Mutagenetix > Incidental Mutations

Incidental Mutation 'R3933:Vmn2r10'

308550

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

V2r16, VR16

MMRRC Submission

040920-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R3933 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

108993412-109006471 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 109002222 bp

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 319 (A319S)

Ref Sequence

ENSEMBL: ENSMUSP00000078162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079163
AA Change: A319S

PolyPhen 2 Score 0.469 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: A319S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176594

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.1%
20x: 94.1%

Validation Efficiency

96% (43/45)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,354,856	F3350L	probably damaging	Het
Acp6	T	C	3: 97,166,183	V146A	probably benign	Het
Ap3b2	C	T	7: 81,473,850		probably benign	Het
Arhgef33	A	G	17: 80,373,320	I630V	probably benign	Het
Astn2	G	A	4: 66,403,955	R136C	unknown	Het
Bcl2l14	A	G	6: 134,423,808	D64G	probably damaging	Het
C1rl	T	A	6: 124,508,822	L384*	probably null	Het
Ccdc130	G	A	8: 84,260,352	A172V	probably benign	Het
Ccdc6	TCCGCCGCCGCC	TCCGCCGCC	10: 70,189,170		probably benign	Het
Coch	T	C	12: 51,603,338	I370T	probably damaging	Het
Ercc5	T	A	1: 44,167,856	M643K	probably benign	Het
Fut8	A	C	12: 77,475,259	K557N	probably damaging	Het
Hsdl2	T	C	4: 59,597,274	Y88H	probably damaging	Het
Hspg2	T	C	4: 137,515,568	V670A	probably damaging	Het
Itga8	A	G	2: 12,189,519	I690T	probably benign	Het
Lepr	T	C	4: 101,765,301		probably benign	Het
Matn2	T	C	15: 34,345,420		probably null	Het
Mei1	A	G	15: 82,083,152	K310E	possibly damaging	Het
Mrc2	G	A	11: 105,348,431		probably null	Het
Msl3	C	T	X: 168,671,817	A87T	probably damaging	Het
Ogdh	T	C	11: 6,342,601	V438A	possibly damaging	Het
Olfr1109	T	A	2: 87,092,762	I212F	probably benign	Het
Olfr1293-ps	T	C	2: 111,527,955	Y232H	probably damaging	Het
Opa1	A	T	16: 29,610,880	E401D	probably damaging	Het
Parp2	G	A	14: 50,819,387	V323M	probably benign	Het
Pip5k1a	A	G	3: 95,072,003	S161P	probably benign	Het
Pold3	T	C	7: 100,121,401	E8G	probably damaging	Het
Pomt1	G	A	2: 32,245,619	V332I	probably benign	Het
Ppp2ca	T	A	11: 52,119,262	N232K	probably damaging	Het
Prune2	A	T	19: 17,123,954	D2274V	probably damaging	Het
Pwwp2b	G	A	7: 139,256,034	V464I	possibly damaging	Het
Rgs7bp	T	C	13: 105,052,998	M98V	probably benign	Het
Rubcn	A	G	16: 32,829,259		probably null	Het
Scai	A	T	2: 39,075,052	D593E	probably benign	Het
Slc24a2	T	C	4: 87,176,185	T366A	probably benign	Het
Sp100	A	G	1: 85,681,109	I320V	probably benign	Het
Syngr2	C	A	11: 117,813,417	P206Q	probably damaging	Het
Tatdn3	A	T	1: 191,046,324		probably null	Het
Thsd7a	C	T	6: 12,555,226	G220S	probably benign	Het
Tmem28	G	A	X: 99,821,864	V266M	possibly damaging	Het
Vmn2r11	C	T	5: 109,053,394	A415T	probably damaging	Het
Vmn2r88	A	G	14: 51,413,978	M258V	probably benign	Het
Wiz	G	A	17: 32,357,898	R561C	probably damaging	Het
Zfp422	T	C	6: 116,626,459	K193R	probably benign	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Vmn2r10	APN	5	109002585	missense	possibly damaging	0.75
IGL01618:Vmn2r10	APN	5	109002479	missense	probably damaging	1.00
IGL01624:Vmn2r10	APN	5	109006246	missense	possibly damaging	0.83
IGL01941:Vmn2r10	APN	5	108995954	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	108997705	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	108995677	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109006259	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	108995922	nonsense	probably null
IGL02503:Vmn2r10	APN	5	109003475	missense	probably damaging	1.00
IGL03275:Vmn2r10	APN	5	109003377	missense	probably benign	0.00
R0035:Vmn2r10	UTSW	5	108997601	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109001993	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109003461	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	108995916	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	108996024	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109006251	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109001995	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109006254	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109003544	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	108996095	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109002222	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109003458	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	108997726	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109006420	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	108995895	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	108995600	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	108995720	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109006255	missense	probably damaging	1.00
R5321:Vmn2r10	UTSW	5	108995639	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	108999044	nonsense	probably null
R5670:Vmn2r10	UTSW	5	108999044	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109003511	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	108999078	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	108995801	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109003462	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	108996078	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	108995622	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109001979	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109002028	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109003334	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	108996440	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109002089	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	108995770	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	108997706	missense	possibly damaging	0.51
Z1088:Vmn2r10	UTSW	5	108996113	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109001988	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTCCATTCCAATGTGTTGTTGAATG -3'
(R):5'- ACATGCAGTTATATATGACAAGGGC -3'

Sequencing Primer
(F):5'- TCCAATGTGTTGTTGAATGTAAAATG -3'
(R):5'- TTATGGAATCAACAGCAAAGGTTG -3'

Posted On

2015-04-17