Incidental Mutation 'R3929:Vmn2r19'
ID 308631
Institutional Source Beutler Lab
Gene Symbol Vmn2r19
Ensembl Gene ENSMUSG00000091260
Gene Name vomeronasal 2, receptor 19
Synonyms EG232358
MMRRC Submission 040824-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R3929 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 123285292-123313496 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123292587 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 210 (Y210H)
Ref Sequence ENSEMBL: ENSMUSP00000073604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073948]
AlphaFold G5E8G4
Predicted Effect probably benign
Transcript: ENSMUST00000073948
AA Change: Y210H

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: Y210H

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 476 2.9e-35 PFAM
Pfam:NCD3G 518 571 8.3e-23 PFAM
Pfam:7tm_3 603 839 7.2e-52 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak5 A C 3: 152,373,444 (GRCm39) L18R probably damaging Het
Atrx T C X: 104,923,523 (GRCm39) I157V possibly damaging Het
C9 T A 15: 6,496,939 (GRCm39) I212N probably benign Het
Cabin1 T C 10: 75,587,452 (GRCm39) probably null Het
Ccnf A G 17: 24,453,356 (GRCm39) V361A probably damaging Het
Ctps1 T A 4: 120,399,093 (GRCm39) H553L probably benign Het
Dmrta1 C T 4: 89,579,681 (GRCm39) Q214* probably null Het
E230025N22Rik T C 18: 36,824,625 (GRCm39) D112G probably damaging Het
Frat1 T C 19: 41,819,087 (GRCm39) C161R probably damaging Het
H1f8 A G 6: 115,925,757 (GRCm39) K185E probably benign Het
Itpr2 C A 6: 146,275,857 (GRCm39) probably null Het
Klhl40 A G 9: 121,609,742 (GRCm39) D509G probably benign Het
Muc5ac T C 7: 141,356,629 (GRCm39) V1072A probably benign Het
Nav3 A G 10: 109,520,064 (GRCm39) Y2340H probably damaging Het
Or10ak9 T C 4: 118,726,179 (GRCm39) L66P probably damaging Het
Or2y17 A T 11: 49,231,820 (GRCm39) M154L probably benign Het
Or51a43 C T 7: 103,717,791 (GRCm39) C149Y probably benign Het
Or5be3 T A 2: 86,864,428 (GRCm39) I46F possibly damaging Het
Or6c2 G A 10: 129,362,100 (GRCm39) M1I probably null Het
Prdm10 T C 9: 31,258,432 (GRCm39) I619T probably damaging Het
Rp1 T C 1: 4,422,868 (GRCm39) T71A probably damaging Het
Rpusd4 A G 9: 35,183,876 (GRCm39) I202V probably benign Het
Sin3a A G 9: 57,025,421 (GRCm39) N1089S probably damaging Het
St6gal2 A G 17: 55,803,324 (GRCm39) D353G possibly damaging Het
Stap2 A C 17: 56,310,156 (GRCm39) F50V probably damaging Het
Stkld1 T A 2: 26,830,059 (GRCm39) probably null Het
Tars3 A G 7: 65,333,791 (GRCm39) probably null Het
Tbl1xr1 G C 3: 22,243,932 (GRCm39) D69H probably damaging Het
Tnrc6c C T 11: 117,614,355 (GRCm39) R838W probably damaging Het
Trim61 A G 8: 65,465,969 (GRCm39) F431L probably benign Het
Trmo C T 4: 46,382,647 (GRCm39) G150S probably damaging Het
Vmn1r61 A G 7: 5,614,176 (GRCm39) I46T probably benign Het
Xrn1 T C 9: 95,870,926 (GRCm39) S584P possibly damaging Het
Other mutations in Vmn2r19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Vmn2r19 APN 6 123,306,826 (GRCm39) missense possibly damaging 0.92
IGL02294:Vmn2r19 APN 6 123,306,937 (GRCm39) missense probably benign 0.19
IGL02442:Vmn2r19 APN 6 123,286,621 (GRCm39) missense possibly damaging 0.94
IGL02871:Vmn2r19 APN 6 123,313,042 (GRCm39) missense probably damaging 1.00
H8562:Vmn2r19 UTSW 6 123,292,861 (GRCm39) missense possibly damaging 0.82
R0025:Vmn2r19 UTSW 6 123,308,506 (GRCm39) missense probably benign 0.01
R0389:Vmn2r19 UTSW 6 123,312,945 (GRCm39) missense possibly damaging 0.53
R0402:Vmn2r19 UTSW 6 123,313,141 (GRCm39) missense probably damaging 1.00
