Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02755:Gucy2g'

306394

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gucy2g

Ensembl Gene

ENSMUSG00000055523

Gene Name

guanylate cyclase 2g

Synonyms

2410077I05Rik, GC-G

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02755

Quality Score

Status

Chromosome

Chromosomal Location

55186531-55229668 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 55198786 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 786 (V786F)

Ref Sequence

ENSEMBL: ENSMUSP00000068253 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069183]

AlphaFold

Q6TL19

Predicted Effect

probably benign
Transcript: ENSMUST00000069183
AA Change: V786F

PolyPhen 2 Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: V786F

Domain	Start	End	E-Value	Type
low complexity region	27	38	N/A	INTRINSIC
Pfam:ANF_receptor	65	416	5.2e-36	PFAM
low complexity region	471	487	N/A	INTRINSIC
Pfam:Pkinase	574	826	2e-26	PFAM
Pfam:Pkinase_Tyr	577	826	6e-35	PFAM
CYCc	865	1059	6.42e-96	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930512M02Rik	T	A	11: 11,539,358 (GRCm39)	N189I	unknown	Het
Adamts19	T	A	18: 59,103,005 (GRCm39)	I682K	probably benign	Het
Adra1a	G	A	14: 66,965,110 (GRCm39)	V367I	probably benign	Het
Alpk3	A	G	7: 80,743,507 (GRCm39)	E1108G	possibly damaging	Het
Ccdc186	A	T	19: 56,801,828 (GRCm39)	N96K	probably benign	Het
Ccnb1	A	G	13: 100,918,168 (GRCm39)	Y160H	possibly damaging	Het
Cebpz	A	T	17: 79,238,759 (GRCm39)	V683E	probably damaging	Het
Cep104	A	G	4: 154,081,416 (GRCm39)	H786R	possibly damaging	Het
Chd9	T	C	8: 91,760,210 (GRCm39)	I1985T	probably benign	Het
Cntn2	T	A	1: 132,457,040 (GRCm39)	T36S	probably benign	Het
Cntnap5c	T	C	17: 58,671,189 (GRCm39)	S1126P	probably benign	Het
Cpt2	A	T	4: 107,764,972 (GRCm39)	V264E	probably damaging	Het
Degs2	T	C	12: 108,658,842 (GRCm39)	T46A	probably benign	Het
Dip2c	T	C	13: 9,600,356 (GRCm39)		probably null	Het
Dnaaf1	A	G	8: 120,317,410 (GRCm39)	D313G	probably damaging	Het
Ephb3	T	G	16: 21,040,448 (GRCm39)	D561E	probably damaging	Het
Eps15	A	G	4: 109,186,895 (GRCm39)	T321A	probably benign	Het
Ercc6	A	G	14: 32,297,705 (GRCm39)		probably benign	Het
Gcn1	T	A	5: 115,742,065 (GRCm39)		probably null	Het
Gm28177	G	A	1: 52,136,031 (GRCm39)		probably benign	Het
H2-M3	T	C	17: 37,581,913 (GRCm39)	V123A	possibly damaging	Het
Hmgxb3	T	C	18: 61,305,260 (GRCm39)	K33E	probably damaging	Het
Ift22	T	C	5: 136,940,640 (GRCm39)	W102R	probably damaging	Het
Lgi4	T	C	7: 30,762,530 (GRCm39)	F44L	probably damaging	Het
Lingo3	T	C	10: 80,671,843 (GRCm39)	E29G	possibly damaging	Het
Nf2	A	G	11: 4,768,542 (GRCm39)	L109P	probably damaging	Het
Ntrk3	T	C	7: 78,110,187 (GRCm39)	H349R	probably benign	Het
Or6c8	T	A	10: 128,915,065 (GRCm39)	M256L	probably benign	Het
Otub1	T	A	19: 7,183,624 (GRCm39)	M1L	probably benign	Het
Pkp3	A	G	7: 140,668,318 (GRCm39)		probably null	Het
Popdc3	C	A	10: 45,191,314 (GRCm39)	H142N	probably damaging	Het
Pot1a	A	G	6: 25,771,612 (GRCm39)	F203S	possibly damaging	Het
Prdx5	A	G	19: 6,886,963 (GRCm39)	V8A	probably benign	Het
Rabgap1	T	C	2: 37,427,326 (GRCm39)	Y636H	probably damaging	Het
Rad51d	A	T	11: 82,772,458 (GRCm39)	I236N	probably benign	Het
Reep3	G	T	10: 66,857,656 (GRCm39)	T145K	possibly damaging	Het
Samd3	G	T	10: 26,120,475 (GRCm39)	L156F	probably damaging	Het
Sh3bp5l	A	G	11: 58,228,829 (GRCm39)	T101A	probably benign	Het
Slc3a1	T	C	17: 85,344,605 (GRCm39)	V257A	probably damaging	Het
Sptbn1	A	G	11: 30,092,247 (GRCm39)	V506A	probably damaging	Het
Stab1	A	T	14: 30,861,595 (GRCm39)	S2471T	probably benign	Het
Vmn2r85	T	C	10: 130,261,381 (GRCm39)	T319A	probably damaging	Het
Vmn2r94	C	T	17: 18,464,761 (GRCm39)	V510I	probably benign	Het
Wscd2	T	A	5: 113,712,092 (GRCm39)	M337K	possibly damaging	Het
Zfp866	A	G	8: 70,219,290 (GRCm39)		probably null	Het

