Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00230:Ighg3'

306805

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg3

Ensembl Gene

ENSMUSG00000076615

Gene Name

Immunoglobulin heavy constant gamma 3

Synonyms

AI324046, IgG3

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL00230

Quality Score

Status

Chromosome

Chromosomal Location

113359575-113361232 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 113359837 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 273 (Y273C)

Gene Model

predicted gene model for transcript(s):

Predicted Effect

unknown
Transcript: ENSMUST00000103423
AA Change: Y273C

SMART Domains

Protein: ENSMUSP00000100219
Gene: ENSMUSG00000076615
AA Change: Y273C

Domain	Start	End	E-Value	Type
IGc1	22	92	3.42e-20	SMART
low complexity region	102	114	N/A	INTRINSIC
IG_like	139	214	5.06e-3	SMART
IGc1	245	318	2.9e-32	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000223179
AA Change: Y273C

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bin1	C	T	18: 32,420,107	A215V	probably damaging	Het
Cyp2j6	C	T	4: 96,536,046	R158H	possibly damaging	Het
Dnaaf2	T	C	12: 69,196,766	D507G	probably benign	Het
Fam13b	T	C	18: 34,487,096	E245G	possibly damaging	Het
Gal3st1	A	T	11: 3,999,070		probably benign	Het
Galnt5	A	T	2: 57,998,973	Q195L	probably benign	Het
Gfm2	A	G	13: 97,155,442	T229A	probably benign	Het
Gigyf1	A	G	5: 137,522,745		probably benign	Het
Gm4353	G	T	7: 116,083,554	T264K	probably damaging	Het
Gsk3b	A	T	16: 38,228,707	I389F	probably benign	Het
Hist1h2bm	G	T	13: 21,722,375	R93L	possibly damaging	Het
Htt	A	G	5: 34,799,408	T194A	probably benign	Het
Kdm5b	T	A	1: 134,620,955	V1066D	probably damaging	Het
Kif1a	G	T	1: 93,054,934	A707E	probably damaging	Het
Maats1	A	G	16: 38,336,342		probably null	Het
Mars	A	G	10: 127,298,006	M674T	probably benign	Het
Mas1	T	C	17: 12,841,990	D182G	probably benign	Het
Metap1d	T	A	2: 71,512,162	D178E	probably damaging	Het
Nhsl1	T	A	10: 18,527,609	D1329E	probably benign	Het
Ninl	T	C	2: 150,966,241	E289G	probably damaging	Het
Pmel	G	T	10: 128,716,089	G264V	possibly damaging	Het
Ruvbl1	T	C	6: 88,484,403		probably benign	Het
Scn8a	T	A	15: 100,955,532		probably benign	Het
Sept9	T	C	11: 117,354,804		probably benign	Het
Sgpp1	G	T	12: 75,716,194	Y404*	probably null	Het
Sgsm1	T	C	5: 113,245,064	I788V	probably benign	Het
Slc13a4	A	T	6: 35,289,824	M112K	probably benign	Het
Slc22a29	T	C	19: 8,217,813	M153V	probably benign	Het
Slc9c1	T	G	16: 45,573,389	V565G	possibly damaging	Het
Sox4	C	A	13: 28,952,973	G17W	probably damaging	Het
Tec	C	T	5: 72,768,768	A314T	probably damaging	Het
Tg	A	G	15: 66,827,290	I803V	probably benign	Het
Trav9-1	A	T	14: 53,488,393	I55F	probably benign	Het
Ttll12	C	A	15: 83,578,656	E536D	probably benign	Het
Ubqln1	C	A	13: 58,177,992	E152*	probably null	Het
Wwtr1	G	A	3: 57,463,491	T338I	probably benign	Het
Zdhhc16	T	C	19: 41,939,660	F206S	probably benign	Het

Other mutations in Ighg3

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02641:Ighg3	APN	12	113360198	missense	unknown
IGL03252:Ighg3	APN	12	113360564	missense	unknown
R0630:Ighg3	UTSW	12	113360094	splice site	probably benign
R4957:Ighg3	UTSW	12	113361130	missense	unknown
R6407:Ighg3	UTSW	12	113360150	missense	unknown
R6745:Ighg3	UTSW	12	113360270	missense	unknown
R7801:Ighg3	UTSW	12	113359816	missense
R7824:Ighg3	UTSW	12	113359806	missense
R8075:Ighg3	UTSW	12	113357477	missense
R8076:Ighg3	UTSW	12	113360538	missense	probably benign

Posted On

2015-04-16