R0411:Vmn2r19 UTSW 6 123,286,703 (GRCm39) missense probably damaging 0.98
R0554:Vmn2r19 UTSW 6 123,313,102 (GRCm39) missense probably damaging 0.99
R0578:Vmn2r19 UTSW 6 123,312,931 (GRCm39) missense probably damaging 1.00
R1102:Vmn2r19 UTSW 6 123,313,132 (GRCm39) missense probably benign 0.28
R1652:Vmn2r19 UTSW 6 123,292,656 (GRCm39) missense possibly damaging 0.68
R1663:Vmn2r19 UTSW 6 123,313,411 (GRCm39) missense probably benign 0.11
R1817:Vmn2r19 UTSW 6 123,307,011 (GRCm39) missense possibly damaging 0.80
R1866:Vmn2r19 UTSW 6 123,308,597 (GRCm39) critical splice donor site probably null
R1928:Vmn2r19 UTSW 6 123,308,589 (GRCm39) missense probably damaging 1.00
R1997:Vmn2r19 UTSW 6 123,292,880 (GRCm39) missense probably damaging 0.98
R2013:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2015:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2088:Vmn2r19 UTSW 6 123,312,795 (GRCm39) missense probably damaging 1.00
R2126:Vmn2r19 UTSW 6 123,293,033 (GRCm39) missense possibly damaging 0.82
R2128:Vmn2r19 UTSW 6 123,285,289 (GRCm39) splice site probably null
R2256:Vmn2r19 UTSW 6 123,306,845 (GRCm39) missense probably benign 0.20
R2517:Vmn2r19 UTSW 6 123,306,937 (GRCm39) missense probably benign 0.19
R3753:Vmn2r19 UTSW 6 123,292,548 (GRCm39) missense possibly damaging 0.80
R3817:Vmn2r19 UTSW 6 123,286,601 (GRCm39) missense probably damaging 1.00
R3934:Vmn2r19 UTSW 6 123,292,628 (GRCm39) missense probably damaging 1.00
R4232:Vmn2r19 UTSW 6 123,306,871 (GRCm39) missense probably benign
R4574:Vmn2r19 UTSW 6 123,292,939 (GRCm39) missense probably benign 0.01
R4886:Vmn2r19 UTSW 6 123,286,800 (GRCm39) missense probably benign 0.05
R4995:Vmn2r19 UTSW 6 123,306,869 (GRCm39) missense probably benign 0.00
R5107:Vmn2r19 UTSW 6 123,286,602 (GRCm39) nonsense probably null
R5232:Vmn2r19 UTSW 6 123,312,916 (GRCm39) missense probably benign
R6102:Vmn2r19 UTSW 6 123,306,907 (GRCm39) missense probably damaging 1.00
R6105:Vmn2r19 UTSW 6 123,293,054 (GRCm39) missense possibly damaging 0.70
R6280:Vmn2r19 UTSW 6 123,313,212 (GRCm39) missense probably benign
R6393:Vmn2r19 UTSW 6 123,293,112 (GRCm39) missense possibly damaging 0.80
R6502:Vmn2r19 UTSW 6 123,293,067 (GRCm39) missense possibly damaging 0.68
R6617:Vmn2r19 UTSW 6 123,313,494 (GRCm39) makesense probably null
R6742:Vmn2r19 UTSW 6 123,306,917 (GRCm39) missense possibly damaging 0.90
R7662:Vmn2r19 UTSW 6 123,308,521 (GRCm39) missense probably benign 0.33
R8041:Vmn2r19 UTSW 6 123,312,750 (GRCm39) missense possibly damaging 0.94
R8054:Vmn2r19 UTSW 6 123,292,998 (GRCm39) missense probably damaging 1.00
R8074:Vmn2r19 UTSW 6 123,312,904 (GRCm39) missense probably damaging 0.96
R8267:Vmn2r19 UTSW 6 123,313,221 (GRCm39) missense possibly damaging 0.50
R8287:Vmn2r19 UTSW 6 123,308,588 (GRCm39) missense probably damaging 1.00
R8937:Vmn2r19 UTSW 6 123,293,283 (GRCm39) critical splice donor site probably null
R9058:Vmn2r19 UTSW 6 123,313,021 (GRCm39) missense possibly damaging 0.53
R9119:Vmn2r19 UTSW 6 123,292,527 (GRCm39) missense possibly damaging 0.68
R9384:Vmn2r19 UTSW 6 123,292,923 (GRCm39) missense probably benign 0.00
X0058:Vmn2r19 UTSW 6 123,285,308 (GRCm39) missense probably benign 0.00
Z1088:Vmn2r19 UTSW 6 123,285,298 (GRCm39) missense probably benign 0.02
Z1177:Vmn2r19 UTSW 6 123,313,036 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- AGATAGACACTCCGTGACCCTG -3'
(R):5'- CACGTGTCAATGAGAATCTTTCC -3'

Sequencing Primer
(F):5'- ACACTCCGTGACCCTGTTTGATAC -3'
(R):5'- CCATAAAACGTTTCCTGTTTACTGTG -3'
Posted On 2015-04-17