Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02756:Qrsl1'

306431

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Qrsl1

Ensembl Gene

ENSMUSG00000019863

Gene Name

glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1

Synonyms

GatA, 2700038P16Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.963) question?

Stock #

IGL02756

Quality Score

Status

Chromosome

Chromosomal Location

43874188-43901745 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 43882114 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 328 (T328A)

Ref Sequence

ENSEMBL: ENSMUSP00000020012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020012]

Predicted Effect

probably benign
Transcript: ENSMUST00000020012
AA Change: T328A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: T328A

Domain	Start	End	E-Value	Type
Pfam:Amidase	22	484	6e-129	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154405

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216786

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	T	10: 87,165,108	D54V	probably damaging	Het
Adamts18	C	A	8: 113,714,344		probably benign	Het
Angptl3	T	A	4: 99,031,162	L53Q	probably damaging	Het
Apc	A	G	18: 34,314,535	T1461A	probably damaging	Het
Arl11	T	A	14: 61,311,086	V115D	probably damaging	Het
Cabp4	C	A	19: 4,138,561	V173L	possibly damaging	Het
Casq1	T	A	1: 172,215,105	D230V	probably damaging	Het
Cdc42bpa	A	G	1: 180,109,259	I821V	possibly damaging	Het
Cfap65	T	C	1: 74,905,080	Y1494C	probably benign	Het
Chd1	T	A	17: 15,730,807	S215T	probably damaging	Het
Csf2rb2	T	C	15: 78,284,849	E593G	possibly damaging	Het
Cstf1	A	G	2: 172,375,875	D136G	probably damaging	Het
Ddx19b	T	C	8: 111,011,278		probably benign	Het
Dido1	A	T	2: 180,661,923	L1396Q	probably benign	Het
Ermn	A	G	2: 58,047,812	I263T	probably damaging	Het
F12	T	A	13: 55,421,067	Q294L	possibly damaging	Het
Far2	A	T	6: 148,157,391	I192F	probably damaging	Het
Fshb	T	A	2: 107,058,873	I29F	probably damaging	Het
Gcgr	T	A	11: 120,536,985	Y251N	probably benign	Het
Gpr158	A	G	2: 21,827,079	I997V	possibly damaging	Het
Gprc5d	A	G	6: 135,116,615	V98A	probably damaging	Het
H2-T23	T	C	17: 36,031,688	E186G	probably damaging	Het
Khdrbs3	C	T	15: 69,024,836	T115I	probably benign	Het
Kifap3	C	T	1: 163,862,028	T527M	probably damaging	Het
Mfsd2a	C	T	4: 122,948,539	A512T	probably benign	Het
Mmp9	A	G	2: 164,949,315	D135G	probably benign	Het
Mylk	T	C	16: 34,963,646	V1394A	probably benign	Het
Nek9	A	C	12: 85,311,336		probably null	Het
Olfr1008	T	C	2: 85,690,058	S210P	probably damaging	Het
Olfr638	T	C	7: 104,003,659	I128T	probably damaging	Het
P2rx2	T	A	5: 110,342,410		probably benign	Het
P4htm	A	G	9: 108,579,778	L410P	probably damaging	Het
Pik3c2a	A	T	7: 116,364,513	W921R	probably benign	Het
Pnisr	T	C	4: 21,862,175	F288L	probably benign	Het
Ppp4r3a	C	T	12: 101,058,323		probably null	Het
Prss34	T	C	17: 25,299,277	S144P	probably damaging	Het
Rab33b	A	T	3: 51,484,524	T65S	probably damaging	Het
Rdh8	A	G	9: 20,825,341	S235G	possibly damaging	Het
Rrp12	T	C	19: 41,896,061	K6R	probably benign	Het
Sec24a	T	C	11: 51,696,733	D1025G	probably benign	Het
Sgo2a	T	G	1: 58,016,350	N564K	probably damaging	Het
Slc43a3	A	T	2: 84,944,268	M130L	probably benign	Het
Soat1	T	C	1: 156,446,575	I89V	probably benign	Het
St3gal5	A	G	6: 72,149,173	D307G	probably null	Het
Stxbp3-ps	C	T	19: 9,557,829		noncoding transcript	Het
Tacr2	A	G	10: 62,261,690		probably benign	Het
Tg	C	T	15: 66,734,586	T193I	probably benign	Het
Tnik	A	G	3: 28,542,030	T191A	probably damaging	Het
Trim27	T	C	13: 21,190,086		probably benign	Het
Usf2	A	T	7: 30,946,992	C134*	probably null	Het
Usp14	A	G	18: 10,001,769		probably null	Het
Usp47	T	C	7: 112,093,063	S911P	possibly damaging	Het
Vmn1r73	T	A	7: 11,756,647	S131T	possibly damaging	Het
Vmn2r80	T	C	10: 79,194,311	I657T	probably damaging	Het
Zfp935	A	T	13: 62,454,887	C166*	probably null	Het

Other mutations in Qrsl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00477:Qrsl1	APN	10	43876492	missense	probably damaging	1.00
IGL01724:Qrsl1	APN	10	43874608	missense	probably benign	0.01
IGL01896:Qrsl1	APN	10	43876504	missense	probably benign	0.02
IGL02192:Qrsl1	APN	10	43885014	missense	probably damaging	1.00
IGL02239:Qrsl1	APN	10	43894600	missense	possibly damaging	0.96
IGL02478:Qrsl1	APN	10	43882162	missense	probably damaging	0.97
IGL03386:Qrsl1	APN	10	43876550	missense	possibly damaging	0.63
R0277:Qrsl1	UTSW	10	43896007	critical splice donor site	probably null
R0323:Qrsl1	UTSW	10	43896007	critical splice donor site	probably null
R0674:Qrsl1	UTSW	10	43896001	splice site	probably benign
R1054:Qrsl1	UTSW	10	43882081	missense	probably damaging	1.00
R1719:Qrsl1	UTSW	10	43896030	missense	probably damaging	0.97
R1743:Qrsl1	UTSW	10	43881515	missense	probably damaging	1.00
R1854:Qrsl1	UTSW	10	43894545	missense	probably damaging	1.00
R2233:Qrsl1	UTSW	10	43896096	missense	probably benign	0.00
R4176:Qrsl1	UTSW	10	43884832	missense	probably damaging	1.00
R4452:Qrsl1	UTSW	10	43882162	missense	probably damaging	1.00
R4732:Qrsl1	UTSW	10	43876663	missense	probably damaging	1.00
R4733:Qrsl1	UTSW	10	43876663	missense	probably damaging	1.00
R5626:Qrsl1	UTSW	10	43881520	missense	probably benign	0.00
R6159:Qrsl1	UTSW	10	43882193	missense	probably benign	0.00
R7563:Qrsl1	UTSW	10	43876517	missense	probably damaging	1.00
R8050:Qrsl1	UTSW	10	43874635	missense	probably damaging	0.98
R8092:Qrsl1	UTSW	10	43884753	missense	probably damaging	1.00
R8221:Qrsl1	UTSW	10	43882084	missense	possibly damaging	0.81
R8331:Qrsl1	UTSW	10	43876525	missense	probably damaging	0.98
Z1176:Qrsl1	UTSW	10	43884948	missense	probably damaging	0.98

Posted On

2015-04-16