Incidental Mutation 'IGL00987:Krt87'
ID306672
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krt87
Ensembl Gene ENSMUSG00000047641
Gene Namekeratin 87
SynonymsKrt83, Krt2-25
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL00987
Quality Score
Status
Chromosome15
Chromosomal Location101431038-101438804 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 101438446 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Tyrosine at position 109 (H109Y)
Ref Sequence ENSEMBL: ENSMUSP00000080613 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081945]
Predicted Effect probably benign
Transcript: ENSMUST00000081945
AA Change: H109Y

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000080613
Gene: ENSMUSG00000047641
AA Change: H109Y

DomainStartEndE-ValueType
Pfam:Keratin_2_head 3 107 1e-12 PFAM
Filament 110 421 6.45e-148 SMART
low complexity region 425 440 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot9 T C X: 155,295,181 I241T probably benign Het
Atp5g3 T A 2: 73,909,926 R19* probably null Het
Celf4 T C 18: 25,486,950 D420G probably damaging Het
Cideb C A 14: 55,754,560 R179L possibly damaging Het
Cmtr1 G A 17: 29,697,169 R591H probably benign Het
Dync1li2 A T 8: 104,442,498 S34T possibly damaging Het
Eri2 A G 7: 119,791,166 Y80H probably damaging Het
Eya2 A G 2: 165,754,481 E304G probably damaging Het
Fam135a A C 1: 24,055,898 L130V probably damaging Het
Fancb A T X: 164,991,598 K410N probably damaging Het
Gabpb2 A C 3: 95,200,191 V191G probably damaging Het
Gfm1 A G 3: 67,438,560 H197R possibly damaging Het
Gm11595 A G 11: 99,772,539 V105A unknown Het
Hectd3 T A 4: 116,999,643 D462E probably damaging Het
Herc1 G T 9: 66,408,052 V1139L probably benign Het
Itgal T C 7: 127,302,011 F190L probably damaging Het
Lmf2 T C 15: 89,354,568 Y115C probably benign Het
Papolg T A 11: 23,876,377 Y259F possibly damaging Het
Parn T C 16: 13,667,603 I10V probably benign Het
Pdcd11 T A 19: 47,114,550 probably benign Het
Phldb2 T A 16: 45,763,102 Q1003L possibly damaging Het
Pigg T A 5: 108,342,078 F850I probably damaging Het
Pkp4 T C 2: 59,308,357 L317P probably damaging Het
Polr2a T C 11: 69,743,794 probably benign Het
Prdm16 G A 4: 154,341,969 T453M possibly damaging Het
Rnf144b A T 13: 47,207,493 E36D possibly damaging Het
Ryr2 G A 13: 11,735,502 T1961I probably damaging Het
Sash1 T A 10: 8,751,413 K305I probably damaging Het
Tbc1d7 A T 13: 43,159,321 I32N probably damaging Het
Thop1 T C 10: 81,081,695 F623L probably damaging Het
Thsd7b G A 1: 129,613,279 G297R probably damaging Het
Tln1 C A 4: 43,551,297 probably benign Het
Vmn1r183 A G 7: 24,055,224 N151D probably damaging Het
Other mutations in Krt87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Krt87 APN 15 101438431 missense possibly damaging 0.84
IGL01066:Krt87 APN 15 101438385 critical splice donor site probably null
IGL01087:Krt87 APN 15 101431825 missense probably benign 0.27
IGL01572:Krt87 APN 15 101436533 missense probably benign 0.33
IGL02716:Krt87 APN 15 101434604 missense possibly damaging 0.52
IGL03287:Krt87 APN 15 101432337 splice site probably benign
R0144:Krt87 UTSW 15 101438661 missense probably benign 0.04
R2196:Krt87 UTSW 15 101438433 missense probably damaging 0.99
R2209:Krt87 UTSW 15 101433108 missense probably benign 0.42
R5651:Krt87 UTSW 15 101434029 missense possibly damaging 0.94
R6437:Krt87 UTSW 15 101438392 missense possibly damaging 0.95
R6615:Krt87 UTSW 15 101436562 missense probably benign 0.02
R6680:Krt87 UTSW 15 101433978 missense probably damaging 1.00
R7541:Krt87 UTSW 15 101438634 missense probably damaging 1.00
R7617:Krt87 UTSW 15 101438545 missense probably benign 0.38
Posted On2015-04-16