Incidental Mutation 'IGL00985:Snap91'
ID 306665
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Snap91
Ensembl Gene ENSMUSG00000033419
Gene Name synaptosomal-associated protein 91
Synonyms F1-20, 91kDa, AP180
Accession Numbers
Essential gene? Probably essential (E-score: 0.867) question?
Stock # IGL00985
Quality Score
Status
Chromosome 9
Chromosomal Location 86647976-86762707 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86703790 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 268 (T268A)
Ref Sequence ENSEMBL: ENSMUSP00000074066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036347] [ENSMUST00000074468] [ENSMUST00000074501] [ENSMUST00000098495]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000036347
AA Change: T268A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000046189
Gene: ENSMUSG00000033419
AA Change: T268A

DomainStartEndE-ValueType
ENTH 20 145 8.41e-48 SMART
low complexity region 334 347 N/A INTRINSIC
low complexity region 357 374 N/A INTRINSIC
low complexity region 403 433 N/A INTRINSIC
low complexity region 439 466 N/A INTRINSIC
low complexity region 477 488 N/A INTRINSIC
low complexity region 499 558 N/A INTRINSIC
internal_repeat_1 559 586 3.27e-5 PROSPERO
internal_repeat_1 584 611 3.27e-5 PROSPERO
low complexity region 616 634 N/A INTRINSIC
low complexity region 652 669 N/A INTRINSIC
low complexity region 699 716 N/A INTRINSIC
low complexity region 728 757 N/A INTRINSIC
low complexity region 802 814 N/A INTRINSIC
low complexity region 850 862 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000074468
AA Change: T268A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000074066
Gene: ENSMUSG00000033419
AA Change: T268A

DomainStartEndE-ValueType
ENTH 20 145 8.41e-48 SMART
low complexity region 334 347 N/A INTRINSIC
low complexity region 357 374 N/A INTRINSIC
low complexity region 403 433 N/A INTRINSIC
low complexity region 439 466 N/A INTRINSIC
low complexity region 477 488 N/A INTRINSIC
low complexity region 499 558 N/A INTRINSIC
internal_repeat_1 559 586 6.86e-5 PROSPERO
internal_repeat_1 584 611 6.86e-5 PROSPERO
low complexity region 616 634 N/A INTRINSIC
low complexity region 652 669 N/A INTRINSIC
low complexity region 702 717 N/A INTRINSIC
low complexity region 733 762 N/A INTRINSIC
low complexity region 833 847 N/A INTRINSIC
low complexity region 883 895 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000074501
AA Change: T268A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074095
Gene: ENSMUSG00000033419
AA Change: T268A

DomainStartEndE-ValueType
ENTH 20 145 8.41e-48 SMART
low complexity region 332 345 N/A INTRINSIC
low complexity region 355 382 N/A INTRINSIC
low complexity region 409 424 N/A INTRINSIC
low complexity region 440 469 N/A INTRINSIC
low complexity region 540 554 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000098495
AA Change: T268A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000096096
Gene: ENSMUSG00000033419
AA Change: T268A

DomainStartEndE-ValueType
ENTH 20 145 8.41e-48 SMART
low complexity region 332 345 N/A INTRINSIC
low complexity region 355 372 N/A INTRINSIC
low complexity region 396 426 N/A INTRINSIC
low complexity region 432 459 N/A INTRINSIC
low complexity region 470 481 N/A INTRINSIC
low complexity region 492 551 N/A INTRINSIC
internal_repeat_1 552 579 4.67e-5 PROSPERO
internal_repeat_1 577 604 4.67e-5 PROSPERO
low complexity region 609 627 N/A INTRINSIC
low complexity region 667 682 N/A INTRINSIC
low complexity region 698 727 N/A INTRINSIC
low complexity region 772 784 N/A INTRINSIC
low complexity region 820 832 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167014
SMART Domains Protein: ENSMUSP00000128738
Gene: ENSMUSG00000033419

