Mutagenetix > Incidental Mutations

Incidental Mutation 'R3950:Olfr1128'

307850

Institutional Source

Beutler Lab

Gene Symbol

Olfr1128

Ensembl Gene

ENSMUSG00000075156

Gene Name

olfactory receptor 1128

Synonyms

GA_x6K02T2Q125-49048592-49047657, MOR176-3

MMRRC Submission

040930-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R3950 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

87544607-87545542 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 87545065 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 160 (T160A)

Ref Sequence

ENSEMBL: ENSMUSP00000099684 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102624]

AlphaFold

Q7TR47

Predicted Effect

probably damaging
Transcript: ENSMUST00000102624
AA Change: T160A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000099684
Gene: ENSMUSG00000075156
AA Change: T160A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	5.3e-46	PFAM
Pfam:7tm_1	41	290	3.2e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120590

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	T	C	2: 68,664,403		probably null	Het
Ahnak2	A	T	12: 112,785,789	I186N	probably damaging	Het
Appbp2	A	G	11: 85,194,706	I458T	probably damaging	Het
Arhgef25	T	C	10: 127,185,144	Y291C	probably damaging	Het
Ate1	T	C	7: 130,467,292	Y415C	probably damaging	Het
B4galt4	G	T	16: 38,768,022	A72S	probably benign	Het
C3	T	C	17: 57,225,286	R178G	probably benign	Het
Cdh23	T	C	10: 60,657,326	Y3C	probably benign	Het
Col11a1	T	C	3: 114,121,445		probably null	Het
Col22a1	A	G	15: 71,977,358	F294L	possibly damaging	Het
Dera	A	G	6: 137,837,120	Y100C	probably damaging	Het
Dync2h1	A	T	9: 7,112,061	Y276*	probably null	Het
Eea1	A	T	10: 96,042,134	N1389I	probably damaging	Het
Epha4	A	T	1: 77,399,716	Y509N	probably damaging	Het
Fat3	G	A	9: 15,998,271	S2145F	probably damaging	Het
Fezf1	T	A	6: 23,247,420	K219*	probably null	Het
Fsd1	G	A	17: 55,995,517		probably null	Het
Haspin	A	G	11: 73,136,395	Y623H	probably damaging	Het
Hsd3b1	C	T	3: 98,856,138	V56M	possibly damaging	Het
Hyou1	C	T	9: 44,385,227	T483I	probably damaging	Het
Kdm2a	A	G	19: 4,343,232	L365S	possibly damaging	Het
Kdm6b	G	T	11: 69,405,615	P609T	probably damaging	Het
Klhl18	T	A	9: 110,428,902	Y490F	probably damaging	Het
Ky	C	T	9: 102,542,428	Q545*	probably null	Het
L1td1	T	C	4: 98,737,353	L595P	probably benign	Het
Map3k20	T	G	2: 72,438,300	I550M	probably damaging	Het
Mug1	T	A	6: 121,878,530	V941E	probably damaging	Het
Ndst1	T	C	18: 60,697,139	N633S	probably benign	Het
Ninl	A	T	2: 150,952,488	I740K	possibly damaging	Het
Npepl1	A	G	2: 174,121,113	N431D	probably damaging	Het
Pacs2	T	C	12: 113,061,113	S408P	probably damaging	Het
Pard6b	C	T	2: 168,099,194	T367I	probably damaging	Het
Pcdhga7	A	G	18: 37,716,515	E525G	probably damaging	Het
Pctp	A	G	11: 89,987,318	I130T	probably benign	Het
Pcx	C	T	19: 4,617,967	H506Y	probably benign	Het
Pdhx	A	G	2: 103,035,241	S199P	probably damaging	Het
Pdia2	C	A	17: 26,197,616		probably null	Het
Pif1	C	A	9: 65,591,834	N445K	probably damaging	Het
Prickle4	T	C	17: 47,688,582	K349E	probably benign	Het
Ptch1	T	G	13: 63,524,959	E944A	probably benign	Het
Ptpdc1	A	T	13: 48,589,194	M173K	probably damaging	Het
Rb1	A	G	14: 73,262,662	L515P	probably damaging	Het
Rcvrn	A	G	11: 67,700,051	K154E	probably damaging	Het
Ros1	C	T	10: 52,066,388	V2059I	probably damaging	Het
Rtn4ip1	T	A	10: 43,909,897		probably null	Het
Sema5a	T	C	15: 32,689,338	Y1050H	probably damaging	Het
Slc25a28	C	T	19: 43,664,269	V318I	probably benign	Het
Srek1	G	A	13: 103,744,895	R408W	unknown	Het
Synrg	C	T	11: 83,989,815	T444I	probably damaging	Het
Ticrr	T	C	7: 79,682,069	L776S	probably damaging	Het
Tmem127	T	C	2: 127,248,657	L31P	probably damaging	Het
Tmprss15	T	A	16: 79,073,186	T190S	probably benign	Het
Trip10	T	A	17: 57,253,411		probably null	Het
Ttc6	A	G	12: 57,649,506	Y31C	probably damaging	Het
Unc80	A	T	1: 66,622,570	H1718L	possibly damaging	Het
Zbtb38	A	G	9: 96,687,546	F495S	probably damaging	Het
Zfp280d	G	T	9: 72,296,019	Q16H	possibly damaging	Het
Zfp521	A	G	18: 13,846,346	S337P	probably damaging	Het
Zswim9	T	A	7: 13,261,577	T218S	possibly damaging	Het

Other mutations in Olfr1128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02122:Olfr1128	APN	2	87545103	missense	probably benign	0.00
IGL02638:Olfr1128	APN	2	87544749	missense	probably damaging	1.00
IGL02749:Olfr1128	APN	2	87544657	missense	probably damaging	1.00
R1650:Olfr1128	UTSW	2	87545428	missense	probably benign	0.01
R1789:Olfr1128	UTSW	2	87544983	missense	probably damaging	1.00
R2100:Olfr1128	UTSW	2	87544825	missense	probably damaging	1.00
R2163:Olfr1128	UTSW	2	87544894	missense	probably damaging	1.00
R3951:Olfr1128	UTSW	2	87545065	missense	probably damaging	1.00
R3952:Olfr1128	UTSW	2	87545065	missense	probably damaging	1.00
R6185:Olfr1128	UTSW	2	87544743	missense	possibly damaging	0.87
R8493:Olfr1128	UTSW	2	87544770	missense	probably damaging	1.00
R8869:Olfr1128	UTSW	2	87545409	missense	probably damaging	1.00
Z1176:Olfr1128	UTSW	2	87544621	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCAGATGGTCGCAATGATGTAG -3'
(R):5'- GGATTCCTTGCAATTTATGTGCTC -3'

Sequencing Primer
(F):5'- TGGTCGCAATGATGTAGCAGTAG -3'
(R):5'- CTTGCAATTTATGTGCTCTTCAGATG -3'

Posted On

2015-04-17