Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00230:Ighg3'

306805

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg3

Ensembl Gene

ENSMUSG00000076615

Gene Name

Immunoglobulin heavy constant gamma 3

Synonyms

IgG3, AI324046

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL00230

Quality Score

Status

Chromosome

Chromosomal Location

113321062-113324852 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 113323457 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 273 (Y273C)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103423
AA Change: Y273C

SMART Domains

Protein: ENSMUSP00000100219
Gene: ENSMUSG00000076615
AA Change: Y273C

Domain	Start	End	E-Value	Type
IGc1	22	92	3.42e-20	SMART
low complexity region	102	114	N/A	INTRINSIC
IG_like	139	214	5.06e-3	SMART
IGc1	245	318	2.9e-32	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000223179
AA Change: Y273C

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bin1	C	T	18: 32,553,160 (GRCm39)	A215V	probably damaging	Het
Cfap91	A	G	16: 38,156,704 (GRCm39)		probably null	Het
Cyp2j6	C	T	4: 96,424,283 (GRCm39)	R158H	possibly damaging	Het
Dnaaf2	T	C	12: 69,243,540 (GRCm39)	D507G	probably benign	Het
Fam13b	T	C	18: 34,620,149 (GRCm39)	E245G	possibly damaging	Het
Gal3st1	A	T	11: 3,949,070 (GRCm39)		probably benign	Het
Galnt5	A	T	2: 57,888,985 (GRCm39)	Q195L	probably benign	Het
Gfm2	A	G	13: 97,291,950 (GRCm39)	T229A	probably benign	Het
Gigyf1	A	G	5: 137,521,007 (GRCm39)		probably benign	Het
Gm4353	G	T	7: 115,682,789 (GRCm39)	T264K	probably damaging	Het
Gsk3b	A	T	16: 38,049,069 (GRCm39)	I389F	probably benign	Het
H2bc14	G	T	13: 21,906,545 (GRCm39)	R93L	possibly damaging	Het
Htt	A	G	5: 34,956,752 (GRCm39)	T194A	probably benign	Het
Kdm5b	T	A	1: 134,548,693 (GRCm39)	V1066D	probably damaging	Het
Kif1a	G	T	1: 92,982,656 (GRCm39)	A707E	probably damaging	Het
Mars1	A	G	10: 127,133,875 (GRCm39)	M674T	probably benign	Het
Mas1	T	C	17: 13,060,877 (GRCm39)	D182G	probably benign	Het
Metap1d	T	A	2: 71,342,506 (GRCm39)	D178E	probably damaging	Het
Nhsl1	T	A	10: 18,403,357 (GRCm39)	D1329E	probably benign	Het
Ninl	T	C	2: 150,808,161 (GRCm39)	E289G	probably damaging	Het
Pmel	G	T	10: 128,551,958 (GRCm39)	G264V	possibly damaging	Het
Ruvbl1	T	C	6: 88,461,385 (GRCm39)		probably benign	Het
Scn8a	T	A	15: 100,853,413 (GRCm39)		probably benign	Het
Septin9	T	C	11: 117,245,630 (GRCm39)		probably benign	Het
Sgpp1	G	T	12: 75,762,968 (GRCm39)	Y404*	probably null	Het
Sgsm1	T	C	5: 113,392,930 (GRCm39)	I788V	probably benign	Het
Slc13a4	A	T	6: 35,266,759 (GRCm39)	M112K	probably benign	Het
Slc22a29	T	C	19: 8,195,177 (GRCm39)	M153V	probably benign	Het
Slc9c1	T	G	16: 45,393,752 (GRCm39)	V565G	possibly damaging	Het
Sox4	C	A	13: 29,136,956 (GRCm39)	G17W	probably damaging	Het
Tec	C	T	5: 72,926,111 (GRCm39)	A314T	probably damaging	Het
Tg	A	G	15: 66,699,139 (GRCm39)	I803V	probably benign	Het
Trav9-1	A	T	14: 53,725,850 (GRCm39)	I55F	probably benign	Het
Ttll12	C	A	15: 83,462,857 (GRCm39)	E536D	probably benign	Het
Ubqln1	C	A	13: 58,325,806 (GRCm39)	E152*	probably null	Het
Wwtr1	G	A	3: 57,370,912 (GRCm39)	T338I	probably benign	Het
Zdhhc16	T	C	19: 41,928,099 (GRCm39)	F206S	probably benign	Het

Other mutations in Ighg3

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02641:Ighg3	APN	12	113,323,818 (GRCm39)	missense	unknown
IGL03252:Ighg3	APN	12	113,324,184 (GRCm39)	missense	unknown
R0630:Ighg3	UTSW	12	113,323,714 (GRCm39)	splice site	probably benign
R4957:Ighg3	UTSW	12	113,324,750 (GRCm39)	missense	unknown
R6407:Ighg3	UTSW	12	113,323,770 (GRCm39)	missense	unknown
R6745:Ighg3	UTSW	12	113,323,890 (GRCm39)	missense	unknown
R7801:Ighg3	UTSW	12	113,323,436 (GRCm39)	missense
R7824:Ighg3	UTSW	12	113,323,426 (GRCm39)	missense
R8075:Ighg3	UTSW	12	113,321,097 (GRCm39)	missense
R8076:Ighg3	UTSW	12	113,324,158 (GRCm39)	missense	probably benign
R8887:Ighg3	UTSW	12	113,323,845 (GRCm39)	missense
R9314:Ighg3	UTSW	12	113,323,946 (GRCm39)	missense

Posted On

2015-04-16