Incidental Mutation 'R3950:Or5w10'
ID 307850
Institutional Source Beutler Lab
Gene Symbol Or5w10
Ensembl Gene ENSMUSG00000075156
Gene Name olfactory receptor family 5 subfamily W member 10
Synonyms MOR176-3, Olfr1128, GA_x6K02T2Q125-49048592-49047657
MMRRC Submission 040930-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R3950 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87374951-87375886 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87375409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 160 (T160A)
Ref Sequence ENSEMBL: ENSMUSP00000099684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102624]
AlphaFold Q7TR47
Predicted Effect probably damaging
Transcript: ENSMUST00000102624
AA Change: T160A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099684
Gene: ENSMUSG00000075156
AA Change: T160A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.3e-46 PFAM
Pfam:7tm_1 41 290 3.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120590
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik T C 2: 68,494,747 (GRCm39) probably null Het
Ahnak2 A T 12: 112,749,409 (GRCm39) I186N probably damaging Het
Appbp2 A G 11: 85,085,532 (GRCm39) I458T probably damaging Het
Arhgef25 T C 10: 127,021,013 (GRCm39) Y291C probably damaging Het
Ate1 T C 7: 130,069,022 (GRCm39) Y415C probably damaging Het
B4galt4 G T 16: 38,588,384 (GRCm39) A72S probably benign Het
C3 T C 17: 57,532,286 (GRCm39) R178G probably benign Het
Cdh23 T C 10: 60,493,105 (GRCm39) Y3C probably benign Het
Col11a1 T C 3: 113,915,094 (GRCm39) probably null Het
Col22a1 A G 15: 71,849,207 (GRCm39) F294L possibly damaging Het
Dera A G 6: 137,814,118 (GRCm39) Y100C probably damaging Het
Dync2h1 A T 9: 7,112,061 (GRCm39) Y276* probably null Het
Eea1 A T 10: 95,877,996 (GRCm39) N1389I probably damaging Het
Epha4 A T 1: 77,376,353 (GRCm39) Y509N probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Fezf1 T A 6: 23,247,419 (GRCm39) K219* probably null Het
Fsd1 G A 17: 56,302,517 (GRCm39) probably null Het
Haspin A G 11: 73,027,221 (GRCm39) Y623H probably damaging Het
Hsd3b1 C T 3: 98,763,454 (GRCm39) V56M possibly damaging Het
Hyou1 C T 9: 44,296,524 (GRCm39) T483I probably damaging Het
Kdm2a A G 19: 4,393,260 (GRCm39) L365S possibly damaging Het
Kdm6b G T 11: 69,296,441 (GRCm39) P609T probably damaging Het
Klhl18 T A 9: 110,257,970 (GRCm39) Y490F probably damaging Het
Ky C T 9: 102,419,627 (GRCm39) Q545* probably null Het
L1td1 T C 4: 98,625,590 (GRCm39) L595P probably benign Het
Map3k20 T G 2: 72,268,644 (GRCm39) I550M probably damaging Het
Mug1 T A 6: 121,855,489 (GRCm39) V941E probably damaging Het
Ndst1 T C 18: 60,830,211 (GRCm39) N633S probably benign Het
Ninl A T 2: 150,794,408 (GRCm39) I740K possibly damaging Het
Npepl1 A G 2: 173,962,906 (GRCm39) N431D probably damaging Het
Pacs2 T C 12: 113,024,733 (GRCm39) S408P probably damaging Het
Pard6b C T 2: 167,941,114 (GRCm39) T367I probably damaging Het
Pcdhga7 A G 18: 37,849,568 (GRCm39) E525G probably damaging Het
Pctp A G 11: 89,878,144 (GRCm39) I130T probably benign Het
Pcx C T 19: 4,667,995 (GRCm39) H506Y probably benign Het
Pdhx A G 2: 102,865,586 (GRCm39) S199P probably damaging Het
Pdia2 C A 17: 26,416,590 (GRCm39) probably null Het
Pif1 C A 9: 65,499,116 (GRCm39) N445K probably damaging Het
Prickle4 T C 17: 47,999,507 (GRCm39) K349E probably benign Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptpdc1 A T 13: 48,742,670 (GRCm39) M173K probably damaging Het
Rb1 A G 14: 73,500,102 (GRCm39) L515P probably damaging Het
Rcvrn A G 11: 67,590,877 (GRCm39) K154E probably damaging Het
Ros1 C T 10: 51,942,484 (GRCm39) V2059I probably damaging Het
Rtn4ip1 T A 10: 43,785,893 (GRCm39) probably null Het
Sema5a T C 15: 32,689,484 (GRCm39) Y1050H probably damaging Het
Slc25a28 C T 19: 43,652,708 (GRCm39) V318I probably benign Het
Srek1 G A 13: 103,881,403 (GRCm39) R408W unknown Het
Synrg C T 11: 83,880,641 (GRCm39) T444I probably damaging Het
Ticrr T C 7: 79,331,817 (GRCm39) L776S probably damaging Het
Tmem127 T C 2: 127,090,577 (GRCm39) L31P probably damaging Het
Tmprss15 T A 16: 78,870,074 (GRCm39) T190S probably benign Het
Trip10 T A 17: 57,560,411 (GRCm39) probably null Het
Ttc6 A G 12: 57,696,292 (GRCm39) Y31C probably damaging Het
Unc80 A T 1: 66,661,729 (GRCm39) H1718L possibly damaging Het
Zbtb38 A G 9: 96,569,599 (GRCm39) F495S probably damaging Het
Zfp280d G T 9: 72,203,301 (GRCm39) Q16H possibly damaging Het
Zfp521 A G 18: 13,979,403 (GRCm39) S337P probably damaging Het
Zswim9 T A 7: 12,995,503 (GRCm39) T218S possibly damaging Het
Other mutations in Or5w10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or5w10 APN 2 87,375,447 (GRCm39) missense probably benign 0.00
IGL02638:Or5w10 APN 2 87,375,093 (GRCm39) missense probably damaging 1.00
IGL02749:Or5w10 APN 2 87,375,001 (GRCm39) missense probably damaging 1.00
R1650:Or5w10 UTSW 2 87,375,772 (GRCm39) missense probably benign 0.01
R1789:Or5w10 UTSW 2 87,375,327 (GRCm39) missense probably damaging 1.00
R2100:Or5w10 UTSW 2 87,375,169 (GRCm39) missense probably damaging 1.00
R2163:Or5w10 UTSW 2 87,375,238 (GRCm39) missense probably damaging 1.00
R3951:Or5w10 UTSW 2 87,375,409 (GRCm39) missense probably damaging 1.00
R3952:Or5w10 UTSW 2 87,375,409 (GRCm39) missense probably damaging 1.00
R6185:Or5w10 UTSW 2 87,375,087 (GRCm39) missense possibly damaging 0.87
R8493:Or5w10 UTSW 2 87,375,114 (GRCm39) missense probably damaging 1.00
R8869:Or5w10 UTSW 2 87,375,753 (GRCm39) missense probably damaging 1.00
Z1176:Or5w10 UTSW 2 87,374,965 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCAGATGGTCGCAATGATGTAG -3'
(R):5'- GGATTCCTTGCAATTTATGTGCTC -3'

Sequencing Primer
(F):5'- TGGTCGCAATGATGTAGCAGTAG -3'
(R):5'- CTTGCAATTTATGTGCTCTTCAGATG -3'
Posted On 2015-04-17