Incidental Mutation 'R3946:Or4f15'
ID 307689
Institutional Source Beutler Lab
Gene Symbol Or4f15
Ensembl Gene ENSMUSG00000109528
Gene Name olfactory receptor family 4 subfamily F member 15
Synonyms MOR245-5, GA_x6K02T2Q125-73031456-73030518, Olfr1309
MMRRC Submission 040827-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.878) question?
Stock # R3946 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111813479-111814441 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 111813642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 259 (T259M)
Ref Sequence ENSEMBL: ENSMUSP00000150871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099604] [ENSMUST00000207885] [ENSMUST00000214537] [ENSMUST00000214935] [ENSMUST00000215045] [ENSMUST00000216948] [ENSMUST00000217452]
AlphaFold Q8VF83
Predicted Effect possibly damaging
Transcript: ENSMUST00000099604
AA Change: T267M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097199
Gene: ENSMUSG00000094747
AA Change: T267M

DomainStartEndE-ValueType
Pfam:7tm_4 38 311 1.5e-36 PFAM
Pfam:7tm_1 49 295 6.5e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207885
AA Change: T267M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214537
AA Change: T259M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214935
AA Change: T259M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215045
AA Change: T259M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216948
AA Change: T259M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217452
AA Change: T259M

PolyPhen 2 Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi2 A G 1: 60,492,913 (GRCm39) Q328R probably damaging Het
Agr3 C A 12: 35,997,512 (GRCm39) probably benign Het
Brca2 T A 5: 150,460,169 (GRCm39) S481R probably damaging Het
Cabin1 T G 10: 75,581,093 (GRCm39) Q411P probably damaging Het
Calr3 A G 8: 73,197,464 (GRCm39) Y22H probably damaging Het
Caprin1 T A 2: 103,627,111 (GRCm39) I59F probably damaging Het
Cdk5rap1 T C 2: 154,190,636 (GRCm39) T442A probably damaging Het
Chn2 T C 6: 54,246,411 (GRCm39) probably benign Het
Cic C A 7: 24,971,771 (GRCm39) R501S possibly damaging Het
Coch A G 12: 51,648,595 (GRCm39) probably null Het
Defa25 G A 8: 21,574,506 (GRCm39) V17I probably null Het
Dglucy T C 12: 100,804,959 (GRCm39) probably null Het
Dtx1 T G 5: 120,819,351 (GRCm39) T616P possibly damaging Het
Eef1g T C 19: 8,947,341 (GRCm39) L171P probably benign Het
Fam135a A G 1: 24,069,475 (GRCm39) S465P probably damaging Het
Gm14412 A T 2: 177,006,478 (GRCm39) C472* probably null Het
Gm7104 T C 12: 88,252,812 (GRCm39) noncoding transcript Het
Got2 A G 8: 96,614,858 (GRCm39) S26P probably benign Het
H2-M11 A G 17: 36,860,123 (GRCm39) I329M probably damaging Het
Hmcn2 T A 2: 31,272,406 (GRCm39) D1295E possibly damaging Het
Hoxd12 G T 2: 74,505,771 (GRCm39) R114L probably damaging Het
Ilkap A C 1: 91,314,972 (GRCm39) D124E probably damaging Het
Maco1 A G 4: 134,531,792 (GRCm39) Y626H probably damaging Het
Med6 T C 12: 81,628,625 (GRCm39) Y88C probably damaging Het
Mep1a A T 17: 43,785,932 (GRCm39) L719* probably null Het
Mmp23 T C 4: 155,736,480 (GRCm39) Y187C probably damaging Het
Myo1g A G 11: 6,470,760 (GRCm39) M32T possibly damaging Het
Ncstn T C 1: 171,895,061 (GRCm39) E614G probably benign Het
Nr2c2 C T 6: 92,140,119 (GRCm39) R464W probably damaging Het
Otub2 T A 12: 103,359,085 (GRCm39) L58* probably null Het
Pcdhga12 G A 18: 37,900,682 (GRCm39) V505I probably benign Het
Pcdhga9 T A 18: 37,870,897 (GRCm39) V242D probably damaging Het
Pex1 C T 5: 3,676,084 (GRCm39) L891F probably damaging Het
Pgm2 C T 5: 64,269,404 (GRCm39) T497I probably benign Het
