Incidental Mutation 'R0375:Myo1f'
ID 30716
Institutional Source Beutler Lab
Gene Symbol Myo1f
Ensembl Gene ENSMUSG00000024300
Gene Name myosin IF
Synonyms C330006B10Rik
MMRRC Submission 038581-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R0375 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33774681-33826738 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33820930 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 879 (V879E)
Ref Sequence ENSEMBL: ENSMUSP00000084887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087605
AA Change: V879E

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300
AA Change: V879E

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 717 909 1.7e-51 PFAM
low complexity region 939 952 N/A INTRINSIC
low complexity region 973 987 N/A INTRINSIC
low complexity region 991 1001 N/A INTRINSIC
SH3 1044 1098 2.09e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173372
SMART Domains Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 716 780 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173426
Meta Mutation Damage Score 0.4023 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.7%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730522E02Rik T A 11: 25,719,092 (GRCm39) Y17F unknown Het
Aars2 A G 17: 45,825,476 (GRCm39) D313G probably damaging Het
Abca9 A T 11: 110,006,273 (GRCm39) D1277E probably benign Het
Adgrl1 G T 8: 84,661,530 (GRCm39) A981S probably damaging Het
Aff3 T G 1: 38,244,021 (GRCm39) K917Q possibly damaging Het
BC049715 A T 6: 136,816,994 (GRCm39) H78L probably benign Het
Bltp1 C T 3: 37,100,401 (GRCm39) T4707I probably damaging Het
Cacna1g C A 11: 94,301,880 (GRCm39) A2027S possibly damaging Het
Camk1g G A 1: 193,038,709 (GRCm39) probably benign Het
Carf T C 1: 60,183,161 (GRCm39) V386A probably damaging Het
Cd46 A G 1: 194,768,472 (GRCm39) S82P probably benign Het
Clic5 A G 17: 44,581,510 (GRCm39) E180G possibly damaging Het
Col27a1 A G 4: 63,143,898 (GRCm39) T529A probably benign Het
Col7a1 C T 9: 108,809,305 (GRCm39) R2627C unknown Het
Cuzd1 G A 7: 130,913,637 (GRCm39) probably benign Het
Cwc27 T C 13: 104,944,331 (GRCm39) D50G possibly damaging Het
Dhx38 A G 8: 110,281,813 (GRCm39) V735A possibly damaging Het
Dhx57 T G 17: 80,565,550 (GRCm39) E834A probably damaging Het
Dsg4 A G 18: 20,603,936 (GRCm39) D801G probably damaging Het
Dtx1 T C 5: 120,819,464 (GRCm39) E578G probably damaging Het
F830016B08Rik A T 18: 60,433,265 (GRCm39) H116L probably damaging Het
Fbxw18 T C 9: 109,517,907 (GRCm39) I360V possibly damaging Het
Fignl2 G A 15: 100,951,974 (GRCm39) P103S probably benign Het
Frmpd1 A G 4: 45,284,196 (GRCm39) T1006A probably benign Het
Ggnbp2 G T 11: 84,727,200 (GRCm39) C545* probably null Het
Gm3336 A G 8: 71,171,294 (GRCm39) probably benign Het
Gpr37 T C 6: 25,669,290 (GRCm39) N518S probably benign Het
Hbs1l T A 10: 21,218,440 (GRCm39) D312E possibly damaging Het
Hoxd10 C A 2: 74,523,064 (GRCm39) S247R probably benign Het
Ifnb1 A T 4: 88,440,981 (GRCm39) F11I probably benign Het
Marf1 T C 16: 13,969,184 (GRCm39) probably benign Het
Naip1 A G 13: 100,545,656 (GRCm39) F1291L probably benign Het
Nckap1l A G 15: 103,382,586 (GRCm39) E529G probably damaging Het
Npm3 T C 19: 45,736,668 (GRCm39) E157G probably damaging Het
Or10x4 A G 1: 174,218,775 (GRCm39) T47A probably damaging Het
Or4a67 T A 2: 88,597,985 (GRCm39) T225S possibly damaging Het
Or4a68 G T 2: 89,269,740 (GRCm39) N294K probably benign Het
Pex16 G A 2: 92,210,802 (GRCm39) G312D probably damaging Het
Ppp6r1 A G 7: 4,636,286 (GRCm39) V768A probably benign Het
Prrc1 A G 18: 57,495,564 (GRCm39) T14A probably damaging Het
Ranbp2 T C 10: 58,313,105 (GRCm39) L1275P probably damaging Het
Rnf214 C A 9: 45,811,121 (GRCm39) V181F probably damaging Het
Ror2 T C 13: 53,286,040 (GRCm39) N58S probably damaging Het
Selplg G A 5: 113,958,069 (GRCm39) T79I probably damaging Het
Setd1b G A 5: 123,295,500 (GRCm39) G1023S unknown Het
Sf3b2 C T 19: 5,324,852 (GRCm39) D845N probably damaging Het
Skint5 A G 4: 113,562,793 (GRCm39) V803A unknown Het
Slc25a46 T C 18: 31,716,319 (GRCm39) I394M possibly damaging Het
Snrnp27 A T 6: 86,657,935 (GRCm39) I101K possibly damaging Het
Spag17 C A 3: 99,934,906 (GRCm39) T704K probably benign Het
Tas2r144 T A 6: 42,193,058 (GRCm39) M266K possibly damaging Het
Tasor2 A G 13: 3,646,842 (GRCm39) V61A possibly damaging Het
Tbc1d31 T A 15: 57,818,746 (GRCm39) L783H probably benign Het
Tbck C A 3: 132,456,993 (GRCm39) probably benign Het
