Incidental Mutation 'R0376:Cyp3a11'
ID 30744
Institutional Source Beutler Lab
Gene Symbol Cyp3a11
Ensembl Gene ENSMUSG00000056035
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms Cyp3a, Pcn, IIIAm1
MMRRC Submission 038582-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0376 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 145791417-145816664 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to C at 145799262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 308 (Y308*)
Ref Sequence ENSEMBL: ENSMUSP00000037665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035918]
AlphaFold Q64459
Predicted Effect probably null
Transcript: ENSMUST00000035918
AA Change: Y308*
SMART Domains Protein: ENSMUSP00000037665
Gene: ENSMUSG00000056035
AA Change: Y308*

DomainStartEndE-ValueType
Pfam:p450 38 494 2.4e-136 PFAM
Meta Mutation Damage Score 0.9706 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.0%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6a T C 12: 113,508,310 (GRCm39) Y228H probably damaging Het
Als2 A G 1: 59,254,724 (GRCm39) F211S probably benign Het
Ankrd12 T A 17: 66,360,004 (GRCm39) Q11L probably damaging Het
Anxa5 T C 3: 36,514,637 (GRCm39) R115G probably damaging Het
Arhgap10 T C 8: 78,177,453 (GRCm39) probably benign Het
Atp2a3 T A 11: 72,873,528 (GRCm39) D782E probably damaging Het
Bcr G T 10: 74,981,159 (GRCm39) L659F probably damaging Het
Cacna1b A G 2: 24,549,015 (GRCm39) probably benign Het
Camp C T 9: 109,677,467 (GRCm39) C122Y probably damaging Het
Cimip1 G A 2: 173,370,120 (GRCm39) E132K probably benign Het
Col12a1 A T 9: 79,600,776 (GRCm39) S769R probably benign Het
Cyp2j6 T A 4: 96,414,260 (GRCm39) K335I probably damaging Het
Flnb G A 14: 7,946,014 (GRCm38) probably null Het
Frmd4a G T 2: 4,577,198 (GRCm39) M351I probably damaging Het
Gabrg2 C T 11: 41,807,142 (GRCm39) S365N possibly damaging Het
Ggn T C 7: 28,872,447 (GRCm39) V609A possibly damaging Het
H60c T C 10: 3,210,435 (GRCm39) probably benign Het
Hexd T A 11: 121,108,991 (GRCm39) probably benign Het
Igsf9b A G 9: 27,245,878 (GRCm39) T1282A probably benign Het
Ikzf4 T C 10: 128,468,625 (GRCm39) N618S probably benign Het
Ints14 A G 9: 64,891,272 (GRCm39) K418E probably damaging Het
Iqgap1 T C 7: 80,373,627 (GRCm39) E1454G probably benign Het
Kif13b T C 14: 64,994,853 (GRCm39) probably benign Het
Krt71 A C 15: 101,646,505 (GRCm39) F328C probably damaging Het
Lama2 T C 10: 26,891,542 (GRCm39) T2524A possibly damaging Het
Mfn2 C T 4: 147,969,983 (GRCm39) V363I probably benign Het
Mkln1 A T 6: 31,454,953 (GRCm39) D496V probably benign Het
Or2q1 A T 6: 42,795,226 (GRCm39) M274L probably benign Het
Patj T A 4: 98,457,224 (GRCm39) I1242N probably damaging Het
Pcnx1 C T 12: 82,021,353 (GRCm39) probably benign Het
Plcb2 T C 2: 118,547,721 (GRCm39) E502G probably damaging Het
Plppr4 G T 3: 117,116,740 (GRCm39) H314Q probably benign Het
Prkcsh A G 9: 21,921,547 (GRCm39) probably benign Het
Prr14 C T 7: 127,075,815 (GRCm39) H181Y probably benign Het
Pus3 A T 9: 35,477,718 (GRCm39) M317L possibly damaging Het
Pwwp2a T A 11: 43,595,499 (GRCm39) D221E probably benign Het
Rbm15 T C 3: 107,238,254 (GRCm39) S715G probably benign Het
Rbm28 A G 6: 29,158,927 (GRCm39) probably benign Het
Rhobtb2 A T 14: 70,034,184 (GRCm39) V347E probably benign Het
Rimbp2 C T 5: 128,880,925 (GRCm39) R161Q probably damaging Het
Scgb1b27 C T 7: 33,721,322 (GRCm39) T70I possibly damaging Het
Slc40a1 T C 1: 45,951,651 (GRCm39) probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spaca9 A G 2: 28,583,672 (GRCm39) V104A probably benign Het
Spag7 T C 11: 70,560,016 (GRCm39) probably benign Het
Sugp1 A G 8: 70,505,288 (GRCm39) D85G probably damaging Het
Sun1 A G 5: 139,212,454 (GRCm39) probably benign Het
Tcp11l1 C A 2: 104,527,850 (GRCm39) probably benign Het
Tead3 A C 17: 28,560,339 (GRCm39) D88E probably damaging Het
Tecpr1 A T 5: 144,144,294 (GRCm39) V636E possibly damaging Het
Tldc2 T C 2: 156,937,225 (GRCm39) W147R probably damaging Het
Tmem161b A G 13: 84,440,502 (GRCm39) T125A probably benign Het