Other mutations in Gucy2g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00801:Gucy2g	APN	19	55,221,535 (GRCm39)	missense	probably benign	0.01
IGL01954:Gucy2g	APN	19	55,187,123 (GRCm39)	missense	probably benign	0.01
IGL01969:Gucy2g	APN	19	55,215,870 (GRCm39)	missense	probably benign	0.00
IGL02164:Gucy2g	APN	19	55,226,455 (GRCm39)	missense	probably benign
IGL02534:Gucy2g	APN	19	55,229,500 (GRCm39)	missense	probably damaging	1.00
IGL02667:Gucy2g	APN	19	55,194,609 (GRCm39)	missense	possibly damaging	0.64
IGL03187:Gucy2g	APN	19	55,219,484 (GRCm39)	missense	possibly damaging	0.91
IGL03354:Gucy2g	APN	19	55,221,512 (GRCm39)	missense	possibly damaging	0.95
PIT4366001:Gucy2g	UTSW	19	55,226,214 (GRCm39)	missense	probably null	0.51
R0040:Gucy2g	UTSW	19	55,205,734 (GRCm39)	missense	possibly damaging	0.73
R0126:Gucy2g	UTSW	19	55,229,598 (GRCm39)	missense	probably benign
R0318:Gucy2g	UTSW	19	55,226,230 (GRCm39)	missense	probably benign	0.00
R0576:Gucy2g	UTSW	19	55,187,202 (GRCm39)	missense	probably damaging	1.00
R0604:Gucy2g	UTSW	19	55,191,519 (GRCm39)	missense	probably benign	0.00
R0962:Gucy2g	UTSW	19	55,198,716 (GRCm39)	nonsense	probably null
R1348:Gucy2g	UTSW	19	55,211,338 (GRCm39)	missense	possibly damaging	0.68
R1458:Gucy2g	UTSW	19	55,203,468 (GRCm39)	splice site	probably benign
R1693:Gucy2g	UTSW	19	55,211,358 (GRCm39)	missense	probably damaging	1.00
R1795:Gucy2g	UTSW	19	55,187,973 (GRCm39)	missense	probably damaging	1.00
R1804:Gucy2g	UTSW	19	55,198,741 (GRCm39)	missense	probably benign	0.34
R1830:Gucy2g	UTSW	19	55,211,362 (GRCm39)	missense	possibly damaging	0.94
R1902:Gucy2g	UTSW	19	55,198,669 (GRCm39)	missense	probably benign	0.20
R1927:Gucy2g	UTSW	19	55,226,191 (GRCm39)	missense	probably benign	0.02
R1969:Gucy2g	UTSW	19	55,221,485 (GRCm39)	missense	probably benign	0.42
R1969:Gucy2g	UTSW	19	55,211,328 (GRCm39)	missense	possibly damaging	0.90
R2071:Gucy2g	UTSW	19	55,210,772 (GRCm39)	missense	possibly damaging	0.72
R2842:Gucy2g	UTSW	19	55,229,379 (GRCm39)	missense	probably damaging	1.00
R2971:Gucy2g	UTSW	19	55,198,708 (GRCm39)	missense	probably damaging	1.00
R4202:Gucy2g	UTSW	19	55,218,201 (GRCm39)	missense	possibly damaging	0.96
R4405:Gucy2g	UTSW	19	55,226,269 (GRCm39)	missense	probably benign	0.08
R4407:Gucy2g	UTSW	19	55,226,269 (GRCm39)	missense	probably benign	0.08
R4614:Gucy2g	UTSW	19	55,190,579 (GRCm39)	nonsense	probably null
R4671:Gucy2g	UTSW	19	55,226,500 (GRCm39)	missense	probably damaging	1.00
R4684:Gucy2g	UTSW	19	55,194,688 (GRCm39)	missense	probably damaging	1.00
R4837:Gucy2g	UTSW	19	55,214,485 (GRCm39)	missense	probably benign
R4969:Gucy2g	UTSW	19	55,214,445 (GRCm39)	missense	probably benign
