Mutagenetix > Incidental Mutation

Incidental Mutation 'R0375:Camk1g'

30670

Institutional Source

Beutler Lab

Gene Symbol

Camk1g

Ensembl Gene

ENSMUSG00000016179

Gene Name

calcium/calmodulin-dependent protein kinase I gamma

Synonyms

CLICK-III, CaMKIgamma

MMRRC Submission

038581-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

R0375 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

193346346-193370298 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 193356401 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000128143 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000016323] [ENSMUST00000169907]

AlphaFold

Q91VB2

Predicted Effect

probably benign
Transcript: ENSMUST00000016323

SMART Domains

Protein: ENSMUSP00000016323
Gene: ENSMUSG00000016179

Domain	Start	End	E-Value	Type
S_TKc	23	277	9.53e-112	SMART
low complexity region	376	389	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163202

SMART Domains

Protein: ENSMUSP00000131451
Gene: ENSMUSG00000016179

Domain	Start	End	E-Value	Type
S_TKc	2	238	5.19e-72	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000165718

Predicted Effect

probably benign
Transcript: ENSMUST00000169907

SMART Domains

Protein: ENSMUSP00000128143
Gene: ENSMUSG00000016179

Domain	Start	End	E-Value	Type
S_TKc	23	277	9.53e-112	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.3%
10x: 96.2%
20x: 92.7%

Validation Efficiency

100% (61/61)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired dendritogenesis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	C	T	3: 37,046,252	T4707I	probably damaging	Het
5730522E02Rik	T	A	11: 25,769,092	Y17F	unknown	Het
Aars2	A	G	17: 45,514,550	D313G	probably damaging	Het
Abca9	A	T	11: 110,115,447	D1277E	probably benign	Het
Adgrl1	G	T	8: 83,934,901	A981S	probably damaging	Het
Aff3	T	G	1: 38,204,940	K917Q	possibly damaging	Het
BC049715	A	T	6: 136,839,996	H78L	probably benign	Het
Cacna1g	C	A	11: 94,411,054	A2027S	possibly damaging	Het
Carf	T	C	1: 60,144,002	V386A	probably damaging	Het
Cd46	A	G	1: 195,086,164	S82P	probably benign	Het
Clic5	A	G	17: 44,270,623	E180G	possibly damaging	Het
Col27a1	A	G	4: 63,225,661	T529A	probably benign	Het
Col7a1	C	T	9: 108,980,237	R2627C	unknown	Het
Cuzd1	G	A	7: 131,311,908		probably benign	Het
Cwc27	T	C	13: 104,807,823	D50G	possibly damaging	Het
Dhx38	A	G	8: 109,555,181	V735A	possibly damaging	Het
Dhx57	T	G	17: 80,258,121	E834A	probably damaging	Het
Dsg4	A	G	18: 20,470,879	D801G	probably damaging	Het
Dtx1	T	C	5: 120,681,399	E578G	probably damaging	Het
F830016B08Rik	A	T	18: 60,300,193	H116L	probably damaging	Het
Fam208b	A	G	13: 3,596,842	V61A	possibly damaging	Het
Fbxw18	T	C	9: 109,688,839	I360V	possibly damaging	Het
Fignl2	G	A	15: 101,054,093	P103S	probably benign	Het
Frmpd1	A	G	4: 45,284,196	T1006A	probably benign	Het
Ggnbp2	G	T	11: 84,836,374	C545*	probably null	Het
Gm3336	A	G	8: 70,718,645		probably benign	Het
Gpr37	T	C	6: 25,669,291	N518S	probably benign	Het
Hbs1l	T	A	10: 21,342,541	D312E	possibly damaging	Het
Hoxd10	C	A	2: 74,692,720	S247R	probably benign	Het
Ifnb1	A	T	4: 88,522,744	F11I	probably benign	Het
Marf1	T	C	16: 14,151,320		probably benign	Het
Myo1f	T	A	17: 33,601,956	V879E	probably benign	Het
Naip1	A	G	13: 100,409,148	F1291L	probably benign	Het
Nckap1l	A	G	15: 103,474,159	E529G	probably damaging	Het
Npm3	T	C	19: 45,748,229	E157G	probably damaging	Het
Olfr1200	T	A	2: 88,767,641	T225S	possibly damaging	Het
Olfr1240	G	T	2: 89,439,396	N294K	probably benign	Het
Olfr248	A	G	1: 174,391,209	T47A	probably damaging	Het
Pex16	G	A	2: 92,380,457	G312D	probably damaging	Het
Ppp6r1	A	G	7: 4,633,287	V768A	probably benign	Het
Prrc1	A	G	18: 57,362,492	T14A	probably damaging	Het
Ranbp2	T	C	10: 58,477,283	L1275P	probably damaging	Het
Rnf214	C	A	9: 45,899,823	V181F	probably damaging	Het
Ror2	T	C	13: 53,132,004	N58S	probably damaging	Het
Selplg	G	A	5: 113,820,008	T79I	probably damaging	Het
Setd1b	G	A	5: 123,157,437	G1023S	unknown	Het
Sf3b2	C	T	19: 5,274,824	D845N	probably damaging	Het
Skint5	A	G	4: 113,705,596	V803A	unknown	Het
Slc25a46	T	C	18: 31,583,266	I394M	possibly damaging	Het
Snrnp27	A	T	6: 86,680,953	I101K	possibly damaging	Het
Spag17	C	A	3: 100,027,590	T704K	probably benign	Het
Tas2r144	T	A	6: 42,216,124	M266K	possibly damaging	Het
Tbc1d31	T	A	15: 57,955,350	L783H	probably benign	Het
Tbck	C	A	3: 132,751,232		probably benign	Het
Vcan	A	G	13: 89,691,275	V2050A	probably damaging	Het
Vmn1r70	T	A	7: 10,634,060	N158K	probably damaging	Het
Vmn2r103	T	A	17: 19,792,859	Y81N	probably benign	Het
Vmn2r103	A	G	17: 19,793,464	T173A	probably benign	Het
Ylpm1	T	G	12: 85,014,980	S552A	unknown	Het
Zdhhc17	A	T	10: 110,982,106	Y58*	probably null	Het

