Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00987:Krt87'

306672

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Krt87

Ensembl Gene

ENSMUSG00000047641

Gene Name

keratin 87

Synonyms

Krt2-25, Krt83

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL00987

Quality Score

Status

Chromosome

Chromosomal Location

101329371-101336685 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 101336327 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 109 (H109Y)

Ref Sequence

ENSEMBL: ENSMUSP00000080613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081945]

AlphaFold

Q6IMF0

Predicted Effect

probably benign
Transcript: ENSMUST00000081945
AA Change: H109Y

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000080613
Gene: ENSMUSG00000047641
AA Change: H109Y

Domain	Start	End	E-Value	Type
Pfam:Keratin_2_head	3	107	1e-12	PFAM
Filament	110	421	6.45e-148	SMART
low complexity region	425	440	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot9	T	C	X: 154,078,177 (GRCm39)	I241T	probably benign	Het
Atp5mc3	T	A	2: 73,740,270 (GRCm39)	R19*	probably null	Het
Celf4	T	C	18: 25,620,007 (GRCm39)	D420G	probably damaging	Het
Cideb	C	A	14: 55,992,017 (GRCm39)	R179L	possibly damaging	Het
Cmtr1	G	A	17: 29,916,143 (GRCm39)	R591H	probably benign	Het
Dync1li2	A	T	8: 105,169,130 (GRCm39)	S34T	possibly damaging	Het
Eri2	A	G	7: 119,390,389 (GRCm39)	Y80H	probably damaging	Het
Eya2	A	G	2: 165,596,401 (GRCm39)	E304G	probably damaging	Het
Fam135a	A	C	1: 24,094,979 (GRCm39)	L130V	probably damaging	Het
Fancb	A	T	X: 163,774,594 (GRCm39)	K410N	probably damaging	Het
Gabpb2	A	C	3: 95,107,502 (GRCm39)	V191G	probably damaging	Het
Gfm1	A	G	3: 67,345,893 (GRCm39)	H197R	possibly damaging	Het
Gm11595	A	G	11: 99,663,365 (GRCm39)	V105A	unknown	Het
Hectd3	T	A	4: 116,856,840 (GRCm39)	D462E	probably damaging	Het
Herc1	G	T	9: 66,315,334 (GRCm39)	V1139L	probably benign	Het
Itgal	T	C	7: 126,901,183 (GRCm39)	F190L	probably damaging	Het
Lmf2	T	C	15: 89,238,771 (GRCm39)	Y115C	probably benign	Het
Papolg	T	A	11: 23,826,377 (GRCm39)	Y259F	possibly damaging	Het
Parn	T	C	16: 13,485,467 (GRCm39)	I10V	probably benign	Het
Pdcd11	T	A	19: 47,102,989 (GRCm39)		probably benign	Het
Phldb2	T	A	16: 45,583,465 (GRCm39)	Q1003L	possibly damaging	Het
Pigg	T	A	5: 108,489,944 (GRCm39)	F850I	probably damaging	Het
Pkp4	T	C	2: 59,138,701 (GRCm39)	L317P	probably damaging	Het
Polr2a	T	C	11: 69,634,620 (GRCm39)		probably benign	Het
Prdm16	G	A	4: 154,426,426 (GRCm39)	T453M	possibly damaging	Het
Rnf144b	A	T	13: 47,360,969 (GRCm39)	E36D	possibly damaging	Het
Ryr2	G	A	13: 11,750,388 (GRCm39)	T1961I	probably damaging	Het
Sash1	T	A	10: 8,627,177 (GRCm39)	K305I	probably damaging	Het
Tbc1d7	A	T	13: 43,312,797 (GRCm39)	I32N	probably damaging	Het
Thop1	T	C	10: 80,917,529 (GRCm39)	F623L	probably damaging	Het
Thsd7b	G	A	1: 129,541,016 (GRCm39)	G297R	probably damaging	Het
Tln1	C	A	4: 43,551,297 (GRCm39)		probably benign	Het
Vmn1r183	A	G	7: 23,754,649 (GRCm39)	N151D	probably damaging	Het

