Incidental Mutation 'R3927:Slc37a2'
ID 308333
Institutional Source Beutler Lab
Gene Symbol Slc37a2
Ensembl Gene ENSMUSG00000032122
Gene Name solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms cI-2, ci2, G3PP, Slc37a1
MMRRC Submission 040822-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R3927 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 37227585-37255738 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37235507 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 338 (T338M)
Ref Sequence ENSEMBL: ENSMUSP00000124569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115068] [ENSMUST00000161114]
AlphaFold Q9WU81
Predicted Effect probably damaging
Transcript: ENSMUST00000115068
AA Change: T338M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110720
Gene: ENSMUSG00000032122
AA Change: T338M

DomainStartEndE-ValueType
Pfam:MFS_1 23 424 1.2e-40 PFAM
transmembrane domain 431 453 N/A INTRINSIC
transmembrane domain 460 482 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000161114
AA Change: T338M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124569
Gene: ENSMUSG00000032122
AA Change: T338M

DomainStartEndE-ValueType
Pfam:MFS_1 24 426 1.2e-40 PFAM
transmembrane domain 431 453 N/A INTRINSIC
transmembrane domain 460 482 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162018
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency 95% (40/42)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 A G 2: 103,708,218 probably null Het
Alpk1 T C 3: 127,677,716 H1039R probably damaging Het
Avpr1a A G 10: 122,449,711 S303G probably benign Het
Axdnd1 A G 1: 156,419,270 L79S probably damaging Het
Baz1a A G 12: 54,921,143 I667T possibly damaging Het
Bend5 A G 4: 111,448,605 Y282C possibly damaging Het
Clstn3 T C 6: 124,451,368 D438G probably damaging Het
Cog3 A G 14: 75,743,558 probably benign Het
Cyp2j6 T C 4: 96,553,288 N55S probably benign Het
Eif4b G A 15: 102,084,310 G101R probably damaging Het
Epha2 T C 4: 141,306,550 L40P probably damaging Het
Fig4 A G 10: 41,263,139 V356A probably benign Het
Hal T C 10: 93,514,026 probably benign Het
Helz A G 11: 107,685,292 Y1770C unknown Het
Meis3 A G 7: 16,177,494 T39A probably benign Het
Nod1 G T 6: 54,944,917 R139S probably benign Het
Olfr430 A T 1: 174,069,312 N5Y probably damaging Het
Pacsin3 C T 2: 91,262,941 probably null Het
Plekhh1 T A 12: 79,053,648 I130N probably damaging Het
Plxna2 G A 1: 194,746,157 E512K probably benign Het
Ppp1r9a A G 6: 5,057,531 I215M probably damaging Het
Ryr3 C G 2: 112,675,873 R3443P probably damaging Het
Sap130 A T 18: 31,674,382 H414L possibly damaging Het
Slc33a1 A G 3: 63,963,724 I156T probably benign Het
Spinkl T A 18: 44,169,163 probably null Het
Tmc5 T A 7: 118,652,655 L657* probably null Het
Tmem217 A G 17: 29,526,703 S18P probably damaging Het
Trim43a GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT 9: 88,582,989 probably benign Het
Tubb4a A G 17: 57,080,967 V353A probably benign Het
Ube3b T C 5: 114,415,680 F974L probably benign Het
Ubqln5 A G 7: 104,128,471 L382P probably damaging Het
Ufsp2 T A 8: 45,983,686 probably null Het
Unkl C T 17: 25,229,329 T66I probably damaging Het
Xrn2 T A 2: 147,038,189 N477K probably benign Het
Zfhx4 C T 3: 5,403,358 P2859S probably benign Het
Zzef1 T C 11: 72,858,382 S899P probably damaging Het
Zzz3 T C 3: 152,455,862 Y298H probably damaging Het
Other mutations in Slc37a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01643:Slc37a2 APN 9 37235553 splice site probably benign
IGL01719:Slc37a2 APN 9 37234178 missense probably damaging 1.00
IGL02039:Slc37a2 APN 9 37233684 missense probably damaging 0.98
IGL02286:Slc37a2 APN 9 37235159 missense probably damaging 1.00
IGL02951:Slc37a2 APN 9 37255315 missense probably benign 0.00
PIT4581001:Slc37a2 UTSW 9 37237405 missense probably benign 0.00
R0547:Slc37a2 UTSW 9 37233122 splice site probably null
R0689:Slc37a2 UTSW 9 37235550 splice site probably benign
R1301:Slc37a2 UTSW 9 37236881 missense probably benign 0.05
R4834:Slc37a2 UTSW 9 37235108 missense probably damaging 0.97
R5154:Slc37a2 UTSW 9 37231643 makesense probably null
R5292:Slc37a2 UTSW 9 37239157 nonsense probably null
R6150:Slc37a2 UTSW 9 37238347 missense probably damaging 1.00
R6959:Slc37a2 UTSW 9 37241334 missense probably benign
R7014:Slc37a2 UTSW 9 37233887 missense probably damaging 1.00
R7605:Slc37a2 UTSW 9 37237328 missense possibly damaging 0.71
R7974:Slc37a2 UTSW 9 37239125 splice site probably null
R8342:Slc37a2 UTSW 9 37238214 critical splice donor site probably null
R8419:Slc37a2 UTSW 9 37237430 missense probably benign 0.00
R9039:Slc37a2 UTSW 9 37237362 missense probably benign
R9314:Slc37a2 UTSW 9 37239186 missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- GCAATGATCACTTTTCTTAGGCCC -3'
(R):5'- TGTCAGGCTGCTGCAAACTC -3'

Sequencing Primer
(F):5'- TTAGGCCCACCCAGTCTAG -3'
(R):5'- AAACTCACCTGGTGGCTCTAG -3'
Posted On 2015-04-17