16: 21,040,448 (GRCm39)	D561E	probably damaging	Het
Eps15	A	G	4: 109,186,895 (GRCm39)	T321A	probably benign	Het
Ercc6	A	G	14: 32,297,705 (GRCm39)		probably benign	Het
Gcn1	T	A	5: 115,742,065 (GRCm39)		probably null	Het
Gm28177	G	A	1: 52,136,031 (GRCm39)		probably benign	Het
Gucy2g	C	A	19: 55,198,786 (GRCm39)	V786F	probably benign	Het
H2-M3	T	C	17: 37,581,913 (GRCm39)	V123A	possibly damaging	Het
Hmgxb3	T	C	18: 61,305,260 (GRCm39)	K33E	probably damaging	Het
Ift22	T	C	5: 136,940,640 (GRCm39)	W102R	probably damaging	Het
Lgi4	T	C	7: 30,762,530 (GRCm39)	F44L	probably damaging	Het
Lingo3	T	C	10: 80,671,843 (GRCm39)	E29G	possibly damaging	Het
Nf2	A	G	11: 4,768,542 (GRCm39)	L109P	probably damaging	Het
Ntrk3	T	C	7: 78,110,187 (GRCm39)	H349R	probably benign	Het
Or6c8	T	A	10: 128,915,065 (GRCm39)	M256L	probably benign	Het
Otub1	T	A	19: 7,183,624 (GRCm39)	M1L	probably benign	Het
Pkp3	A	G	7: 140,668,318 (GRCm39)		probably null	Het
Popdc3	C	A	10: 45,191,314 (GRCm39)	H142N	probably damaging	Het
Pot1a	A	G	6: 25,771,612 (GRCm39)	F203S	possibly damaging	Het
Prdx5	A	G	19: 6,886,963 (GRCm39)	V8A	probably benign	Het
Rabgap1	T	C	2: 37,427,326 (GRCm39)	Y636H	probably damaging	Het
Rad51d	A	T	11: 82,772,458 (GRCm39)	I236N	probably benign	Het
Reep3	G	T	10: 66,857,656 (GRCm39)	T145K	possibly damaging	Het
Samd3	G	T	10: 26,120,475 (GRCm39)	L156F	probably damaging	Het
Sh3bp5l	A	G	11: 58,228,829 (GRCm39)	T101A	probably benign	Het
Slc3a1	T	C	17: 85,344,605 (GRCm39)	V257A	probably damaging	Het
Sptbn1	A	G	11: 30,092,247 (GRCm39)	V506A	probably damaging	Het
Stab1	A	T	14: 30,861,595 (GRCm39)	S2471T	probably benign	Het
Vmn2r85	T	C	10: 130,261,381 (GRCm39)	T319A	probably damaging	Het
Vmn2r94	C	T	17: 18,464,761 (GRCm39)	V510I	probably benign	Het
Zfp866	A	G	8: 70,219,290 (GRCm39)		probably null	Het

Other mutations in Wscd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00323:Wscd2	APN	5	113,689,236 (GRCm39)	missense	possibly damaging	0.56
IGL01113:Wscd2	APN	5	113,708,800 (GRCm39)	missense	probably damaging	1.00
IGL01476:Wscd2	APN	5	113,710,382 (GRCm39)	missense	probably damaging	0.99
IGL01894:Wscd2	APN	5	113,710,357 (GRCm39)	missense	probably damaging	0.96
IGL02560:Wscd2	APN	5	113,699,045 (GRCm39)	missense	probably benign	0.01
froggie	UTSW	5	113,726,206 (GRCm39)	makesense	probably null
R0381:Wscd2	UTSW	5	113,689,192 (GRCm39)	missense	probably damaging	0.96
R1144:Wscd2	UTSW	5	113,699,151 (GRCm39)	splice site	probably null
R1858:Wscd2	UTSW	5	113,689,231 (GRCm39)	missense	possibly damaging	0.63
R3695:Wscd2	UTSW	5	113,689,078 (GRCm39)	missense	possibly damaging	0.82
R4231:Wscd2	UTSW	5	113,699,045 (GRCm39)	missense	probably benign	0.00
R4232:Wscd2	UTSW	5	113,699,045 (GRCm39)	missense	probably benign	0.00
R4667:Wscd2	UTSW	5	113,715,333 (GRCm39)	missense	probably damaging	1.00
R4696:Wscd2	UTSW	5	113,689,240 (GRCm39)	missense	probably benign
R5727:Wscd2	UTSW	5	113,715,411 (GRCm39)	missense	possibly damaging	0.89
R6401:Wscd2	UTSW	5	113,726,206 (GRCm39)	makesense	probably null
R7413:Wscd2	UTSW	5	113,715,402 (GRCm39)	missense	probably benign	0.02
R7642:Wscd2	UTSW	5	113,715,475 (GRCm39)	missense	possibly damaging	0.67
R7837:Wscd2	UTSW	5	113,710,394 (GRCm39)	missense	probably damaging	1.00
R8046:Wscd2	UTSW	5	113,689,176 (GRCm39)	missense	probably benign	0.05
R8331:Wscd2	UTSW	5	113,688,996 (GRCm39)	start codon destroyed	probably null	0.99
R8348:Wscd2	UTSW	5	113,710,371 (GRCm39)	missense	possibly damaging	0.89
R8680:Wscd2	UTSW	5	113,712,235 (GRCm39)	missense	probably damaging	1.00
R8928:Wscd2	UTSW	5	113,715,401 (GRCm39)	missense	possibly damaging	0.90
R9125:Wscd2	UTSW	5	113,715,417 (GRCm39)	missense	probably benign	0.33

Posted On

2015-04-16