Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00990:Vmn2r117'

306720

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL00990

Quality Score

Status

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 23475429 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 481 (K481N)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably damaging
Transcript: ENSMUST00000171996
AA Change: K481N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: K481N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 148 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430531B16Rik	A	C	7: 139,978,103	V60G	probably damaging	Het
Adcy8	C	A	15: 64,822,313	V372L	probably benign	Het
Bod1l	T	C	5: 41,828,865	D458G	probably benign	Het
C87414	T	A	5: 93,636,477	Q376L	probably damaging	Het
Cacna1c	G	T	6: 118,613,295	H1416N	probably damaging	Het
Cacna2d1	T	C	5: 15,935,069	I19T	probably benign	Het
Cadps	T	A	14: 12,715,374	T153S	possibly damaging	Het
Cd200r1	A	T	16: 44,794,309	D317V	possibly damaging	Het
Dcaf5	C	T	12: 80,338,832	R840H	probably benign	Het
Dnhd1	A	C	7: 105,721,688	H4725P	possibly damaging	Het
Echdc3	C	A	2: 6,195,727	L149F	probably benign	Het
Efhb	T	G	17: 53,462,621	Q220P	possibly damaging	Het
Efr3b	A	T	12: 3,975,411	Y18*	probably null	Het
Eri1	T	C	8: 35,482,682	K41R	possibly damaging	Het
Eri1	C	A	8: 35,482,646	G53V	probably benign	Het
Gm10212	A	G	19: 11,569,560		noncoding transcript	Het
Gm11168	T	G	9: 3,005,124	F201C	probably damaging	Het
Gm14412	A	C	2: 177,315,686	S139A	probably benign	Het
Gm21411	C	T	4: 146,892,610	S69N	possibly damaging	Het
Gm21671	A	C	5: 25,954,224	W41G	probably benign	Het
Gm21738	A	G	14: 19,418,885	C16R	probably benign	Het
Gm21967	T	A	13: 119,609,535		probably benign	Het
Gm4952	A	T	19: 12,623,623	D69V	probably damaging	Het
Gm5591	T	G	7: 38,520,414	K345T	probably benign	Het
Gm7647	T	C	5: 94,962,980	S7P	probably benign	Het
Gm9733	C	T	3: 15,332,145		probably null	Het
Gm9758	G	A	5: 14,913,508		probably benign	Het
Gtse1	C	A	15: 85,868,817	Q378K	possibly damaging	Het
Haus3	T	C	5: 34,166,346	K307E	probably benign	Het
Hjurp	A	G	1: 88,270,269	L96S	probably benign	Het
Ifi205	T	A	1: 174,027,333		probably benign	Het
Ighg1	A	G	12: 113,329,184	V255A	unknown	Het
Ighv14-4	T	A	12: 114,176,632	M49L	probably benign	Het
Jak1	A	C	4: 101,171,357	L508R	probably damaging	Het
Kif18a	A	G	2: 109,334,422	Q821R	probably benign	Het
Kif21b	T	C	1: 136,152,342	S539P	possibly damaging	Het
Klhdc2	T	C	12: 69,307,213	V266A	probably benign	Het
Lonp2	G	T	8: 86,641,533		probably benign	Het
Mpdz	C	T	4: 81,303,584		probably benign	Het
Mroh2a	G	A	1: 88,230,746	E172K	probably damaging	Het
Mroh2a	G	T	1: 88,244,970	M823I	probably benign	Het
Mroh2a	G	A	1: 88,234,120	G309D	possibly damaging	Het
Mtif3	C	A	5: 146,959,104	G58*	probably null	Het
Muc4	T	G	16: 32,753,863	N1246K	probably benign	Het
Muc4	G	T	16: 32,753,848	K1241N	probably benign	Het
