Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00230:Trav9-1'

306804

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trav9-1

Ensembl Gene

ENSMUSG00000096900

Gene Name

T cell receptor alpha variable 9-1

Synonyms

Gm13947

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL00230

Quality Score

Status

Chromosome

Chromosomal Location

53725563-53726024 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 53725850 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 55 (I55F)

Ref Sequence

ENSEMBL: ENSMUSP00000100358 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103581] [ENSMUST00000181210] [ENSMUST00000183488]

AlphaFold

A0A075B601

Predicted Effect

probably benign
Transcript: ENSMUST00000103581
AA Change: I55F

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000100358
Gene: ENSMUSG00000096900
AA Change: I55F

Domain	Start	End	E-Value	Type
IGv	36	111	1.61e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000181210

SMART Domains

Protein: ENSMUSP00000137814
Gene: ENSMUSG00000096149

Domain	Start	End	E-Value	Type
IG	27	112	4.04e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183488

SMART Domains

Protein: ENSMUSP00000139176
Gene: ENSMUSG00000096149

Domain	Start	End	E-Value	Type
IG	26	111	4.04e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bin1	C	T	18: 32,553,160 (GRCm39)	A215V	probably damaging	Het
Cfap91	A	G	16: 38,156,704 (GRCm39)		probably null	Het
Cyp2j6	C	T	4: 96,424,283 (GRCm39)	R158H	possibly damaging	Het
Dnaaf2	T	C	12: 69,243,540 (GRCm39)	D507G	probably benign	Het
Fam13b	T	C	18: 34,620,149 (GRCm39)	E245G	possibly damaging	Het
Gal3st1	A	T	11: 3,949,070 (GRCm39)		probably benign	Het
Galnt5	A	T	2: 57,888,985 (GRCm39)	Q195L	probably benign	Het
Gfm2	A	G	13: 97,291,950 (GRCm39)	T229A	probably benign	Het
Gigyf1	A	G	5: 137,521,007 (GRCm39)		probably benign	Het
Gm4353	G	T	7: 115,682,789 (GRCm39)	T264K	probably damaging	Het
Gsk3b	A	T	16: 38,049,069 (GRCm39)	I389F	probably benign	Het
H2bc14	G	T	13: 21,906,545 (GRCm39)	R93L	possibly damaging	Het
Htt	A	G	5: 34,956,752 (GRCm39)	T194A	probably benign	Het
Ighg3	T	C	12: 113,323,457 (GRCm39)	Y273C	unknown	Het
Kdm5b	T	A	1: 134,548,693 (GRCm39)	V1066D	probably damaging	Het
Kif1a	G	T	1: 92,982,656 (GRCm39)	A707E	probably damaging	Het
Mars1	A	G	10: 127,133,875 (GRCm39)	M674T	probably benign	Het
Mas1	T	C	17: 13,060,877 (GRCm39)	D182G	probably benign	Het
Metap1d	T	A	2: 71,342,506 (GRCm39)	D178E	probably damaging	Het
Nhsl1	T	A	10: 18,403,357 (GRCm39)	D1329E	probably benign	Het
Ninl	T	C	2: 150,808,161 (GRCm39)	E289G	probably damaging	Het
Pmel	G	T	10: 128,551,958 (GRCm39)	G264V	possibly damaging	Het
Ruvbl1	T	C	6: 88,461,385 (GRCm39)		probably benign	Het
Scn8a	T	A	15: 100,853,413 (GRCm39)		probably benign	Het
Septin9	T	C	11: 117,245,630 (GRCm39)		probably benign	Het
Sgpp1	G	T	12: 75,762,968 (GRCm39)	Y404*	probably null	Het
Sgsm1	T	C	5: 113,392,930 (GRCm39)	I788V	probably benign	Het
Slc13a4	A	T	6: 35,266,759 (GRCm39)	M112K	probably benign	Het
Slc22a29	T	C	19: 8,195,177 (GRCm39)	M153V	probably benign	Het
Slc9c1	T	G	16: 45,393,752 (GRCm39)	V565G	possibly damaging	Het
Sox4	C	A	13: 29,136,956 (GRCm39)	G17W	probably damaging	Het
Tec	C	T	5: 72,926,111 (GRCm39)	A314T	probably damaging	Het
Tg	A	G	15: 66,699,139 (GRCm39)	I803V	probably benign	Het
Ttll12	C	A	15: 83,462,857 (GRCm39)	E536D	probably benign	Het
Ubqln1	C	A	13: 58,325,806 (GRCm39)	E152*	probably null	Het
Wwtr1	G	A	3: 57,370,912 (GRCm39)	T338I	probably benign	Het
Zdhhc16	T	C	19: 41,928,099 (GRCm39)	F206S	probably benign	Het

Other mutations in Trav9-1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00557:Trav9-1	APN	14	53,725,815 (GRCm39)	missense	probably damaging	0.98
R5383:Trav9-1	UTSW	14	53,725,833 (GRCm39)	missense	probably benign	0.00
R7569:Trav9-1	UTSW	14	53,725,581 (GRCm39)	missense	probably benign	0.00
R8947:Trav9-1	UTSW	14	53,725,584 (GRCm39)	missense	probably benign
Z1176:Trav9-1	UTSW	14	53,725,931 (GRCm39)	missense	probably benign	0.14

Posted On

2015-04-16