Vcan A G 13: 89,839,394 (GRCm39) V2050A probably damaging Het
Vmn1r70 T A 7: 10,367,987 (GRCm39) N158K probably damaging Het
Vmn2r103 T A 17: 20,013,121 (GRCm39) Y81N probably benign Het
Vmn2r103 A G 17: 20,013,726 (GRCm39) T173A probably benign Het
Ylpm1 T G 12: 85,061,754 (GRCm39) S552A unknown Het
Zdhhc17 A T 10: 110,817,967 (GRCm39) Y58* probably null Het
Other mutations in Myo1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00851:Myo1f APN 17 33,800,938 (GRCm39) missense probably benign 0.01
IGL01019:Myo1f APN 17 33,811,977 (GRCm39) missense possibly damaging 0.93
IGL01524:Myo1f APN 17 33,798,857 (GRCm39) missense probably damaging 1.00
IGL01744:Myo1f APN 17 33,802,654 (GRCm39) splice site probably benign
IGL01951:Myo1f APN 17 33,816,991 (GRCm39) missense possibly damaging 0.64
IGL02132:Myo1f APN 17 33,798,945 (GRCm39) missense probably benign 0.10
IGL02170:Myo1f APN 17 33,797,246 (GRCm39) missense probably benign 0.14
IGL02173:Myo1f APN 17 33,826,318 (GRCm39) missense probably damaging 1.00
IGL02277:Myo1f APN 17 33,798,835 (GRCm39) splice site probably null
IGL02550:Myo1f APN 17 33,799,124 (GRCm39) unclassified probably benign
IGL02550:Myo1f APN 17 33,807,116 (GRCm39) missense probably damaging 1.00
IGL02615:Myo1f APN 17 33,823,630 (GRCm39) missense probably benign
IGL02801:Myo1f APN 17 33,797,111 (GRCm39) missense probably damaging 1.00
IGL02817:Myo1f APN 17 33,823,532 (GRCm39) missense probably benign 0.06
IGL02904:Myo1f APN 17 33,804,632 (GRCm39) nonsense probably null
IGL03056:Myo1f APN 17 33,804,574 (GRCm39) missense probably damaging 1.00
IGL03334:Myo1f APN 17 33,817,168 (GRCm39) missense probably damaging 1.00
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0321:Myo1f UTSW 17 33,811,986 (GRCm39) missense probably benign 0.31
R0487:Myo1f UTSW 17 33,797,258 (GRCm39) missense probably damaging 1.00
R0925:Myo1f UTSW 17 33,797,107 (GRCm39) missense probably damaging 0.96
R1394:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1395:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1474:Myo1f UTSW 17 33,813,001 (GRCm39) missense possibly damaging 0.77
R1760:Myo1f UTSW 17 33,805,172 (GRCm39) missense probably benign 0.03
R1965:Myo1f UTSW 17 33,817,146 (GRCm39) nonsense probably null
R2409:Myo1f UTSW 17 33,795,641 (GRCm39) missense probably damaging 1.00
R2432:Myo1f UTSW 17 33,794,823 (GRCm39) missense probably damaging 1.00
R4610:Myo1f UTSW 17 33,801,306 (GRCm39) missense probably damaging 1.00
R4785:Myo1f UTSW 17 33,817,165 (GRCm39) missense possibly damaging 0.95
R5239:Myo1f UTSW 17 33,820,709 (GRCm39) missense probably benign 0.00
R5881:Myo1f UTSW 17 33,799,259 (GRCm39) missense possibly damaging 0.46
R5881:Myo1f UTSW 17 33,795,627 (GRCm39) missense probably damaging 1.00
R6160:Myo1f UTSW 17 33,823,318 (GRCm39) missense probably benign
R6210:Myo1f UTSW 17 33,820,044 (GRCm39) missense probably damaging 1.00
R6365:Myo1f UTSW 17 33,805,090 (GRCm39) missense probably benign
R6464:Myo1f UTSW 17 33,795,621 (GRCm39) missense probably damaging 1.00
R6532:Myo1f UTSW 17 33,794,820 (GRCm39) missense probably damaging 1.00
R6678:Myo1f UTSW 17 33,794,819 (GRCm39) missense probably damaging 1.00
R7241:Myo1f UTSW 17 33,798,902 (GRCm39) missense probably damaging 0.99
R7266:Myo1f UTSW 17 33,820,668 (GRCm39) missense probably benign
R7513:Myo1f UTSW 17 33,794,788 (GRCm39) missense probably damaging 1.00
R7606:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R7779:Myo1f UTSW 17 33,797,247 (GRCm39) missense probably benign 0.27
R7853:Myo1f UTSW 17 33,795,672 (GRCm39) missense probably damaging 1.00
R7884:Myo1f UTSW 17 33,817,270 (GRCm39) missense probably damaging 1.00
R8507:Myo1f UTSW 17 33,816,992 (GRCm39) missense probably benign 0.09
R8807:Myo1f UTSW 17 33,794,879 (GRCm39) missense probably damaging 1.00
R9009:Myo1f UTSW 17 33,823,662 (GRCm39) missense probably benign 0.12
R9083:Myo1f UTSW 17 33,813,036 (GRCm39) missense probably damaging 0.99
R9227:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9230:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9528:Myo1f UTSW 17 33,797,156 (GRCm39) critical splice donor site probably null
X0028:Myo1f UTSW 17 33,795,412 (GRCm39) missense possibly damaging 0.67
X0065:Myo1f UTSW 17 33,820,957 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AATGCAACTCAGGTCCTGCCCTAC -3'
(R):5'- ATGATGCCCAGTTCTGGTTCCAGC -3'

Sequencing Primer
(F):5'- TCAAGACCGAGTTTGTCAGC -3'
(R):5'- AGCTGACTTACTGGTGCTC -3'
Posted On 2013-04-24