Incidental Mutation 'R3954:Ndst4'
ID 308089
Institutional Source Beutler Lab
Gene Symbol Ndst4
Ensembl Gene ENSMUSG00000027971
Gene Name N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms 4930439H17Rik
MMRRC Submission 040831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R3954 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 125197725-125522548 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 125231554 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 41 (M41T)
Ref Sequence ENSEMBL: ENSMUSP00000133341 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173932]
AlphaFold Q9EQW8
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000144344
SMART Domains Protein: ENSMUSP00000120687
Gene: ENSMUSG00000027971

DomainStartEndE-ValueType
Pfam:HSNSD 19 505 1.3e-270 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147016
Predicted Effect probably benign
Transcript: ENSMUST00000173932
AA Change: M41T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000133341
Gene: ENSMUSG00000027971
AA Change: M41T

DomainStartEndE-ValueType
Pfam:HSNSD 20 505 1.2e-251 PFAM
Pfam:Sulfotransfer_1 594 857 1.2e-43 PFAM
Meta Mutation Damage Score 0.0604 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (42/43)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit a phenotype restricted to the colonic epithelium that includes an increased number of colon goblet cells, a decreased number of colonocytes, and increased apoptosis of colonic epithelial cells in the proximal colon. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,100,805 (GRCm39) K393E possibly damaging Het
Aagab A G 9: 63,526,442 (GRCm39) E155G probably damaging Het
Acad11 A G 9: 103,963,351 (GRCm39) probably benign Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
Ankle2 A G 5: 110,399,541 (GRCm39) T633A probably benign Het
Arhgef19 A G 4: 140,983,645 (GRCm39) Y726C probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
B3galnt2 A G 13: 14,141,039 (GRCm39) Q87R probably benign Het
Carmil1 A G 13: 24,197,390 (GRCm39) S1349P probably benign Het
Cfap52 C A 11: 67,821,691 (GRCm39) V446L probably benign Het
Cgnl1 T C 9: 71,631,945 (GRCm39) N469D probably benign Het
Clspn ACGGCGGCGGC A 4: 126,460,230 (GRCm39) probably null Het
Cpsf3 A G 12: 21,363,806 (GRCm39) D632G probably benign Het
Cyp3a57 A T 5: 145,286,135 (GRCm39) probably null Het
Dennd5a A G 7: 109,504,906 (GRCm39) M868T probably benign Het
Dlg1 T C 16: 31,676,826 (GRCm39) Y792H probably damaging Het
Dusp13b T A 14: 21,790,175 (GRCm39) D57V probably damaging Het
Galnt6 A G 15: 100,595,049 (GRCm39) V484A possibly damaging Het
Hbq1a T C 11: 32,250,214 (GRCm39) probably null Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igkv4-79 A G 6: 69,020,229 (GRCm39) S29P possibly damaging Het
Lamp5 G A 2: 135,902,928 (GRCm39) D216N probably damaging Het
Me2 A G 18: 73,914,203 (GRCm39) F443L probably damaging Het
Ncam2 G A 16: 81,386,612 (GRCm39) V664M probably damaging Het
Nkx6-3 G T 8: 23,643,742 (GRCm39) A48S possibly damaging Het
Ntng2 A G 2: 29,097,547 (GRCm39) C305R probably damaging Het
Nup210l A T 3: 90,100,361 (GRCm39) R1462S possibly damaging Het
Odad1 A G 7: 45,591,100 (GRCm39) K192E probably damaging Het
Omd A T 13: 49,743,213 (GRCm39) I88F probably benign Het
Or51f1 A G 7: 102,505,824 (GRCm39) C222R probably damaging Het
Pi4k2a G A 19: 42,104,338 (GRCm39) A367T probably damaging Het
Pramel30 A C 4: 144,058,238 (GRCm39) M282L probably benign Het
Prph2 T C 17: 47,221,644 (GRCm39) F8L probably benign Het
Qng1 A G 13: 58,532,203 (GRCm39) S118P probably damaging Het
Rasgrf2 A G 13: 92,130,974 (GRCm39) S696P probably damaging Het
Slc26a1 T C 5: 108,821,448 (GRCm39) D147G possibly damaging Het
Tec T C 5: 72,939,520 (GRCm39) probably null Het
Tmem131l C A 3: 83,817,726 (GRCm39) C1257F probably damaging Het
Trim30d C T 7: 104,121,728 (GRCm39) G339D probably damaging Het
Ttc6 T C 12: 57,744,238 (GRCm39) V1290A probably benign Het
Vmn1r124 A G 7: 20,994,448 (GRCm39) V32A possibly damaging Het
Zc3h13 T A 14: 75,567,178 (GRCm39) S921T possibly damaging Het
Other mutations in Ndst4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00920:Ndst4 APN 3 125,231,860 (GRCm39) missense probably damaging 0.98
IGL00926:Ndst4 APN 3 125,355,102 (GRCm39) missense probably benign 0.01
IGL01292:Ndst4 APN 3 125,232,403 (GRCm39) missense probably damaging 1.00
IGL01797:Ndst4 APN 3 125,476,802 (GRCm39) missense probably damaging 0.99
R0004:Ndst4 UTSW 3 125,364,475 (GRCm39) missense probably benign 0.03
