Incidental Mutation 'R3947:Tdrd3'
ID 307763
Institutional Source Beutler Lab
Gene Symbol Tdrd3
Ensembl Gene ENSMUSG00000022019
Gene Name tudor domain containing 3
Synonyms 4732418C03Rik
MMRRC Submission 040927-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.429) question?
Stock # R3947 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 87654075-87782940 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87744035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 655 (D655V)
Ref Sequence ENSEMBL: ENSMUSP00000126189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168275] [ENSMUST00000169504] [ENSMUST00000170865]
AlphaFold Q91W18
Predicted Effect probably damaging
Transcript: ENSMUST00000168275
AA Change: D661V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129019
Gene: ENSMUSG00000022019
AA Change: D661V

DomainStartEndE-ValueType
DUF1767 6 88 4.85e-24 SMART
low complexity region 269 280 N/A INTRINSIC
UBA 288 325 1.67e-7 SMART
low complexity region 338 348 N/A INTRINSIC
low complexity region 446 460 N/A INTRINSIC
TUDOR 646 705 1.07e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000169504
AA Change: D661V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131542
Gene: ENSMUSG00000022019
AA Change: D661V

DomainStartEndE-ValueType
DUF1767 6 88 4.85e-24 SMART
low complexity region 269 280 N/A INTRINSIC
UBA 288 325 1.67e-7 SMART
low complexity region 338 348 N/A INTRINSIC
low complexity region 446 460 N/A INTRINSIC
TUDOR 646 705 1.07e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170865
AA Change: D655V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126189
Gene: ENSMUSG00000022019
AA Change: D655V

