Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00990:Gm21738'

306714

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL00990

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19418885 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 16 (C16R)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: C16R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: C16R

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 150 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430531B16Rik	A	C	7: 139,978,103	V60G	probably damaging	Het
Adcy8	C	A	15: 64,822,313	V372L	probably benign	Het
Bod1l	T	C	5: 41,828,865	D458G	probably benign	Het
C87414	T	A	5: 93,636,477	Q376L	probably damaging	Het
Cacna1c	G	T	6: 118,613,295	H1416N	probably damaging	Het
Cacna2d1	T	C	5: 15,935,069	I19T	probably benign	Het
Cadps	T	A	14: 12,715,374	T153S	possibly damaging	Het
Cd200r1	A	T	16: 44,794,309	D317V	possibly damaging	Het
Dcaf5	C	T	12: 80,338,832	R840H	probably benign	Het
Dnhd1	A	C	7: 105,721,688	H4725P	possibly damaging	Het
Echdc3	C	A	2: 6,195,727	L149F	probably benign	Het
Efhb	T	G	17: 53,462,621	Q220P	possibly damaging	Het
Efr3b	A	T	12: 3,975,411	Y18*	probably null	Het
Eri1	T	C	8: 35,482,682	K41R	possibly damaging	Het
Eri1	C	A	8: 35,482,646	G53V	probably benign	Het
Gm10212	A	G	19: 11,569,560		noncoding transcript	Het
Gm11168	T	G	9: 3,005,124	F201C	probably damaging	Het
Gm14412	A	C	2: 177,315,686	S139A	probably benign	Het
Gm21411	C	T	4: 146,892,610	S69N	possibly damaging	Het
Gm21671	A	C	5: 25,954,224	W41G	probably benign	Het
Gm21967	T	A	13: 119,609,535		probably benign	Het
Gm4952	A	T	19: 12,623,623	D69V	probably damaging	Het
Gm5591	T	G	7: 38,520,414	K345T	probably benign	Het
Gm7647	T	C	5: 94,962,980	S7P	probably benign	Het
Gm9733	C	T	3: 15,332,145		probably null	Het
Gm9758	G	A	5: 14,913,508		probably benign	Het
Gtse1	C	A	15: 85,868,817	Q378K	possibly damaging	Het
Haus3	T	C	5: 34,166,346	K307E	probably benign	Het
Hjurp	A	G	1: 88,270,269	L96S	probably benign	Het
Ifi205	T	A	1: 174,027,333		probably benign	Het
Ighg1	A	G	12: 113,329,184	V255A	unknown	Het
Ighv14-4	T	A	12: 114,176,632	M49L	probably benign	Het
Jak1	A	C	4: 101,171,357	L508R	probably damaging	Het
Kif18a	A	G	2: 109,334,422	Q821R	probably benign	Het
Kif21b	T	C	1: 136,152,342	S539P	possibly damaging	Het
Klhdc2	T	C	12: 69,307,213	V266A	probably benign	Het
Lonp2	G	T	8: 86,641,533		probably benign	Het
Mpdz	C	T	4: 81,303,584		probably benign	Het
Mroh2a	G	A	1: 88,230,746	E172K	probably damaging	Het
Mroh2a	G	T	1: 88,244,970	M823I	probably benign	Het
Mroh2a	G	A	1: 88,234,120	G309D	possibly damaging	Het
Mtif3	C	A	5: 146,959,104	G58*	probably null	Het
Muc4	G	T	16: 32,753,848	K1241N	probably benign	Het
Muc4	G	A	16: 32,753,849	G1242R	probably benign	Het
Muc4	C	T	16: 32,755,805		probably benign	Het
Muc4	C	T	16: 32,753,823	P1233L	probably benign	Het