R0118:Ndst4 UTSW 3 125,405,210 (GRCm39) nonsense probably null
R0652:Ndst4 UTSW 3 125,405,188 (GRCm39) missense possibly damaging 0.93
R1437:Ndst4 UTSW 3 125,355,099 (GRCm39) missense probably damaging 0.97
R1502:Ndst4 UTSW 3 125,231,407 (GRCm39) start gained probably benign
R1900:Ndst4 UTSW 3 125,491,544 (GRCm39) splice site probably null
R1960:Ndst4 UTSW 3 125,232,331 (GRCm39) nonsense probably null
R2249:Ndst4 UTSW 3 125,231,823 (GRCm39) missense probably benign 0.16
R2334:Ndst4 UTSW 3 125,501,825 (GRCm39) missense possibly damaging 0.86
R2345:Ndst4 UTSW 3 125,501,769 (GRCm39) missense possibly damaging 0.95
R3617:Ndst4 UTSW 3 125,231,782 (GRCm39) missense probably benign 0.00
R3713:Ndst4 UTSW 3 125,355,154 (GRCm39) missense possibly damaging 0.93
R3715:Ndst4 UTSW 3 125,355,154 (GRCm39) missense possibly damaging 0.93
R4013:Ndst4 UTSW 3 125,476,819 (GRCm39) missense probably damaging 1.00
R4035:Ndst4 UTSW 3 125,232,385 (GRCm39) missense probably damaging 1.00
R4085:Ndst4 UTSW 3 125,403,131 (GRCm39) missense probably benign
R4496:Ndst4 UTSW 3 125,476,922 (GRCm39) missense probably damaging 1.00
R4498:Ndst4 UTSW 3 125,232,007 (GRCm39) missense probably damaging 1.00
R5187:Ndst4 UTSW 3 125,231,560 (GRCm39) missense probably damaging 0.98
R5233:Ndst4 UTSW 3 125,503,766 (GRCm39) missense probably damaging 1.00
R5518:Ndst4 UTSW 3 125,232,105 (GRCm39) missense probably benign
R5575:Ndst4 UTSW 3 125,231,479 (GRCm39) missense probably benign 0.41
R5687:Ndst4 UTSW 3 125,232,258 (GRCm39) missense possibly damaging 0.79
R5940:Ndst4 UTSW 3 125,355,068 (GRCm39) splice site probably benign
R6027:Ndst4 UTSW 3 125,507,025 (GRCm39) missense probably benign 0.38
R6406:Ndst4 UTSW 3 125,232,150 (GRCm39) missense probably benign
R6540:Ndst4 UTSW 3 125,515,801 (GRCm39) nonsense probably null
R6941:Ndst4 UTSW 3 125,403,160 (GRCm39) missense possibly damaging 0.93
R7108:Ndst4 UTSW 3 125,355,120 (GRCm39) missense probably damaging 0.96
R7269:Ndst4 UTSW 3 125,232,007 (GRCm39) missense probably damaging 1.00
R7278:Ndst4 UTSW 3 125,231,952 (GRCm39) missense probably benign 0.00
R7345:Ndst4 UTSW 3 125,508,308 (GRCm39) missense probably benign 0.07
R7405:Ndst4 UTSW 3 125,476,865 (GRCm39) missense probably benign
R7418:Ndst4 UTSW 3 125,501,800 (GRCm39) missense probably damaging 0.99
R7592:Ndst4 UTSW 3 125,364,436 (GRCm39) missense probably damaging 0.99
R7714:Ndst4 UTSW 3 125,364,493 (GRCm39) missense probably benign 0.08
R7955:Ndst4 UTSW 3 125,231,831 (GRCm39) nonsense probably null
R8070:Ndst4 UTSW 3 125,508,293 (GRCm39) missense probably damaging 1.00
R8412:Ndst4 UTSW 3 125,364,439 (GRCm39) missense possibly damaging 0.76
R8553:Ndst4 UTSW 3 125,503,756 (GRCm39) missense probably damaging 1.00
R8744:Ndst4 UTSW 3 125,506,989 (GRCm39) missense possibly damaging 0.94
R8933:Ndst4 UTSW 3 125,405,155 (GRCm39) missense probably damaging 0.99
R8940:Ndst4 UTSW 3 125,474,802 (GRCm39) start gained probably benign
R8984:Ndst4 UTSW 3 125,515,810 (GRCm39) missense probably damaging 1.00
R9147:Ndst4 UTSW 3 125,231,722 (GRCm39) missense probably damaging 1.00
R9148:Ndst4 UTSW 3 125,231,722 (GRCm39) missense probably damaging 1.00
R9194:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9196:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9202:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9203:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9217:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9311:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9355:Ndst4 UTSW 3 125,403,246 (GRCm39) missense probably damaging 1.00
R9402:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9415:Ndst4 UTSW 3 125,518,385 (GRCm39) missense probably benign 0.19
R9475:Ndst4 UTSW 3 125,508,296 (GRCm39) nonsense probably null
R9544:Ndst4 UTSW 3 125,476,808 (GRCm39) missense probably damaging 1.00
R9588:Ndst4 UTSW 3 125,476,808 (GRCm39) missense probably damaging 1.00
R9626:Ndst4 UTSW 3 125,476,829 (GRCm39) missense probably damaging 1.00
R9640:Ndst4 UTSW 3 125,232,196 (GRCm39) missense probably damaging 0.99
R9691:Ndst4 UTSW 3 125,518,344 (GRCm39) missense unknown
R9716:Ndst4 UTSW 3 125,232,211 (GRCm39) missense probably damaging 1.00
X0027:Ndst4 UTSW 3 125,231,595 (GRCm39) missense probably benign
Z1177:Ndst4 UTSW 3 125,364,389 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- TCTCCCATGATTTGCAATGGTTAC -3'
(R):5'- CGACTGGACTCCAAGATTGC -3'

Sequencing Primer
(F):5'- GGCAACATCTTAGTATATGTTCTCC -3'
(R):5'- GCTATAATATCTTGACCAAGTTGCG -3'
Posted On 2015-04-17