Trrap A G 5: 144,753,149 (GRCm39) M1825V probably benign Het
Ttbk2 A G 2: 120,608,062 (GRCm39) F186L probably damaging Het
U2surp C T 9: 95,366,496 (GRCm39) V470I probably benign Het
Zc3h7a T C 16: 10,974,066 (GRCm39) M240V probably benign Het
Zc3hc1 G C 6: 30,372,789 (GRCm39) S351W probably damaging Het
Zfp366 T C 13: 99,370,759 (GRCm39) M493T probably benign Het
Zfp93 C T 7: 23,975,286 (GRCm39) P424S probably damaging Het
Other mutations in Cyp3a11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Cyp3a11 APN 5 145,799,275 (GRCm39) missense probably damaging 1.00
IGL01316:Cyp3a11 APN 5 145,791,961 (GRCm39) missense possibly damaging 0.78
IGL01348:Cyp3a11 APN 5 145,805,817 (GRCm39) missense possibly damaging 0.80
IGL01591:Cyp3a11 APN 5 145,812,291 (GRCm39) splice site probably benign
IGL01665:Cyp3a11 APN 5 145,805,475 (GRCm39) missense probably benign 0.00
IGL02203:Cyp3a11 APN 5 145,805,976 (GRCm39) missense probably damaging 1.00
IGL02894:Cyp3a11 APN 5 145,805,836 (GRCm39) nonsense probably null
IGL03201:Cyp3a11 APN 5 145,797,189 (GRCm39) missense possibly damaging 0.94
IGL03342:Cyp3a11 APN 5 145,791,927 (GRCm39) missense probably damaging 0.96
PIT4486001:Cyp3a11 UTSW 5 145,797,302 (GRCm39) missense probably damaging 0.99
R0347:Cyp3a11 UTSW 5 145,802,735 (GRCm39) missense possibly damaging 0.93
R0378:Cyp3a11 UTSW 5 145,805,417 (GRCm39) missense probably benign 0.43
R0448:Cyp3a11 UTSW 5 145,799,204 (GRCm39) missense probably benign 0.00
R0567:Cyp3a11 UTSW 5 145,805,959 (GRCm39) missense probably damaging 1.00
R0968:Cyp3a11 UTSW 5 145,799,324 (GRCm39) splice site probably benign
R1292:Cyp3a11 UTSW 5 145,802,804 (GRCm39) missense probably benign 0.04
R1400:Cyp3a11 UTSW 5 145,799,299 (GRCm39) missense probably damaging 0.98
R1478:Cyp3a11 UTSW 5 145,795,581 (GRCm39) missense probably benign 0.01
R1520:Cyp3a11 UTSW 5 145,799,263 (GRCm39) missense probably damaging 1.00
R1716:Cyp3a11 UTSW 5 145,805,776 (GRCm39) missense probably benign
R2060:Cyp3a11 UTSW 5 145,791,891 (GRCm39) missense probably benign 0.00
R2076:Cyp3a11 UTSW 5 145,816,576 (GRCm39) missense probably benign
R2227:Cyp3a11 UTSW 5 145,805,357 (GRCm39) missense possibly damaging 0.90
R3725:Cyp3a11 UTSW 5 145,802,810 (GRCm39) missense probably benign 0.02
R4222:Cyp3a11 UTSW 5 145,797,276 (GRCm39) missense probably damaging 0.99
R4256:Cyp3a11 UTSW 5 145,806,005 (GRCm39) missense probably benign 0.04
R4294:Cyp3a11 UTSW 5 145,806,005 (GRCm39) missense probably benign 0.04
R4852:Cyp3a11 UTSW 5 145,797,305 (GRCm39) missense probably damaging 1.00
R5229:Cyp3a11 UTSW 5 145,791,945 (GRCm39) missense probably benign 0.00
R5285:Cyp3a11 UTSW 5 145,791,893 (GRCm39) missense probably benign 0.00
R5590:Cyp3a11 UTSW 5 145,802,787 (GRCm39) missense probably benign 0.00
R5703:Cyp3a11 UTSW 5 145,797,183 (GRCm39) missense probably benign
R5786:Cyp3a11 UTSW 5 145,799,284 (GRCm39) missense possibly damaging 0.47
R6291:Cyp3a11 UTSW 5 145,799,237 (GRCm39) missense possibly damaging 0.89
R6405:Cyp3a11 UTSW 5 145,799,230 (GRCm39) missense probably damaging 0.96
R6892:Cyp3a11 UTSW 5 145,797,258 (GRCm39) missense probably damaging 0.98
R7114:Cyp3a11 UTSW 5 145,795,593 (GRCm39) missense probably benign 0.16
R7243:Cyp3a11 UTSW 5 145,795,613 (GRCm39) missense probably damaging 0.96
R7438:Cyp3a11 UTSW 5 145,802,710 (GRCm39) missense probably benign 0.39
R7611:Cyp3a11 UTSW 5 145,797,191 (GRCm39) missense probably benign 0.25
R8346:Cyp3a11 UTSW 5 145,795,612 (GRCm39) missense probably damaging 1.00
R8371:Cyp3a11 UTSW 5 145,805,438 (GRCm39) missense possibly damaging 0.92
R8895:Cyp3a11 UTSW 5 145,797,330 (GRCm39) missense probably benign
R9043:Cyp3a11 UTSW 5 145,805,995 (GRCm39) missense probably benign 0.02
R9300:Cyp3a11 UTSW 5 145,799,164 (GRCm39) missense possibly damaging 0.60
R9404:Cyp3a11 UTSW 5 145,799,258 (GRCm39) missense probably benign 0.40
Predicted Primers PCR Primer
(F):5'- CACCATTGCAAGTGACCAAACTGTG -3'
(R):5'- GGACAATCTGCCTGAAGCCTTCTC -3'

Sequencing Primer
(F):5'- ACCAAACTGTGTCTTTGTTGAG -3'
(R):5'- TCTCAGTGTGACTGAACAGC -3'
Posted On 2013-04-24