Incidental Mutation 'R3945:Vmn1r113'
ID307643
Institutional Source Beutler Lab
Gene Symbol Vmn1r113
Ensembl Gene ENSMUSG00000091638
Gene Namevomeronasal 1 receptor 113
SynonymsGm5748
MMRRC Submission 040926-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R3945 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location20787285-20788208 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 20787712 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 143 (Y143C)
Ref Sequence ENSEMBL: ENSMUSP00000133307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168794] [ENSMUST00000173723]
Predicted Effect probably benign
Transcript: ENSMUST00000168794
AA Change: Y143C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000126041
Gene: ENSMUSG00000091638
AA Change: Y143C

DomainStartEndE-ValueType
Pfam:TAS2R 8 288 4.2e-8 PFAM
Pfam:V1R 41 288 2.8e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173723
AA Change: Y143C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000133307
Gene: ENSMUSG00000091638
AA Change: Y143C

DomainStartEndE-ValueType
Pfam:TAS2R 8 298 4e-16 PFAM
Pfam:7tm_1 31 290 9.3e-7 PFAM
Pfam:V1R 41 298 5e-17 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik T C 11: 78,289,964 I2229T probably damaging Het
4930407I10Rik T C 15: 82,065,400 L1166P probably damaging Het
Actn4 T C 7: 28,912,236 probably null Het
Adamts17 A T 7: 67,120,939 E905V probably benign Het
Adck5 A G 15: 76,595,200 N485S probably damaging Het
Agr3 C A 12: 35,947,513 probably benign Het
Ankrd12 G A 17: 65,976,103 T1921I probably damaging Het
Ascl2 T C 7: 142,967,971 S247G probably benign Het
Atp7b T C 8: 22,020,864 E422G probably benign Het
C630050I24Rik C T 8: 107,119,262 R15* probably null Het
Cabin1 T G 10: 75,745,259 Q411P probably damaging Het
Chrne T C 11: 70,617,043 I277V possibly damaging Het
Coch A G 12: 51,601,812 probably null Het
Corin A G 5: 72,358,424 V429A probably damaging Het
Cpa3 A T 3: 20,225,117 N219K probably damaging Het
Creb3l1 T C 2: 91,991,211 E273G probably damaging Het
Csmd1 A C 8: 15,910,619 probably null Het
Ddx59 A G 1: 136,434,618 D527G probably damaging Het
Defa25 G A 8: 21,084,490 V17I probably null Het
Efs A G 14: 54,920,651 probably benign Het
Ern2 A G 7: 122,176,530 M447T probably benign Het
Fgfr2 C T 7: 130,177,755 E596K possibly damaging Het
Filip1 T C 9: 79,818,367 K990R probably benign Het
Ipo8 T A 6: 148,818,117 Q110L probably damaging Het
Kank4 T A 4: 98,771,280 I854F probably damaging Het
Mst1 G A 9: 108,084,853 C681Y probably damaging Het
Nr2c2 C T 6: 92,163,138 R464W probably damaging Het
Olfr1289 C T 2: 111,483,687 Q86* probably null Het
Olfr1496 A G 19: 13,781,422 E270G probably benign Het
Pde11a T C 2: 76,075,931 probably benign Het
Ptprq A G 10: 107,686,392 probably benign Het
Rcbtb1 G A 14: 59,224,776 probably null Het
Rpl37 G A 15: 5,117,694 R72H probably benign Het
Samd9l A T 6: 3,377,029 S77R possibly damaging Het
Sin3b A G 8: 72,733,439 D218G possibly damaging Het
Slc22a23 A G 13: 34,183,126 I633T probably damaging Het
Spen T C 4: 141,477,353 D1321G unknown Het
Ssh2 T C 11: 77,454,668 S1160P possibly damaging Het
Synrg T A 11: 84,023,406 D952E probably damaging Het
Tigd3 A G 19: 5,892,433 F223S probably damaging Het
Trim66 G A 7: 109,472,268 T608I possibly damaging Het
Trmt13 A G 3: 116,581,518 F447S probably damaging Het
Trpc2 T C 7: 102,088,279 I800T possibly damaging Het
Ugt3a2 A T 15: 9,370,098 I443F possibly damaging Het
Vamp2 C A 11: 69,089,174 P24Q unknown Het
Vmn1r14 T A 6: 57,234,269 N277K probably benign Het
Vmn1r181 T A 7: 23,984,152 V14E probably damaging Het
Wdfy4 A T 14: 32,966,395 I3086N probably damaging Het
Zfp988 A C 4: 147,332,785 K559Q probably benign Het
Other mutations in Vmn1r113
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01908:Vmn1r113 APN 7 20788018 missense probably damaging 1.00
IGL02082:Vmn1r113 APN 7 20787747 missense probably benign
IGL02148:Vmn1r113 APN 7 20787822 missense probably benign 0.14
IGL03169:Vmn1r113 APN 7 20788087 missense probably benign 0.11
R0593:Vmn1r113 UTSW 7 20787463 missense probably damaging 0.99
R0669:Vmn1r113 UTSW 7 20787420 missense probably benign 0.00
R1212:Vmn1r113 UTSW 7 20787431 missense probably benign 0.19
R1693:Vmn1r113 UTSW 7 20787607 missense probably damaging 0.98
R2228:Vmn1r113 UTSW 7 20787907 missense probably damaging 1.00
R4209:Vmn1r113 UTSW 7 20787610 missense probably benign 0.44
R5038:Vmn1r113 UTSW 7 20787494 missense possibly damaging 0.70
R6306:Vmn1r113 UTSW 7 20787867 missense probably damaging 1.00
R6623:Vmn1r113 UTSW 7 20788066 missense probably benign 0.01
R6675:Vmn1r113 UTSW 7 20787978 missense probably benign 0.02
R6677:Vmn1r113 UTSW 7 20787978 missense probably benign 0.02
R6678:Vmn1r113 UTSW 7 20787978 missense probably benign 0.02
R6968:Vmn1r113 UTSW 7 20787951 missense probably damaging 1.00
R7054:Vmn1r113 UTSW 7 20787502 missense probably benign 0.14
R7256:Vmn1r113 UTSW 7 20787445 missense probably damaging 1.00
R8926:Vmn1r113 UTSW 7 20787949 missense possibly damaging 0.82
Predicted Primers PCR Primer
(F):5'- CAACATGATGGCTTTTGCTCC -3'
(R):5'- CTGCATTCGCTGGTGATGTC -3'

Sequencing Primer
(F):5'- GATGGCTTTTGCTCCAAAAACTC -3'
(R):5'- TGGAGACACTGGTCCAGAC -3'
Posted On2015-04-17