Incidental Mutation 'R3928:Trmo'
ID 308360
Institutional Source Beutler Lab
Gene Symbol Trmo
Ensembl Gene ENSMUSG00000028331
Gene Name tRNA methyltransferase O
Synonyms 5830415F09Rik
MMRRC Submission 040823-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3928 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 46376505-46389437 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 46382647 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 150 (G150S)
Ref Sequence ENSEMBL: ENSMUSP00000083752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030015] [ENSMUST00000086563] [ENSMUST00000151903]
AlphaFold Q562D6
Predicted Effect probably damaging
Transcript: ENSMUST00000030015
AA Change: G150S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030015
Gene: ENSMUSG00000028331
AA Change: G150S

DomainStartEndE-ValueType
Pfam:UPF0066 42 165 2.3e-45 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000086563
AA Change: G150S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083752
Gene: ENSMUSG00000028331
AA Change: G150S

DomainStartEndE-ValueType
Pfam:UPF0066 44 164 1.2e-46 PFAM
low complexity region 431 442 N/A INTRINSIC
low complexity region 443 456 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000151903
AA Change: G157S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119785
Gene: ENSMUSG00000028331
AA Change: G157S

DomainStartEndE-ValueType
Pfam:UPF0066 49 172 4.1e-45 PFAM
Meta Mutation Damage Score 0.5877 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 100% (48/48)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abr A T 11: 76,359,561 (GRCm39) H181Q probably benign Het
Atrx T C X: 104,923,523 (GRCm39) I157V possibly damaging Het
Birc6 A G 17: 74,918,170 (GRCm39) D1856G possibly damaging Het
Birc6 A G 17: 74,945,404 (GRCm39) T2811A probably damaging Het
Brsk2 T C 7: 141,552,155 (GRCm39) F108S probably damaging Het
Clasp2 C A 9: 113,735,173 (GRCm39) H1004N probably benign Het
Cntd1 G A 11: 101,178,345 (GRCm39) V315I probably benign Het
Col13a1 A G 10: 61,703,304 (GRCm39) probably benign Het
Ctps1 T A 4: 120,399,093 (GRCm39) H553L probably benign Het
Dpysl2 A G 14: 67,061,880 (GRCm39) I242T possibly damaging Het
Exoc3l C T 8: 106,017,549 (GRCm39) probably benign Het
Fam229a A G 4: 129,385,204 (GRCm39) probably benign Het
Fshr C T 17: 89,292,962 (GRCm39) R572H probably damaging Het
Gm5501 A G 18: 9,917,267 (GRCm39) noncoding transcript Het
Gmpr A G 13: 45,683,223 (GRCm39) I165V probably benign Het
Gnat3 G A 5: 18,208,892 (GRCm39) probably benign Het
H1f8 A G 6: 115,925,757 (GRCm39) K185E probably benign Het
H2-Q4 T G 17: 35,598,666 (GRCm39) L16R unknown Het
Hs2st1 T C 3: 144,140,389 (GRCm39) K311E possibly damaging Het
Kcnj15 A G 16: 95,097,368 (GRCm39) E330G possibly damaging Het
Kif3a A G 11: 53,461,441 (GRCm39) K29E probably benign Het
Krtap4-1 A G 11: 99,518,983 (GRCm39) V9A unknown Het
Lmntd2 C T 7: 140,791,117 (GRCm39) G432S probably damaging Het
Me3 T C 7: 89,482,898 (GRCm39) probably benign Het
Myo1d G T 11: 80,375,087 (GRCm39) R996S probably benign Het
Myo9a T A 9: 59,802,566 (GRCm39) W2018R probably damaging Het
Nphp3 G T 9: 103,888,929 (GRCm39) V265F probably damaging Het
Or10ak9 T C 4: 118,726,179 (GRCm39) L66P probably damaging Het
