Incidental Mutation 'R3938:Slc25a10'
ID 307291
Institutional Source Beutler Lab
Gene Symbol Slc25a10
Ensembl Gene ENSMUSG00000025792
Gene Name solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms Dic
MMRRC Submission 040825-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3938 (G1)
Quality Score 213
Status Validated
Chromosome 11
Chromosomal Location 120382666-120390013 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 120382819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 3 (E3*)
Ref Sequence ENSEMBL: ENSMUSP00000026899 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026899] [ENSMUST00000043627]
AlphaFold Q9QZD8
Predicted Effect probably null
Transcript: ENSMUST00000026899
AA Change: E3*
SMART Domains Protein: ENSMUSP00000026899
Gene: ENSMUSG00000025792
AA Change: E3*

DomainStartEndE-ValueType
Pfam:Mito_carr 5 92 4.1e-20 PFAM
Pfam:Mito_carr 94 191 2e-18 PFAM
Pfam:Mito_carr 195 284 7.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000043627
SMART Domains Protein: ENSMUSP00000044417
Gene: ENSMUSG00000039640

DomainStartEndE-ValueType
low complexity region 14 26 N/A INTRINSIC
Pfam:Ribosomal_L12_N 64 120 4.5e-13 PFAM
Pfam:Ribosomal_L12 133 201 5.4e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123373
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127349
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137619
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138874
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144706
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180595
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142520
Meta Mutation Damage Score 0.9711 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts1 C T 16: 85,592,507 (GRCm39) V634M possibly damaging Het
Arid4b A T 13: 14,361,513 (GRCm39) N659I probably benign Het
BC049715 T C 6: 136,817,453 (GRCm39) I231T possibly damaging Het
Bmp4 T C 14: 46,621,536 (GRCm39) Y336C probably damaging Het
Ccdc30 G A 4: 119,209,870 (GRCm39) T293I probably benign Het
Chd5 A T 4: 152,461,512 (GRCm39) T1275S probably benign Het
Chtf8 A T 8: 107,612,537 (GRCm39) M134K probably benign Het
Col11a2 A T 17: 34,258,599 (GRCm39) probably benign Het
Cyp8b1 A G 9: 121,744,684 (GRCm39) V216A probably benign Het
Dnah8 C T 17: 31,073,911 (GRCm39) T4527M probably damaging Het
Elavl3 A G 9: 21,930,040 (GRCm39) V288A probably damaging Het
Erap1 T A 13: 74,816,147 (GRCm39) L92Q probably damaging Het
Exoc3l G T 8: 106,020,037 (GRCm39) P296H probably damaging Het
Fcgbpl1 C T 7: 27,853,719 (GRCm39) P1561L probably damaging Het
Foxl3 A T 5: 138,806,723 (GRCm39) N78Y probably damaging Het
Hacl1 T C 14: 31,356,148 (GRCm39) probably benign Het
Hrnr T A 3: 93,230,162 (GRCm39) N133K probably benign Het
Itgax G T 7: 127,735,445 (GRCm39) R504S possibly damaging Het
Itgb4 A G 11: 115,896,752 (GRCm39) S1461G possibly damaging Het
Klkb1 G T 8: 45,735,838 (GRCm39) T175K probably damaging Het
Lrrk2 A T 15: 91,596,983 (GRCm39) D525V possibly damaging Het
Lrrk2 C A 15: 91,662,707 (GRCm39) T1912K probably damaging Het
Mdga1 G T 17: 30,076,596 (GRCm39) Q59K probably damaging Het
Mpp4 A G 1: 59,163,842 (GRCm39) V466A possibly damaging Het
Myh6 T C 14: 55,200,512 (GRCm39) D203G probably benign Het
Myo5b T C 18: 74,849,108 (GRCm39) S1116P probably damaging Het
Nemp1 T C 10: 127,531,342 (GRCm39) L311P probably damaging Het
Nup205 A G 6: 35,196,677 (GRCm39) R1138G probably damaging Het
Nup54 A G 5: 92,565,388 (GRCm39) M443T probably damaging Het