Muc4	C	A	16: 32,753,955	T1277K	possibly damaging	Het
Muc4	A	G	16: 32,754,071	R1316G	probably benign	Het
Muc4	T	G	16: 32,753,863	N1246K	probably benign	Het
Muc4	A	T	16: 32,753,886	E1254V	probably benign	Het
Muc4	C	T	16: 32,752,569	P816S	probably benign	Het
Muc6	C	T	7: 141,638,890	A1957T	possibly damaging	Het
Naca	T	A	10: 128,043,800		probably benign	Het
Nars2	A	T	7: 97,002,790		probably benign	Het
Odf3l1	T	C	9: 56,849,057	E225G	probably benign	Het
Olfr1445	G	T	19: 12,883,901	V7L	probably benign	Het
Olfr342	A	C	2: 36,527,993	I194L	probably benign	Het
Olfr549	G	T	7: 102,554,891	L202F	probably damaging	Het
Olfr812	T	C	10: 129,842,473	T190A	probably damaging	Het
Pcdh7	G	A	5: 57,720,464	E454K	possibly damaging	Het
Pip5kl1	C	A	2: 32,583,347	A332D	probably benign	Het
Pisd	A	T	5: 32,739,358	S280T	probably benign	Het
Pramel5	A	G	4: 144,273,979	L9P	probably damaging	Het
Prkd3	G	T	17: 78,954,523	N787K	probably benign	Het
Prkdc	A	T	16: 15,702,115	H1139L	probably benign	Het
R3hdm1	A	G	1: 128,162,196		probably benign	Het
Rbfox2	T	C	15: 77,102,936	N206D	probably damaging	Het
Rlf	T	C	4: 121,148,339	E1258G	possibly damaging	Het
Rpl8	T	C	15: 76,905,042		probably benign	Het
Senp5	A	C	16: 31,990,274	V27G	probably benign	Het
Serpina1b	T	A	12: 103,728,266	K406N	probably damaging	Het
Sfi1	G	A	11: 3,134,337	A975V	probably benign	Het
Sfi1	T	C	11: 3,143,689		probably benign	Het
Sfi1	C	T	11: 3,135,671	A853T	probably damaging	Het
Shc1	T	C	3: 89,424,229	S154P	probably damaging	Het
Skint5	A	G	4: 113,542,873		probably null	Het
Slc17a8	T	C	10: 89,576,530	D531G	probably benign	Het
Slc4a10	A	C	2: 62,286,940	T718P	probably damaging	Het
Slc7a11	C	T	3: 50,379,069	R411Q	probably damaging	Het
Slitrk3	A	G	3: 73,050,081	F453L	probably damaging	Het
Slk	A	C	19: 47,580,252	Q20P	probably damaging	Het
Smg5	T	C	3: 88,343,038		probably null	Het
Sp110	G	A	1: 85,586,281	R252C	possibly damaging	Het
Sp140	C	T	1: 85,626,165	R242C	possibly damaging	Het
Sp140	G	A	1: 85,626,133	R231K	probably benign	Het
Speer4b	G	A	5: 27,501,274	P30S	probably damaging	Het
Stim1	T	A	7: 102,426,747	H395Q	probably damaging	Het
Sult2a1	T	C	7: 13,804,036	I187M	probably benign	Het
Thap1	G	A	8: 26,162,731	D189N	probably benign	Het
Thap1	C	T	8: 26,160,882	P37L	possibly damaging	Het
Thrap3	C	T	4: 126,165,395		probably benign	Het
Tmem132d	C	T	5: 127,784,832	V742I	possibly damaging	Het
Tmprss9	A	G	10: 80,892,292	D572G	possibly damaging	Het
Tmtc1	T	G	6: 148,443,944	T86P	probably benign	Het
Trip12	A	T	1: 84,751,884	N1026K	probably damaging	Het
Ttll5	T	A	12: 85,876,589	V280E	probably damaging	Het
Ubn2	T	A	6: 38,482,605	D592E	possibly damaging	Het
Ubr1	T	G	2: 120,930,872	H608P	probably damaging	Het
Ugt1a6b	A	T	1: 88,215,178		probably null	Het
Vmn1r77	C	A	7: 12,041,768	S89Y	probably benign	Het
Vmn1r77	A	C	7: 12,041,476	I60L	probably benign	Het