Muc4	G	A	16: 32,753,849	G1242R	probably benign	Het
Muc4	C	T	16: 32,755,805		probably benign	Het
Muc4	C	T	16: 32,753,823	P1233L	probably benign	Het
Muc4	C	A	16: 32,753,955	T1277K	possibly damaging	Het
Muc4	A	G	16: 32,754,071	R1316G	probably benign	Het
Muc4	A	T	16: 32,753,886	E1254V	probably benign	Het
Muc4	C	T	16: 32,752,569	P816S	probably benign	Het
Muc6	C	T	7: 141,638,890	A1957T	possibly damaging	Het
Naca	T	A	10: 128,043,800		probably benign	Het
Nars2	A	T	7: 97,002,790		probably benign	Het
Odf3l1	T	C	9: 56,849,057	E225G	probably benign	Het
Olfr1445	G	T	19: 12,883,901	V7L	probably benign	Het
Olfr342	A	C	2: 36,527,993	I194L	probably benign	Het
Olfr549	G	T	7: 102,554,891	L202F	probably damaging	Het
Olfr812	T	C	10: 129,842,473	T190A	probably damaging	Het
Pcdh7	G	A	5: 57,720,464	E454K	possibly damaging	Het
Pip5kl1	C	A	2: 32,583,347	A332D	probably benign	Het
Pisd	A	T	5: 32,739,358	S280T	probably benign	Het
Pramel5	A	G	4: 144,273,979	L9P	probably damaging	Het
Prkd3	G	T	17: 78,954,523	N787K	probably benign	Het
Prkdc	A	T	16: 15,702,115	H1139L	probably benign	Het
R3hdm1	A	G	1: 128,162,196		probably benign	Het
Rbfox2	T	C	15: 77,102,936	N206D	probably damaging	Het
Rlf	T	C	4: 121,148,339	E1258G	possibly damaging	Het
Rpl8	T	C	15: 76,905,042		probably benign	Het
Senp5	A	C	16: 31,990,274	V27G	probably benign	Het
Serpina1b	T	A	12: 103,728,266	K406N	probably damaging	Het
Sfi1	G	A	11: 3,134,337	A975V	probably benign	Het
Sfi1	T	C	11: 3,143,689		probably benign	Het
Sfi1	C	T	11: 3,135,671	A853T	probably damaging	Het
Shc1	T	C	3: 89,424,229	S154P	probably damaging	Het
Skint5	A	G	4: 113,542,873		probably null	Het
Slc17a8	T	C	10: 89,576,530	D531G	probably benign	Het
Slc4a10	A	C	2: 62,286,940	T718P	probably damaging	Het
Slc7a11	C	T	3: 50,379,069	R411Q	probably damaging	Het
Slitrk3	A	G	3: 73,050,081	F453L	probably damaging	Het
Slk	A	C	19: 47,580,252	Q20P	probably damaging	Het
Smg5	T	C	3: 88,343,038		probably null	Het
Sp110	G	A	1: 85,586,281	R252C	possibly damaging	Het
Sp140	C	T	1: 85,626,165	R242C	possibly damaging	Het
Sp140	G	A	1: 85,626,133	R231K	probably benign	Het
Speer4b	G	A	5: 27,501,274	P30S	probably damaging	Het
Stim1	T	A	7: 102,426,747	H395Q	probably damaging	Het
Sult2a1	T	C	7: 13,804,036	I187M	probably benign	Het
Thap1	G	A	8: 26,162,731	D189N	probably benign	Het
Thap1	C	T	8: 26,160,882	P37L	possibly damaging	Het
Thrap3	C	T	4: 126,165,395		probably benign	Het
Tmem132d	C	T	5: 127,784,832	V742I	possibly damaging	Het
Tmprss9	A	G	10: 80,892,292	D572G	possibly damaging	Het
Tmtc1	T	G	6: 148,443,944	T86P	probably benign	Het
Trip12	A	T	1: 84,751,884	N1026K	probably damaging	Het
Ttll5	T	A	12: 85,876,589	V280E	probably damaging	Het
Ubn2	T	A	6: 38,482,605	D592E	possibly damaging	Het
Ubr1	T	G	2: 120,930,872	H608P	probably damaging	Het
Ugt1a6b	A	T	1: 88,215,178		probably null	Het
Vmn1r77	C	A	7: 12,041,768	S89Y	probably benign	Het
