Mutagenetix > Incidental Mutation

Incidental Mutation 'R3941:Vmn1r175'

307446

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r175

Ensembl Gene

ENSMUSG00000095632

Gene Name

vomeronasal 1 receptor 175

Synonyms

Gm6299

MMRRC Submission

040923-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R3941 (G1)

Quality Score

161

Status

Validated

Chromosome

Chromosomal Location

23507711-23508625 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23508393 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 78 (V78A)

Ref Sequence

ENSEMBL: ENSMUSP00000154170 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166141] [ENSMUST00000228383]

AlphaFold

K7N6T9

Predicted Effect

probably benign
Transcript: ENSMUST00000166141
AA Change: V78A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: V78A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	8.8e-15	PFAM
Pfam:7tm_1	13	285	2.5e-6	PFAM
Pfam:V1R	41	295	4.4e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228383
AA Change: V78A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.3%

Validation Efficiency

98% (55/56)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc1	A	T	16: 14,214,263 (GRCm39)	T193S	probably benign	Het
Arhgap11a	A	T	2: 113,667,242 (GRCm39)	L435Q	probably damaging	Het
Bin1	T	C	18: 32,539,211 (GRCm39)	V48A	probably damaging	Het
Brinp3	C	A	1: 146,627,599 (GRCm39)	D277E	probably damaging	Het
Btn1a1	T	G	13: 23,643,434 (GRCm39)	R338S	probably benign	Het
Cacnb4	C	A	2: 52,359,501 (GRCm39)	R169L	probably damaging	Het
Ccdc80	A	G	16: 44,916,455 (GRCm39)	T404A	probably benign	Het
Cd2ap	G	C	17: 43,119,690 (GRCm39)	H488D	probably damaging	Het
Cdon	A	G	9: 35,375,467 (GRCm39)	T498A	probably benign	Het
Cngb3	A	G	4: 19,396,786 (GRCm39)	N380D	probably benign	Het
Col6a5	G	A	9: 105,817,033 (GRCm39)	S426F	unknown	Het
Cr2	A	T	1: 194,848,122 (GRCm39)	H345Q	probably damaging	Het
Cttnbp2	T	A	6: 18,427,452 (GRCm39)	K743M	probably benign	Het
Depdc1b	T	C	13: 108,505,370 (GRCm39)	S245P	probably damaging	Het
Dync2h1	G	A	9: 7,124,825 (GRCm39)	H2016Y	probably benign	Het
Eif2s3y	G	T	Y: 1,012,079 (GRCm39)	R98L	probably benign	Het
Eml6	C	T	11: 29,753,167 (GRCm39)	G915S	probably damaging	Het
Fcgr1	A	G	3: 96,193,349 (GRCm39)	L216P	probably benign	Het
Fpr-rs3	T	C	17: 20,845,111 (GRCm39)	N10S	probably benign	Het
Frem3	T	C	8: 81,341,649 (GRCm39)	I1314T	possibly damaging	Het
Gabrr3	A	G	16: 59,253,864 (GRCm39)	N194D	probably damaging	Het
Hey1	A	G	3: 8,729,638 (GRCm39)	L273P	probably damaging	Het
Irf6	A	G	1: 192,850,857 (GRCm39)	K365E	probably benign	Het
Kit	A	G	5: 75,769,978 (GRCm39)	D130G	probably benign	Het
Lrp1	G	A	10: 127,389,265 (GRCm39)	A3217V	probably damaging	Het
Mei4	C	T	9: 81,809,336 (GRCm39)	R140C	probably benign	Het
Mir100hg	T	C	9: 41,501,570 (GRCm39)	L143P	probably damaging	Het
Mpo	A	T	11: 87,688,175 (GRCm39)	K278M	probably benign	Het
Mprip	T	C	11: 59,622,328 (GRCm39)		probably benign	Het
Mug2	G	C	6: 122,040,522 (GRCm39)	G691R	probably benign	Het
Neto2	G	A	8: 86,400,747 (GRCm39)	T16I	probably damaging	Het
Nipal4	C	T	11: 46,041,473 (GRCm39)	V241M	probably damaging	Het
Nlrp2	A	T	7: 5,330,551 (GRCm39)	L615*	probably null	Het
Pcdh1	A	G	18: 38,332,511 (GRCm39)	V164A	probably benign	Het
Phc2	T	C	4: 128,641,037 (GRCm39)		probably null	Het
Plekhg3	A	G	12: 76,620,133 (GRCm39)	E623G	probably damaging	Het
Psors1c2	G	T	17: 35,844,825 (GRCm39)	G29*	probably null	Het
Slc25a54	A	T	3: 109,019,479 (GRCm39)	D361V	probably damaging	Het
Slc39a12	A	T	2: 14,400,992 (GRCm39)	H123L	possibly damaging	Het
Sorl1	T	C	9: 41,900,764 (GRCm39)		probably null	Het
Strn	A	T	17: 78,965,369 (GRCm39)	I641N	probably damaging	Het
Tapbp	A	G	17: 34,139,457 (GRCm39)	E151G	possibly damaging	Het
Ticrr	T	C	7: 79,343,445 (GRCm39)		probably benign	Het
Tnfrsf21	G	A	17: 43,348,901 (GRCm39)	C171Y	probably damaging	Het
Ttyh1	T	A	7: 4,132,317 (GRCm39)	L155H	probably damaging	Het
Utrn	T	A	10: 12,587,329 (GRCm39)		probably null	Het
Vmn1r73	T	C	7: 11,490,682 (GRCm39)	Y167H	probably damaging	Het
Washc1	T	C	17: 66,425,123 (GRCm39)	S376P	probably damaging	Het
Wnt10a	T	A	1: 74,842,656 (GRCm39)		probably null	Het
Xrcc4	A	G	13: 90,219,752 (GRCm39)	V16A	probably benign	Het
Zeb1	T	C	18: 5,767,799 (GRCm39)	V770A	probably benign	Het
Zfp410	A	G	12: 84,385,527 (GRCm39)	N90S	probably damaging	Het

