Incidental Mutation 'R0375:Vmn2r103'
| ID |
30714 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
038581-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R0375 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19792859 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 81
(Y81N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: Y81N
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: Y81N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.7%
|
| Validation Efficiency |
100% (61/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932438A13Rik |
C |
T |
3: 37,046,252 (GRCm38) |
T4707I |
probably damaging |
Het |
| 5730522E02Rik |
T |
A |
11: 25,769,092 (GRCm38) |
Y17F |
unknown |
Het |
| Aars2 |
A |
G |
17: 45,514,550 (GRCm38) |
D313G |
probably damaging |
Het |
| Abca9 |
A |
T |
11: 110,115,447 (GRCm38) |
D1277E |
probably benign |
Het |
| Adgrl1 |
G |
T |
8: 83,934,901 (GRCm38) |
A981S |
probably damaging |
Het |
| Aff3 |
T |
G |
1: 38,204,940 (GRCm38) |
K917Q |
possibly damaging |
Het |
| BC049715 |
A |
T |
6: 136,839,996 (GRCm38) |
H78L |
probably benign |
Het |
| Cacna1g |
C |
A |
11: 94,411,054 (GRCm38) |
A2027S |
possibly damaging |
Het |
| Camk1g |
G |
A |
1: 193,356,401 (GRCm38) |
|
probably benign |
Het |
| Carf |
T |
C |
1: 60,144,002 (GRCm38) |
V386A |
probably damaging |
Het |
| Cd46 |
A |
G |
1: 195,086,164 (GRCm38) |
S82P |
probably benign |
Het |
| Clic5 |
A |
G |
17: 44,270,623 (GRCm38) |
E180G |
possibly damaging |
Het |
| Col27a1 |
A |
G |
4: 63,225,661 (GRCm38) |
T529A |
probably benign |
Het |
| Col7a1 |
C |
T |
9: 108,980,237 (GRCm38) |
R2627C |
unknown |
Het |
| Cuzd1 |
G |
A |
7: 131,311,908 (GRCm38) |
|
probably benign |
Het |
| Cwc27 |
T |
C |
13: 104,807,823 (GRCm38) |
D50G |
possibly damaging |
Het |
| Dhx38 |
A |
G |
8: 109,555,181 (GRCm38) |
V735A |
possibly damaging |
Het |
| Dhx57 |
T |
G |
17: 80,258,121 (GRCm38) |
E834A |
probably damaging |
Het |
| Dsg4 |
A |
G |
18: 20,470,879 (GRCm38) |
D801G |
probably damaging |
Het |
| Dtx1 |
T |
C |
5: 120,681,399 (GRCm38) |
E578G |
probably damaging |
Het |
| F830016B08Rik |
A |
T |
18: 60,300,193 (GRCm38) |
H116L |
probably damaging |
Het |
| Fam208b |
A |
G |
13: 3,596,842 (GRCm38) |
V61A |
possibly damaging |
Het |
| Fbxw18 |
T |
C |
9: 109,688,839 (GRCm38) |
I360V |
possibly damaging |
Het |
| Fignl2 |
G |
A |
15: 101,054,093 (GRCm38) |
P103S |
probably benign |
Het |
| Frmpd1 |
A |
G |
4: 45,284,196 (GRCm38) |
T1006A |
probably benign |
Het |
| Ggnbp2 |
G |
T |
11: 84,836,374 (GRCm38) |
C545* |
probably null |
Het |
| Gm3336 |
A |
G |
8: 70,718,645 (GRCm38) |
|
probably benign |
Het |
| Gpr37 |
T |
C |
6: 25,669,291 (GRCm38) |