Vmn1r77	A	C	7: 12,041,476	I60L	probably benign	Het
Vmn2r114	A	T	17: 23,291,238	L756Q	probably damaging	Het
Vmn2r114	G	T	17: 23,290,983	S841Y	probably benign	Het
Vmn2r114	G	A	17: 23,290,965	A847V	probably benign	Het
Vmn2r115	G	A	17: 23,359,779	G742D	probably damaging	Het
Vmn2r115	C	T	17: 23,346,264	S375F	probably benign	Het
Vmn2r115	G	T	17: 23,348,034	G507*	probably null	Het
Vmn2r115	T	A	17: 23,359,824	L757Q	probably damaging	Het
Vmn2r115	G	A	17: 23,346,278	E380K	probably benign	Het
Vmn2r115	A	G	17: 23,356,960	M511V	probably benign	Het
Vmn2r115	C	T	17: 23,346,371	Q411*	probably null	Het
Vmn2r115	A	G	17: 23,346,372	Q411R	probably benign	Het
Vmn2r115	C	T	17: 23,359,397	P615S	probably damaging	Het
Vmn2r115	A	G	17: 23,346,161	N341D	probably benign	Het
Vmn2r115	G	T	17: 23,359,349	A599S	probably benign	Het
Vmn2r115	A	C	17: 23,346,339	N400T	probably damaging	Het
Vmn2r115	C	T	17: 23,346,176	P346S	probably benign	Het
Vmn2r115	A	T	17: 23,346,206	M356L	possibly damaging	Het
Vmn2r116	C	T	17: 23,397,727	P540S	probably damaging	Het
Vmn2r116	C	T	17: 23,387,236	S374F	probably benign	Het
Vmn2r121	C	T	X: 124,133,716	E73K	probably benign	Het
Vmn2r121	T	A	X: 124,127,783	N847Y	possibly damaging	Het
Vmn2r121	T	G	X: 124,127,802	K840N	probably benign	Het
Vmn2r125	T	C	4: 156,350,966	V213A	probably benign	Het
Vmn2r125	T	C	4: 156,351,383	M352T	probably benign	Het
Vmn2r125	C	T	4: 156,351,038	T237I	probably benign	Het
Vmn2r125	A	T	4: 156,351,037	T237S	probably benign	Het
Vmn2r125	A	C	4: 156,350,900	Q191P	probably benign	Het
Vmn2r125	C	A	4: 156,350,899	Q191K	probably benign	Het
Vmn2r125	T	A	4: 156,351,226	L300M	probably benign	Het
Vmn2r88	T	C	14: 51,413,060	F77L	probably benign	Het
Vmn2r88	T	C	14: 51,413,256	I142T	probably benign	Het
Vmn2r88	C	T	14: 51,416,802	P539L	possibly damaging	Het
Vmn2r88	A	G	14: 51,413,125	I98M	probably benign	Het
Vmn2r89	A	C	14: 51,455,971	Q259H	probably benign	Het
Vmn2r89	T	G	14: 51,457,493	L477V	probably benign	Het
Vmn2r-ps159	T	C	4: 156,334,263		noncoding transcript	Het
Vmn2r-ps159	C	A	4: 156,338,435		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,338,460		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,334,562		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,338,484		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,334,397		noncoding transcript	Het
Vmn2r-ps159	A	T	4: 156,338,146		noncoding transcript	Het
Zfp180	G	A	7: 24,104,416	C85Y	possibly damaging	Het
Zfp180	C	T	7: 24,104,830	R225C	probably benign	Het
Zfp180	G	A	7: 24,104,995	V280M	possibly damaging	Het
Zfp982	G	A	4: 147,512,369	C61Y	probably benign	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23477225	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23459784	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23477707	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23460106	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Posted On

2015-04-16