DomainStartEndE-ValueType
ENTH 20 145 8.41e-48 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189762
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display postnatal growth retardation, limb clasping, altered behavior, defects in synaptic vesicle reformation, impaired neurotransmission, excitatory/inhibitory imbalance, epileptic seizures, and premature death. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630091E08Rik G T 7: 98,193,125 (GRCm39) noncoding transcript Het
Abca15 G A 7: 119,996,241 (GRCm39) G1389E probably damaging Het
Adcy3 T C 12: 4,184,600 (GRCm39) V92A probably damaging Het
Aoc1l1 A G 6: 48,954,481 (GRCm39) S540G probably benign Het
Aplnr A T 2: 84,968,007 (GRCm39) Y344F probably benign Het
Atm A T 9: 53,371,116 (GRCm39) V2241E probably damaging Het
Cep290 T C 10: 100,403,023 (GRCm39) probably benign Het
Cnpy1 A T 5: 28,414,152 (GRCm39) Y91* probably null Het
Cobl C A 11: 12,204,843 (GRCm39) G613W probably damaging Het
Csn1s2a T C 5: 87,932,439 (GRCm39) S121P possibly damaging Het
Flg2 A T 3: 93,110,585 (GRCm39) Y871F unknown Het
Gapvd1 T A 2: 34,585,575 (GRCm39) D1008V probably damaging Het
Gask1a T C 9: 121,807,401 (GRCm39) L515P probably damaging Het
Igfl3 T C 7: 17,914,000 (GRCm39) probably null Het
Kmt2b A T 7: 30,279,352 (GRCm39) V1470E probably damaging Het
Mcc A T 18: 44,624,306 (GRCm39) L413Q probably damaging Het
Mia2 G A 12: 59,235,146 (GRCm39) G610D probably damaging Het
Mlst8 A T 17: 24,696,287 (GRCm39) D147E probably damaging Het
Muc19 G T 15: 91,770,943 (GRCm39) noncoding transcript Het
Mybpc3 A G 2: 90,965,704 (GRCm39) E1172G probably benign Het
Niban3 T C 8: 72,057,507 (GRCm39) probably benign Het
Nop14 A T 5: 34,802,133 (GRCm39) L557Q probably damaging Het
P3h3 T C 6: 124,822,552 (GRCm39) T540A probably benign Het
Phc3 T A 3: 30,968,346 (GRCm39) I897F probably benign Het
Plekhh2 G A 17: 84,871,356 (GRCm39) V205I probably benign Het
Poc5 A G 13: 96,547,254 (GRCm39) K506E probably damaging Het
Pum1 C A 4: 130,471,100 (GRCm39) T450K probably damaging Het
Retnlg G A 16: 48,694,688 (GRCm39) R112H possibly damaging Het
Rgl2 T C 17: 34,151,075 (GRCm39) V101A probably damaging Het
Serinc5 A G 13: 92,842,779 (GRCm39) T410A probably damaging Het
Shroom1 T C 11: 53,356,796 (GRCm39) V553A probably benign Het
Slco4c1 A T 1: 96,768,912 (GRCm39) W317R probably damaging Het
Supt16 T C 14: 52,399,148 (GRCm39) K1044E possibly damaging Het
Tarbp1 A T 8: 127,185,900 (GRCm39) L431I probably damaging Het
Tas2r124 C T 6: 132,732,492 (GRCm39) T267I probably benign Het
Tm7sf3 C T 6: 146,507,692 (GRCm39) V457I possibly damaging Het
Tmem132c A T 5: 127,581,930 (GRCm39) S382C probably damaging Het
Tmprss7 C A 16: 45,482,685 (GRCm39) C582F probably damaging Het
Tsc2 T C 17: 24,816,105 (GRCm39) E1694G probably damaging Het
Txndc2 G T 17: 65,945,544 (GRCm39) S211Y possibly damaging Het
Ubr3 A C 2: 69,833,775 (GRCm39) T205P probably damaging Het
Vmn2r116 G A 17: 23,620,489 (GRCm39) G741D probably damaging Het
Vps8 G A 16: 21,296,334 (GRCm39) probably benign Het
Wdr19 G A 5: 65,409,642 (GRCm39) D1127N probably benign Het
Zim1 T A 7: 6,685,759 (GRCm39) Y83F possibly damaging Het
Other mutations in Snap91
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01147:Snap91 APN 9 86,680,611 (GRCm39) missense probably benign 0.37
IGL01358:Snap91 APN 9 86,688,613 (GRCm39) missense probably damaging 1.00
IGL01501:Snap91 APN 9 86,720,178 (GRCm39) missense probably damaging 0.99
IGL01883:Snap91 APN 9 86,657,665 (GRCm39) missense probably damaging 1.00
IGL02632:Snap91 APN 9 86,721,575 (GRCm39) missense possibly damaging 0.94
IGL02864:Snap91 APN 9 86,720,141 (GRCm39) missense possibly damaging 0.95
IGL03276:Snap91 APN 9 86,707,065 (GRCm39) missense possibly damaging 0.78
PIT4514001:Snap91 UTSW 9 86,761,486 (GRCm39) missense possibly damaging 0.86
R1564:Snap91 UTSW 9 86,674,249 (GRCm39) missense possibly damaging 0.85
R1804:Snap91 UTSW 9 86,665,470 (GRCm39) missense probably benign 0.01
R1840:Snap91 UTSW 9 86,697,518 (GRCm39) missense probably damaging 1.00
R1869:Snap91 UTSW 9 86,672,194 (GRCm39) critical splice acceptor site probably null
R2156:Snap91 UTSW 9 86,707,130 (GRCm39) missense probably damaging 1.00
R2221:Snap91 UTSW 9 86,674,580 (GRCm39) missense possibly damaging 0.53
R2223:Snap91 UTSW 9 86,674,580 (GRCm39) missense possibly damaging 0.53
R2233:Snap91 UTSW 9 86,680,624 (GRCm39) missense probably benign 0.23
R2680:Snap91 UTSW 9 86,761,603 (GRCm39) start codon destroyed probably null 1.00
R3077:Snap91 UTSW 9 86,720,907 (GRCm39) missense possibly damaging 0.95
R3702:Snap91 UTSW 9 86,688,573 (GRCm39) missense probably damaging 0.99
R3840:Snap91 UTSW 9 86,721,618 (GRCm39) missense probably damaging 1.00
R3912:Snap91 UTSW 9 86,674,610 (GRCm39) missense possibly damaging 0.53
R3913:Snap91 UTSW 9 86,674,610 (GRCm39) missense possibly damaging 0.53
R3958:Snap91 UTSW 9 86,720,183 (GRCm39) missense probably damaging 1.00
R3963:Snap91 UTSW 9 86,657,665 (GRCm39) missense probably damaging 1.00
R4043:Snap91 UTSW 9 86,659,102 (GRCm39) missense probably damaging 1.00
R4133:Snap91 UTSW 9 86,659,102 (GRCm39) missense probably damaging 1.00
R4641:Snap91 UTSW 9 86,761,528 (GRCm39) missense probably damaging 1.00
R4674:Snap91 UTSW 9 86,674,070 (GRCm39) missense possibly damaging 0.73
R4770:Snap91 UTSW 9 86,655,654 (GRCm39) missense possibly damaging 0.86
R4798:Snap91 UTSW 9 86,665,507 (GRCm39) intron probably benign
R4849:Snap91 UTSW 9 86,674,613 (GRCm39) missense possibly damaging 0.53
R4991:Snap91 UTSW 9 86,672,207 (GRCm39) splice site probably null
R5200:Snap91 UTSW 9 86,697,497 (GRCm39) missense probably damaging 1.00
R5354:Snap91 UTSW 9 86,717,177 (GRCm39) missense possibly damaging 0.84
R5644:Snap91 UTSW 9 86,672,206 (GRCm39) splice site probably null
R6029:Snap91 UTSW 9 86,707,133 (GRCm39) splice site probably null
R6091:Snap91 UTSW 9 86,721,681 (GRCm39) missense probably damaging 1.00
R6175:Snap91 UTSW 9 86,707,053 (GRCm39) missense probably damaging 1.00
R6191:Snap91 UTSW 9 86,720,105 (GRCm39) missense probably damaging 1.00
R6611:Snap91 UTSW 9 86,672,180 (GRCm39) missense probably benign 0.33
R6764:Snap91 UTSW 9 86,674,234 (GRCm39) missense probably benign 0.33
R6881:Snap91 UTSW 9 86,655,646 (GRCm39) missense possibly damaging 0.73
R7201:Snap91 UTSW 9 86,672,199 (GRCm39) splice site probably null
R7223:Snap91 UTSW 9 86,761,610 (GRCm39) start gained probably benign
R7247:Snap91 UTSW 9 86,674,669 (GRCm39) missense unknown
R7327:Snap91 UTSW 9 86,655,598 (GRCm39) missense unknown
R7520:Snap91 UTSW 9 86,721,702 (GRCm39) missense probably damaging 1.00
R7572:Snap91 UTSW 9 86,688,547 (GRCm39) missense possibly damaging 0.58
R7616:Snap91 UTSW 9 86,721,674 (GRCm39) missense probably damaging 1.00
R7690:Snap91 UTSW 9 86,707,031 (GRCm39) missense possibly damaging 0.95
R7750:Snap91 UTSW 9 86,680,762 (GRCm39) splice site probably null
R8747:Snap91 UTSW 9 86,686,577 (GRCm39) missense probably damaging 0.99
R8918:Snap91 UTSW 9 86,651,611 (GRCm39) missense unknown
R9171:Snap91 UTSW 9 86,680,672 (GRCm39) missense probably benign 0.03
R9512:Snap91 UTSW 9 86,665,392 (GRCm39) missense unknown
R9764:Snap91 UTSW 9 86,707,094 (GRCm39) missense possibly damaging 0.60
X0027:Snap91 UTSW 9 86,680,881 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16