Incidental Mutation 'R3934:Slc35f1'
ID 306945
Institutional Source Beutler Lab
Gene Symbol Slc35f1
Ensembl Gene ENSMUSG00000038602
Gene Name solute carrier family 35, member F1
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3934 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 52690533-53111622 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 53108218 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 358 (T358I)
Ref Sequence ENSEMBL: ENSMUSP00000101113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105473]
AlphaFold Q8BGK5
Predicted Effect probably damaging
Transcript: ENSMUST00000105473
AA Change: T358I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: T358I

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:SLC35F 56 355 1.4e-151 PFAM
Pfam:CRT-like 66 315 2.3e-13 PFAM
Pfam:EamA 217 355 1.7e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218783
Meta Mutation Damage Score 0.3129 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency 100% (40/40)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik T A 12: 18,534,081 (GRCm38) Y381N possibly damaging Het
Adgrf3 T C 5: 30,200,434 (GRCm38) probably benign Het
Adgrv1 A G 13: 81,475,047 (GRCm38) F3819S probably benign Het
Aig1 T C 10: 13,801,912 (GRCm38) D112G probably damaging Het
Akap6 C T 12: 53,140,444 (GRCm38) T1547M possibly damaging Het
Alk T A 17: 72,205,954 (GRCm38) I337F probably damaging Het
C2cd5 C T 6: 143,041,380 (GRCm38) V499I possibly damaging Het
Capn11 A T 17: 45,634,287 (GRCm38) probably benign Het
Clstn3 G A 6: 124,457,942 (GRCm38) T338I probably damaging Het
Cmbl A G 15: 31,589,787 (GRCm38) D221G possibly damaging Het
Enpp2 A G 15: 54,845,921 (GRCm38) V766A probably benign Het
Fastk G T 5: 24,442,259 (GRCm38) S317* probably null Het
Fgfr1op2 T A 6: 146,595,171 (GRCm38) probably benign Het
Gpr85 A G 6: 13,836,045 (GRCm38) F287L probably benign Het
Hectd4 G A 5: 121,320,101 (GRCm38) probably null Het
Hmcn2 T A 2: 31,380,484 (GRCm38) probably null Het
Hspbp1 A T 7: 4,664,595 (GRCm38) M271K probably benign Het
Itgb6 G A 2: 60,611,411 (GRCm38) T685M possibly damaging Het
Itih5 G A 2: 10,245,544 (GRCm38) V685I probably damaging Het
Kalrn T C 16: 34,310,531 (GRCm38) S421G probably benign Het
Mcm2 G A 6: 88,893,008 (GRCm38) R60C probably damaging Het
Mitf C T 6: 97,993,253 (GRCm38) P54S probably damaging Het
Perm1 A G 4: 156,219,170 (GRCm38) T724A probably benign Het
Pex5l T C 3: 33,007,172 (GRCm38) E176G probably damaging Het
Polk A T 13: 96,501,635 (GRCm38) M192K possibly damaging Het
Polr3a T C 14: 24,476,101 (GRCm38) I401V probably benign Het
Prpf38b T C 3: 108,904,425 (GRCm38) probably benign Het
Sema3c T C 5: 17,681,940 (GRCm38) S330P probably damaging Het
Slc16a7 C A 10: 125,230,843 (GRCm38) R309L probably damaging Het
Slc39a12 T A 2: 14,434,363 (GRCm38) probably benign Het
Sod3 T C 5: 52,368,645 (GRCm38) S229P probably benign Het
Sorcs3 T A 19: 48,713,504 (GRCm38) V608D probably damaging Het