N518S |
probably benign |
Het |
| Hbs1l |
T |
A |
10: 21,342,541 (GRCm38) |
D312E |
possibly damaging |
Het |
| Hoxd10 |
C |
A |
2: 74,692,720 (GRCm38) |
S247R |
probably benign |
Het |
| Ifnb1 |
A |
T |
4: 88,522,744 (GRCm38) |
F11I |
probably benign |
Het |
| Marf1 |
T |
C |
16: 14,151,320 (GRCm38) |
|
probably benign |
Het |
| Myo1f |
T |
A |
17: 33,601,956 (GRCm38) |
V879E |
probably benign |
Het |
| Naip1 |
A |
G |
13: 100,409,148 (GRCm38) |
F1291L |
probably benign |
Het |
| Nckap1l |
A |
G |
15: 103,474,159 (GRCm38) |
E529G |
probably damaging |
Het |
| Npm3 |
T |
C |
19: 45,748,229 (GRCm38) |
E157G |
probably damaging |
Het |
| Olfr1200 |
T |
A |
2: 88,767,641 (GRCm38) |
T225S |
possibly damaging |
Het |
| Olfr1240 |
G |
T |
2: 89,439,396 (GRCm38) |
N294K |
probably benign |
Het |
| Olfr248 |
A |
G |
1: 174,391,209 (GRCm38) |
T47A |
probably damaging |
Het |
| Pex16 |
G |
A |
2: 92,380,457 (GRCm38) |
G312D |
probably damaging |
Het |
| Ppp6r1 |
A |
G |
7: 4,633,287 (GRCm38) |
V768A |
probably benign |
Het |
| Prrc1 |
A |
G |
18: 57,362,492 (GRCm38) |
T14A |
probably damaging |
Het |
| Ranbp2 |
T |
C |
10: 58,477,283 (GRCm38) |
L1275P |
probably damaging |
Het |
| Rnf214 |
C |
A |
9: 45,899,823 (GRCm38) |
V181F |
probably damaging |
Het |
| Ror2 |
T |
C |
13: 53,132,004 (GRCm38) |
N58S |
probably damaging |
Het |
| Selplg |
G |
A |
5: 113,820,008 (GRCm38) |
T79I |
probably damaging |
Het |
| Setd1b |
G |
A |
5: 123,157,437 (GRCm38) |
G1023S |
unknown |
Het |
| Sf3b2 |
C |
T |
19: 5,274,824 (GRCm38) |
D845N |
probably damaging |
Het |
| Skint5 |
A |
G |
4: 113,705,596 (GRCm38) |
V803A |
unknown |
Het |
| Slc25a46 |
T |
C |
18: 31,583,266 (GRCm38) |
I394M |
possibly damaging |
Het |
| Snrnp27 |
A |
T |
6: 86,680,953 (GRCm38) |
I101K |
possibly damaging |
Het |
| Spag17 |
C |
A |
3: 100,027,590 (GRCm38) |
T704K |
probably benign |
Het |
| Tas2r144 |
T |
A |
6: 42,216,124 (GRCm38) |
M266K |
possibly damaging |
Het |
| Tbc1d31 |
T |
A |
15: 57,955,350 (GRCm38) |
L783H |
probably benign |
Het |
| Tbck |
C |
A |
3: 132,751,232 (GRCm38) |
|
probably benign |
Het |
| Vcan |
A |
G |
13: 89,691,275 (GRCm38) |
V2050A |
probably damaging |
Het |
| Vmn1r70 |
T |
A |
7: 10,634,060 (GRCm38) |
N158K |
probably damaging |
Het |
| Ylpm1 |
T |
G |
12: 85,014,980 (GRCm38) |
S552A |
unknown |
Het |
| Zdhhc17 |
A |
T |
10: 110,982,106 (GRCm38) |
Y58* |
probably null |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGAAGGCCAAAGTTCTACATTCC -3'
(R):5'- ATCCATGATGTTCCTGTGAGTGCTG -3'
Sequencing Primer
(F):5'- TCCCGACTTATAAACAGAATGTGC -3'
(R):5'- CTTTCTATGCACAAGAGCTGTG -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation