Incidental Mutation 'R3926:Ogfod3'
ID 308293
Institutional Source Beutler Lab
Gene Symbol Ogfod3
Ensembl Gene ENSMUSG00000025169
Gene Name 2-oxoglutarate and iron-dependent oxygenase domain containing 3
Synonyms 1110031I02Rik
MMRRC Submission 040821-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R3926 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 121068419-121095474 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121074255 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 265 (T265A)
Ref Sequence ENSEMBL: ENSMUSP00000026169 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026169]
AlphaFold Q9D136
Predicted Effect probably damaging
Transcript: ENSMUST00000026169
AA Change: T265A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000026169
Gene: ENSMUSG00000025169
AA Change: T265A

DomainStartEndE-ValueType
transmembrane domain 39 61 N/A INTRINSIC
P4Hc 104 302 1.82e-25 SMART
Meta Mutation Damage Score 0.2954 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Ahnak G A 19: 8,983,692 (GRCm39) D1659N probably benign Het
Arfgap2 C T 2: 91,105,150 (GRCm39) R405W probably damaging Het
Asb14 T C 14: 26,619,695 (GRCm39) I48T possibly damaging Het
Astn1 A T 1: 158,407,227 (GRCm39) I559F possibly damaging Het
Atg7 C T 6: 114,650,639 (GRCm39) T83M possibly damaging Het
Bco1 T C 8: 117,854,211 (GRCm39) S379P probably benign Het
Becn2 T C 1: 175,748,852 (GRCm39) V306A probably benign Het
Bst1 T C 5: 43,997,796 (GRCm39) V265A possibly damaging Het
Car11 T C 7: 45,349,915 (GRCm39) F45L probably benign Het
Cdkl2 T C 5: 92,180,998 (GRCm39) I214V possibly damaging Het
Cluap1 T A 16: 3,729,398 (GRCm39) S141T probably damaging Het
Col11a1 C T 3: 113,883,773 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Corin T G 5: 72,529,473 (GRCm39) D294A probably damaging Het
Crct1 C A 3: 92,922,014 (GRCm39) probably benign Het
Ddx41 A G 13: 55,679,083 (GRCm39) L559P probably damaging Het
Ddx59 T A 1: 136,344,482 (GRCm39) V51D probably benign Het
Dennd1b A G 1: 139,071,697 (GRCm39) N397D probably benign Het
Evc2 T A 5: 37,540,574 (GRCm39) L590Q probably damaging Het
Fhl5 A T 4: 25,214,790 (GRCm39) probably benign Het
Flg2 A G 3: 93,110,522 (GRCm39) Y850C unknown Het
Gal3st2b G T 1: 93,868,512 (GRCm39) V246L probably benign Het
Jam3 A T 9: 27,017,701 (GRCm39) I29K possibly damaging Het
Klhl1 A T 14: 96,584,316 (GRCm39) C305S possibly damaging Het
Lims2 A G 18: 32,090,996 (GRCm39) S327G probably benign Het
Lynx1 A G 15: 74,623,205 (GRCm39) Y76H probably damaging Het
Mycbp2 G A 14: 103,441,936 (GRCm39) P1943L probably damaging Het
Myo3a A G 2: 22,455,053 (GRCm39) D86G probably damaging Het
Nkx3-2 T A 5: 41,919,223 (GRCm39) Q255L probably damaging Het
Notch3 C T 17: 32,372,531 (GRCm39) R641H possibly damaging Het
Nr2c2 T A 6: 92,137,382 (GRCm39) M431K probably damaging Het
Pcdh9 G T 14: 94,124,246 (GRCm39) Y641* probably null Het
Pcdha9 T A 18: 37,132,465 (GRCm39) D511E probably damaging Het
Pcdhgb8 A G 18: 37,895,443 (GRCm39) Y171C probably damaging Het
Pcnx1 T C 12: 82,005,505 (GRCm39) C1075R probably damaging Het
Pik3c3 C A 18: 30,444,382 (GRCm39) probably benign Het
Pkhd1 T C 1: 20,621,097 (GRCm39) T854A probably benign Het
Pycr1 T C 11: 120,532,961 (GRCm39) T100A probably benign Het
Rhof T C 5: 123,242,593 (GRCm39) probably null Het
Scn9a T A 2: 66,357,217 (GRCm39) D1028V possibly damaging Het
Serpina3f T C 12: 104,185,740 (GRCm39) I315T possibly damaging Het
Slc1a6 T A 10: 78,648,715 (GRCm39) S479T possibly damaging Het
Tmcc1 T C 6: 116,019,874 (GRCm39) D166G probably damaging Het
Trav3-3 A G 14: 53,903,828 (GRCm39) K49E probably benign Het
Usp28 T C 9: 48,942,223 (GRCm39) probably null Het
Utrn C T 10: 12,573,786 (GRCm39) V1095I probably benign Het
Zfp217 T C 2: 169,954,438 (GRCm39) D1038G probably damaging Het
Zfp709 A G 8: 72,644,397 (GRCm39) R609G probably damaging Het
Zfp729a T A 13: 67,768,310 (GRCm39) K640* probably null Het
Zfp986 A T 4: 145,619,090 (GRCm39) probably benign Het
Zkscan6 A T 11: 65,719,051 (GRCm39) H357L probably benign Het
Other mutations in Ogfod3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01954:Ogfod3 APN 11 121,093,851 (GRCm39) missense probably benign 0.06
IGL02398:Ogfod3 APN 11 121,093,851 (GRCm39) missense probably benign 0.06
IGL02458:Ogfod3 APN 11 121,091,749 (GRCm39) missense probably benign 0.22
IGL03411:Ogfod3 APN 11 121,068,630 (GRCm39) makesense probably null
PIT4403001:Ogfod3 UTSW 11 121,087,561 (GRCm39) critical splice donor site probably null
R0145:Ogfod3 UTSW 11 121,085,896 (GRCm39) splice site probably benign
R1302:Ogfod3 UTSW 11 121,074,300 (GRCm39) missense probably damaging 1.00
R4823:Ogfod3 UTSW 11 121,086,027 (GRCm39) missense probably benign 0.42
R4825:Ogfod3 UTSW 11 121,086,027 (GRCm39) missense probably benign 0.42
R4909:Ogfod3 UTSW 11 121,088,318 (GRCm39) missense probably damaging 1.00
R6378:Ogfod3 UTSW 11 121,093,761 (GRCm39) missense probably benign 0.01
R6953:Ogfod3 UTSW 11 121,093,824 (GRCm39) missense probably benign
R7051:Ogfod3 UTSW 11 121,086,031 (GRCm39) missense probably damaging 0.99
R7618:Ogfod3 UTSW 11 121,093,804 (GRCm39) missense probably damaging 0.96
R7741:Ogfod3 UTSW 11 121,074,362 (GRCm39) critical splice acceptor site probably null
R8112:Ogfod3 UTSW 11 121,095,376 (GRCm39) missense probably damaging 1.00
R8714:Ogfod3 UTSW 11 121,087,608 (GRCm39) missense possibly damaging 0.79
R9769:Ogfod3 UTSW 11 121,074,357 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCGCTTAGAGTAAAGGCCACC -3'
(R):5'- GGGTCCAAAGCCTCATTTCTG -3'

Sequencing Primer
(F):5'- GCTTAGAGTAAAGGCCACCTCACC -3'
(R):5'- AGGCGATCCACATTGACTG -3'
Posted On 2015-04-17