Other mutations in Camk1g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00433:Camk1g	APN	1	193347349	unclassified	probably benign
IGL02637:Camk1g	APN	1	193348388	missense	probably benign	0.38
G1patch:Camk1g	UTSW	1	193350320	missense	possibly damaging	0.80
I2288:Camk1g	UTSW	1	193351106	splice site	probably benign
R0433:Camk1g	UTSW	1	193354058	missense	probably damaging	0.99
R0967:Camk1g	UTSW	1	193350296	missense	probably damaging	1.00
R1161:Camk1g	UTSW	1	193348354	missense	probably benign
R1227:Camk1g	UTSW	1	193347433	missense	possibly damaging	0.73
R1469:Camk1g	UTSW	1	193362091	missense	possibly damaging	0.89
R1469:Camk1g	UTSW	1	193362091	missense	possibly damaging	0.89
R1641:Camk1g	UTSW	1	193356357	missense	probably benign	0.25
R3109:Camk1g	UTSW	1	193354993	missense	probably damaging	1.00
R3160:Camk1g	UTSW	1	193359807	missense	possibly damaging	0.66
R3161:Camk1g	UTSW	1	193359807	missense	possibly damaging	0.66
R3162:Camk1g	UTSW	1	193359807	missense	possibly damaging	0.66
R3162:Camk1g	UTSW	1	193359807	missense	possibly damaging	0.66
R4638:Camk1g	UTSW	1	193356359	missense	probably damaging	1.00
R4642:Camk1g	UTSW	1	193356359	missense	probably damaging	1.00
R4644:Camk1g	UTSW	1	193356359	missense	probably damaging	1.00
R4756:Camk1g	UTSW	1	193362085	missense	probably benign	0.03
R4781:Camk1g	UTSW	1	193356344	missense	probably benign	0.00
R4987:Camk1g	UTSW	1	193348475	missense	probably damaging	0.99
R5224:Camk1g	UTSW	1	193355034	missense	probably damaging	1.00
R5407:Camk1g	UTSW	1	193347372	splice site	probably null
R5932:Camk1g	UTSW	1	193354039	missense	probably benign	0.25
R6725:Camk1g	UTSW	1	193350320	missense	possibly damaging	0.80
R7071:Camk1g	UTSW	1	193359809	missense	probably benign	0.10
R7808:Camk1g	UTSW	1	193350285	missense	possibly damaging	0.51
R7908:Camk1g	UTSW	1	193359774	missense	probably damaging	1.00
R8135:Camk1g	UTSW	1	193354027	missense	possibly damaging	0.79
R8355:Camk1g	UTSW	1	193351047	missense	probably damaging	1.00
R8737:Camk1g	UTSW	1	193348486	critical splice acceptor site	probably null
R8811:Camk1g	UTSW	1	193362100	missense	probably damaging	1.00
R9506:Camk1g	UTSW	1	193348055	critical splice donor site	probably null
R9680:Camk1g	UTSW	1	193348175	missense	probably benign	0.00
R9688:Camk1g	UTSW	1	193348721	missense	probably damaging	1.00
Z1176:Camk1g	UTSW	1	193362100	missense	probably damaging	1.00

Predicted Primers

Posted On

2013-04-24