Pikfyve T C 1: 65,235,840 (GRCm39) F171L probably damaging Het
Pilrb1 T G 5: 137,855,654 (GRCm39) K79T probably benign Het
Pin1 C T 9: 20,566,660 (GRCm39) R21W probably damaging Het
Prxl2c T C 13: 64,456,912 (GRCm39) I104V probably damaging Het
Ptprq A G 10: 107,522,253 (GRCm39) probably benign Het
Rad17 G A 13: 100,759,371 (GRCm39) A552V possibly damaging Het
Rbbp8 A G 18: 11,851,925 (GRCm39) T249A probably benign Het
Rtkn A T 6: 83,112,957 (GRCm39) I10F probably benign Het
Scube2 T A 7: 109,456,797 (GRCm39) I103F possibly damaging Het
Sec23b A G 2: 144,423,893 (GRCm39) H514R probably benign Het
Serbp1 T A 6: 67,249,204 (GRCm39) D223E probably benign Het
Slc14a1 C A 18: 78,154,607 (GRCm39) V260L probably benign Het
Slc22a23 A G 13: 34,367,109 (GRCm39) I633T probably damaging Het
Stk19 A T 17: 35,043,723 (GRCm39) probably benign Het
Svs5 T C 2: 164,079,047 (GRCm39) M287V probably benign Het
Syne3 T A 12: 104,924,325 (GRCm39) Q358L probably damaging Het
Synj1 A G 16: 90,806,984 (GRCm39) F58L possibly damaging Het
Tg T C 15: 66,545,872 (GRCm39) V198A probably damaging Het
Tle4 A T 19: 14,574,752 (GRCm39) Y9N probably damaging Het
Tmx3 G A 18: 90,542,459 (GRCm39) A186T possibly damaging Het
Traf3 G A 12: 111,221,679 (GRCm39) S280N possibly damaging Het
Trmt13 A G 3: 116,375,167 (GRCm39) F447S probably damaging Het
Trp53bp1 T A 2: 121,059,107 (GRCm39) H918L probably damaging Het
Ush2a T G 1: 188,460,701 (GRCm39) V2654G probably benign Het
Vinac1 A G 2: 128,881,521 (GRCm39) L135P probably damaging Het
Vmn2r25 A G 6: 123,817,057 (GRCm39) Y175H probably damaging Het
Zfp335 T C 2: 164,734,109 (GRCm39) D1330G probably damaging Het
Other mutations in Or4f15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Or4f15 APN 2 111,814,278 (GRCm39) missense probably damaging 1.00
IGL02479:Or4f15 APN 2 111,813,730 (GRCm39) missense probably benign 0.35
R0234:Or4f15 UTSW 2 111,813,645 (GRCm39) missense probably damaging 0.99
R0234:Or4f15 UTSW 2 111,813,645 (GRCm39) missense probably damaging 0.99
R1777:Or4f15 UTSW 2 111,814,042 (GRCm39) missense possibly damaging 0.64
R1994:Or4f15 UTSW 2 111,814,429 (GRCm39) missense probably benign
R3892:Or4f15 UTSW 2 111,813,486 (GRCm39) missense probably benign 0.03
R4541:Or4f15 UTSW 2 111,813,981 (GRCm39) missense probably benign 0.01
R5150:Or4f15 UTSW 2 111,814,366 (GRCm39) missense probably benign 0.11
R5275:Or4f15 UTSW 2 111,814,174 (GRCm39) missense probably damaging 1.00
R5293:Or4f15 UTSW 2 111,813,611 (GRCm39) missense probably damaging 0.99
R6080:Or4f15 UTSW 2 111,814,050 (GRCm39) missense probably damaging 1.00
R6258:Or4f15 UTSW 2 111,814,396 (GRCm39) missense probably benign 0.05
R6260:Or4f15 UTSW 2 111,814,396 (GRCm39) missense probably benign 0.05
R6291:Or4f15 UTSW 2 111,813,969 (GRCm39) missense probably benign 0.00
R6442:Or4f15 UTSW 2 111,813,874 (GRCm39) missense probably damaging 0.99
R7013:Or4f15 UTSW 2 111,814,308 (GRCm39) missense probably benign 0.31
R7326:Or4f15 UTSW 2 111,813,672 (GRCm39) nonsense probably null
R7483:Or4f15 UTSW 2 111,814,124 (GRCm39) missense probably damaging 0.98
R8078:Or4f15 UTSW 2 111,813,615 (GRCm39) missense probably damaging 1.00
R9055:Or4f15 UTSW 2 111,814,049 (GRCm39) nonsense probably null
R9800:Or4f15 UTSW 2 111,814,194 (GRCm39) missense possibly damaging 0.91
X0062:Or4f15 UTSW 2 111,813,946 (GRCm39) missense probably benign 0.00
Z1176:Or4f15 UTSW 2 111,814,098 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TGGTACCTTCTTTGAAATGTCCATG -3'
(R):5'- TCAACAGTGGGCTCATTTCTG -3'

Sequencing Primer
(F):5'- ACCTTCTTTGAAATGTCCATGATGGG -3'
(R):5'- GTGGGCTCCTTTCTTCTACTGG -3'
Posted On 2015-04-17