Incidental Mutation 'R3922:Or9i2'
ID 307003
Institutional Source Beutler Lab
Gene Symbol Or9i2
Ensembl Gene ENSMUSG00000057270
Gene Name olfactory receptor family 9 subfamily I member 2
Synonyms GA_x6K02T2RE5P-4171358-4170411, Olfr1501, MOR212-3
MMRRC Submission 040819-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R3922 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13815588-13816535 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13816130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 136 (T136A)
Ref Sequence ENSEMBL: ENSMUSP00000151094 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073966] [ENSMUST00000208493] [ENSMUST00000215350]
AlphaFold Q8VFQ3
Predicted Effect probably damaging
Transcript: ENSMUST00000073966
AA Change: T136A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073620
Gene: ENSMUSG00000057270
AA Change: T136A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-45 PFAM
Pfam:7tm_1 40 306 7.1e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208493
AA Change: T136A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215350
AA Change: T136A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
4921504E06Rik T A 2: 19,485,371 (GRCm39) E432V probably benign Het
Ahnak G A 19: 8,983,692 (GRCm39) D1659N probably benign Het
Arfgap2 C T 2: 91,105,150 (GRCm39) R405W probably damaging Het
Arhgef28 A G 13: 98,130,452 (GRCm39) L462P possibly damaging Het
Arid1b T C 17: 5,393,316 (GRCm39) V2282A probably damaging Het
Becn2 T C 1: 175,748,852 (GRCm39) V306A probably benign Het
Cdkl1 G T 12: 69,803,373 (GRCm39) R168S probably damaging Het
Cep70 T A 9: 99,157,632 (GRCm39) *117R probably null Het
Cnnm1 A G 19: 43,428,884 (GRCm39) M1V probably null Het
Cntrl A G 2: 35,019,751 (GRCm39) E526G probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Ddx59 T A 1: 136,344,482 (GRCm39) V51D probably benign Het
Dtd2 G C 12: 52,051,734 (GRCm39) probably null Het
Eea1 T A 10: 95,872,495 (GRCm39) N1068K probably benign Het
Egfr T A 11: 16,831,495 (GRCm39) C555S probably damaging Het
Esd A T 14: 74,980,667 (GRCm39) Q130H probably benign Het
Gpr89 A T 3: 96,798,215 (GRCm39) I147N probably damaging Het
H2-M10.1 T A 17: 36,636,577 (GRCm39) I76L probably benign Het
Lgi4 A T 7: 30,766,873 (GRCm39) D300V probably benign Het
Lrp1b C A 2: 40,567,593 (GRCm39) V276L unknown Het
Lrp2 T C 2: 69,336,720 (GRCm39) K1351E probably benign Het
Mroh8 T C 2: 157,064,731 (GRCm39) I782V probably benign Het
Msrb1 T C 17: 24,959,057 (GRCm39) S70P probably damaging Het
Nek10 T C 14: 14,861,585 (GRCm38) M547T possibly damaging Het
Or51ah3 T C 7: 103,209,912 (GRCm39) V76A probably benign Het
Or6c2b C A 10: 128,947,482 (GRCm39) V271F possibly damaging Het
P4htm T C 9: 108,460,094 (GRCm39) N227D probably benign Het
Plekhm2 T C 4: 141,356,843 (GRCm39) T787A probably benign Het
Pramel5 A G 4: 143,999,622 (GRCm39) L155P probably damaging Het
Sbno1 T C 5: 124,519,993 (GRCm39) Y1122C probably damaging Het
Scn9a T A 2: 66,357,217 (GRCm39) D1028V possibly damaging Het
Sft2d1 G T 17: 8,537,714 (GRCm39) L34F possibly damaging Het
Slc19a3 A T 1: 83,000,678 (GRCm39) F113Y probably damaging Het
Slc27a3 G T 3: 90,294,392 (GRCm39) H460N possibly damaging Het
Slc35g2 A T 9: 100,434,780 (GRCm39) I297N probably benign Het
Ssh1 T G 5: 114,080,769 (GRCm39) Q865P possibly damaging Het
Trp63 A G 16: 25,707,759 (GRCm39) D583G probably damaging Het
Usp28 T C 9: 48,942,223 (GRCm39) probably null Het
Wdr43 A G 17: 71,945,296 (GRCm39) probably benign Het
Zfhx4 A G 3: 5,465,707 (GRCm39) Y1955C probably damaging Het
Zfp108 G A 7: 23,960,773 (GRCm39) G455R probably damaging Het
Zfp353-ps A T 8: 42,536,049 (GRCm39) noncoding transcript Het
Other mutations in Or9i2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or9i2 APN 19 13,816,316 (GRCm39) missense probably damaging 0.98
IGL01724:Or9i2 APN 19 13,816,225 (GRCm39) missense probably damaging 1.00
IGL02075:Or9i2 APN 19 13,815,830 (GRCm39) missense probably damaging 0.99
IGL02179:Or9i2 APN 19 13,815,851 (GRCm39) missense probably benign 0.01
IGL02410:Or9i2 APN 19 13,816,495 (GRCm39) missense probably benign
IGL02927:Or9i2 APN 19 13,816,288 (GRCm39) missense probably benign 0.05
R0234:Or9i2 UTSW 19 13,815,902 (GRCm39) missense possibly damaging 0.62
R0234:Or9i2 UTSW 19 13,815,902 (GRCm39) missense possibly damaging 0.62
R2149:Or9i2 UTSW 19 13,815,946 (GRCm39) missense probably damaging 1.00
R3442:Or9i2 UTSW 19 13,816,370 (GRCm39) missense possibly damaging 0.92
R3924:Or9i2 UTSW 19 13,816,130 (GRCm39) missense probably damaging 1.00
R4856:Or9i2 UTSW 19 13,815,643 (GRCm39) missense probably damaging 0.99
R4886:Or9i2 UTSW 19 13,815,643 (GRCm39) missense probably damaging 0.99
R5175:Or9i2 UTSW 19 13,815,680 (GRCm39) missense probably damaging 1.00
R5636:Or9i2 UTSW 19 13,815,701 (GRCm39) missense possibly damaging 0.78
R5716:Or9i2 UTSW 19 13,816,003 (GRCm39) missense probably damaging 1.00
R6080:Or9i2 UTSW 19 13,816,464 (GRCm39) missense possibly damaging 0.76
R6849:Or9i2 UTSW 19 13,816,203 (GRCm39) nonsense probably null
R7011:Or9i2 UTSW 19 13,816,403 (GRCm39) missense probably benign 0.04
R8223:Or9i2 UTSW 19 13,816,225 (GRCm39) missense probably damaging 1.00
R8508:Or9i2 UTSW 19 13,815,766 (GRCm39) missense possibly damaging 0.80
R9176:Or9i2 UTSW 19 13,815,796 (GRCm39) missense probably damaging 1.00
X0026:Or9i2 UTSW 19 13,816,021 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- TCGCGTAACTTAGTCTCACTAC -3'
(R):5'- AATTCAGAGTGACCCTCGGC -3'

Sequencing Primer
(F):5'- TAGTCTCACTACAGGAAAGCTTCAG -3'
(R):5'- GAGTGACCCTCGGCTCCAAAC -3'
Posted On 2015-04-17