Incidental Mutation 'R3885:Mgst3'
ID 308701
Institutional Source Beutler Lab
Gene Symbol Mgst3
Ensembl Gene ENSMUSG00000026688
Gene Name microsomal glutathione S-transferase 3
Synonyms 2010306B17Rik, GST-III, 2700004G04Rik, 2010012L10Rik
MMRRC Submission 040905-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3885 (G1)
Quality Score 224
Status Validated
Chromosome 1
Chromosomal Location 167199535-167221410 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 167200131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 135 (Q135K)
Ref Sequence ENSEMBL: ENSMUSP00000028005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028004] [ENSMUST00000028005]
AlphaFold Q9CPU4
Predicted Effect probably benign
Transcript: ENSMUST00000028004
SMART Domains Protein: ENSMUSP00000028004
Gene: ENSMUSG00000026687

DomainStartEndE-ValueType
Pfam:Aldedh 46 507 1.5e-174 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000028005
AA Change: Q135K

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000028005
Gene: ENSMUSG00000026688
AA Change: Q135K

DomainStartEndE-ValueType
Pfam:MAPEG 11 134 8.9e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191715
Meta Mutation Damage Score 0.0770 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 95% (40/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak8 G A 2: 28,623,897 (GRCm39) V161I possibly damaging Het
Ank3 A T 10: 69,734,866 (GRCm39) I792F probably damaging Het
B930094E09Rik G A 18: 31,742,742 (GRCm39) S59N unknown Het
Boc T C 16: 44,307,976 (GRCm39) probably benign Het
Bptf G A 11: 106,965,339 (GRCm39) T1170M probably damaging Het
Ccdc85a T A 11: 28,526,677 (GRCm39) E310D probably benign Het
Cfap221 A G 1: 119,881,876 (GRCm39) probably null Het
Dmxl1 T A 18: 50,011,326 (GRCm39) M1161K probably damaging Het
Eif2ak1 A T 5: 143,821,479 (GRCm39) Q265L probably benign Het
Eif2s1 T A 12: 78,927,999 (GRCm39) I225N probably damaging Het
Ephb2 C T 4: 136,498,345 (GRCm39) G245S probably damaging Het
Exoc4 T C 6: 33,243,066 (GRCm39) probably null Het
Foxd2 T C 4: 114,765,483 (GRCm39) H179R unknown Het
Gck T C 11: 5,860,318 (GRCm39) Y108C probably damaging Het
Gjc3 T A 5: 137,956,105 (GRCm39) N60I possibly damaging Het
Gm5145 A T 17: 20,791,272 (GRCm39) T217S probably benign Het
Gpc5 T C 14: 115,607,472 (GRCm39) M358T probably benign Het
Gpr150 T C 13: 76,204,657 (GRCm39) Q96R probably damaging Het
H2ac22 A G 13: 21,971,039 (GRCm39) L117P probably damaging Het
H2ac8 G T 13: 23,755,053 (GRCm39) T77K possibly damaging Het
Itga2 A T 13: 115,005,835 (GRCm39) H448Q probably benign Het
Lcor T A 19: 41,546,795 (GRCm39) S126R probably damaging Het
Lrch2 C G X: 146,256,003 (GRCm39) A437P probably damaging Het
Lrriq1 T C 10: 103,051,967 (GRCm39) I262V probably damaging Het
Nrxn1 T A 17: 90,930,899 (GRCm39) T766S probably damaging Het
Or11j4 A T 14: 50,630,326 (GRCm39) I38F probably benign Het
Ovch2 A G 7: 107,395,775 (GRCm39) I81T probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rictor A T 15: 6,789,091 (GRCm39) N236Y probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rreb1 G T 13: 38,077,941 (GRCm39) R51L probably damaging Het
Senp7 A G 16: 56,006,442 (GRCm39) E922G probably damaging Het
Slc15a2 A G 16: 36,602,666 (GRCm39) F65S probably damaging Het
Slitrk5 T A 14: 111,917,229 (GRCm39) C284* probably null Het
Steap4 G T 5: 8,030,494 (GRCm39) R450L probably damaging Het
Usp40 A T 1: 87,894,991 (GRCm39) L843Q probably damaging Het
Vmn2r97 C T 17: 19,148,596 (GRCm39) L164F possibly damaging Het
Wiz G T 17: 32,576,012 (GRCm39) A798E possibly damaging Het
Other mutations in Mgst3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Mgst3 UTSW 1 167,201,374 (GRCm39) missense probably damaging 1.00
R1283:Mgst3 UTSW 1 167,205,865 (GRCm39) missense possibly damaging 0.74
R1594:Mgst3 UTSW 1 167,201,379 (GRCm39) missense probably damaging 0.99
R2267:Mgst3 UTSW 1 167,201,368 (GRCm39) missense probably benign 0.23
R4659:Mgst3 UTSW 1 167,204,848 (GRCm39) missense probably damaging 1.00
R6139:Mgst3 UTSW 1 167,205,874 (GRCm39) missense possibly damaging 0.95
R8778:Mgst3 UTSW 1 167,203,032 (GRCm39) missense probably benign 0.00
R9251:Mgst3 UTSW 1 167,205,860 (GRCm39) critical splice donor site probably null
R9374:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
R9551:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
R9552:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGGAGCTTTAGGTATGAGGC -3'
(R):5'- TCTAGCGTACTGGTGGCTCTAG -3'

Sequencing Primer
(F):5'- AGCTTTAGGTATGAGGCTGATGC -3'
(R):5'- TAGAGTTGGCCAACCTCCC -3'
Posted On 2015-04-17