Incidental Mutation 'IGL00092:Tars3'
ID 306526
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tars3
Ensembl Gene ENSMUSG00000030515
Gene Name threonyl-tRNA synthetase 3
Synonyms A530046H20Rik, Tarsl2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # IGL00092
Quality Score
Status
Chromosome 7
Chromosomal Location 65294646-65341839 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) G to T at 65302007 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000032728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032728] [ENSMUST00000032728]
AlphaFold Q8BLY2
Predicted Effect probably null
Transcript: ENSMUST00000032728
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000032728
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126941
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,892,430 (GRCm39) D443G probably benign Het
Atg16l1 T C 1: 87,693,119 (GRCm39) I28T possibly damaging Het
Bpi T A 2: 158,116,716 (GRCm39) V371E probably damaging Het
Cd109 T G 9: 78,524,251 (GRCm39) V55G probably damaging Het
Cd300c2 T C 11: 114,892,375 (GRCm39) probably benign Het
Cic C T 7: 24,991,549 (GRCm39) R1280C probably damaging Het
Cngb1 G A 8: 95,968,812 (GRCm39) probably benign Het
Cntn4 G T 6: 106,483,186 (GRCm39) C247F probably damaging Het
Disp3 C T 4: 148,325,991 (GRCm39) V1256I probably benign Het
Farsb A T 1: 78,439,630 (GRCm39) S338T probably benign Het
Fcnb T C 2: 27,966,813 (GRCm39) N240S probably benign Het
Flg2 A G 3: 93,127,162 (GRCm39) S5G possibly damaging Het
Git1 T C 11: 77,396,783 (GRCm39) L635P probably benign Het
Gm21985 T G 2: 112,181,679 (GRCm39) W685G probably damaging Het
Gpt2 T C 8: 86,238,953 (GRCm39) V262A probably benign Het
Hecw2 A G 1: 53,869,896 (GRCm39) V1444A probably damaging Het
Herc1 T C 9: 66,391,248 (GRCm39) V4017A probably benign Het
Klhl17 T C 4: 156,318,147 (GRCm39) T129A possibly damaging Het
Krt84 T G 15: 101,437,170 (GRCm39) D331A probably damaging Het
Lrrc9 C T 12: 72,533,017 (GRCm39) T963M possibly damaging Het
Mtcl1 C T 17: 66,651,314 (GRCm39) V935I probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Myocd T C 11: 65,071,770 (GRCm39) probably null Het
Nid1 A G 13: 13,650,977 (GRCm39) N505D probably damaging Het
Ninj1 A T 13: 49,347,210 (GRCm39) probably null Het
Or14a260 C T 7: 85,985,269 (GRCm39) V112I probably benign Het
Or1x6 C A 11: 50,939,227 (GRCm39) Q98K probably benign Het
Or4d10c A T 19: 12,065,357 (GRCm39) D266E probably benign Het
Plscr2 T A 9: 92,172,685 (GRCm39) probably benign Het
Ppfia2 A G 10: 106,655,353 (GRCm39) T307A probably benign Het
Sart3 T C 5: 113,884,730 (GRCm39) R625G probably benign Het
Sohlh2 T A 3: 55,115,236 (GRCm39) L407H probably damaging Het
Sorcs1 A G 19: 50,178,492 (GRCm39) S877P probably damaging Het
Stat1 T C 1: 52,161,754 (GRCm39) M1T probably null Het
Szt2 C T 4: 118,241,447 (GRCm39) probably benign Het
Terb2 T A 2: 122,028,867 (GRCm39) S141R probably benign Het
Tgfbrap1 T C 1: 43,099,283 (GRCm39) Y177C probably damaging Het
Trappc9 A T 15: 72,897,875 (GRCm39) I169N possibly damaging Het
Trim47 A G 11: 115,997,020 (GRCm39) L578P probably damaging Het
Usp34 G A 11: 23,386,020 (GRCm39) R2149H probably damaging Het
Vmn2r90 T C 17: 17,953,758 (GRCm39) S641P probably benign Het
Vwa5a T A 9: 38,649,110 (GRCm39) probably null Het
Zzef1 T A 11: 72,765,952 (GRCm39) I1493N probably benign Het
Other mutations in Tars3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00470:Tars3 APN 7 65,338,656 (GRCm39) missense probably benign 0.03
IGL00594:Tars3 APN 7 65,325,880 (GRCm39) critical splice donor site probably null
