Incidental Mutation 'R3936:Or13c7b'
ID 307166
Institutional Source Beutler Lab
Gene Symbol Or13c7b
Ensembl Gene ENSMUSG00000110970
Gene Name olfactory receptor family 13 subfamily C member 7B
Synonyms mOR37b, GA_x6K02T2N78B-16125144-16126100, Olfr37b, OR37B, Olfr156, MOR262-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R3936 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 43820335-43821433 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 43821359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000148995 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079234] [ENSMUST00000079465] [ENSMUST00000079465] [ENSMUST00000079465] [ENSMUST00000079465] [ENSMUST00000214843] [ENSMUST00000215406]
AlphaFold Q8VGA9
Predicted Effect probably benign
Transcript: ENSMUST00000079234
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078226
Gene: ENSMUSG00000110970
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 4.8e-58 PFAM
Pfam:7tm_1 41 296 2.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079465
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078431
Gene: ENSMUSG00000110970
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.2e-58 PFAM
Pfam:7tm_1 41 296 6.5e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079465
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078431
Gene: ENSMUSG00000110970
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.2e-58 PFAM
Pfam:7tm_1 41 296 6.5e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079465
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078431
Gene: ENSMUSG00000110970
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.2e-58 PFAM
Pfam:7tm_1 41 296 6.5e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079465
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078431
Gene: ENSMUSG00000110970
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.2e-58 PFAM
Pfam:7tm_1 41 296 6.5e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214843
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000215406
AA Change: M1L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 C T 12: 53,187,227 (GRCm39) T1547M possibly damaging Het
Alk T A 17: 72,512,949 (GRCm39) I337F probably damaging Het
Ank3 A T 10: 69,715,819 (GRCm39) K491* probably null Het
Arx T A X: 92,340,975 (GRCm39) L554Q probably damaging Het
Axdnd1 T C 1: 156,159,209 (GRCm39) N203S probably benign Het
Baz2b A G 2: 59,743,105 (GRCm39) V1622A possibly damaging Het
Btnl6 T A 17: 34,736,316 (GRCm39) H4L probably benign Het
Dync2h1 C A 9: 7,001,482 (GRCm39) L3835F probably damaging Het
Fcgbp T C 7: 27,774,824 (GRCm39) F133L probably benign Het
Fnip1 A G 11: 54,371,065 (GRCm39) probably null Het
G6pc1 A G 11: 101,265,429 (GRCm39) I154V probably benign Het
Golgb1 G T 16: 36,734,418 (GRCm39) E1222* probably null Het
Gpr85 A G 6: 13,836,044 (GRCm39) F287L probably benign Het
Gzmk A T 13: 113,309,559 (GRCm39) S164T probably damaging Het
Il22ra2 T A 10: 19,507,456 (GRCm39) S156R probably benign Het
Kansl1 A T 11: 104,234,369 (GRCm39) D712E possibly damaging Het
Mc3r T A 2: 172,091,216 (GRCm39) I146N probably damaging Het
Mcm2 G A 6: 88,869,990 (GRCm39) R60C probably damaging Het
Mitf C T 6: 97,970,214 (GRCm39) P54S probably damaging Het
P4hb A C 11: 120,453,235 (GRCm39) H440Q probably benign Het
Pbsn T C X: 76,891,702 (GRCm39) T32A probably damaging Het
Rptn A C 3: 93,302,883 (GRCm39) H72P possibly damaging Het
Scn1a T C 2: 66,158,120 (GRCm39) I418V probably damaging Het
Sf3a1 T A 11: 4,130,024 (GRCm39) probably null Het
Slc35f1 C T 10: 52,984,314 (GRCm39) T358I probably damaging Het
Slc9c1 A G 16: 45,427,193 (GRCm39) probably benign Het
Sorcs3 T A 19: 48,701,943 (GRCm39) V608D probably damaging Het
Sult2b1 C T 7: 45,391,640 (GRCm39) V49M probably benign Het
Tlr11 A G 14: 50,600,192 (GRCm39) E726G possibly damaging Het
Treh C T 9: 44,595,840 (GRCm39) R342W probably benign Het
Other mutations in Or13c7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02508:Or13c7b APN 4 43,821,289 (GRCm39) missense possibly damaging 0.83
IGL02690:Or13c7b APN 4 43,821,190 (GRCm39) missense possibly damaging 0.50
R1454:Or13c7b UTSW 4 43,820,639 (GRCm39) missense probably damaging 1.00
R1465:Or13c7b UTSW 4 43,820,723 (GRCm39) missense probably benign 0.00
R1465:Or13c7b UTSW 4 43,820,723 (GRCm39) missense probably benign 0.00
R1859:Or13c7b UTSW 4 43,820,779 (GRCm39) missense possibly damaging 0.91
R2146:Or13c7b UTSW 4 43,821,178 (GRCm39) missense probably damaging 1.00
R3160:Or13c7b UTSW 4 43,820,544 (GRCm39) missense probably benign 0.04
R3162:Or13c7b UTSW 4 43,820,544 (GRCm39) missense probably benign 0.04
R3162:Or13c7b UTSW 4 43,820,544 (GRCm39) missense probably benign 0.04
R3414:Or13c7b UTSW 4 43,821,258 (GRCm39) missense probably benign 0.00
R4497:Or13c7b UTSW 4 43,821,175 (GRCm39) missense probably damaging 1.00
R4631:Or13c7b UTSW 4 43,820,563 (GRCm39) missense probably benign 0.08
R5125:Or13c7b UTSW 4 43,820,480 (GRCm39) missense probably benign 0.15
R5371:Or13c7b UTSW 4 43,821,058 (GRCm39) missense probably damaging 1.00
R5698:Or13c7b UTSW 4 43,821,183 (GRCm39) missense probably damaging 1.00
R5807:Or13c7b UTSW 4 43,820,912 (GRCm39) missense probably benign 0.00
R5889:Or13c7b UTSW 4 43,820,492 (GRCm39) missense possibly damaging 0.89
R6461:Or13c7b UTSW 4 43,821,355 (GRCm39) missense probably benign
R6865:Or13c7b UTSW 4 43,821,346 (GRCm39) missense probably benign 0.00
R7566:Or13c7b UTSW 4 43,820,711 (GRCm39) missense probably damaging 1.00
R7908:Or13c7b UTSW 4 43,821,086 (GRCm39) missense probably damaging 1.00
R9048:Or13c7b UTSW 4 43,820,584 (GRCm39) missense probably damaging 1.00
R9252:Or13c7b UTSW 4 43,821,109 (GRCm39) missense probably benign 0.13
Z1177:Or13c7b UTSW 4 43,821,337 (GRCm39) missense probably benign
Z1177:Or13c7b UTSW 4 43,820,900 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AAGTACATGGGCGTGTGCAG -3'
(R):5'- TGGCCTGACTATATCGCGTC -3'

Sequencing Primer
(F):5'- GGTGGGAGTCGAGGATGCTC -3'
(R):5'- ATCTATCTCAGTTGGCTACCAGAGG -3'
Posted On 2015-04-17