Other mutations in Krt87

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00481:Krt87	APN	15	101,386,092 (GRCm39)	missense	probably benign	0.17
IGL01019:Krt87	APN	15	101,336,312 (GRCm39)	missense	possibly damaging	0.84
IGL01066:Krt87	APN	15	101,336,266 (GRCm39)	critical splice donor site	probably null
IGL01087:Krt87	APN	15	101,329,706 (GRCm39)	missense	probably benign	0.27
IGL01315:Krt87	APN	15	101,384,848 (GRCm39)	splice site	probably benign
IGL01572:Krt87	APN	15	101,334,414 (GRCm39)	missense	probably benign	0.33
IGL01702:Krt87	APN	15	101,389,099 (GRCm39)	missense	probably benign	0.18
IGL02123:Krt87	APN	15	101,385,466 (GRCm39)	missense	possibly damaging	0.49
IGL02353:Krt87	APN	15	101,383,339 (GRCm39)	missense	probably benign
IGL02360:Krt87	APN	15	101,383,339 (GRCm39)	missense	probably benign
IGL02395:Krt87	APN	15	101,385,833 (GRCm39)	missense	probably benign	0.18
IGL02633:Krt87	APN	15	101,389,095 (GRCm39)	missense	probably damaging	1.00
IGL02716:Krt87	APN	15	101,332,485 (GRCm39)	missense	possibly damaging	0.52
IGL03287:Krt87	APN	15	101,330,218 (GRCm39)	splice site	probably benign
R0144:Krt87	UTSW	15	101,336,542 (GRCm39)	missense	probably benign	0.04
R0357:Krt87	UTSW	15	101,384,900 (GRCm39)	missense	probably benign	0.17
R0650:Krt87	UTSW	15	101,384,921 (GRCm39)	missense	probably damaging	0.99
R0928:Krt87	UTSW	15	101,389,161 (GRCm39)	missense	probably benign	0.00
R1126:Krt87	UTSW	15	101,385,363 (GRCm39)	missense	probably damaging	0.98
R1196:Krt87	UTSW	15	101,389,314 (GRCm39)	missense	probably benign	0.03
R1252:Krt87	UTSW	15	101,385,711 (GRCm39)	missense	probably damaging	1.00
R1513:Krt87	UTSW	15	101,387,538 (GRCm39)	missense	probably benign	0.30
R1612:Krt87	UTSW	15	101,386,092 (GRCm39)	missense	probably benign	0.17
R1870:Krt87	UTSW	15	101,385,071 (GRCm39)	missense	probably benign
R2173:Krt87	UTSW	15	101,385,818 (GRCm39)	missense	probably damaging	0.98
R2196:Krt87	UTSW	15	101,336,314 (GRCm39)	missense	probably damaging	0.99
R2209:Krt87	UTSW	15	101,330,989 (GRCm39)	missense	probably benign	0.42
R2432:Krt87	UTSW	15	101,386,037 (GRCm39)	nonsense	probably null
R2568:Krt87	UTSW	15	101,385,708 (GRCm39)	missense	possibly damaging	0.67
R2696:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign	0.01
R3508:Krt87	UTSW	15	101,386,039 (GRCm39)	missense	probably benign	0.04
R4364:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4366:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4606:Krt87	UTSW	15	101,384,930 (GRCm39)	missense	probably benign	0.18
R4721:Krt87	UTSW	15	101,385,863 (GRCm39)	missense	probably damaging	1.00
R4784:Krt87	UTSW	15	101,385,837 (GRCm39)	missense	probably damaging	1.00
R4987:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign
R5008:Krt87	UTSW	15	101,389,105 (GRCm39)	missense	probably damaging	1.00
R5101:Krt87	UTSW	15	101,385,391 (GRCm39)	missense	probably benign	0.14
R5367:Krt87	UTSW	15	101,384,875 (GRCm39)	missense	probably damaging	1.00
R5516:Krt87	UTSW	15	101,385,002 (GRCm39)	nonsense	probably null
R5651:Krt87	UTSW	15	101,331,910 (GRCm39)	missense	possibly damaging	0.94
R5949:Krt87	UTSW	15	101,385,476 (GRCm39)	missense	probably damaging	0.99
R5972:Krt87	UTSW	15	101,385,467 (GRCm39)	missense	probably benign
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6135:Krt87	UTSW	15	101,385,415 (GRCm39)	missense	probably damaging	1.00
R6437:Krt87	UTSW	15	101,336,273 (GRCm39)	missense	possibly damaging	0.95
R6615:Krt87	UTSW	15	101,334,443 (GRCm39)	missense	probably benign	0.02
R6680:Krt87	UTSW	15	101,331,859 (GRCm39)	missense	probably damaging	1.00
R7151:Krt87	UTSW	15	101,387,529 (GRCm39)	missense	probably damaging	1.00
R7186:Krt87	UTSW	15	101,385,083 (GRCm39)	splice site	probably null
R7297:Krt87	UTSW	15	101,387,528 (GRCm39)	missense	probably benign	0.42
R7541:Krt87	UTSW	15	101,336,515 (GRCm39)	missense	probably damaging	1.00
R7617:Krt87	UTSW	15	101,336,426 (GRCm39)	missense	probably benign	0.38
R7708:Krt87	UTSW	15	101,385,813 (GRCm39)	missense	probably benign	0.00
R7796:Krt87	UTSW	15	101,383,865 (GRCm39)	missense	possibly damaging	0.95
R8172:Krt87	UTSW	15	101,383,284 (GRCm39)	missense	probably benign	0.25
R8463:Krt87	UTSW	15	101,332,506 (GRCm39)	missense	probably benign	0.05
R8669:Krt87	UTSW	15	101,385,777 (GRCm39)	missense	probably benign	0.00
R8695:Krt87	UTSW	15	101,331,901 (GRCm39)	missense	probably benign	0.00
R8771:Krt87	UTSW	15	101,385,779 (GRCm39)	missense	probably benign	0.00
R9478:Krt87	UTSW	15	101,385,449 (GRCm39)	missense	probably benign	0.06
R9489:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9592:Krt87	UTSW	15	101,386,060 (GRCm39)	missense	probably benign
R9605:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9629:Krt87	UTSW	15	101,389,048 (GRCm39)	missense	probably benign	0.01
R9642:Krt87	UTSW	15	101,385,074 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16