Or5p67 A G 7: 107,922,232 (GRCm39) I217T probably benign Het
Or8c16 T C 9: 38,130,131 (GRCm39) M1T probably null Het
Pgp A G 17: 24,690,315 (GRCm39) E247G probably damaging Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Plch1 G A 3: 63,675,044 (GRCm39) A202V probably damaging Het
Rbm11 G A 16: 75,389,932 (GRCm39) probably null Het
Scg5 T C 2: 113,622,230 (GRCm39) K124R probably damaging Het
Serpina3j A T 12: 104,285,916 (GRCm39) H357L probably damaging Het
St6gal2 A G 17: 55,803,324 (GRCm39) D353G possibly damaging Het
Tdpoz3 T C 3: 93,734,216 (GRCm39) I297T possibly damaging Het
Tdrd5 G A 1: 156,128,348 (GRCm39) T136I probably benign Het
Tfcp2l1 T A 1: 118,597,206 (GRCm39) I429K possibly damaging Het
Tnrc6c C T 11: 117,614,355 (GRCm39) R838W probably damaging Het
Top1 T C 2: 160,529,669 (GRCm39) probably benign Het
Trim61 A G 8: 65,465,969 (GRCm39) F431L probably benign Het
Vmn1r183 T C 7: 23,754,997 (GRCm39) S267P probably damaging Het
Xirp2 T A 2: 67,342,013 (GRCm39) F1418Y possibly damaging Het
Zfp114 T C 7: 23,880,467 (GRCm39) V271A possibly damaging Het
Zfp710 A G 7: 79,731,134 (GRCm39) R104G probably damaging Het
Other mutations in Trmo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00593:Trmo APN 4 46,382,490 (GRCm39) missense probably benign
IGL01296:Trmo APN 4 46,387,589 (GRCm39) missense probably damaging 1.00
IGL01308:Trmo APN 4 46,377,053 (GRCm39) utr 3 prime probably benign
IGL01544:Trmo APN 4 46,386,169 (GRCm39) missense probably damaging 1.00
IGL01545:Trmo APN 4 46,386,169 (GRCm39) missense probably damaging 1.00
IGL01722:Trmo APN 4 46,386,092 (GRCm39) critical splice donor site probably null
IGL02085:Trmo APN 4 46,380,217 (GRCm39) missense probably damaging 1.00
IGL02927:Trmo APN 4 46,387,602 (GRCm39) missense probably damaging 1.00
R0645:Trmo UTSW 4 46,377,083 (GRCm39) utr 3 prime probably benign
R0745:Trmo UTSW 4 46,382,104 (GRCm39) missense probably damaging 1.00
R1365:Trmo UTSW 4 46,380,278 (GRCm39) missense probably damaging 1.00
R1835:Trmo UTSW 4 46,380,158 (GRCm39) missense probably damaging 1.00
R3929:Trmo UTSW 4 46,382,647 (GRCm39) missense probably damaging 1.00
R4497:Trmo UTSW 4 46,382,140 (GRCm39) missense probably damaging 1.00
R4938:Trmo UTSW 4 46,382,388 (GRCm39) missense probably benign 0.00
R4980:Trmo UTSW 4 46,389,364 (GRCm39) nonsense probably null
R5209:Trmo UTSW 4 46,387,740 (GRCm39) missense probably damaging 0.99
R5639:Trmo UTSW 4 46,382,073 (GRCm39) missense probably benign 0.00
R5855:Trmo UTSW 4 46,382,568 (GRCm39) missense probably benign 0.43
R6151:Trmo UTSW 4 46,389,390 (GRCm39) missense probably damaging 1.00
R7351:Trmo UTSW 4 46,387,716 (GRCm39) missense possibly damaging 0.78
R8684:Trmo UTSW 4 46,386,253 (GRCm39) critical splice acceptor site probably null
R8684:Trmo UTSW 4 46,386,251 (GRCm39) nonsense probably null
R8823:Trmo UTSW 4 46,382,604 (GRCm39) missense probably damaging 1.00
R8856:Trmo UTSW 4 46,387,625 (GRCm39) missense probably benign 0.01
R9039:Trmo UTSW 4 46,382,322 (GRCm39) missense probably benign 0.00
R9331:Trmo UTSW 4 46,387,642 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- TCTGGCGAGGCTGTACTTTC -3'
(R):5'- ATGACGTGTTCTATGAGAGCCTTG -3'

Sequencing Primer
(F):5'- GAGGCTGTACTTTCCCACG -3'
(R):5'- ACGTGTTCTATGAGAGCCTTGAAGAG -3'
Posted On 2015-04-17