Incidental Mutation 'IGL00225:Gm8356'
ID306785
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8356
Ensembl Gene ENSMUSG00000090627
Gene Namepredicted gene 8356
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00225
Quality Score
Status
Chromosome14
Chromosomal Location6528612-6537290 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 6537141 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 24 (K24E)
Ref Sequence ENSEMBL: ENSMUSP00000137204 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163636] [ENSMUST00000164917] [ENSMUST00000178896]
Predicted Effect possibly damaging
Transcript: ENSMUST00000163636
AA Change: K24E

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127661
Gene: ENSMUSG00000090627
AA Change: K24E

DomainStartEndE-ValueType
Pfam:Takusan 46 129 1.9e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000164917
AA Change: K24E

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000133130
Gene: ENSMUSG00000090627
AA Change: K24E

DomainStartEndE-ValueType
Pfam:Takusan 46 129 4.4e-37 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000178896
AA Change: K24E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000137204
Gene: ENSMUSG00000090627
AA Change: K24E

DomainStartEndE-ValueType
Pfam:Takusan 46 129 1.9e-36 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Flii T C 11: 60,723,415 N93D probably benign Het
Hars G A 18: 36,768,172 T409M probably damaging Het
Ivns1abp A G 1: 151,351,112 probably null Het
Kcnq4 G A 4: 120,698,016 Q657* probably null Het
Kdm4c T G 4: 74,345,567 V696G probably benign Het
Klrb1f T A 6: 129,053,175 probably benign Het
Lrp4 G A 2: 91,495,026 V1399I probably benign Het
Mki67 A G 7: 135,690,120 V3168A probably benign Het
Nf1 T A 11: 79,395,905 I177K probably damaging Het
Nnt A T 13: 119,369,997 N371K probably damaging Het
Olfr472 C T 7: 107,903,104 P129L probably damaging Het
Olfr60 A G 7: 140,345,210 Y260H probably damaging Het
Oraov1 G A 7: 144,917,668 G86D possibly damaging Het
Prkdc G T 16: 15,809,644 V3389L possibly damaging Het
Prr16 T A 18: 51,303,120 Y224N possibly damaging Het
Ptgs1 G A 2: 36,237,219 C39Y probably damaging Het
Sla T C 15: 66,782,630 D269G possibly damaging Het
Stk38l T A 6: 146,758,473 M1K probably null Het
Trim24 T A 6: 37,903,648 N160K possibly damaging Het
Zfp451 A G 1: 33,786,540 probably benign Het
Other mutations in Gm8356
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6302:Gm8356 UTSW 14 6535128 missense probably damaging 1.00
R7484:Gm8356 UTSW 14 6535135 missense probably benign 0.16
R8013:Gm8356 UTSW 14 6536303 missense probably damaging 0.98
R8014:Gm8356 UTSW 14 6536303 missense probably damaging 0.98
Posted On2015-04-16