R5050:Gucy2g	UTSW	19	55,229,367 (GRCm39)	missense	probably benign	0.05
R5059:Gucy2g	UTSW	19	55,214,503 (GRCm39)	missense	probably benign	0.00
R5070:Gucy2g	UTSW	19	55,218,219 (GRCm39)	missense	probably damaging	0.98
R5288:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5384:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5386:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5497:Gucy2g	UTSW	19	55,187,133 (GRCm39)	missense	probably benign	0.00
R5531:Gucy2g	UTSW	19	55,229,572 (GRCm39)	missense	probably benign	0.24
R5536:Gucy2g	UTSW	19	55,226,359 (GRCm39)	missense	probably benign	0.05
R5679:Gucy2g	UTSW	19	55,219,511 (GRCm39)	missense	possibly damaging	0.87
R5715:Gucy2g	UTSW	19	55,221,587 (GRCm39)	missense	possibly damaging	0.93
R5941:Gucy2g	UTSW	19	55,203,563 (GRCm39)	missense	probably damaging	1.00
R6250:Gucy2g	UTSW	19	55,205,856 (GRCm39)	missense	probably damaging	0.99
R6288:Gucy2g	UTSW	19	55,215,945 (GRCm39)	missense	probably benign	0.01
R6378:Gucy2g	UTSW	19	55,229,377 (GRCm39)	missense	probably benign	0.00
R6605:Gucy2g	UTSW	19	55,229,460 (GRCm39)	missense	probably damaging	1.00
R7020:Gucy2g	UTSW	19	55,221,482 (GRCm39)	missense	probably damaging	0.98
R7064:Gucy2g	UTSW	19	55,198,764 (GRCm39)	missense	probably benign	0.01
R7078:Gucy2g	UTSW	19	55,229,583 (GRCm39)	missense	probably damaging	1.00
R7402:Gucy2g	UTSW	19	55,194,725 (GRCm39)	missense	probably damaging	1.00
R7539:Gucy2g	UTSW	19	55,191,586 (GRCm39)	missense	probably damaging	0.99
R7561:Gucy2g	UTSW	19	55,194,772 (GRCm39)	missense	probably benign	0.38
R7583:Gucy2g	UTSW	19	55,224,047 (GRCm39)	missense	probably damaging	1.00
R7804:Gucy2g	UTSW	19	55,216,584 (GRCm39)	missense	probably benign	0.02
R7880:Gucy2g	UTSW	19	55,194,712 (GRCm39)	missense	probably damaging	1.00
R8442:Gucy2g	UTSW	19	55,205,833 (GRCm39)	missense	probably benign	0.00
R8559:Gucy2g	UTSW	19	55,198,786 (GRCm39)	missense	probably benign	0.10
R8970:Gucy2g	UTSW	19	55,191,478 (GRCm39)	missense	possibly damaging	0.56
R8972:Gucy2g	UTSW	19	55,226,406 (GRCm39)	missense	probably benign	0.17
R9085:Gucy2g	UTSW	19	55,221,597 (GRCm39)	nonsense	probably null
R9390:Gucy2g	UTSW	19	55,190,607 (GRCm39)	missense	probably null	1.00
R9462:Gucy2g	UTSW	19	55,221,469 (GRCm39)	critical splice donor site	probably null
R9502:Gucy2g	UTSW	19	55,198,816 (GRCm39)	missense	probably damaging	1.00
R9610:Gucy2g	UTSW	19	55,194,605 (GRCm39)	missense	probably damaging	1.00
R9611:Gucy2g	UTSW	19	55,194,605 (GRCm39)	missense	probably damaging	1.00
R9644:Gucy2g	UTSW	19	55,219,537 (GRCm39)	missense	probably benign	0.05
Z1177:Gucy2g	UTSW	19	55,198,809 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16