Incidental Mutation 'IGL00230:Trav9-1'
ID306804
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav9-1
Ensembl Gene ENSMUSG00000096900
Gene NameT cell receptor alpha variable 9-1
SynonymsGm13947
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00230
Quality Score
Status
Chromosome14
Chromosomal Location53488045-53488566 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 53488393 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 55 (I55F)
Ref Sequence ENSEMBL: ENSMUSP00000100358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103581] [ENSMUST00000181210] [ENSMUST00000183488]
Predicted Effect probably benign
Transcript: ENSMUST00000103581
AA Change: I55F

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000100358
Gene: ENSMUSG00000096900
AA Change: I55F

DomainStartEndE-ValueType
IGv 36 111 1.61e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181210
SMART Domains Protein: ENSMUSP00000137814
Gene: ENSMUSG00000096149

DomainStartEndE-ValueType
IG 27 112 4.04e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000183488
SMART Domains Protein: ENSMUSP00000139176
Gene: ENSMUSG00000096149

DomainStartEndE-ValueType
IG 26 111 4.04e0 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bin1 C T 18: 32,420,107 A215V probably damaging Het
Cyp2j6 C T 4: 96,536,046 R158H possibly damaging Het
Dnaaf2 T C 12: 69,196,766 D507G probably benign Het
Fam13b T C 18: 34,487,096 E245G possibly damaging Het
Gal3st1 A T 11: 3,999,070 probably benign Het
Galnt5 A T 2: 57,998,973 Q195L probably benign Het
Gfm2 A G 13: 97,155,442 T229A probably benign Het
Gigyf1 A G 5: 137,522,745 probably benign Het
Gm4353 G T 7: 116,083,554 T264K probably damaging Het
Gsk3b A T 16: 38,228,707 I389F probably benign Het
Hist1h2bm G T 13: 21,722,375 R93L possibly damaging Het
Htt A G 5: 34,799,408 T194A probably benign Het
Ighg3 T C 12: 113,359,837 Y273C unknown Het
Kdm5b T A 1: 134,620,955 V1066D probably damaging Het
Kif1a G T 1: 93,054,934 A707E probably damaging Het
Maats1 A G 16: 38,336,342 probably null Het
Mars A G 10: 127,298,006 M674T probably benign Het
Mas1 T C 17: 12,841,990 D182G probably benign Het
Metap1d T A 2: 71,512,162 D178E probably damaging Het
Nhsl1 T A 10: 18,527,609 D1329E probably benign Het
Ninl T C 2: 150,966,241 E289G probably damaging Het
Pmel G T 10: 128,716,089 G264V possibly damaging Het
Ruvbl1 T C 6: 88,484,403 probably benign Het
Scn8a T A 15: 100,955,532 probably benign Het
Sept9 T C 11: 117,354,804 probably benign Het
Sgpp1 G T 12: 75,716,194 Y404* probably null Het
Sgsm1 T C 5: 113,245,064 I788V probably benign Het
Slc13a4 A T 6: 35,289,824 M112K probably benign Het
Slc22a29 T C 19: 8,217,813 M153V probably benign Het
Slc9c1 T G 16: 45,573,389 V565G possibly damaging Het
Sox4 C A 13: 28,952,973 G17W probably damaging Het
Tec C T 5: 72,768,768 A314T probably damaging Het
Tg A G 15: 66,827,290 I803V probably benign Het
Ttll12 C A 15: 83,578,656 E536D probably benign Het
Ubqln1 C A 13: 58,177,992 E152* probably null Het
Wwtr1 G A 3: 57,463,491 T338I probably benign Het
Zdhhc16 T C 19: 41,939,660 F206S probably benign Het
Other mutations in Trav9-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Trav9-1 APN 14 53488358 missense probably damaging 0.98
R5383:Trav9-1 UTSW 14 53488376 missense probably benign 0.00
R7569:Trav9-1 UTSW 14 53488124 missense probably benign 0.00
Z1176:Trav9-1 UTSW 14 53488474 missense probably benign 0.14
Posted On2015-04-16