Incidental Mutation 'R3954:Omd'
ID 308118
Institutional Source Beutler Lab
Gene Symbol Omd
Ensembl Gene ENSMUSG00000048368
Gene Name osteomodulin
Synonyms osteoadherin, SLRR2C, OSAD
MMRRC Submission 040831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3954 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 49735938-49746088 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49743213 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 88 (I88F)
Ref Sequence ENSEMBL: ENSMUSP00000152066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021818] [ENSMUST00000065494] [ENSMUST00000221170]
AlphaFold O35103
Predicted Effect probably benign
Transcript: ENSMUST00000021818
SMART Domains Protein: ENSMUSP00000021818
Gene: ENSMUSG00000021391

DomainStartEndE-ValueType
coiled coil region 1 34 N/A INTRINSIC
Pfam:CENP-P 102 278 3.9e-89 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065494
AA Change: I88F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000065706
Gene: ENSMUSG00000048368
AA Change: I88F

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRRNT 61 95 3.14e-11 SMART
LRR 115 139 2.15e2 SMART
LRR 140 160 2.2e1 SMART
LRR 162 184 4.21e1 SMART
LRR 185 210 1.01e2 SMART
LRR 211 234 6.96e0 SMART
LRR 235 255 8.49e1 SMART
LRR 256 279 1.76e-1 SMART
LRR 300 322 7.8e1 SMART
Blast:LRR 330 353 6e-8 BLAST
low complexity region 385 391 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000221170
AA Change: I88F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221751
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (42/43)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in impaired cued contextual conditioning behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,100,805 (GRCm39) K393E possibly damaging Het
Aagab A G 9: 63,526,442 (GRCm39) E155G probably damaging Het
Acad11 A G 9: 103,963,351 (GRCm39) probably benign Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
Ankle2 A G 5: 110,399,541 (GRCm39) T633A probably benign Het
Arhgef19 A G 4: 140,983,645 (GRCm39) Y726C probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
B3galnt2 A G 13: 14,141,039 (GRCm39) Q87R probably benign Het
Carmil1 A G 13: 24,197,390 (GRCm39) S1349P probably benign Het
Cfap52 C A 11: 67,821,691 (GRCm39) V446L probably benign Het
Cgnl1 T C 9: 71,631,945 (GRCm39) N469D probably benign Het
Clspn ACGGCGGCGGC A 4: 126,460,230 (GRCm39) probably null Het
Cpsf3 A G 12: 21,363,806 (GRCm39) D632G probably benign Het
Cyp3a57 A T 5: 145,286,135 (GRCm39) probably null Het
Dennd5a A G 7: 109,504,906 (GRCm39) M868T probably benign Het
Dlg1 T C 16: 31,676,826 (GRCm39) Y792H probably damaging Het
Dusp13b T A 14: 21,790,175 (GRCm39) D57V probably damaging Het
Galnt6 A G 15: 100,595,049 (GRCm39) V484A possibly damaging Het
Hbq1a T C 11: 32,250,214 (GRCm39) probably null Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igkv4-79 A G 6: 69,020,229 (GRCm39) S29P possibly damaging Het
Lamp5 G A 2: 135,902,928 (GRCm39) D216N probably damaging Het
Me2 A G 18: 73,914,203 (GRCm39) F443L probably damaging Het
Ncam2 G A 16: 81,386,612 (GRCm39) V664M probably damaging Het
Ndst4 T C 3: 125,231,554 (GRCm39) M41T probably benign Het
Nkx6-3 G T 8: 23,643,742 (GRCm39) A48S possibly damaging Het