Peak1 T C 9: 56,167,649 (GRCm39) E93G probably benign Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Plekhj1 A G 10: 80,633,609 (GRCm39) I76T probably damaging Het
Poll A G 19: 45,546,857 (GRCm39) probably benign Het
Ppp1r3a A T 6: 14,719,073 (GRCm39) S614T probably damaging Het
Pygm A T 19: 6,442,980 (GRCm39) I556F probably benign Het
Ranbp2 T C 10: 58,312,294 (GRCm39) F1005L probably benign Het
Rcor3 G T 1: 191,785,385 (GRCm39) T361K possibly damaging Het
Robo4 A G 9: 37,313,313 (GRCm39) probably benign Het
Rps15 T C 10: 80,129,673 (GRCm39) V96A probably benign Het
Rrm2 T A 12: 24,759,431 (GRCm39) N55K probably damaging Het
Shank2 T C 7: 143,682,112 (GRCm39) Y382H probably benign Het
Slc7a8 T A 14: 54,973,298 (GRCm39) E223V probably benign Het
Snx13 A G 12: 35,194,096 (GRCm39) K880E probably benign Het
Spinkl T G 18: 44,301,216 (GRCm39) M41L probably benign Het
Srp54a A C 12: 55,136,042 (GRCm39) N19T probably benign Het
Sun2 T C 15: 79,618,356 (GRCm39) K268E probably benign Het
Sytl1 G A 4: 132,982,935 (GRCm39) Q359* probably null Het
Tlr6 A T 5: 65,110,938 (GRCm39) F656L probably damaging Het
Tmem185a C T X: 69,505,792 (GRCm39) probably null Het
Tmem45a2 C T 16: 56,859,398 (GRCm39) D278N probably benign Het
Trav7-1 T C 14: 52,892,791 (GRCm39) probably benign Het
Trpc2 T A 7: 101,742,781 (GRCm39) M597K probably damaging Het
Ttc21a A G 9: 119,779,882 (GRCm39) probably benign Het
Usp9y C T Y: 1,313,741 (GRCm39) M2188I probably damaging Het
Utrn C A 10: 12,625,774 (GRCm39) probably null Het
Vmn1r35 T A 6: 66,656,057 (GRCm39) R204S probably damaging Het
Zfp955b T A 17: 33,524,390 (GRCm39) Y59F probably damaging Het
Other mutations in Slc25a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Slc25a10 APN 11 120,387,933 (GRCm39) critical splice donor site probably null
IGL00816:Slc25a10 APN 11 120,385,976 (GRCm39) splice site probably benign
IGL02448:Slc25a10 APN 11 120,387,879 (GRCm39) missense probably benign 0.01
R2291:Slc25a10 UTSW 11 120,387,900 (GRCm39) missense probably benign
R2860:Slc25a10 UTSW 11 120,386,003 (GRCm39) missense probably damaging 0.98
R2861:Slc25a10 UTSW 11 120,386,003 (GRCm39) missense probably damaging 0.98
R4019:Slc25a10 UTSW 11 120,388,265 (GRCm39) missense probably damaging 0.99
R4020:Slc25a10 UTSW 11 120,388,265 (GRCm39) missense probably damaging 0.99
R4457:Slc25a10 UTSW 11 120,387,915 (GRCm39) missense probably benign
R4542:Slc25a10 UTSW 11 120,388,807 (GRCm39) splice site probably null
R5643:Slc25a10 UTSW 11 120,387,202 (GRCm39) intron probably benign
R5869:Slc25a10 UTSW 11 120,388,943 (GRCm39) missense probably damaging 0.98
R6032:Slc25a10 UTSW 11 120,385,784 (GRCm39) critical splice acceptor site probably null
R6032:Slc25a10 UTSW 11 120,385,784 (GRCm39) critical splice acceptor site probably null
R6455:Slc25a10 UTSW 11 120,386,031 (GRCm39) missense probably damaging 1.00
R6574:Slc25a10 UTSW 11 120,387,903 (GRCm39) missense probably benign
R6954:Slc25a10 UTSW 11 120,388,973 (GRCm39) missense probably benign
R7302:Slc25a10 UTSW 11 120,382,782 (GRCm39) unclassified probably benign
R7618:Slc25a10 UTSW 11 120,387,797 (GRCm39) splice site probably null
R7671:Slc25a10 UTSW 11 120,386,286 (GRCm39) missense probably benign 0.18
R7883:Slc25a10 UTSW 11 120,385,340 (GRCm39) missense possibly damaging 0.84
R8855:Slc25a10 UTSW 11 120,385,795 (GRCm39) missense probably damaging 1.00
R9683:Slc25a10 UTSW 11 120,386,312 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTTTAAGACCAGAGGCGG -3'
(R):5'- TAATTACCGGGTGCGCAGTC -3'

Sequencing Primer
(F):5'- CTTTAAGACCAGAGGCGGAGTCTC -3'
(R):5'- TTGAAGCTCAGGCTCACT -3'
Posted On 2015-04-17