Other mutations in Vmn1r175

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02944:Vmn1r175	APN	7	23,508,591 (GRCm39)	missense	probably damaging	0.97
PIT4531001:Vmn1r175	UTSW	7	23,508,603 (GRCm39)	missense	possibly damaging	0.62
R1163:Vmn1r175	UTSW	7	23,507,937 (GRCm39)	missense	probably benign	0.30
R1901:Vmn1r175	UTSW	7	23,508,218 (GRCm39)	missense	probably benign	0.00
R1926:Vmn1r175	UTSW	7	23,508,466 (GRCm39)	missense	possibly damaging	0.81
R1957:Vmn1r175	UTSW	7	23,507,808 (GRCm39)	missense	probably benign	0.21
R2163:Vmn1r175	UTSW	7	23,508,352 (GRCm39)	missense	probably benign	0.29
R2381:Vmn1r175	UTSW	7	23,508,093 (GRCm39)	missense	probably benign	0.31
R3109:Vmn1r175	UTSW	7	23,508,393 (GRCm39)	missense	probably benign	0.00
R3419:Vmn1r175	UTSW	7	23,508,075 (GRCm39)	missense	probably damaging	0.96
R4982:Vmn1r175	UTSW	7	23,508,494 (GRCm39)	missense	possibly damaging	0.61
R5191:Vmn1r175	UTSW	7	23,508,447 (GRCm39)	missense	possibly damaging	0.91
R5326:Vmn1r175	UTSW	7	23,508,531 (GRCm39)	missense	possibly damaging	0.88
R5333:Vmn1r175	UTSW	7	23,508,004 (GRCm39)	missense	possibly damaging	0.69
R5476:Vmn1r175	UTSW	7	23,508,556 (GRCm39)	missense	possibly damaging	0.82
R5542:Vmn1r175	UTSW	7	23,508,531 (GRCm39)	missense	possibly damaging	0.88
R5761:Vmn1r175	UTSW	7	23,507,905 (GRCm39)	missense	probably benign	0.01
R5918:Vmn1r175	UTSW	7	23,508,372 (GRCm39)	missense	probably damaging	1.00
R6163:Vmn1r175	UTSW	7	23,508,591 (GRCm39)	missense	possibly damaging	0.71
R6563:Vmn1r175	UTSW	7	23,508,030 (GRCm39)	missense	possibly damaging	0.61
R7476:Vmn1r175	UTSW	7	23,507,847 (GRCm39)	missense	probably benign	0.01
R7616:Vmn1r175	UTSW	7	23,508,031 (GRCm39)	missense	possibly damaging	0.79
R8100:Vmn1r175	UTSW	7	23,508,012 (GRCm39)	missense	probably damaging	1.00
R8157:Vmn1r175	UTSW	7	23,508,523 (GRCm39)	missense	probably benign	0.00
R8699:Vmn1r175	UTSW	7	23,508,234 (GRCm39)	missense	probably benign	0.01
R8744:Vmn1r175	UTSW	7	23,508,403 (GRCm39)	missense	probably benign	0.00
R9595:Vmn1r175	UTSW	7	23,508,508 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CATTGACTTTCATTGGAATGTGAGC -3'
(R):5'- AGGTCCTCTTGCTTTGCCAG -3'

Sequencing Primer
(F):5'- CAAATATACCTCACAAATTTGGGGGC -3'
(R):5'- CCTCTTGCTTTGCCAGGTTGG -3'

Posted On

2015-04-17