Incidental Mutation 'R3951:Or5w10'
ID 307920
Institutional Source Beutler Lab
Gene Symbol Or5w10
Ensembl Gene ENSMUSG00000075156
Gene Name olfactory receptor family 5 subfamily W member 10
Synonyms MOR176-3, Olfr1128, GA_x6K02T2Q125-49048592-49047657
MMRRC Submission 040828-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R3951 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87374951-87375886 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87375409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 160 (T160A)
Ref Sequence ENSEMBL: ENSMUSP00000099684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102624]
AlphaFold Q7TR47
Predicted Effect probably damaging
Transcript: ENSMUST00000102624
AA Change: T160A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000099684
Gene: ENSMUSG00000075156
AA Change: T160A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.3e-46 PFAM
Pfam:7tm_1 41 290 3.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120590
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,451,158 (GRCm39) probably benign Het
4932414N04Rik T C 2: 68,494,747 (GRCm39) probably null Het
Akr1c18 C T 13: 4,185,284 (GRCm39) V283I probably benign Het
Atp2b2 T A 6: 113,737,792 (GRCm39) M861L possibly damaging Het
Cdh23 T C 10: 60,493,105 (GRCm39) Y3C probably benign Het
Clspn A G 4: 126,470,172 (GRCm39) E814G probably damaging Het
Csgalnact1 T C 8: 68,913,914 (GRCm39) Q97R probably benign Het
Dera A G 6: 137,814,118 (GRCm39) Y100C probably damaging Het
Ect2 A T 3: 27,184,269 (GRCm39) D517E probably benign Het
Epha4 A T 1: 77,376,353 (GRCm39) Y509N probably damaging Het
Fat2 T C 11: 55,187,208 (GRCm39) T1213A probably benign Het
Fkbp8 T A 8: 70,985,311 (GRCm39) L275Q probably damaging Het
Gabrb2 A G 11: 42,517,708 (GRCm39) Y510C probably damaging Het
Gda T C 19: 21,449,809 (GRCm39) T16A probably benign Het
Ggcx G A 6: 72,403,541 (GRCm39) G363R probably benign Het
Gm527 T G 12: 64,970,276 (GRCm39) probably benign Het
Hoxb2 A G 11: 96,244,001 (GRCm39) E204G probably damaging Het
Hsd17b11 G A 5: 104,140,803 (GRCm39) probably benign Het
Kat14 T C 2: 144,249,249 (GRCm39) probably benign Het
Kif16b C T 2: 142,549,279 (GRCm39) V1079I probably benign Het
Klhl29 T A 12: 5,190,660 (GRCm39) S112C probably damaging Het
Lpcat2 G T 8: 93,591,531 (GRCm39) M58I probably benign Het
Lrrc8d G T 5: 105,962,142 (GRCm39) V851F probably benign Het
Ltbp3 T C 19: 5,806,029 (GRCm39) V929A probably damaging Het
Map3k20 T G 2: 72,268,644 (GRCm39) I550M probably damaging Het
Map3k9 T C 12: 81,769,295 (GRCm39) M941V probably benign Het
Myom2 A T 8: 15,134,556 (GRCm39) Y453F probably benign Het
Ncapd2 T C 6: 125,163,747 (GRCm39) K78E probably damaging Het
Ncor2 G T 5: 125,109,320 (GRCm39) D1496E possibly damaging Het
Ndnf T C 6: 65,680,125 (GRCm39) Y135H possibly damaging Het
Ndst1 T C 18: 60,830,211 (GRCm39) N633S probably benign Het
Nmur2 G C 11: 55,931,051 (GRCm39) P220R probably damaging Het
Nsd1 G C 13: 55,416,267 (GRCm39) E1438Q probably benign Het
Or5al7 G T 2: 85,992,962 (GRCm39) C110* probably null Het
Or8g2 A T 9: 39,822,021 (GRCm39) R307S probably benign Het
Or9s23 T A 1: 92,501,511 (GRCm39) M206K possibly damaging Het
Pom121l2 T G 13: 22,166,298 (GRCm39) S190A probably damaging Het
Prb1b G A 6: 132,289,657 (GRCm39) P56S unknown Het
Rtn4ip1 T A 10: 43,785,893 (GRCm39) probably null Het
Scarb1 A C 5: 125,364,475 (GRCm39) C85G probably damaging Het
Sh2d4b A G 14: 40,594,503 (GRCm39) I159T probably damaging Het
Skic3 T G 13: 76,278,338 (GRCm39) L551V probably damaging Het
Sntg1 C T 1: 8,853,125 (GRCm39) probably benign Het
Sos1 G A 17: 80,731,610 (GRCm39) T630I probably damaging Het
Spata7 T A 12: 98,635,732 (GRCm39) D517E probably damaging Het
Tcaf1 T C 6: 42,655,993 (GRCm39) T328A probably benign Het
Ticrr T C 7: 79,331,817 (GRCm39) L776S probably damaging Het
Trpc2 T A 7: 101,742,781 (GRCm39) M597K probably damaging Het
Tubb3 C A 8: 124,148,003 (GRCm39) T312N probably damaging Het
Ubr4 G A 4: 139,120,405 (GRCm39) V277M probably damaging Het
Uhrf2 G A 19: 30,057,261 (GRCm39) R473Q probably damaging Het
Vmn2r43 T A 7: 8,258,319 (GRCm39) H298L probably benign Het
Other mutations in Or5w10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or5w10 APN 2 87,375,447 (GRCm39) missense probably benign 0.00
IGL02638:Or5w10 APN 2 87,375,093 (GRCm39) missense probably damaging 1.00
IGL02749:Or5w10 APN 2 87,375,001 (GRCm39) missense probably damaging 1.00
R1650:Or5w10 UTSW 2 87,375,772 (GRCm39) missense probably benign 0.01
R1789:Or5w10 UTSW 2 87,375,327 (GRCm39) missense probably damaging 1.00
R2100:Or5w10 UTSW 2 87,375,169 (GRCm39) missense probably damaging 1.00
R2163:Or5w10 UTSW 2 87,375,238 (GRCm39) missense probably damaging 1.00
R3950:Or5w10 UTSW 2 87,375,409 (GRCm39) missense probably damaging 1.00
R3952:Or5w10 UTSW 2 87,375,409 (GRCm39) missense probably damaging 1.00
R6185:Or5w10 UTSW 2 87,375,087 (GRCm39) missense possibly damaging 0.87
R8493:Or5w10 UTSW 2 87,375,114 (GRCm39) missense probably damaging 1.00
R8869:Or5w10 UTSW 2 87,375,753 (GRCm39) missense probably damaging 1.00
Z1176:Or5w10 UTSW 2 87,374,965 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGATGGTCGCAATGATGTAGC -3'
(R):5'- GGATTCCTTGCAATTTATGTGCTC -3'

Sequencing Primer
(F):5'- TGGTCGCAATGATGTAGCAGTAG -3'
(R):5'- CTTGCAATTTATGTGCTCTTCAGATG -3'
Posted On 2015-04-17