Spink5 G T 18: 44,016,427 (GRCm38) K958N probably damaging Het
Ttc7 A C 17: 87,370,738 (GRCm38) probably benign Het
Ush2a T A 1: 188,263,511 (GRCm38) probably null Het
Vmn2r19 T A 6: 123,315,669 (GRCm38) D223E probably damaging Het
Vwf T A 6: 125,555,499 (GRCm38) S87T probably damaging Het
Wdr35 G T 12: 9,008,014 (GRCm38) G513C probably damaging Het
Other mutations in Slc35f1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Slc35f1 APN 10 53,062,452 (GRCm38) missense probably damaging 1.00
IGL01073:Slc35f1 APN 10 53,021,960 (GRCm38) missense probably benign 0.16
IGL01433:Slc35f1 APN 10 53,073,446 (GRCm38) splice site probably benign
IGL01566:Slc35f1 APN 10 53,089,455 (GRCm38) missense probably damaging 1.00
IGL02693:Slc35f1 APN 10 52,933,128 (GRCm38) missense probably damaging 1.00
IGL02870:Slc35f1 APN 10 52,933,207 (GRCm38) missense possibly damaging 0.82
IGL03082:Slc35f1 APN 10 52,933,138 (GRCm38) missense probably benign
R0884:Slc35f1 UTSW 10 53,089,347 (GRCm38) missense probably damaging 1.00
R1340:Slc35f1 UTSW 10 53,089,454 (GRCm38) missense probably damaging 1.00
R1781:Slc35f1 UTSW 10 53,062,436 (GRCm38) splice site probably null
R1813:Slc35f1 UTSW 10 52,933,195 (GRCm38) missense probably damaging 1.00
R1908:Slc35f1 UTSW 10 53,021,904 (GRCm38) missense possibly damaging 0.84
R2044:Slc35f1 UTSW 10 53,089,347 (GRCm38) missense probably damaging 1.00
R2518:Slc35f1 UTSW 10 53,073,534 (GRCm38) missense probably benign 0.07
R3872:Slc35f1 UTSW 10 53,021,910 (GRCm38) missense possibly damaging 0.87
R3935:Slc35f1 UTSW 10 53,108,218 (GRCm38) missense probably damaging 1.00
R3936:Slc35f1 UTSW 10 53,108,218 (GRCm38) missense probably damaging 1.00
R4118:Slc35f1 UTSW 10 53,089,368 (GRCm38) missense probably damaging 0.98
R4921:Slc35f1 UTSW 10 53,062,602 (GRCm38) missense probably damaging 0.99
R5116:Slc35f1 UTSW 10 53,021,895 (GRCm38) missense probably benign 0.39
R5378:Slc35f1 UTSW 10 52,691,061 (GRCm38) missense possibly damaging 0.86
R5387:Slc35f1 UTSW 10 53,108,164 (GRCm38) missense probably damaging 1.00
R5500:Slc35f1 UTSW 10 52,933,222 (GRCm38) missense probably damaging 0.99
R5590:Slc35f1 UTSW 10 53,108,178 (GRCm38) missense possibly damaging 0.63
R5743:Slc35f1 UTSW 10 53,089,450 (GRCm38) missense probably benign 0.06
R5916:Slc35f1 UTSW 10 52,933,221 (GRCm38) nonsense probably null
R6985:Slc35f1 UTSW 10 53,021,911 (GRCm38) missense probably benign 0.02
R7068:Slc35f1 UTSW 10 53,062,500 (GRCm38) missense probably damaging 1.00
R7295:Slc35f1 UTSW 10 53,062,541 (GRCm38) missense probably benign 0.00
R7427:Slc35f1 UTSW 10 53,089,414 (GRCm38) missense probably damaging 1.00
R7428:Slc35f1 UTSW 10 53,089,414 (GRCm38) missense probably damaging 1.00
R8334:Slc35f1 UTSW 10 53,108,148 (GRCm38) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TCACTTTCCATCAAGAGTATCAGC -3'
(R):5'- ACACATGGCCTCTGAGTTGTC -3'

Sequencing Primer
(F):5'- GAGTATCAGCTACCTCATCAAATTGC -3'
(R):5'- GAGTTGTCCTCAGTGGGC -3'
Posted On 2015-04-17