DomainStartEndE-ValueType
DUF1767 3 82 1.36e-18 SMART
low complexity region 263 274 N/A INTRINSIC
UBA 282 319 1.67e-7 SMART
low complexity region 332 342 N/A INTRINSIC
low complexity region 440 454 N/A INTRINSIC
TUDOR 640 699 1.07e-7 SMART
Meta Mutation Damage Score 0.9172 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 97% (32/33)
MGI Phenotype PHENOTYPE: Homozygous mice for a hypomorphic allele show increased genomic instability, and increased c-Myc/Igh translocation and R loop formation in B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 T A 14: 54,916,790 (GRCm39) Q133L possibly damaging Het
Adgrg4 C T X: 55,963,114 (GRCm39) T1561I probably benign Het
Avl9 T C 6: 56,705,650 (GRCm39) probably null Het
C87436 T A 6: 86,423,168 (GRCm39) H247Q probably damaging Het
Cfap43 G T 19: 47,754,418 (GRCm39) H969N probably benign Het
Chst15 T A 7: 131,849,604 (GRCm39) N446Y probably damaging Het
Col4a3 T A 1: 82,693,053 (GRCm39) I1446N probably damaging Het
Disc1 A G 8: 125,814,874 (GRCm39) E246G probably damaging Het
Dyrk4 A G 6: 126,862,268 (GRCm39) I408T probably damaging Het
Fnbp1l G T 3: 122,338,228 (GRCm39) A481D possibly damaging Het
Gm10608 TACACACACACACACACACACACACACACACACACACACACACACACACACACACA TACACACACACACACACACACACACACACACACACACACACACACACACA 9: 118,989,730 (GRCm39) probably benign Het
Grk2 G A 19: 4,342,445 (GRCm39) T129M possibly damaging Het
Ino80d G T 1: 63,113,662 (GRCm39) Q263K probably benign Het
Iqsec3 A T 6: 121,364,783 (GRCm39) Y835* probably null Het
Irak3 T A 10: 120,006,278 (GRCm39) M213L probably benign Het
Macf1 T C 4: 123,274,213 (GRCm39) R6388G probably damaging Het
Mtnr1a T C 8: 45,540,557 (GRCm39) Y173H probably damaging Het
Myo5b C T 18: 74,828,474 (GRCm39) R709W probably damaging Het
Nebl A T 2: 17,382,917 (GRCm39) probably null Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or2g1 A T 17: 38,107,006 (GRCm39) I224L probably benign Het
Pex11g G A 8: 3,515,787 (GRCm39) T82I probably benign Het
Pgr A G 9: 8,961,453 (GRCm39) I842V probably benign Het
Pkd1 T A 17: 24,797,011 (GRCm39) probably benign Het
Rbm20 T C 19: 53,801,768 (GRCm39) I92T probably benign Het
Ryr3 C G 2: 112,506,218 (GRCm39) R3443P probably damaging Het
Ssh2 A G 11: 77,289,082 (GRCm39) D88G probably damaging Het
Suclg2 G T 6: 95,556,219 (GRCm39) probably null Het
Tex2 C T 11: 106,410,829 (GRCm39) D896N unknown Het
Tmem168 C A 6: 13,583,051 (GRCm39) R610L probably damaging Het
Ttc17 A G 2: 94,206,491 (GRCm39) probably benign Het
Vmn2r99 T C 17: 19,599,252 (GRCm39) M312T probably benign Het
Wdfy3 T C 5: 102,017,902 (GRCm39) E2546G probably damaging Het
Other mutations in Tdrd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Tdrd3 APN 14 87,709,618 (GRCm39) missense probably damaging 1.00
IGL01339:Tdrd3 APN 14 87,718,230 (GRCm39) missense possibly damaging 0.75
IGL01565:Tdrd3 APN 14 87,709,668 (GRCm39) missense probably benign 0.01
IGL02505:Tdrd3 APN 14 87,749,118 (GRCm39) missense probably damaging 1.00
R0121:Tdrd3 UTSW 14 87,776,915 (GRCm39) missense probably damaging 1.00
R0550:Tdrd3 UTSW 14 87,723,656 (GRCm39) missense probably damaging 1.00
R0648:Tdrd3 UTSW 14 87,709,618 (GRCm39) missense probably damaging 1.00
R1080:Tdrd3 UTSW 14 87,743,834 (GRCm39) missense probably benign 0.00
R1099:Tdrd3 UTSW 14 87,724,675 (GRCm39) missense probably damaging 1.00
R1126:Tdrd3 UTSW 14 87,718,210 (GRCm39) missense probably damaging 1.00
R1370:Tdrd3 UTSW 14 87,695,490 (GRCm39) intron probably benign
R1592:Tdrd3 UTSW 14 87,743,322 (GRCm39) missense probably damaging 1.00
R1881:Tdrd3 UTSW 14 87,723,783 (GRCm39) splice site probably null
R2096:Tdrd3 UTSW 14 87,743,788 (GRCm39) nonsense probably null
R2162:Tdrd3 UTSW 14 87,718,221 (GRCm39) missense probably damaging 0.98
R3833:Tdrd3 UTSW 14 87,718,221 (GRCm39) missense probably damaging 0.98
R4421:Tdrd3 UTSW 14 87,723,719 (GRCm39) missense probably damaging 1.00
R4783:Tdrd3 UTSW 14 87,709,537 (GRCm39) missense probably damaging 1.00
R4957:Tdrd3 UTSW 14 87,743,223 (GRCm39) missense probably benign 0.06
R5212:Tdrd3 UTSW 14 87,743,651 (GRCm39) missense probably damaging 0.98
R5291:Tdrd3 UTSW 14 87,743,234 (GRCm39) missense probably benign 0.21
R5318:Tdrd3 UTSW 14 87,714,899 (GRCm39) critical splice donor site probably null
R5383:Tdrd3 UTSW 14 87,718,227 (GRCm39) nonsense probably null
R5718:Tdrd3 UTSW 14 87,743,876 (GRCm39) missense probably benign 0.05
R6240:Tdrd3 UTSW 14 87,743,322 (GRCm39) missense probably damaging 1.00
R6292:Tdrd3 UTSW 14 87,743,690 (GRCm39) missense probably benign
R6532:Tdrd3 UTSW 14 87,743,252 (GRCm39) missense probably damaging 0.98
R6850:Tdrd3 UTSW 14 87,695,515 (GRCm39) intron probably benign
R6958:Tdrd3 UTSW 14 87,694,532 (GRCm39) missense probably damaging 1.00
R7224:Tdrd3 UTSW 14 87,714,839 (GRCm39) missense probably damaging 1.00
R7240:Tdrd3 UTSW 14 87,696,239 (GRCm39) missense probably benign 0.06
R7565:Tdrd3 UTSW 14 87,744,029 (GRCm39) nonsense probably null
R7818:Tdrd3 UTSW 14 87,709,636 (GRCm39) missense probably damaging 1.00
R7861:Tdrd3 UTSW 14 87,709,590 (GRCm39) missense probably damaging 1.00
R8108:Tdrd3 UTSW 14 87,723,702 (GRCm39) missense possibly damaging 0.95
R8206:Tdrd3 UTSW 14 87,749,214 (GRCm39) missense probably benign 0.11
R8383:Tdrd3 UTSW 14 87,743,744 (GRCm39) missense probably benign 0.26
R8786:Tdrd3 UTSW 14 87,709,637 (GRCm39) nonsense probably null
R8985:Tdrd3 UTSW 14 87,743,597 (GRCm39) missense possibly damaging 0.69
R9081:Tdrd3 UTSW 14 87,743,717 (GRCm39) missense probably benign 0.00
R9520:Tdrd3 UTSW 14 87,724,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGACCGATTAAGTCAGCAGG -3'
(R):5'- CTGCGTGAACTATGGCTGAAC -3'

Sequencing Primer
(F):5'- AGGACCTGTCACAGCTGTG -3'
(R):5'- GAGTACCACGAGAATATTGC -3'
Posted On 2015-04-17