Incidental Mutation 'IGL00092:Or1x6'
ID |
306517 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Or1x6
|
Ensembl Gene |
ENSMUSG00000057890 |
Gene Name |
olfactory receptor family 1 subfamily X member 6 |
Synonyms |
MOR126-2, Olfr1375, Olfr1375-ps1, GA_x6K02T2QP88-4389999-4389056 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.062)
|
Stock # |
IGL00092
|
Quality Score |
|
Status
|
|
Chromosome |
11 |
Chromosomal Location |
50938936-50939877 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 50939227 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Lysine
at position 98
(Q98K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000144756
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073543]
|
AlphaFold |
A0A0N4SUP0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000073543
AA Change: Q98K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000073233 Gene: ENSMUSG00000057890 AA Change: Q98K
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
33 |
309 |
6.4e-60 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
37 |
306 |
3.9e-6 |
PFAM |
Pfam:7tm_1
|
43 |
291 |
9.5e-26 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000073543
AA Change: Q98K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000144756 Gene: ENSMUSG00000057890 AA Change: Q98K
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
33 |
309 |
6.4e-60 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
37 |
306 |
3.9e-6 |
PFAM |
Pfam:7tm_1
|
43 |
291 |
9.5e-26 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb5 |
T |
C |
12: 118,892,430 (GRCm39) |
D443G |
probably benign |
Het |
Atg16l1 |
T |
C |
1: 87,693,119 (GRCm39) |
I28T |
possibly damaging |
Het |
Bpi |
T |
A |
2: 158,116,716 (GRCm39) |
V371E |
probably damaging |
Het |
Cd109 |
T |
G |
9: 78,524,251 (GRCm39) |
V55G |
probably damaging |
Het |
Cd300c2 |
T |
C |
11: 114,892,375 (GRCm39) |
|
probably benign |
Het |
Cic |
C |
T |
7: 24,991,549 (GRCm39) |
R1280C |
probably damaging |
Het |
Cngb1 |
G |
A |
8: 95,968,812 (GRCm39) |
|
probably benign |
Het |
Cntn4 |
G |
T |
6: 106,483,186 (GRCm39) |
C247F |
probably damaging |
Het |
Disp3 |
C |
T |
4: 148,325,991 (GRCm39) |
V1256I |
probably benign |
Het |
Farsb |
A |
T |
1: 78,439,630 (GRCm39) |
S338T |
probably benign |
Het |
Fcnb |
T |
C |
2: 27,966,813 (GRCm39) |
N240S |
probably benign |
Het |
Flg2 |
A |
G |
3: 93,127,162 (GRCm39) |
S5G |
possibly damaging |
Het |
Git1 |
T |
C |
11: 77,396,783 (GRCm39) |
L635P |
probably benign |
Het |
Gm21985 |
T |
G |
2: 112,181,679 (GRCm39) |
W685G |
probably damaging |
Het |
Gpt2 |
T |
C |
8: 86,238,953 (GRCm39) |
V262A |
probably benign |
Het |
Hecw2 |
A |
G |
1: 53,869,896 (GRCm39) |
V1444A |
probably damaging |
Het |
Herc1 |
T |
C |
9: 66,391,248 (GRCm39) |
V4017A |
probably benign |
Het |
Klhl17 |
T |
C |
4: 156,318,147 (GRCm39) |
T129A |
possibly damaging |
Het |
Krt84 |
T |
G |
15: 101,437,170 (GRCm39) |
D331A |
probably damaging |
Het |
Lrrc9 |
C |
T |
12: 72,533,017 (GRCm39) |
T963M |
possibly damaging |
Het |
Mtcl1 |
C |
T |
17: 66,651,314 (GRCm39) |
V935I |
probably benign |
Het |
Muc4 |
G |
A |
16: 32,754,086 (GRCm38) |
G1321R |
probably benign |
Het |
Myocd |
T |
C |
11: 65,071,770 (GRCm39) |
|
probably null |
Het |
Nid1 |
A |
G |
13: 13,650,977 (GRCm39) |
N505D |
probably damaging |
Het |
Ninj1 |
A |
T |
13: 49,347,210 (GRCm39) |
|
probably null |
Het |
Or14a260 |
C |
T |
7: 85,985,269 (GRCm39) |
V112I |
probably benign |
Het |
Or4d10c |
A |
T |
19: 12,065,357 (GRCm39) |
D266E |
probably benign |
Het |
Plscr2 |
T |
A |
9: 92,172,685 (GRCm39) |
