Incidental Mutation 'IGL00092:Or1x6'
ID 306517
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1x6
Ensembl Gene ENSMUSG00000057890
Gene Name olfactory receptor family 1 subfamily X member 6
Synonyms MOR126-2, Olfr1375, Olfr1375-ps1, GA_x6K02T2QP88-4389999-4389056
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL00092
Quality Score
Status
Chromosome 11
Chromosomal Location 50938936-50939877 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50939227 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 98 (Q98K)
Ref Sequence ENSEMBL: ENSMUSP00000144756 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073543]
AlphaFold A0A0N4SUP0
Predicted Effect probably benign
Transcript: ENSMUST00000073543
AA Change: Q98K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000073233
Gene: ENSMUSG00000057890
AA Change: Q98K

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 37 306 3.9e-6 PFAM
Pfam:7tm_1 43 291 9.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000073543
AA Change: Q98K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000144756
Gene: ENSMUSG00000057890
AA Change: Q98K

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 37 306 3.9e-6 PFAM
Pfam:7tm_1 43 291 9.5e-26 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,892,430 (GRCm39) D443G probably benign Het
Atg16l1 T C 1: 87,693,119 (GRCm39) I28T possibly damaging Het
Bpi T A 2: 158,116,716 (GRCm39) V371E probably damaging Het
Cd109 T G 9: 78,524,251 (GRCm39) V55G probably damaging Het
Cd300c2 T C 11: 114,892,375 (GRCm39) probably benign Het
Cic C T 7: 24,991,549 (GRCm39) R1280C probably damaging Het
Cngb1 G A 8: 95,968,812 (GRCm39) probably benign Het
Cntn4 G T 6: 106,483,186 (GRCm39) C247F probably damaging Het
Disp3 C T 4: 148,325,991 (GRCm39) V1256I probably benign Het
Farsb A T 1: 78,439,630 (GRCm39) S338T probably benign Het
Fcnb T C 2: 27,966,813 (GRCm39) N240S probably benign Het
Flg2 A G 3: 93,127,162 (GRCm39) S5G possibly damaging Het
Git1 T C 11: 77,396,783 (GRCm39) L635P probably benign Het
Gm21985 T G 2: 112,181,679 (GRCm39) W685G probably damaging Het
Gpt2 T C 8: 86,238,953 (GRCm39) V262A probably benign Het
Hecw2 A G 1: 53,869,896 (GRCm39) V1444A probably damaging Het
Herc1 T C 9: 66,391,248 (GRCm39) V4017A probably benign Het
Klhl17 T C 4: 156,318,147 (GRCm39) T129A possibly damaging Het
Krt84 T G 15: 101,437,170 (GRCm39) D331A probably damaging Het
Lrrc9 C T 12: 72,533,017 (GRCm39) T963M possibly damaging Het
Mtcl1 C T 17: 66,651,314 (GRCm39) V935I probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Myocd T C 11: 65,071,770 (GRCm39) probably null Het
Nid1 A G 13: 13,650,977 (GRCm39) N505D probably damaging Het
Ninj1 A T 13: 49,347,210 (GRCm39) probably null Het
Or14a260 C T 7: 85,985,269 (GRCm39) V112I probably benign Het
Or4d10c A T 19: 12,065,357 (GRCm39) D266E probably benign Het
Plscr2 T A 9: 92,172,685 (GRCm39) probably benign Het
Ppfia2 A G 10: 106,655,353 (GRCm39) T307A probably benign Het
Sart3 T C 5: 113,884,730 (GRCm39) R625G probably benign Het
Sohlh2 T A 3: 55,115,236 (GRCm39) L407H probably damaging Het
Sorcs1 A G 19: 50,178,492 (GRCm39) S877P probably damaging Het
Stat1 T C 1: 52,161,754 (GRCm39) M1T probably null Het
Szt2 C T 4: 118,241,447 (GRCm39) probably benign Het
Tars3 G T 7: 65,302,007 (GRCm39) probably null Het
Terb2 T A 2: 122,028,867 (GRCm39) S141R probably benign Het
Tgfbrap1 T C 1: 43,099,283 (GRCm39) Y177C probably damaging Het
Trappc9 A T 15: 72,897,875 (GRCm39) I169N possibly damaging Het
Trim47 A G 11: 115,997,020 (GRCm39) L578P probably damaging Het
Usp34 G A 11: 23,386,020 (GRCm39) R2149H probably damaging Het
Vmn2r90 T C 17: 17,953,758 (GRCm39) S641P probably benign Het
Vwa5a T A 9: 38,649,110 (GRCm39) probably null Het
Zzef1 T A 11: 72,765,952 (GRCm39) I1493N probably benign Het
Other mutations in Or1x6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0268:Or1x6 UTSW 11 50,939,768 (GRCm39) missense probably damaging 1.00
R0462:Or1x6 UTSW 11 50,939,336 (GRCm39) missense probably damaging 1.00
R0478:Or1x6 UTSW 11 50,939,539 (GRCm39) missense probably benign 0.03
R0839:Or1x6 UTSW 11 50,939,254 (GRCm39) missense probably benign 0.06
R2517:Or1x6 UTSW 11 50,939,300 (GRCm39) missense probably damaging 1.00
R4688:Or1x6 UTSW 11 50,939,815 (GRCm39) missense probably damaging 1.00
R4781:Or1x6 UTSW 11 50,939,307 (GRCm39) missense probably damaging 1.00
R5396:Or1x6 UTSW 11 50,939,297 (GRCm39) missense probably damaging 1.00
R6163:Or1x6 UTSW 11 50,939,595 (GRCm39) nonsense probably null
R6739:Or1x6 UTSW 11 50,939,564 (GRCm39) missense probably damaging 0.97
R7344:Or1x6 UTSW 11 50,939,122 (GRCm39) missense probably damaging 1.00
R7994:Or1x6 UTSW 11 50,938,967 (GRCm39) missense probably benign 0.31
R8054:Or1x6 UTSW 11 50,939,090 (GRCm39) missense probably benign 0.22
R8129:Or1x6 UTSW 11 50,939,210 (GRCm39) missense probably benign 0.00
R8940:Or1x6 UTSW 11 50,939,455 (GRCm39) missense probably benign 0.01
R9005:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9008:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9016:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9018:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9028:Or1x6 UTSW 11 50,939,660 (GRCm39) missense probably damaging 1.00
R9051:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9052:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9203:Or1x6 UTSW 11 50,939,161 (GRCm39) missense possibly damaging 0.82
R9364:Or1x6 UTSW 11 50,939,223 (GRCm39) nonsense probably null
R9376:Or1x6 UTSW 11 50,939,662 (GRCm39) missense probably damaging 1.00
R9554:Or1x6 UTSW 11 50,939,223 (GRCm39) nonsense probably null
R9641:Or1x6 UTSW 11 50,939,207 (GRCm39) missense probably benign 0.34
Z1176:Or1x6 UTSW 11 50,939,662 (GRCm39) missense probably damaging 1.00
Z1177:Or1x6 UTSW 11 50,939,353 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16