Incidental Mutation 'R3881:Or10ak9'
ID 308752
Institutional Source Beutler Lab
Gene Symbol Or10ak9
Ensembl Gene ENSMUSG00000073769
Gene Name olfactory receptor family 10 subfamily AK member 9
Synonyms MOR259-3P, GA_x6K02T2QD9B-18670866-18669913, Olfr1331
MMRRC Submission 040795-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R3881 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 118725980-118726933 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118726550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 191 (M191V)
Ref Sequence ENSEMBL: ENSMUSP00000101967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]
AlphaFold K7N684
Predicted Effect probably benign
Transcript: ENSMUST00000094831
AA Change: M191V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: M191V

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.1e-53 PFAM
Pfam:7tm_1 42 291 3.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106360
AA Change: M191V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: M191V

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.2e-28 PFAM
Pfam:7tm_4 139 283 2.8e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216589
AA Change: M190V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010003K11Rik T G 19: 4,548,417 (GRCm39) K44T possibly damaging Het
4933402N03Rik T C 7: 130,740,823 (GRCm39) E131G probably benign Het
Angptl4 G A 17: 33,996,008 (GRCm39) P323S possibly damaging Het
Cep41 A G 6: 30,658,397 (GRCm39) S201P probably damaging Het
Cep95 A G 11: 106,697,118 (GRCm39) I257V probably damaging Het
Clca4a T C 3: 144,663,079 (GRCm39) N590S probably benign Het
Cyfip2 A G 11: 46,099,162 (GRCm39) L716P probably damaging Het
Cyp2d34 T A 15: 82,502,818 (GRCm39) Q136L probably benign Het
Def6 T C 17: 28,439,189 (GRCm39) C267R probably damaging Het
Dgat2 G A 7: 98,818,950 (GRCm39) Q69* probably null Het
Dlgap1 T A 17: 71,093,810 (GRCm39) S710R probably damaging Het
Dnah10 T C 5: 124,850,095 (GRCm39) I1539T probably benign Het
Dnah2 T A 11: 69,342,173 (GRCm39) I2932F possibly damaging Het
Enpp2 A G 15: 54,783,088 (GRCm39) S76P probably damaging Het
Esr2 T C 12: 76,214,394 (GRCm39) D19G probably damaging Het
Fam13b A T 18: 34,595,112 (GRCm39) probably null Het
Fbxw14 A T 9: 109,100,262 (GRCm39) V464D possibly damaging Het
Fcgbpl1 T A 7: 27,839,463 (GRCm39) C425* probably null Het
Gm21961 A G 15: 64,886,716 (GRCm39) probably null Het
Gpd2 C T 2: 57,228,987 (GRCm39) R264* probably null Het
Hps5 A G 7: 46,421,420 (GRCm39) V648A possibly damaging Het
Ints4 A G 7: 97,165,464 (GRCm39) T517A possibly damaging Het
Itpr3 A G 17: 27,332,814 (GRCm39) N1860S probably benign Het
Itsn2 G A 12: 4,684,546 (GRCm39) probably benign Het
Jup A G 11: 100,269,207 (GRCm39) V402A probably benign Het
Letm2 C A 8: 26,083,884 (GRCm39) E116* probably null Het
Ly6c1 T C 15: 74,917,436 (GRCm39) T71A probably benign Het
Mcm3ap G A 10: 76,342,280 (GRCm39) S1591N probably benign Het
Mier2 C T 10: 79,384,584 (GRCm39) probably null Het
Mocs2 T A 13: 114,955,882 (GRCm39) L10* probably null Het
Myo6 A G 9: 80,171,538 (GRCm39) D513G probably damaging Het
Myoz2 T C 3: 122,807,369 (GRCm39) Y147C probably damaging Het
Nin C T 12: 70,089,315 (GRCm39) V1367M probably benign Het
Nr2f6 C T 8: 71,828,675 (GRCm39) A200T probably damaging Het
