Incidental Mutation 'IGL02755:Olfr767'
ID306380
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr767
Ensembl Gene ENSMUSG00000059762
Gene Nameolfactory receptor 767
SynonymsMOR115-1, GA_x6K02T2PULF-10765431-10764502
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02755
Quality Score
Status
Chromosome10
Chromosomal Location129074825-129082910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129079196 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 256 (M256L)
Ref Sequence ENSEMBL: ENSMUSP00000150151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082131] [ENSMUST00000213579]
Predicted Effect probably benign
Transcript: ENSMUST00000082131
AA Change: M256L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000080775
Gene: ENSMUSG00000059762
AA Change: M256L

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.9e-49 PFAM
Pfam:7tm_1 39 288 3.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213579
AA Change: M256L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930512M02Rik T A 11: 11,589,358 N189I unknown Het
Adamts19 T A 18: 58,969,933 I682K probably benign Het
Adra1a G A 14: 66,727,661 V367I probably benign Het
Alpk3 A G 7: 81,093,759 E1108G possibly damaging Het
Ccdc186 A T 19: 56,813,396 N96K probably benign Het
Ccnb1 A G 13: 100,781,660 Y160H possibly damaging Het
Cebpz A T 17: 78,931,330 V683E probably damaging Het
Cep104 A G 4: 153,996,959 H786R possibly damaging Het
Chd9 T C 8: 91,033,582 I1985T probably benign Het
Cntn2 T A 1: 132,529,302 T36S probably benign Het
Cntnap5c T C 17: 58,364,194 S1126P probably benign Het
Cpt2 A T 4: 107,907,775 V264E probably damaging Het
Degs2 T C 12: 108,692,583 T46A probably benign Het
Dip2c T C 13: 9,550,320 probably null Het
Dnaaf1 A G 8: 119,590,671 D313G probably damaging Het
Ephb3 T G 16: 21,221,698 D561E probably damaging Het
Eps15 A G 4: 109,329,698 T321A probably benign Het
Ercc6 A G 14: 32,575,748 probably benign Het
Gcn1l1 T A 5: 115,604,006 probably null Het
Gm28177 G A 1: 52,096,872 probably benign Het
Gucy2g C A 19: 55,210,354 V786F probably benign Het
H2-M3 T C 17: 37,271,022 V123A possibly damaging Het
Hmgxb3 T C 18: 61,172,188 K33E probably damaging Het
Ift22 T C 5: 136,911,786 W102R probably damaging Het
Lgi4 T C 7: 31,063,105 F44L probably damaging Het
Lingo3 T C 10: 80,836,009 E29G possibly damaging Het
Nf2 A G 11: 4,818,542 L109P probably damaging Het
Ntrk3 T C 7: 78,460,439 H349R probably benign Het
Otub1 T A 19: 7,206,259 M1L probably benign Het
Pkp3 A G 7: 141,088,405 probably null Het
Popdc3 C A 10: 45,315,218 H142N probably damaging Het
Pot1a A G 6: 25,771,613 F203S possibly damaging Het
Prdx5 A G 19: 6,909,595 V8A probably benign Het
Rabgap1 T C 2: 37,537,314 Y636H probably damaging Het
Rad51d A T 11: 82,881,632 I236N probably benign Het
Reep3 G T 10: 67,021,877 T145K possibly damaging Het
Samd3 G T 10: 26,244,577 L156F probably damaging Het
Sh3bp5l A G 11: 58,338,003 T101A probably benign Het
Slc3a1 T C 17: 85,037,177 V257A probably damaging Het
Sptbn1 A G 11: 30,142,247 V506A probably damaging Het
Stab1 A T 14: 31,139,638 S2471T probably benign Het
Vmn2r85 T C 10: 130,425,512 T319A probably damaging Het
Vmn2r94 C T 17: 18,244,499 V510I probably benign Het
Wscd2 T A 5: 113,574,031 M337K possibly damaging Het
Zfp866 A G 8: 69,766,640 probably null Het
Other mutations in Olfr767
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01784:Olfr767 APN 10 129079355 missense probably benign 0.13
IGL01945:Olfr767 APN 10 129079303 missense probably damaging 1.00
IGL02341:Olfr767 APN 10 129079461 nonsense probably null
IGL02389:Olfr767 APN 10 129079230 missense probably damaging 0.97
IGL02516:Olfr767 APN 10 129079793 missense possibly damaging 0.95
R0145:Olfr767 UTSW 10 129079363 missense probably damaging 0.97
R0453:Olfr767 UTSW 10 129079771 missense probably damaging 0.97
R0578:Olfr767 UTSW 10 129079193 missense probably damaging 1.00
R1034:Olfr767 UTSW 10 129079961 start codon destroyed probably benign 0.43
R1494:Olfr767 UTSW 10 129079615 missense probably damaging 1.00
R1941:Olfr767 UTSW 10 129079954 missense probably damaging 0.99
R3707:Olfr767 UTSW 10 129079385 missense probably benign 0.31
R5405:Olfr767 UTSW 10 129079396 missense probably damaging 0.99
R5716:Olfr767 UTSW 10 129079555 missense probably benign 0.00
Z1177:Olfr767 UTSW 10 129080052
Posted On2015-04-16