Ntng2 A G 2: 29,097,547 (GRCm39) C305R probably damaging Het
Nup210l A T 3: 90,100,361 (GRCm39) R1462S possibly damaging Het
Odad1 A G 7: 45,591,100 (GRCm39) K192E probably damaging Het
Or51f1 A G 7: 102,505,824 (GRCm39) C222R probably damaging Het
Pi4k2a G A 19: 42,104,338 (GRCm39) A367T probably damaging Het
Pramel30 A C 4: 144,058,238 (GRCm39) M282L probably benign Het
Prph2 T C 17: 47,221,644 (GRCm39) F8L probably benign Het
Qng1 A G 13: 58,532,203 (GRCm39) S118P probably damaging Het
Rasgrf2 A G 13: 92,130,974 (GRCm39) S696P probably damaging Het
Slc26a1 T C 5: 108,821,448 (GRCm39) D147G possibly damaging Het
Tec T C 5: 72,939,520 (GRCm39) probably null Het
Tmem131l C A 3: 83,817,726 (GRCm39) C1257F probably damaging Het
Trim30d C T 7: 104,121,728 (GRCm39) G339D probably damaging Het
Ttc6 T C 12: 57,744,238 (GRCm39) V1290A probably benign Het
Vmn1r124 A G 7: 20,994,448 (GRCm39) V32A possibly damaging Het
Zc3h13 T A 14: 75,567,178 (GRCm39) S921T possibly damaging Het
Other mutations in Omd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01976:Omd APN 13 49,743,119 (GRCm39) nonsense probably null
IGL01982:Omd APN 13 49,742,973 (GRCm39) missense possibly damaging 0.88
IGL02678:Omd APN 13 49,745,757 (GRCm39) missense probably benign 0.37
IGL03069:Omd APN 13 49,745,870 (GRCm39) utr 3 prime probably benign
R1036:Omd UTSW 13 49,743,447 (GRCm39) missense probably damaging 1.00
R4030:Omd UTSW 13 49,743,125 (GRCm39) missense probably benign 0.08
R4335:Omd UTSW 13 49,743,712 (GRCm39) missense probably benign 0.02
R5095:Omd UTSW 13 49,743,174 (GRCm39) missense possibly damaging 0.95
R5137:Omd UTSW 13 49,743,552 (GRCm39) missense probably benign 0.05
R5400:Omd UTSW 13 49,745,703 (GRCm39) missense probably benign 0.37
R5596:Omd UTSW 13 49,745,814 (GRCm39) missense probably benign 0.16
R5930:Omd UTSW 13 49,743,112 (GRCm39) missense possibly damaging 0.63
R6132:Omd UTSW 13 49,743,843 (GRCm39) missense probably damaging 0.97
R6294:Omd UTSW 13 49,743,467 (GRCm39) missense probably damaging 1.00
R6454:Omd UTSW 13 49,743,345 (GRCm39) missense probably damaging 0.99
R6680:Omd UTSW 13 49,743,004 (GRCm39) missense possibly damaging 0.74
R6704:Omd UTSW 13 49,743,349 (GRCm39) missense probably damaging 1.00
R6932:Omd UTSW 13 49,743,710 (GRCm39) missense probably damaging 1.00
R7427:Omd UTSW 13 49,745,745 (GRCm39) missense possibly damaging 0.68
R7884:Omd UTSW 13 49,743,630 (GRCm39) missense probably damaging 1.00
R7971:Omd UTSW 13 49,743,730 (GRCm39) missense probably benign 0.00
R8129:Omd UTSW 13 49,745,565 (GRCm39) missense probably damaging 0.99
R8399:Omd UTSW 13 49,743,345 (GRCm39) missense possibly damaging 0.50
R8914:Omd UTSW 13 49,745,718 (GRCm39) missense probably damaging 1.00
R8959:Omd UTSW 13 49,745,790 (GRCm39) missense possibly damaging 0.57
R8984:Omd UTSW 13 49,743,576 (GRCm39) missense possibly damaging 0.92
R9415:Omd UTSW 13 49,745,837 (GRCm39) missense probably benign
R9718:Omd UTSW 13 49,743,336 (GRCm39) missense probably damaging 1.00
R9723:Omd UTSW 13 49,743,838 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACGATTATGACCAAGAGCCAAATG -3'
(R):5'- CCCGTCCATGGCATTTGTTG -3'

Sequencing Primer
(F):5'- CCAAGAGCCAAATGAGGATTATGATC -3'
(R):5'- CATTATAACCAAGAAGGAGTCTTTCC -3'
Posted On 2015-04-17