Obscn C T 11: 58,947,775 (GRCm39) C4418Y probably damaging Het
Or10q12 T C 19: 13,746,144 (GRCm39) V146A probably benign Het
Or5g26 T A 2: 85,494,769 (GRCm39) H3L probably benign Het
Paxip1 C T 5: 27,953,837 (GRCm39) R953Q probably damaging Het
Pcdha1 A T 18: 37,064,454 (GRCm39) I373F possibly damaging Het
Pcdha7 G A 18: 37,108,432 (GRCm39) E486K probably benign Het
Recql5 G A 11: 115,784,780 (GRCm39) P849L probably benign Het
Recql5 G T 11: 115,784,781 (GRCm39) P849T probably benign Het
Rnf180 A T 13: 105,386,915 (GRCm39) M131K possibly damaging Het
Rplp1 A G 9: 61,821,704 (GRCm39) S3P probably benign Het
Rpp38 T A 2: 3,330,283 (GRCm39) R206S probably benign Het
Sdha G T 13: 74,487,311 (GRCm39) P159Q probably damaging Het
Shank2 T C 7: 143,959,121 (GRCm39) V199A probably benign Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Timm50 C A 7: 28,010,432 (GRCm39) A41S probably benign Het
Tmbim1 A G 1: 74,329,157 (GRCm39) probably benign Het
Tmprss11a C T 5: 86,593,664 (GRCm39) V29M possibly damaging Het
Ttc28 A T 5: 111,331,106 (GRCm39) H411L probably damaging Het
Ube4b A T 4: 149,449,861 (GRCm39) probably null Het
Zdhhc22 T A 12: 87,030,400 (GRCm39) M183L probably benign Het
Zfp106 A G 2: 120,362,630 (GRCm39) S830P probably benign Het
Other mutations in Or10ak9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Or10ak9 APN 4 118,726,484 (GRCm39) missense probably damaging 1.00
IGL01314:Or10ak9 APN 4 118,726,328 (GRCm39) missense probably benign 0.26
IGL02025:Or10ak9 APN 4 118,726,362 (GRCm39) missense probably damaging 1.00
IGL02458:Or10ak9 APN 4 118,726,497 (GRCm39) missense possibly damaging 0.83
IGL02793:Or10ak9 APN 4 118,726,794 (GRCm39) missense probably damaging 1.00
IGL02827:Or10ak9 APN 4 118,726,157 (GRCm39) missense probably damaging 0.99
IGL02863:Or10ak9 APN 4 118,726,083 (GRCm39) missense possibly damaging 0.52
IGL03125:Or10ak9 APN 4 118,726,118 (GRCm39) missense possibly damaging 0.95
R0078:Or10ak9 UTSW 4 118,726,424 (GRCm39) missense probably benign
R0152:Or10ak9 UTSW 4 118,726,083 (GRCm39) missense possibly damaging 0.89
R0299:Or10ak9 UTSW 4 118,726,613 (GRCm39) missense probably benign 0.00
R3928:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R3929:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R5288:Or10ak9 UTSW 4 118,726,772 (GRCm39) missense probably damaging 1.00
R5552:Or10ak9 UTSW 4 118,726,665 (GRCm39) missense probably damaging 1.00
R5672:Or10ak9 UTSW 4 118,726,379 (GRCm39) missense possibly damaging 0.83
R5773:Or10ak9 UTSW 4 118,726,718 (GRCm39) missense probably damaging 0.97
R6117:Or10ak9 UTSW 4 118,726,341 (GRCm39) missense probably benign 0.39
R6910:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6911:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6912:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R7164:Or10ak9 UTSW 4 118,726,922 (GRCm39) missense probably benign 0.30
R7446:Or10ak9 UTSW 4 118,726,019 (GRCm39) missense possibly damaging 0.83
R9747:Or10ak9 UTSW 4 118,726,217 (GRCm39) missense probably damaging 1.00
T0975:Or10ak9 UTSW 4 118,726,500 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGCCATTTGCTATCCACTGAG -3'
(R):5'- TGTAAGTGGCTGGAGCATAG -3'

Sequencing Primer
(F):5'- GAGCTATACTGTCATCCTCAACTGGG -3'
(R):5'- CTGGAGCATAGAAGAATGTGACCAC -3'
Posted On 2015-04-17