Vmn2r114	G	A	17: 23,290,965	A847V	probably benign	Het
Vmn2r114	A	T	17: 23,291,238	L756Q	probably damaging	Het
Vmn2r114	G	T	17: 23,290,983	S841Y	probably benign	Het
Vmn2r115	C	T	17: 23,346,264	S375F	probably benign	Het
Vmn2r115	G	A	17: 23,359,779	G742D	probably damaging	Het
Vmn2r115	T	A	17: 23,359,824	L757Q	probably damaging	Het
Vmn2r115	G	T	17: 23,348,034	G507*	probably null	Het
Vmn2r115	G	A	17: 23,346,278	E380K	probably benign	Het
Vmn2r115	A	G	17: 23,356,960	M511V	probably benign	Het
Vmn2r115	C	T	17: 23,346,371	Q411*	probably null	Het
Vmn2r115	A	G	17: 23,346,372	Q411R	probably benign	Het
Vmn2r115	C	T	17: 23,359,397	P615S	probably damaging	Het
Vmn2r115	A	G	17: 23,346,161	N341D	probably benign	Het
Vmn2r115	G	T	17: 23,359,349	A599S	probably benign	Het
Vmn2r115	A	C	17: 23,346,339	N400T	probably damaging	Het
Vmn2r115	C	T	17: 23,346,176	P346S	probably benign	Het
Vmn2r115	A	T	17: 23,346,206	M356L	possibly damaging	Het
Vmn2r116	C	T	17: 23,397,727	P540S	probably damaging	Het
Vmn2r116	C	T	17: 23,387,236	S374F	probably benign	Het
Vmn2r117	C	T	17: 23,477,840	A198T	probably damaging	Het
Vmn2r117	T	G	17: 23,475,429	K481N	probably damaging	Het
Vmn2r117	A	C	17: 23,479,546	S18A	probably benign	Het
Vmn2r121	T	G	X: 124,127,802	K840N	probably benign	Het
Vmn2r121	T	A	X: 124,127,783	N847Y	possibly damaging	Het
Vmn2r121	C	T	X: 124,133,716	E73K	probably benign	Het
Vmn2r125	A	C	4: 156,350,900	Q191P	probably benign	Het
Vmn2r125	C	A	4: 156,350,899	Q191K	probably benign	Het
Vmn2r125	T	C	4: 156,351,383	M352T	probably benign	Het
Vmn2r125	T	C	4: 156,350,966	V213A	probably benign	Het
Vmn2r125	C	T	4: 156,351,038	T237I	probably benign	Het
Vmn2r125	A	T	4: 156,351,037	T237S	probably benign	Het
Vmn2r125	T	A	4: 156,351,226	L300M	probably benign	Het
Vmn2r88	A	G	14: 51,413,125	I98M	probably benign	Het
Vmn2r88	T	C	14: 51,413,256	I142T	probably benign	Het
Vmn2r88	C	T	14: 51,416,802	P539L	possibly damaging	Het
Vmn2r88	T	C	14: 51,413,060	F77L	probably benign	Het
Vmn2r89	A	C	14: 51,455,971	Q259H	probably benign	Het
Vmn2r89	T	G	14: 51,457,493	L477V	probably benign	Het
Vmn2r-ps159	T	C	4: 156,334,263		noncoding transcript	Het
Vmn2r-ps159	C	A	4: 156,338,435		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,338,460		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,334,562		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,338,484		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,334,397		noncoding transcript	Het
Vmn2r-ps159	A	T	4: 156,338,146		noncoding transcript	Het
Zfp180	G	A	7: 24,104,416	C85Y	possibly damaging	Het
Zfp180	C	T	7: 24,104,830	R225C	probably benign	Het
Zfp180	G	A	7: 24,104,995	V280M	possibly damaging	Het
Zfp982	G	A	4: 147,512,369	C61Y	probably benign	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19418856	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2015-04-16