Incidental Mutation 'R3883:Or13p5'
ID 308811
Institutional Source Beutler Lab
Gene Symbol Or13p5
Ensembl Gene ENSMUSG00000070820
Gene Name olfactory receptor family 13 subfamily P member 5
Synonyms Olfr1339, MOR258-2, GA_x6K02T2QD9B-18815145-18814198
MMRRC Submission 040796-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R3883 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 118591728-118592675 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118591882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 52 (I52T)
Ref Sequence ENSEMBL: ENSMUSP00000148988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094832] [ENSMUST00000217522]
AlphaFold Q8VGB1
Predicted Effect probably benign
Transcript: ENSMUST00000094832
AA Change: I52T

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000092428
Gene: ENSMUSG00000070820
AA Change: I52T

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 307 4.1e-7 PFAM
Pfam:7tm_1 44 293 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217522
AA Change: I52T

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl1 C T 8: 46,980,228 (GRCm39) S423L probably benign Het
Ankmy1 T G 1: 92,813,874 (GRCm39) E435A probably damaging Het
Ano5 T A 7: 51,216,052 (GRCm39) M343K probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
C3 T C 17: 57,524,173 (GRCm39) probably null Het
Cdk17 T C 10: 93,047,939 (GRCm39) probably null Het
Cntn2 A G 1: 132,456,677 (GRCm39) V123A probably damaging Het
Cracd T A 5: 77,004,421 (GRCm39) W261R unknown Het
Dchs1 A G 7: 105,411,770 (GRCm39) Y1449H probably damaging Het
Ddx42 T A 11: 106,138,518 (GRCm39) N772K probably benign Het
Dnah11 T C 12: 117,942,188 (GRCm39) probably benign Het
Edn1 T A 13: 42,455,382 (GRCm39) F4L probably benign Het
Epb41l3 C T 17: 69,581,111 (GRCm39) R552* probably null Het
Epc1 T C 18: 6,452,258 (GRCm39) D267G possibly damaging Het
Fbxo22 A T 9: 55,130,546 (GRCm39) T169S probably benign Het
Fmnl1 A G 11: 103,072,940 (GRCm39) N144D probably damaging Het
Folh1 A G 7: 86,424,864 (GRCm39) L35P possibly damaging Het
Gm10220 A C 5: 26,321,908 (GRCm39) S255A possibly damaging Het
Gm15446 G T 5: 110,088,313 (GRCm39) V9L probably damaging Het
Hipk2 A G 6: 38,676,200 (GRCm39) L1011P probably damaging Het
Kif4-ps G T 12: 101,112,473 (GRCm39) V201L probably damaging Het
Klk1b16 T C 7: 43,788,887 (GRCm39) V40A possibly damaging Het
Lgsn C A 1: 31,215,540 (GRCm39) D3E probably benign Het
Mavs T C 2: 131,087,218 (GRCm39) S239P probably benign Het
Mrtfb T A 16: 13,219,322 (GRCm39) V667D probably damaging Het
Mtrf1 A G 14: 79,656,707 (GRCm39) Y403C probably damaging Het
Mycbp2 A C 14: 103,532,686 (GRCm39) L390V probably damaging Het
Neto2 A G 8: 86,389,894 (GRCm39) S190P probably damaging Het
Ngly1 A G 14: 16,270,574 (GRCm38) I195V probably damaging Het
Or10d4c A G 9: 39,558,420 (GRCm39) I133V probably benign Het
Pde4dip T C 3: 97,620,504 (GRCm39) K1632E probably damaging Het
Pigk T C 3: 152,419,832 (GRCm39) S21P probably benign Het
Rabggtb A G 3: 153,616,417 (GRCm39) F82L probably damaging Het
Reep6 G A 10: 80,171,369 (GRCm39) R415Q probably benign Het
Serpinb13 T C 1: 106,926,302 (GRCm39) V159A probably benign Het
Slc5a8 T A 10: 88,738,325 (GRCm39) M196K possibly damaging Het
Sprr1a G A 3: 92,391,827 (GRCm39) P58L probably damaging Het
Taf1a A T 1: 183,172,288 (GRCm39) T10S possibly damaging Het
Tap1 T A 17: 34,412,232 (GRCm39) V479E probably damaging Het
Trpm4 C T 7: 44,971,422 (GRCm39) probably null Het
Ush2a T C 1: 187,995,579 (GRCm39) Y117H probably benign Het
Vmn2r58 A T 7: 41,513,914 (GRCm39) L243* probably null Het
Zbtb32 A G 7: 30,290,569 (GRCm39) I242T probably benign Het
Zbtb7a T C 10: 80,983,859 (GRCm39) C434R probably damaging Het
Other mutations in Or13p5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Or13p5 APN 4 118,591,803 (GRCm39) missense probably benign 0.01
R0433:Or13p5 UTSW 4 118,592,287 (GRCm39) missense probably benign 0.20
R0600:Or13p5 UTSW 4 118,591,986 (GRCm39) missense probably damaging 0.99
R0737:Or13p5 UTSW 4 118,592,421 (GRCm39) missense probably benign 0.01
R1167:Or13p5 UTSW 4 118,591,829 (GRCm39) missense possibly damaging 0.83
R1655:Or13p5 UTSW 4 118,592,196 (GRCm39) missense probably benign 0.18
R2152:Or13p5 UTSW 4 118,592,446 (GRCm39) missense possibly damaging 0.90
R4715:Or13p5 UTSW 4 118,591,852 (GRCm39) missense probably damaging 1.00
R4750:Or13p5 UTSW 4 118,591,930 (GRCm39) missense possibly damaging 0.66
R4887:Or13p5 UTSW 4 118,591,885 (GRCm39) missense probably benign 0.20
R4888:Or13p5 UTSW 4 118,591,885 (GRCm39) missense probably benign 0.20
R5624:Or13p5 UTSW 4 118,592,568 (GRCm39) missense probably damaging 1.00
R7268:Or13p5 UTSW 4 118,592,605 (GRCm39) missense probably damaging 1.00
R7783:Or13p5 UTSW 4 118,592,099 (GRCm39) missense probably damaging 1.00
R7796:Or13p5 UTSW 4 118,591,882 (GRCm39) missense probably damaging 0.97
R8676:Or13p5 UTSW 4 118,592,235 (GRCm39) missense probably damaging 1.00
Z1177:Or13p5 UTSW 4 118,592,653 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGCGTTCTAAGATGTGCCAC -3'
(R):5'- GAACAACCAGCCCTCAGTGATG -3'

Sequencing Primer
(F):5'- CTAAGATGTGCCACTAGGTCC -3'
(R):5'- GCCCTCAGTGATGCCTAAC -3'
Posted On 2015-04-17