IGL01352:Tars3 APN 7 65,308,658 (GRCm39) missense possibly damaging 0.80
IGL01519:Tars3 APN 7 65,313,634 (GRCm39) missense probably damaging 1.00
IGL01726:Tars3 APN 7 65,332,566 (GRCm39) missense possibly damaging 0.46
IGL02370:Tars3 APN 7 65,310,913 (GRCm39) missense probably benign 0.17
IGL02729:Tars3 APN 7 65,332,567 (GRCm39) missense probably damaging 0.97
IGL03234:Tars3 APN 7 65,302,026 (GRCm39) missense probably benign 0.06
gary UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R8254_tarsl2_650 UTSW 7 65,325,809 (GRCm39) missense probably benign
smart_money UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R0127:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R0153:Tars3 UTSW 7 65,333,829 (GRCm39) missense probably damaging 1.00
R0605:Tars3 UTSW 7 65,327,819 (GRCm39) missense probably damaging 1.00
R1070:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1450:Tars3 UTSW 7 65,297,244 (GRCm39) missense probably benign 0.01
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R2142:Tars3 UTSW 7 65,308,645 (GRCm39) missense probably benign
R2143:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2144:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2145:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2208:Tars3 UTSW 7 65,332,596 (GRCm39) missense probably damaging 1.00
R3713:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3715:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3914:Tars3 UTSW 7 65,333,556 (GRCm39) missense probably benign 0.05
R3929:Tars3 UTSW 7 65,333,791 (GRCm39) splice site probably null
R4008:Tars3 UTSW 7 65,327,876 (GRCm39) missense probably damaging 1.00
R4064:Tars3 UTSW 7 65,302,018 (GRCm39) missense possibly damaging 0.90
R4367:Tars3 UTSW 7 65,332,567 (GRCm39) missense probably damaging 0.97
R4652:Tars3 UTSW 7 65,339,717 (GRCm39) missense probably damaging 1.00
R4825:Tars3 UTSW 7 65,297,302 (GRCm39) missense probably benign 0.38
R4901:Tars3 UTSW 7 65,341,042 (GRCm39) missense probably benign 0.05
R4999:Tars3 UTSW 7 65,308,683 (GRCm39) missense probably damaging 0.99
R5423:Tars3 UTSW 7 65,333,567 (GRCm39) missense probably benign 0.00
R5756:Tars3 UTSW 7 65,325,724 (GRCm39) missense probably benign 0.22
R5772:Tars3 UTSW 7 65,333,873 (GRCm39) missense probably damaging 1.00
R6160:Tars3 UTSW 7 65,332,527 (GRCm39) missense probably benign 0.32
R6230:Tars3 UTSW 7 65,336,184 (GRCm39) splice site probably null
R6424:Tars3 UTSW 7 65,305,487 (GRCm39) missense probably damaging 1.00
R6615:Tars3 UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R6792:Tars3 UTSW 7 65,312,051 (GRCm39) missense probably damaging 1.00
R7350:Tars3 UTSW 7 65,308,672 (GRCm39) missense probably damaging 1.00
R7549:Tars3 UTSW 7 65,297,341 (GRCm39) missense probably damaging 0.96
R7592:Tars3 UTSW 7 65,308,619 (GRCm39) missense probably benign 0.01
R7634:Tars3 UTSW 7 65,325,760 (GRCm39) missense probably damaging 0.99
R7710:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R7808:Tars3 UTSW 7 65,302,009 (GRCm39) missense probably benign 0.01
R7875:Tars3 UTSW 7 65,327,899 (GRCm39) missense probably benign 0.05
R8254:Tars3 UTSW 7 65,325,809 (GRCm39) missense probably benign
R8793:Tars3 UTSW 7 65,294,673 (GRCm39) start gained probably benign
R9162:Tars3 UTSW 7 65,332,518 (GRCm39) missense probably benign 0.01
R9200:Tars3 UTSW 7 65,302,013 (GRCm39) missense probably benign
R9461:Tars3 UTSW 7 65,339,719 (GRCm39) missense possibly damaging 0.68
R9533:Tars3 UTSW 7 65,333,808 (GRCm39) critical splice acceptor site probably null
Z1177:Tars3 UTSW 7 65,302,012 (GRCm39) nonsense probably null
Posted On 2015-04-16