|
probably benign |
Het |
Ppfia2 |
A |
G |
10: 106,655,353 (GRCm39) |
T307A |
probably benign |
Het |
Sart3 |
T |
C |
5: 113,884,730 (GRCm39) |
R625G |
probably benign |
Het |
Sohlh2 |
T |
A |
3: 55,115,236 (GRCm39) |
L407H |
probably damaging |
Het |
Sorcs1 |
A |
G |
19: 50,178,492 (GRCm39) |
S877P |
probably damaging |
Het |
Stat1 |
T |
C |
1: 52,161,754 (GRCm39) |
M1T |
probably null |
Het |
Szt2 |
C |
T |
4: 118,241,447 (GRCm39) |
|
probably benign |
Het |
Tars3 |
G |
T |
7: 65,302,007 (GRCm39) |
|
probably null |
Het |
Terb2 |
T |
A |
2: 122,028,867 (GRCm39) |
S141R |
probably benign |
Het |
Tgfbrap1 |
T |
C |
1: 43,099,283 (GRCm39) |
Y177C |
probably damaging |
Het |
Trappc9 |
A |
T |
15: 72,897,875 (GRCm39) |
I169N |
possibly damaging |
Het |
Trim47 |
A |
G |
11: 115,997,020 (GRCm39) |
L578P |
probably damaging |
Het |
Usp34 |
G |
A |
11: 23,386,020 (GRCm39) |
R2149H |
probably damaging |
Het |
Vmn2r90 |
T |
C |
17: 17,953,758 (GRCm39) |
S641P |
probably benign |
Het |
Vwa5a |
T |
A |
9: 38,649,110 (GRCm39) |
|
probably null |
Het |
Zzef1 |
T |
A |
11: 72,765,952 (GRCm39) |
I1493N |
probably benign |
Het |
|
Other mutations in Or1x6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0268:Or1x6
|
UTSW |
11 |
50,939,768 (GRCm39) |
missense |
probably damaging |
1.00 |
R0462:Or1x6
|
UTSW |
11 |
50,939,336 (GRCm39) |
missense |
probably damaging |
1.00 |
R0478:Or1x6
|
UTSW |
11 |
50,939,539 (GRCm39) |
missense |
probably benign |
0.03 |
R0839:Or1x6
|
UTSW |
11 |
50,939,254 (GRCm39) |
missense |
probably benign |
0.06 |
R2517:Or1x6
|
UTSW |
11 |
50,939,300 (GRCm39) |
missense |
probably damaging |
1.00 |
R4688:Or1x6
|
UTSW |
11 |
50,939,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R4781:Or1x6
|
UTSW |
11 |
50,939,307 (GRCm39) |
missense |
probably damaging |
1.00 |
R5396:Or1x6
|
UTSW |
11 |
50,939,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R6163:Or1x6
|
UTSW |
11 |
50,939,595 (GRCm39) |
nonsense |
probably null |
|
R6739:Or1x6
|
UTSW |
11 |
50,939,564 (GRCm39) |
missense |
probably damaging |
0.97 |
R7344:Or1x6
|
UTSW |
11 |
50,939,122 (GRCm39) |
missense |
probably damaging |
1.00 |
R7994:Or1x6
|
UTSW |
11 |
50,938,967 (GRCm39) |
missense |
probably benign |
0.31 |
R8054:Or1x6
|
UTSW |
11 |
50,939,090 (GRCm39) |
missense |
probably benign |
0.22 |
R8129:Or1x6
|
UTSW |
11 |
50,939,210 (GRCm39) |
missense |
probably benign |
0.00 |
R8940:Or1x6
|
UTSW |
11 |
50,939,455 (GRCm39) |
missense |
probably benign |
0.01 |
R9005:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9008:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9016:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9018:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9028:Or1x6
|
UTSW |
11 |
50,939,660 (GRCm39) |
missense |
probably damaging |
1.00 |
R9051:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9052:Or1x6
|
UTSW |
11 |
50,938,938 (GRCm39) |
start codon destroyed |
probably null |
0.18 |
R9203:Or1x6
|
UTSW |
11 |
50,939,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
R9364:Or1x6
|
UTSW |
11 |
50,939,223 (GRCm39) |
nonsense |
probably null |
|
R9376:Or1x6
|
UTSW |
11 |
50,939,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R9554:Or1x6
|
UTSW |
11 |
50,939,223 (GRCm39) |
nonsense |
probably null |
|
R9641:Or1x6
|
UTSW |
11 |
50,939,207 (GRCm39) |
missense |
probably benign |
0.34 |
Z1176:Or1x6
|
UTSW |
11 |
50,939,662 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Or1x6
|
UTSW |
11 |
50,939,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2015-04-16 |